ZA200907353B - Sulfur compounds as inhibitors of Hepatitis C Virus NS3 serine protease - Google Patents
Sulfur compounds as inhibitors of Hepatitis C Virus NS3 serine proteaseInfo
- Publication number
- ZA200907353B ZA200907353B ZA200907353A ZA200907353A ZA200907353B ZA 200907353 B ZA200907353 B ZA 200907353B ZA 200907353 A ZA200907353 A ZA 200907353A ZA 200907353 A ZA200907353 A ZA 200907353A ZA 200907353 B ZA200907353 B ZA 200907353B
- Authority
- ZA
- South Africa
- Prior art keywords
- hepatitis
- virus
- inhibitors
- serine protease
- sulfur compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/733,479 US7816326B2 (en) | 2004-02-27 | 2007-04-10 | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200907353B true ZA200907353B (en) | 2010-07-28 |
Family
ID=39743035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200907353A ZA200907353B (en) | 2007-04-10 | 2009-10-20 | Sulfur compounds as inhibitors of Hepatitis C Virus NS3 serine protease |
Country Status (22)
Country | Link |
---|---|
US (1) | US7816326B2 (de) |
EP (1) | EP2134739B1 (de) |
JP (1) | JP2010523666A (de) |
KR (1) | KR20100016185A (de) |
CN (1) | CN101679484A (de) |
AR (1) | AR065984A1 (de) |
AT (1) | ATE490265T1 (de) |
AU (1) | AU2008236644A1 (de) |
BR (1) | BRPI0810851A2 (de) |
CA (1) | CA2683639A1 (de) |
CL (1) | CL2008001005A1 (de) |
CO (1) | CO6231036A2 (de) |
DE (1) | DE602008003777D1 (de) |
EC (1) | ECSP099685A (de) |
ES (1) | ES2355015T3 (de) |
IL (1) | IL201427A0 (de) |
MX (1) | MX2009011064A (de) |
PE (1) | PE20090228A1 (de) |
RU (1) | RU2009141187A (de) |
TW (1) | TW200902044A (de) |
WO (1) | WO2008124148A2 (de) |
ZA (1) | ZA200907353B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
US7816326B2 (en) | 2004-02-27 | 2010-10-19 | Schering Corporation | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
DE602005021760D1 (de) * | 2004-02-27 | 2010-07-22 | Schering Corp | Schwefelverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus |
JP5249028B2 (ja) | 2005-07-25 | 2013-07-31 | インターミューン・インコーポレーテッド | C型肝炎ウイルス複製の新規大環状阻害剤 |
DE602006019323D1 (de) * | 2005-10-11 | 2011-02-10 | Intermune Inc | Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus |
CN102046622A (zh) | 2008-04-15 | 2011-05-04 | 因特蒙公司 | 丙型肝炎病毒复制的新颖大环抑制剂 |
JP2012505897A (ja) * | 2008-10-15 | 2012-03-08 | インターミューン・インコーポレーテッド | 治療用抗ウイルス性ペプチド |
AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
US8980920B2 (en) | 2009-05-29 | 2015-03-17 | Merck Sharp & Dohme Corp. | Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C |
US20120276047A1 (en) | 2009-11-25 | 2012-11-01 | Rosenblum Stuart B | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
JP2013515068A (ja) | 2009-12-22 | 2013-05-02 | メルク・シャープ・アンド・ドーム・コーポレーション | ウイルス性疾患の治療のための縮合三環式化合物およびその使用方法 |
MX2012010392A (es) | 2010-03-09 | 2012-10-03 | Merck Sharp & Dohme | Compuesto de sililo triciclicos fusionados y metodos de uso de los mismos para el tratamiento de enfermedades virales. |
US20140377223A1 (en) | 2010-07-26 | 2014-12-25 | Joseph A. Kozlowski | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
AU2011314168A1 (en) | 2010-09-29 | 2013-04-04 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
CN103582420B (zh) | 2011-04-13 | 2016-10-19 | 默沙东公司 | 2’-取代的核苷衍生物和使用其治疗病毒病的方法 |
US9156872B2 (en) | 2011-04-13 | 2015-10-13 | Merck Sharp & Dohme Corp. | 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
WO2013033901A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
WO2013033900A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases |
WO2013033899A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases |
EP2755981A4 (de) | 2011-09-14 | 2015-03-25 | Merck Sharp & Dohme | Silylhaltige heterocyclische derivate sowie verfahren zu ihrer verwendung zur behandlung von virenerkrankungen |
KR101560994B1 (ko) * | 2011-11-29 | 2015-10-15 | 길리어드 파마셋 엘엘씨 | 간염 c 바이러스 치료를 위한 조성물 및 방법 |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
WO2015065817A1 (en) | 2013-10-30 | 2015-05-07 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof |
US10874686B2 (en) | 2015-10-01 | 2020-12-29 | Memorial Sloan-Kettering Cancer Center | Anthranilyl-adenosinemonosulfamate analogs and uses thereof |
US20180273573A1 (en) * | 2015-10-01 | 2018-09-27 | Memorial Sloan-Kettering Cancer Center | Inhibitors of menaquinone biosynthesis |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7675491A (en) | 1990-04-04 | 1991-10-30 | Chiron Corporation | Hepatitis c virus protease |
US5922757A (en) | 1996-09-30 | 1999-07-13 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
EE04023B1 (et) | 1996-10-18 | 2003-04-15 | Vertex Pharmaceuticals Incorporated | Seriinproteaaside, eriti C-hepatiidi viiruse NS3-proteaasi inhibiitorid |
GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
HUP0100100A3 (en) | 1997-08-11 | 2001-12-28 | Boehringer Ingelheim Ca Ltd | Hepatitis c inhibitor peptide analogues, pharmaceutical compositions comprising thereof and their use |
AR022061A1 (es) | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
US6608027B1 (en) | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
EP1268519B1 (de) | 2000-04-03 | 2005-06-15 | Vertex Pharmaceuticals Incorporated | Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease |
CN1441806A (zh) | 2000-04-05 | 2003-09-10 | 先灵公司 | 包含n-环p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂 |
AU2001253621A1 (en) | 2000-04-19 | 2001-11-07 | Schering Corporation | Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties |
AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
CZ303213B6 (cs) | 2000-07-21 | 2012-05-23 | Schering Corporation | Peptidové inhibitory serinové proteázy NS3 a farmaceutický prostredek |
CA2410682A1 (en) | 2000-07-21 | 2002-01-31 | Schering Corporation | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus |
AU2001277967A1 (en) | 2000-07-21 | 2002-02-05 | Corvas International, Inc. | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
IL155842A0 (en) * | 2000-12-12 | 2003-12-23 | Schering Corp | Diaryl peptides as ns3-serine protease inhibitors of hepatitis c virus |
US7816326B2 (en) | 2004-02-27 | 2010-10-19 | Schering Corporation | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
DE602005021760D1 (de) | 2004-02-27 | 2010-07-22 | Schering Corp | Schwefelverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus |
JP5160415B2 (ja) | 2005-06-02 | 2013-03-13 | メルク・シャープ・アンド・ドーム・コーポレーション | 医薬処方物およびそれを用いる治療方法 |
-
2007
- 2007-04-10 US US11/733,479 patent/US7816326B2/en active Active
-
2008
- 2008-04-08 MX MX2009011064A patent/MX2009011064A/es active IP Right Grant
- 2008-04-08 PE PE2008000629A patent/PE20090228A1/es not_active Application Discontinuation
- 2008-04-08 WO PCT/US2008/004549 patent/WO2008124148A2/en active Application Filing
- 2008-04-08 KR KR1020097022983A patent/KR20100016185A/ko not_active Application Discontinuation
- 2008-04-08 BR BRPI0810851-0A2A patent/BRPI0810851A2/pt not_active Application Discontinuation
- 2008-04-08 AT AT08742663T patent/ATE490265T1/de not_active IP Right Cessation
- 2008-04-08 RU RU2009141187/04A patent/RU2009141187A/ru not_active Application Discontinuation
- 2008-04-08 CN CN200880019227A patent/CN101679484A/zh active Pending
- 2008-04-08 AR ARP080101450A patent/AR065984A1/es unknown
- 2008-04-08 AU AU2008236644A patent/AU2008236644A1/en not_active Abandoned
- 2008-04-08 CA CA002683639A patent/CA2683639A1/en not_active Abandoned
- 2008-04-08 EP EP08742663A patent/EP2134739B1/de active Active
- 2008-04-08 ES ES08742663T patent/ES2355015T3/es active Active
- 2008-04-08 JP JP2010503039A patent/JP2010523666A/ja not_active Withdrawn
- 2008-04-08 DE DE602008003777T patent/DE602008003777D1/de active Active
- 2008-04-09 CL CL200801005A patent/CL2008001005A1/es unknown
- 2008-04-09 TW TW097112895A patent/TW200902044A/zh unknown
-
2009
- 2009-10-08 EC EC2009009685A patent/ECSP099685A/es unknown
- 2009-10-09 CO CO09112538A patent/CO6231036A2/es not_active Application Discontinuation
- 2009-10-11 IL IL201427A patent/IL201427A0/en unknown
- 2009-10-20 ZA ZA200907353A patent/ZA200907353B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
TW200902044A (en) | 2009-01-16 |
EP2134739B1 (de) | 2010-12-01 |
AR065984A1 (es) | 2009-07-15 |
CA2683639A1 (en) | 2008-10-16 |
CN101679484A (zh) | 2010-03-24 |
AU2008236644A1 (en) | 2008-10-16 |
CO6231036A2 (es) | 2010-12-20 |
JP2010523666A (ja) | 2010-07-15 |
MX2009011064A (es) | 2009-10-29 |
ECSP099685A (es) | 2009-11-30 |
ES2355015T3 (es) | 2011-03-22 |
KR20100016185A (ko) | 2010-02-12 |
BRPI0810851A2 (pt) | 2014-10-29 |
WO2008124148A3 (en) | 2009-05-07 |
PE20090228A1 (es) | 2009-03-28 |
EP2134739A2 (de) | 2009-12-23 |
DE602008003777D1 (de) | 2011-01-13 |
US20070197448A1 (en) | 2007-08-23 |
ATE490265T1 (de) | 2010-12-15 |
IL201427A0 (en) | 2010-05-31 |
WO2008124148A2 (en) | 2008-10-16 |
US7816326B2 (en) | 2010-10-19 |
CL2008001005A1 (es) | 2008-10-17 |
RU2009141187A (ru) | 2011-05-20 |
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