AU2016375634B2 - Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity - Google Patents
Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity Download PDFInfo
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- AU2016375634B2 AU2016375634B2 AU2016375634A AU2016375634A AU2016375634B2 AU 2016375634 B2 AU2016375634 B2 AU 2016375634B2 AU 2016375634 A AU2016375634 A AU 2016375634A AU 2016375634 A AU2016375634 A AU 2016375634A AU 2016375634 B2 AU2016375634 B2 AU 2016375634B2
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- hydroxy
- carboxamide
- benzoxazole
- phenyl
- alkyl
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- Chemical & Material Sciences (AREA)
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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| PCT/EP2016/077914 WO2017108282A1 (en) | 2015-12-22 | 2016-11-16 | Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity |
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| AU2016375634A1 AU2016375634A1 (en) | 2018-07-26 |
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| JP7293343B2 (ja) * | 2018-05-09 | 2023-06-19 | アプリノイア セラピューティクス リミテッド | ヘテロアリール化合物及びその使用 |
| EP3833344A4 (en) * | 2018-08-06 | 2022-07-06 | The Board of Trustees of the Leland Stanford Junior University | 2-ARYLBENZIMIDAZOLES USEFUL AS PPARGC1A ACTIVATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
| CN112566916B (zh) | 2018-08-08 | 2023-10-20 | 百时美施贵宝公司 | 作为pad4抑制剂的经取代的噻吩并吡咯 |
| EP3833440A1 (en) | 2018-08-08 | 2021-06-16 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of pad enzymes |
| KR102146741B1 (ko) * | 2018-10-31 | 2020-08-21 | 계명대학교 산학협력단 | 항바이러스 조성물 |
| EP3883572A4 (en) * | 2018-11-23 | 2022-11-30 | Chong Kun Dang Pharmaceutical Corp. | PHARMACEUTICAL COMPOSITION WITH HISTONE DEACETYLASE-6 INHIBITORS |
| CR20220325A (es) | 2019-12-20 | 2022-08-19 | Tenaya Therapeutics Inc | Fluoroalquil-oxadiazoles y sus usos |
| TW202140477A (zh) * | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環pad4抑制劑 |
| JP2023530788A (ja) * | 2020-06-08 | 2023-07-19 | アンジー ファーマシューティカル カンパニー リミテッド | 選択的hdac6阻害剤として有用なキナゾリン誘導体 |
| CN112516142B (zh) * | 2020-12-11 | 2021-10-15 | 北京华氏精恒医药科技有限公司 | 一种具有hdac抑制活性的药物组合物、制备方法及其用途 |
| IL307883A (en) | 2021-04-23 | 2023-12-01 | Tenaya Therapeutics Inc | HDAC6 inhibitors for use in the treatment of dilated myocardial disease |
| CA3216768A1 (en) | 2021-05-04 | 2022-11-10 | Jin Yang | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
| CN114409638B (zh) * | 2022-02-09 | 2023-02-14 | 深圳大学 | 组蛋白去乙酰化酶8选择性降解剂、制备方法及其在抗肿瘤活性中的应用 |
| CA3254742A1 (en) * | 2022-03-17 | 2025-03-04 | Univ Sookmyung Womens Ind Acad Coop Found | NEW HETEROCYCLIC HISTONE DEACETYLASE INHIBITOR, AND PHARMACEUTICAL COMPOSITION INCLUDING IT |
| WO2025160629A1 (en) * | 2024-01-31 | 2025-08-07 | Certa Therapeutics Pty Ltd | Proton sensing gpcr modulators |
| WO2025215092A1 (en) | 2024-04-10 | 2025-10-16 | Institut National de la Santé et de la Recherche Médicale | Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1 |
| CN118459418B (zh) * | 2024-04-26 | 2025-04-08 | 河北中医药大学 | 一种异羟肟酸类hdac抑制剂及其在制备抗肿瘤药物中的应用 |
Citations (1)
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| WO2005066151A2 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
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| US6861533B2 (en) | 2001-11-23 | 2005-03-01 | Irm Llc | Solution phase sythesis of arylbenzoxazoles |
| MY142589A (en) * | 2003-09-22 | 2010-12-15 | S Bio Pte Ltd | Benzimidazole derivatives : preparation and pharmaceutical applications |
| ZA200602181B (en) * | 2003-09-22 | 2007-06-27 | S Bio Pte Ltd | Benzimidazole derivatives: Preparation and pharmaceutical applications |
| ITFI20050041A1 (it) * | 2005-03-15 | 2006-09-16 | Menarini Internat Operations Luxembourg Sa | Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono |
| JP5313883B2 (ja) | 2007-04-18 | 2013-10-09 | キッセイ薬品工業株式会社 | 含窒素縮合環誘導体、それを含有する医薬組成物及びその医薬用途 |
| WO2008129276A1 (en) | 2007-04-19 | 2008-10-30 | Boehringer Ingelheim International Gmbh | Disulfonamides useful in the treatment of inflammation |
| RU2501787C2 (ru) | 2007-11-02 | 2013-12-20 | Метилджен Инк. | Ингибиторы гистондеацетилазы |
| UA103013C2 (uk) | 2007-12-06 | 2013-09-10 | Тиботек Фармасьютикелз | Амідні сполуки як активатори противірусних препаратів |
| US8466193B2 (en) * | 2008-04-15 | 2013-06-18 | Pharmacyclics, Inc. | Selective inhibitors of histone deacetylase |
| WO2010061903A1 (ja) | 2008-11-27 | 2010-06-03 | 塩野義製薬株式会社 | Pi3k阻害活性を有するピリミジン誘導体およびピリジン誘導体 |
| US20120015943A1 (en) | 2010-07-19 | 2012-01-19 | Millennium Pharmacuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2014015088A1 (en) | 2012-07-19 | 2014-01-23 | Bristol-Myers Squibb Company | Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase |
| RU2016111675A (ru) | 2013-08-30 | 2017-10-04 | Эмбит Байосайенсиз Корпорейшн | Соединения биарилацетамида и способы их применения |
| EP3116859B1 (en) | 2014-03-12 | 2018-08-01 | Chong Kun Dang Pharmaceutical Corp. | Novel compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same |
| WO2015188015A1 (en) | 2014-06-04 | 2015-12-10 | Haro Pharmaceutical Inc. | 18-20 member bi-polycyclic compounds |
| WO2016180472A1 (en) | 2015-05-11 | 2016-11-17 | Kancera Ab | Benzimidazole derivates useful as inhibitors of mammalian histone deacetylase activity |
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- 2016-11-16 CN CN201680072487.1A patent/CN108602812B/zh not_active Expired - Fee Related
- 2016-11-16 US US16/063,682 patent/US10654814B2/en not_active Expired - Fee Related
- 2016-11-16 ES ES16797555T patent/ES2893099T3/es active Active
- 2016-11-16 JP JP2018532429A patent/JP6927589B2/ja not_active Expired - Fee Related
- 2016-11-16 AU AU2016375634A patent/AU2016375634B2/en not_active Ceased
- 2016-11-16 WO PCT/EP2016/077914 patent/WO2017108282A1/en not_active Ceased
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- 2016-11-16 RU RU2018126815A patent/RU2747431C2/ru active
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2018
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005066151A2 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
Also Published As
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| EP3394052B1 (en) | 2021-07-28 |
| KR20180098593A (ko) | 2018-09-04 |
| US10654814B2 (en) | 2020-05-19 |
| RU2018126815A3 (enExample) | 2020-01-31 |
| WO2017108282A1 (en) | 2017-06-29 |
| CN108602812A (zh) | 2018-09-28 |
| RU2747431C2 (ru) | 2021-05-05 |
| RU2018126815A (ru) | 2020-01-23 |
| JP6927589B2 (ja) | 2021-09-01 |
| JP2019505500A (ja) | 2019-02-28 |
| US20190284147A1 (en) | 2019-09-19 |
| EP3394052A1 (en) | 2018-10-31 |
| ES2893099T3 (es) | 2022-02-08 |
| AU2016375634A1 (en) | 2018-07-26 |
| CN108602812B (zh) | 2021-11-02 |
| ZA201804568B (en) | 2019-09-25 |
| CA3007025A1 (en) | 2017-06-29 |
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