ZA200908342B - Methods and compositions for the specific inhibition of gene expression by double-stranded RNA - Google Patents
Methods and compositions for the specific inhibition of gene expression by double-stranded RNAInfo
- Publication number
- ZA200908342B ZA200908342B ZA200908342A ZA200908342A ZA200908342B ZA 200908342 B ZA200908342 B ZA 200908342B ZA 200908342 A ZA200908342 A ZA 200908342A ZA 200908342 A ZA200908342 A ZA 200908342A ZA 200908342 B ZA200908342 B ZA 200908342B
- Authority
- ZA
- South Africa
- Prior art keywords
- compositions
- double
- methods
- gene expression
- stranded rna
- Prior art date
Links
- 108091032973 (ribonucleotides)n+m Proteins 0.000 title 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 title 1
- 230000014509 gene expression Effects 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/33—Chemical structure of the base
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/797,216 US20070265220A1 (en) | 2004-03-15 | 2007-05-01 | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200908342B true ZA200908342B (en) | 2010-08-25 |
Family
ID=39944357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200908342A ZA200908342B (en) | 2007-05-01 | 2009-11-25 | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
Country Status (9)
| Country | Link |
|---|---|
| US (11) | US20070265220A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2155772A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010525813A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101848923A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008246307A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0811475A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2685453A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008136902A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200908342B (cg-RX-API-DMAC7.html) |
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3222724B1 (en) | 2002-08-05 | 2018-10-31 | Silence Therapeutics GmbH | Further novel forms of interfering rna molecules |
| US7892793B2 (en) * | 2002-11-04 | 2011-02-22 | University Of Massachusetts | Allele-specific RNA interference |
| DK1633767T3 (en) * | 2003-06-02 | 2019-03-25 | Univ Massachusetts | METHODS AND COMPOSITIONS FOR MANAGING THE EFFECT OF RNA SILENCING |
| EP1633890B2 (en) * | 2003-06-02 | 2020-11-18 | University of Massachusetts | METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF FNAi |
| US7750144B2 (en) * | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| ES2485848T3 (es) * | 2003-09-12 | 2014-08-14 | University Of Massachusetts | ARN de interferencia para el tratamiento de trastornos relacionados con la ganancia de función |
| US8680063B2 (en) | 2003-09-12 | 2014-03-25 | University Of Massachusetts | RNA interference for the treatment of gain-of-function disorders |
| US20060134787A1 (en) | 2004-12-22 | 2006-06-22 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA |
| US20070265220A1 (en) * | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| EP2514758B2 (en) * | 2004-03-15 | 2021-06-23 | City of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| CA2619534A1 (en) * | 2005-08-18 | 2007-02-22 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating neurological disease |
| SI2056845T1 (en) | 2006-08-08 | 2018-02-28 | Rheinische Friedrich-Wilhelms-Universitaet Bonn | STRUCTURE AND USE 5 'PHOSPHATE OF OLIGONUCLEOTES |
| WO2008143774A2 (en) * | 2007-05-01 | 2008-11-27 | University Of Massachusetts | Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy |
| JP5689413B2 (ja) | 2008-05-21 | 2015-03-25 | ライニッシュ フリードリッヒ−ウィルヘルムズ−ユニバーシタット ボン | 平滑末端を有する5’三リン酸オリゴヌクレオチドおよびその使用 |
| TWI455944B (zh) | 2008-07-01 | 2014-10-11 | Daiichi Sankyo Co Ltd | 雙股多核苷酸 |
| US9089610B2 (en) | 2008-08-19 | 2015-07-28 | Nektar Therapeutics | Complexes of small-interfering nucleic acids |
| US8225729B2 (en) * | 2008-12-16 | 2012-07-24 | Kimberly-Clark Worldwide, Inc. | Three-dimensional wiping substrate and method therefor |
| US20100184841A1 (en) * | 2008-12-18 | 2010-07-22 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| US11414664B2 (en) | 2008-12-18 | 2022-08-16 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| WO2010093788A2 (en) | 2009-02-11 | 2010-08-19 | Dicerna Pharmaceuticals, Inc. | Multiplex dicer substrate rna interference molecules having joining sequences |
| JP2012521763A (ja) * | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いたシグナル伝達性転写因子1(STAT1)遺伝子発現のRNA干渉媒介性阻害 |
| EP2756845B1 (en) * | 2009-04-03 | 2017-03-15 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA |
| DK2756845T3 (en) | 2009-04-03 | 2017-06-12 | Dicerna Pharmaceuticals Inc | Methods and compositions for specific inhibition of KRAS with asymmetric double stranded RNA |
| US20120114710A1 (en) * | 2009-05-18 | 2012-05-10 | Lynn Kirkpatrick | Carbon nanotubes complexed with multiple bioactive agents and methods related thereto |
| WO2010141933A1 (en) * | 2009-06-05 | 2010-12-09 | Dicerna Pharmaceuticals, Inc. | Specific inhibition of gene expression by nucleic acid containing a dicer substrate |
| EP2440666B1 (en) | 2009-06-10 | 2017-03-01 | Temasek Life Sciences Laboratory Limited | Virus induced gene silencing (vigs) for functional analysis of genes in cotton |
| CA2767127A1 (en) | 2009-07-01 | 2011-01-06 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for delivery of therapeutic agents to solid tumors |
| WO2011011447A1 (en) | 2009-07-20 | 2011-01-27 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing ebola virus gene expression |
| US8916693B2 (en) | 2009-09-17 | 2014-12-23 | Nektar Therapeutics | Monoconjugated chitosans as delivery agents for small interfering nucleic acids |
| WO2011038160A2 (en) | 2009-09-23 | 2011-03-31 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing genes expressed in cancer |
| AU2010328104B2 (en) * | 2009-12-09 | 2014-10-30 | Nitto Denko Corporation | Modulation of hsp47 expression |
| WO2011072292A2 (en) * | 2009-12-11 | 2011-06-16 | Dicerna Pharmaceuticals, Inc. | Phase changing formulations of rna and rna derivatives |
| JP5257796B2 (ja) * | 2009-12-28 | 2013-08-07 | 株式会社村田製作所 | 固体電解コンデンサ素子及びその製造方法 |
| ES2635388T3 (es) | 2010-07-06 | 2017-10-03 | Dicerna Pharmaceuticals, Inc. | Métodos y composiciones para la inhibición específica de beta-catenina por RNA bicatenario |
| AU2011276363A1 (en) | 2010-07-06 | 2013-01-10 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of androgen receptor by double-stranded RNA |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| ES3005233T3 (en) | 2010-10-01 | 2025-03-14 | Modernatx Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| US20140134231A1 (en) | 2010-10-11 | 2014-05-15 | Sanford-Burnham Medical Research Institute | Mir-211 expression and related pathways in human melanoma |
| WO2012056440A1 (en) * | 2010-10-28 | 2012-05-03 | Nanodoc Ltd. | COMPOSITIONS AND METHODS FOR ACTIVATING EXPRESSION BY A SPECIFIC ENDOGENOUS miRNA |
| CN103492572A (zh) | 2011-03-03 | 2014-01-01 | 夸克医药公司 | 用于治疗肺疾病和损伤的组合物和方法 |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| WO2012169969A1 (en) | 2011-06-10 | 2012-12-13 | Temasek Life Sciences Laboratory Limited | Genetic manipulation and expression systems for pucciniomycotina and us tilaginom ycotina subphyla |
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| US20070265220A1 (en) | 2007-11-15 |
| CN101848923A (zh) | 2010-09-29 |
| US20180142241A1 (en) | 2018-05-24 |
| US20090035854A1 (en) | 2009-02-05 |
| US20090029936A1 (en) | 2009-01-29 |
| US20090043085A1 (en) | 2009-02-12 |
| US20150110860A1 (en) | 2015-04-23 |
| US20090029466A1 (en) | 2009-01-29 |
| US9441227B2 (en) | 2016-09-13 |
| AU2008246307A1 (en) | 2008-11-13 |
| US20120258535A1 (en) | 2012-10-11 |
| CA2685453A1 (en) | 2008-11-13 |
| EP2155772A1 (en) | 2010-02-24 |
| US8883996B2 (en) | 2014-11-11 |
| US20160376590A1 (en) | 2016-12-29 |
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