ATE490265T1 - Schwefelverbindungen als hemmer der ns3-serin- protease des hepatitis-c-virus - Google Patents
Schwefelverbindungen als hemmer der ns3-serin- protease des hepatitis-c-virusInfo
- Publication number
- ATE490265T1 ATE490265T1 AT08742663T AT08742663T ATE490265T1 AT E490265 T1 ATE490265 T1 AT E490265T1 AT 08742663 T AT08742663 T AT 08742663T AT 08742663 T AT08742663 T AT 08742663T AT E490265 T1 ATE490265 T1 AT E490265T1
- Authority
- AT
- Austria
- Prior art keywords
- hepatitis
- virus
- inhibitors
- serine protease
- sulfur compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/733,479 US7816326B2 (en) | 2004-02-27 | 2007-04-10 | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
PCT/US2008/004549 WO2008124148A2 (en) | 2007-04-10 | 2008-04-08 | Sulfur compounds as inhiibitors of hepatitis c virus ns3 serine protease |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE490265T1 true ATE490265T1 (de) | 2010-12-15 |
Family
ID=39743035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08742663T ATE490265T1 (de) | 2007-04-10 | 2008-04-08 | Schwefelverbindungen als hemmer der ns3-serin- protease des hepatitis-c-virus |
Country Status (22)
Country | Link |
---|---|
US (1) | US7816326B2 (de) |
EP (1) | EP2134739B1 (de) |
JP (1) | JP2010523666A (de) |
KR (1) | KR20100016185A (de) |
CN (1) | CN101679484A (de) |
AR (1) | AR065984A1 (de) |
AT (1) | ATE490265T1 (de) |
AU (1) | AU2008236644A1 (de) |
BR (1) | BRPI0810851A2 (de) |
CA (1) | CA2683639A1 (de) |
CL (1) | CL2008001005A1 (de) |
CO (1) | CO6231036A2 (de) |
DE (1) | DE602008003777D1 (de) |
EC (1) | ECSP099685A (de) |
ES (1) | ES2355015T3 (de) |
IL (1) | IL201427A0 (de) |
MX (1) | MX2009011064A (de) |
PE (1) | PE20090228A1 (de) |
RU (1) | RU2009141187A (de) |
TW (1) | TW200902044A (de) |
WO (1) | WO2008124148A2 (de) |
ZA (1) | ZA200907353B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
ES2346233T3 (es) * | 2004-02-27 | 2010-10-13 | Schering Corporation | Compuestos de azufre como inhibidores de serina proteasa ns3 del virus de la hepatitis c. |
US7816326B2 (en) * | 2004-02-27 | 2010-10-19 | Schering Corporation | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
EP2305695A3 (de) | 2005-07-25 | 2011-07-27 | Intermune, Inc. | Makrocyclische Inhibitoren der Replikation des Hepatitis-C-Virus |
CN101415705B (zh) * | 2005-10-11 | 2011-10-26 | 因特蒙公司 | 抑制丙型肝炎病毒复制的化合物和方法 |
MX2010011306A (es) * | 2008-04-15 | 2010-11-09 | Intermune Inc | Nuevos inhibidores macrociclicos de la replicacion del virus de la hepatitis c. |
AP2011005695A0 (en) * | 2008-10-15 | 2011-06-30 | Intermune Inc | Therapeutic antiviral poptides. |
AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
WO2010138791A1 (en) | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
WO2011066241A1 (en) | 2009-11-25 | 2011-06-03 | Schering Corporation | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
US20130156731A1 (en) | 2009-12-22 | 2013-06-20 | Kevin X. Chen | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas |
ES2558554T3 (es) | 2010-03-09 | 2016-02-05 | Merck Sharp & Dohme Corp. | Compuestos de sililo tricíclicos condensados y métodos de uso de los mismos para el tratamiento de enfermedades víricas |
WO2012018534A2 (en) | 2010-07-26 | 2012-02-09 | Schering Corporation | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
EP2621279B1 (de) | 2010-09-29 | 2018-04-04 | Merck Sharp & Dohme Corp. | Kondensierte tetrazyklische derivate und verfahren zu ihrer verwendung zur behandlung von virenerkrankungen |
EA201391519A1 (ru) | 2011-04-13 | 2014-03-31 | Мерк Шарп И Доум Корп. | 2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний |
WO2012142075A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
WO2013033899A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases |
WO2013033901A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
WO2013033900A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases |
WO2013039876A1 (en) | 2011-09-14 | 2013-03-21 | Merck Sharp & Dohme Corp. | Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
BR112014012739A8 (pt) * | 2011-11-29 | 2017-06-20 | Gilead Pharmasset Llc | composições e métodos para o tratamento do vírus da hepatite c |
US10167298B2 (en) | 2013-10-30 | 2019-01-01 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an HCV NS5A inhibitor and uses thereof |
CA3000709A1 (en) * | 2015-10-01 | 2017-04-06 | Memorial Sloan-Kettering Cancer Center | Inhibitors of menaquinone biosynthesis |
WO2017059446A1 (en) | 2015-10-01 | 2017-04-06 | Memorial Sloan-Kettering Cancer Center | Anthranilyl-adenosinemonosulfamate analogs and uses thereof |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7675491A (en) * | 1990-04-04 | 1991-10-30 | Chiron Corporation | Hepatitis c virus protease |
US5922757A (en) | 1996-09-30 | 1999-07-13 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
PL194025B1 (pl) | 1996-10-18 | 2007-04-30 | Vertex Pharma | Inhibitory proteaz serynowych, a zwłaszcza proteazy wirusa NS3 zapalenia wątroby C, kompozycja farmaceutyczna i zastosowanie inhibitorów proteaz serynowych |
GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
DE69827956T2 (de) | 1997-08-11 | 2005-04-14 | Boehringer Ingelheim (Canada) Ltd., Laval | Peptidanaloga mit inhibitorischer wirkung auf hepatitis c |
AR022061A1 (es) | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
AU2001251165A1 (en) | 2000-04-03 | 2001-10-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
WO2001077113A2 (en) | 2000-04-05 | 2001-10-18 | Schering Corporation | Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising n-cyclic p2 moieties |
PL358591A1 (en) | 2000-04-19 | 2004-08-09 | Schering Corporation | Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising alkyl and aryl alanine p2 moieties |
US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
EP1301527A2 (de) | 2000-07-21 | 2003-04-16 | Corvas International, Inc. | Peptide als inhibitoren der ns3-serinprotease des hepatitis c virus |
AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
MXPA03000626A (es) | 2000-07-21 | 2004-07-30 | Schering Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de la hepatitis c. |
CN102372764A (zh) * | 2000-07-21 | 2012-03-14 | 先灵公司 | 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 |
KR20030091946A (ko) | 2000-12-12 | 2003-12-03 | 쉐링 코포레이션 | C형 간염 바이러스의 ns3-세린 프로테아제억제제로서의 디아릴 펩티드 |
US7816326B2 (en) | 2004-02-27 | 2010-10-19 | Schering Corporation | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
ES2346233T3 (es) | 2004-02-27 | 2010-10-13 | Schering Corporation | Compuestos de azufre como inhibidores de serina proteasa ns3 del virus de la hepatitis c. |
CA2611155A1 (en) | 2005-06-02 | 2006-12-07 | Schering Corporation | Pharmaceutical formulations and methods of treatment using the same |
-
2007
- 2007-04-10 US US11/733,479 patent/US7816326B2/en active Active
-
2008
- 2008-04-08 WO PCT/US2008/004549 patent/WO2008124148A2/en active Application Filing
- 2008-04-08 KR KR1020097022983A patent/KR20100016185A/ko not_active Application Discontinuation
- 2008-04-08 AR ARP080101450A patent/AR065984A1/es unknown
- 2008-04-08 EP EP08742663A patent/EP2134739B1/de active Active
- 2008-04-08 AT AT08742663T patent/ATE490265T1/de not_active IP Right Cessation
- 2008-04-08 CN CN200880019227A patent/CN101679484A/zh active Pending
- 2008-04-08 PE PE2008000629A patent/PE20090228A1/es not_active Application Discontinuation
- 2008-04-08 MX MX2009011064A patent/MX2009011064A/es active IP Right Grant
- 2008-04-08 DE DE602008003777T patent/DE602008003777D1/de active Active
- 2008-04-08 ES ES08742663T patent/ES2355015T3/es active Active
- 2008-04-08 BR BRPI0810851-0A2A patent/BRPI0810851A2/pt not_active Application Discontinuation
- 2008-04-08 JP JP2010503039A patent/JP2010523666A/ja not_active Withdrawn
- 2008-04-08 RU RU2009141187/04A patent/RU2009141187A/ru not_active Application Discontinuation
- 2008-04-08 AU AU2008236644A patent/AU2008236644A1/en not_active Abandoned
- 2008-04-08 CA CA002683639A patent/CA2683639A1/en not_active Abandoned
- 2008-04-09 CL CL200801005A patent/CL2008001005A1/es unknown
- 2008-04-09 TW TW097112895A patent/TW200902044A/zh unknown
-
2009
- 2009-10-08 EC EC2009009685A patent/ECSP099685A/es unknown
- 2009-10-09 CO CO09112538A patent/CO6231036A2/es not_active Application Discontinuation
- 2009-10-11 IL IL201427A patent/IL201427A0/en unknown
- 2009-10-20 ZA ZA200907353A patent/ZA200907353B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AR065984A1 (es) | 2009-07-15 |
CN101679484A (zh) | 2010-03-24 |
TW200902044A (en) | 2009-01-16 |
ZA200907353B (en) | 2010-07-28 |
IL201427A0 (en) | 2010-05-31 |
ES2355015T3 (es) | 2011-03-22 |
EP2134739B1 (de) | 2010-12-01 |
DE602008003777D1 (de) | 2011-01-13 |
KR20100016185A (ko) | 2010-02-12 |
US7816326B2 (en) | 2010-10-19 |
RU2009141187A (ru) | 2011-05-20 |
AU2008236644A1 (en) | 2008-10-16 |
JP2010523666A (ja) | 2010-07-15 |
CA2683639A1 (en) | 2008-10-16 |
CL2008001005A1 (es) | 2008-10-17 |
BRPI0810851A2 (pt) | 2014-10-29 |
PE20090228A1 (es) | 2009-03-28 |
CO6231036A2 (es) | 2010-12-20 |
EP2134739A2 (de) | 2009-12-23 |
WO2008124148A3 (en) | 2009-05-07 |
ECSP099685A (es) | 2009-11-30 |
US20070197448A1 (en) | 2007-08-23 |
MX2009011064A (es) | 2009-10-29 |
WO2008124148A2 (en) | 2008-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |