ZA201804568B - Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity - Google Patents
Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activityInfo
- Publication number
- ZA201804568B ZA201804568B ZA2018/04568A ZA201804568A ZA201804568B ZA 201804568 B ZA201804568 B ZA 201804568B ZA 2018/04568 A ZA2018/04568 A ZA 2018/04568A ZA 201804568 A ZA201804568 A ZA 201804568A ZA 201804568 B ZA201804568 B ZA 201804568B
- Authority
- ZA
- South Africa
- Prior art keywords
- inhibitors
- histone deacetylase
- acids useful
- hydroxamic acids
- deacetylase activity
- Prior art date
Links
- -1 Bicyclic hydroxamic acids Chemical class 0.000 title 1
- 102000003964 Histone deacetylase Human genes 0.000 title 1
- 108090000353 Histone deacetylase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
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- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
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| EP15201841 | 2015-12-22 | ||
| PCT/EP2016/077914 WO2017108282A1 (en) | 2015-12-22 | 2016-11-16 | Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity |
Publications (1)
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| ZA201804568B true ZA201804568B (en) | 2019-09-25 |
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| ZA2018/04568A ZA201804568B (en) | 2015-12-22 | 2018-07-09 | Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity |
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| US (1) | US10654814B2 (enExample) |
| EP (1) | EP3394052B1 (enExample) |
| JP (1) | JP6927589B2 (enExample) |
| KR (1) | KR20180098593A (enExample) |
| CN (1) | CN108602812B (enExample) |
| AU (1) | AU2016375634B2 (enExample) |
| CA (1) | CA3007025A1 (enExample) |
| ES (1) | ES2893099T3 (enExample) |
| RU (1) | RU2747431C2 (enExample) |
| WO (1) | WO2017108282A1 (enExample) |
| ZA (1) | ZA201804568B (enExample) |
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| TW201946624A (zh) * | 2018-05-09 | 2019-12-16 | 新旭生技股份有限公司 | 雜芳基化合物及其用途 |
| KR20210068399A (ko) * | 2018-08-06 | 2021-06-09 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티 | 신경퇴행성 질병의 치료를 위한 피피에이알지씨1알파 활성제로서 2-아릴벤즈이미다졸 |
| US11524959B1 (en) | 2018-08-08 | 2022-12-13 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of pad enzymes |
| ES2929200T3 (es) | 2018-08-08 | 2022-11-25 | Bristol Myers Squibb Co | Tienopirroles sustituidos como inhibidores de PAD4 |
| KR102146741B1 (ko) * | 2018-10-31 | 2020-08-21 | 계명대학교 산학협력단 | 항바이러스 조성물 |
| KR20200061310A (ko) * | 2018-11-23 | 2020-06-02 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제를 포함하는 약학적 조성물 |
| AU2020407664A1 (en) | 2019-12-20 | 2022-08-18 | Tenaya Therapeutics, Inc. | Fluoroalkyl-oxadiazoles and uses thereof |
| TW202140477A (zh) * | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環pad4抑制劑 |
| EP4161908A1 (en) * | 2020-06-08 | 2023-04-12 | Annji Pharmaceutical Co., Ltd. | Quinazoline derivatives useful as selective hdac6 inhibitors |
| CN112516142B (zh) * | 2020-12-11 | 2021-10-15 | 北京华氏精恒医药科技有限公司 | 一种具有hdac抑制活性的药物组合物、制备方法及其用途 |
| IL307883A (en) | 2021-04-23 | 2023-12-01 | Tenaya Therapeutics Inc | HDAC6 inhibitors for use in the treatment of dilated myocardial disease |
| EP4333841A1 (en) | 2021-05-04 | 2024-03-13 | Tenaya Therapeutics, Inc. | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
| CN114409638B (zh) * | 2022-02-09 | 2023-02-14 | 深圳大学 | 组蛋白去乙酰化酶8选择性降解剂、制备方法及其在抗肿瘤活性中的应用 |
| CN119212701A (zh) * | 2022-03-17 | 2024-12-27 | 淑明女子大学校 产学协力团 | 新型组蛋白脱乙酰酶杂环抑制剂及包含该抑制剂的药物组合物 |
| WO2025215092A1 (en) | 2024-04-10 | 2025-10-16 | Institut National de la Santé et de la Recherche Médicale | Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1 |
| CN118459418B (zh) * | 2024-04-26 | 2025-04-08 | 河北中医药大学 | 一种异羟肟酸类hdac抑制剂及其在制备抗肿瘤药物中的应用 |
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| US6861533B2 (en) | 2001-11-23 | 2005-03-01 | Irm Llc | Solution phase sythesis of arylbenzoxazoles |
| TWI349664B (en) * | 2003-09-22 | 2011-10-01 | S Bio Pte Ltd | Benzimidazole derivatives: preparation and pharmaceutical applications |
| CN100546980C (zh) * | 2003-09-22 | 2009-10-07 | S*Bio私人有限公司 | 苯并咪唑衍生物:制备方法及医药应用 |
| US20050137234A1 (en) * | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
| ITFI20050041A1 (it) * | 2005-03-15 | 2006-09-16 | Menarini Internat Operations Luxembourg Sa | Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono |
| KR101524817B1 (ko) | 2007-04-18 | 2015-06-01 | 깃세이 야쿠힌 고교 가부시키가이샤 | 질소 함유 축합환 유도체, 그것을 함유하는 의약 조성물 및 그 의약 용도 |
| WO2008129276A1 (en) | 2007-04-19 | 2008-10-30 | Boehringer Ingelheim International Gmbh | Disulfonamides useful in the treatment of inflammation |
| EP2217588A4 (en) * | 2007-11-02 | 2013-12-04 | Methylgene Inc | INHIBITORS OF HISTONE DEACETYLASE |
| UA103013C2 (uk) | 2007-12-06 | 2013-09-10 | Тиботек Фармасьютикелз | Амідні сполуки як активатори противірусних препаратів |
| WO2009129335A2 (en) * | 2008-04-15 | 2009-10-22 | Pharmacyclics, Inc. | Selective inhibitors of histone deacetylase |
| TW201028399A (en) * | 2008-11-27 | 2010-08-01 | Shionogi & Co | Pyrimidine derivative and pyridine derivative both having pi3k inhibitory activity |
| US20120015943A1 (en) * | 2010-07-19 | 2012-01-19 | Millennium Pharmacuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8987314B2 (en) | 2012-07-19 | 2015-03-24 | Bristol-Myers Squibb Company | Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase |
| RU2016111675A (ru) | 2013-08-30 | 2017-10-04 | Эмбит Байосайенсиз Корпорейшн | Соединения биарилацетамида и способы их применения |
| ES2694053T3 (es) | 2014-03-12 | 2018-12-17 | Chong Kun Dang Pharmaceutical Corp. | Compuestos novedosos como inhibidores de histona desacetilasa 6 y composiciones farmacéuticas que comprenden los mismos |
| EP3152190B1 (en) * | 2014-06-04 | 2024-07-31 | Haro Pharmaceutical Inc. | 18-20 member bi-polycyclic compounds |
| WO2016180472A1 (en) | 2015-05-11 | 2016-11-17 | Kancera Ab | Benzimidazole derivates useful as inhibitors of mammalian histone deacetylase activity |
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2016
- 2016-11-16 RU RU2018126815A patent/RU2747431C2/ru active
- 2016-11-16 AU AU2016375634A patent/AU2016375634B2/en not_active Ceased
- 2016-11-16 JP JP2018532429A patent/JP6927589B2/ja not_active Expired - Fee Related
- 2016-11-16 CA CA3007025A patent/CA3007025A1/en not_active Abandoned
- 2016-11-16 ES ES16797555T patent/ES2893099T3/es active Active
- 2016-11-16 WO PCT/EP2016/077914 patent/WO2017108282A1/en not_active Ceased
- 2016-11-16 US US16/063,682 patent/US10654814B2/en not_active Expired - Fee Related
- 2016-11-16 CN CN201680072487.1A patent/CN108602812B/zh not_active Expired - Fee Related
- 2016-11-16 EP EP16797555.6A patent/EP3394052B1/en active Active
- 2016-11-16 KR KR1020187021065A patent/KR20180098593A/ko not_active Withdrawn
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2018
- 2018-07-09 ZA ZA2018/04568A patent/ZA201804568B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3394052A1 (en) | 2018-10-31 |
| JP6927589B2 (ja) | 2021-09-01 |
| CN108602812A (zh) | 2018-09-28 |
| AU2016375634B2 (en) | 2021-03-25 |
| RU2747431C2 (ru) | 2021-05-05 |
| EP3394052B1 (en) | 2021-07-28 |
| AU2016375634A1 (en) | 2018-07-26 |
| RU2018126815A (ru) | 2020-01-23 |
| JP2019505500A (ja) | 2019-02-28 |
| US10654814B2 (en) | 2020-05-19 |
| CA3007025A1 (en) | 2017-06-29 |
| WO2017108282A1 (en) | 2017-06-29 |
| ES2893099T3 (es) | 2022-02-08 |
| RU2018126815A3 (enExample) | 2020-01-31 |
| US20190284147A1 (en) | 2019-09-19 |
| CN108602812B (zh) | 2021-11-02 |
| KR20180098593A (ko) | 2018-09-04 |
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