ZA200900562B - Dimeric IAP Antagonists - Google Patents
Dimeric IAP AntagonistsInfo
- Publication number
- ZA200900562B ZA200900562B ZA200900562A ZA200900562A ZA200900562B ZA 200900562 B ZA200900562 B ZA 200900562B ZA 200900562 A ZA200900562 A ZA 200900562A ZA 200900562 A ZA200900562 A ZA 200900562A ZA 200900562 B ZA200900562 B ZA 200900562B
- Authority
- ZA
- South Africa
- Prior art keywords
- iap antagonists
- dimeric iap
- dimeric
- antagonists
- iap
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82015606P | 2006-07-24 | 2006-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200900562B true ZA200900562B (en) | 2010-06-30 |
Family
ID=38904713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200900562A ZA200900562B (en) | 2006-07-24 | 2009-01-23 | Dimeric IAP Antagonists |
Country Status (15)
Country | Link |
---|---|
US (2) | US7985735B2 (pt) |
EP (2) | EP2049563B1 (pt) |
JP (1) | JP5228202B2 (pt) |
KR (1) | KR20090041391A (pt) |
CN (1) | CN101516904A (pt) |
AR (1) | AR063943A1 (pt) |
AU (1) | AU2007276760B2 (pt) |
BR (1) | BRPI0715195A2 (pt) |
CA (1) | CA2657706A1 (pt) |
CL (1) | CL2007002167A1 (pt) |
IL (1) | IL196423A0 (pt) |
MX (1) | MX2009000824A (pt) |
NZ (1) | NZ574311A (pt) |
WO (1) | WO2008014263A2 (pt) |
ZA (1) | ZA200900562B (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006020060A2 (en) | 2004-07-15 | 2006-02-23 | Tetralogic Pharmaceuticals Corporation | Iap binding compounds |
US7517906B2 (en) | 2005-02-25 | 2009-04-14 | Tetralogic Pharmaceuticals Corporation | Dimeric IAP inhibitors |
JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Birドメイン結合化合物 |
KR20080067357A (ko) | 2005-10-25 | 2008-07-18 | 에게라 쎄라퓨틱스 인코포레이티드 | Iap bir 도메인 결합 화합물 |
TWI543988B (zh) | 2006-03-16 | 2016-08-01 | 科學製藥股份有限公司 | 結合於細胞凋亡抑制蛋白(iap)之桿狀病毒iap重複序列(bir)區域之化合物 |
EP2019671B1 (en) * | 2006-05-05 | 2014-09-24 | The Regents Of The University Of Michigan | Intermediates for the preparation of bivalent smac mimetics |
US8202902B2 (en) * | 2006-05-05 | 2012-06-19 | The Regents Of The University Of Michigan | Bivalent SMAC mimetics and the uses thereof |
EP2024362A4 (en) | 2006-05-16 | 2012-01-25 | Pharmascience Inc | IAP BIR DOMAIN BINDING COMPOUNDS |
EP2265604A4 (en) | 2008-04-11 | 2011-10-26 | Univ Michigan | HETEROARYL-SUBSTITUTED BICYCLIC SMAC MIMETICA AND ITS APPLICATIONS |
US9266630B2 (en) * | 2009-02-25 | 2016-02-23 | Liqui-Box Corporation | Process for pouch forming with optimized fill-accuracy and headspace |
US20100317593A1 (en) * | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
US9284350B2 (en) | 2010-02-12 | 2016-03-15 | Pharmascience Inc. | IAP BIR domain binding compounds |
UY33236A (es) * | 2010-02-25 | 2011-09-30 | Novartis Ag | Inhibidores dimericos de las iap |
WO2012044993A1 (en) * | 2010-09-30 | 2012-04-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders |
UY33794A (es) | 2010-12-13 | 2012-07-31 | Novartis Ag | Inhibidores diméricos de las iap |
US20130196927A1 (en) * | 2012-01-27 | 2013-08-01 | Christopher BENETATOS | Smac Mimetic Therapy |
KR102427777B1 (ko) | 2012-06-26 | 2022-08-01 | 델 마 파마슈티컬스 | 디안하이드로갈락티톨, 디아세틸디안하이드로갈락티톨, 디브로모둘시톨, 또는 그의 유사체 또는 유도체를 이용하여 유전학적 다형성이 있는 환자에 있어서 티로신-키나아제-억제제 내성 악성종양, ahi1 조절곤란 또는 돌연변이를 치료하는 방법 |
NZ704554A (en) * | 2012-08-01 | 2015-12-24 | Tetralogic Pharm Corp | Combination therapy of a smac mimetic and gm-csf |
JP2016519684A (ja) | 2013-04-08 | 2016-07-07 | デニス エム ブラウン | 準最適に投与された薬物療法の有効性を改善するための及び/又は副作用を低減するための方法および組成物 |
US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
CN105585583B (zh) * | 2016-01-20 | 2018-04-13 | 广东工业大学 | 一种非肽类凋亡抑制蛋白拮抗剂及其合成方法与应用 |
CN105566447B (zh) * | 2016-01-20 | 2019-09-20 | 广东工业大学 | 一种凋亡抑制蛋白的类肽拮抗剂及其合成方法与应用 |
CN109071508B (zh) * | 2016-04-27 | 2021-09-03 | 南京明德新药研发股份有限公司 | 作为新型二价iap拮抗剂的苯并咪唑联吲哚化合物 |
CN106188098B (zh) * | 2016-07-06 | 2017-11-03 | 广东工业大学 | 一种杂化抗癌药物及其制备方法与应用 |
CN106265764B (zh) * | 2016-08-18 | 2018-03-16 | 广州威溶特医药科技有限公司 | Iap抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用 |
CN108440507B (zh) * | 2017-02-16 | 2022-10-18 | 南京圣和药物研发有限公司 | 作为细胞凋亡蛋白抑制剂的化合物及其应用 |
BR112019023979A2 (pt) * | 2017-05-17 | 2020-06-09 | Denali Therapeutics Inc | compostos, composições e métodos |
WO2019080928A1 (zh) * | 2017-10-27 | 2019-05-02 | 南京明德新药研发股份有限公司 | 一种iap拮抗剂的晶型及其制备方法 |
CN111655713B (zh) * | 2018-02-09 | 2023-06-27 | 广东东阳光药业有限公司 | Iap抑制剂及其在药物中的应用 |
JP2021038192A (ja) * | 2019-05-31 | 2021-03-11 | 均 石井 | Dna変性剤を使用する成長促進剤。 |
CN112521372B (zh) * | 2019-09-18 | 2022-07-08 | 南京华威医药科技集团有限公司 | 一种细胞凋亡蛋白抑制剂及其制备方法和用途 |
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US6110691A (en) | 2000-01-06 | 2000-08-29 | Board Of Regents, The University Of Texas System | Activators of caspases |
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WO2002016418A2 (en) | 2000-08-24 | 2002-02-28 | Thomas Jefferson University | An iap binding peptide or polypeptide and methods of using the same |
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JP2004531731A (ja) | 2001-05-31 | 2004-10-14 | ザ トラスティーズ オブ プリンストン ユニバーシテイ | Iap結合ペプチドおよびiapに結合する化合物を同定するアッセイ |
CA2456269A1 (en) | 2001-08-23 | 2003-03-06 | The Government Of The United States Of America | Methods of inhibiting formation of vascular channels and profileration using pyridinone derivatives |
US20060258581A1 (en) | 2001-11-21 | 2006-11-16 | Reed John C | Methods and composition for derepressions of IAP-inhibited caspase |
CA2467892A1 (en) | 2001-11-21 | 2003-06-05 | The Burnham Institute | Methods and compositions for derepression of iap-inhibited caspase |
BR0312408A (pt) | 2002-07-02 | 2005-04-19 | Novartis Ag | Inibidores de peptìdeo de ligação de proteìna smac a inibidor de apoptose de proteìnas (iap) |
US20080199439A1 (en) | 2003-02-12 | 2008-08-21 | Mclendon George L | IAP-binding cargo molecules and peptidomimetics for use in diagnostic and therapeutic methods |
US7932382B2 (en) | 2004-01-16 | 2011-04-26 | The Regents Of The University Of Michigan | Conformationally constrained Smac mimetics and the uses thereof |
CA2553871A1 (en) | 2004-01-16 | 2005-08-04 | The Regents Of The University Of Michigan | Smac peptidomimetics and the uses thereof |
CA2552937A1 (en) | 2004-02-05 | 2005-08-18 | Novartis Ag | Combination of (a) a dna topoisomerase inhibitor and (b) an iap inhibitor |
US20070217607A1 (en) | 2004-02-15 | 2007-09-20 | Matrixview Limited | Repetition Coded Compression For Encrypting Highly Correlated Data |
CA2582734C (en) | 2004-03-01 | 2011-05-03 | Board Of Regents, The University Of Texas System | Dimeric small molecule potentiators of apoptosis |
AU2005228950B2 (en) | 2004-03-23 | 2012-02-02 | Genentech, Inc. | Azabicyclo-octane inhibitors of IAP |
AR048927A1 (es) | 2004-04-07 | 2006-06-14 | Novartis Ag | Compuestos heterociclicos como inhibidores de proteinas de apoptosis (iap); composiciones farmaceuticas que los contienen y su uso en el tratamiento de una enfermedad proliferativa |
RS53734B1 (en) | 2004-07-02 | 2015-06-30 | Genentech Inc. | IAP INHIBITORS |
US7674787B2 (en) | 2004-07-09 | 2010-03-09 | The Regents Of The University Of Michigan | Conformationally constrained Smac mimetics and the uses thereof |
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WO2006020060A2 (en) * | 2004-07-15 | 2006-02-23 | Tetralogic Pharmaceuticals Corporation | Iap binding compounds |
NZ589670A (en) | 2004-12-20 | 2013-01-25 | Genentech Inc | Pyrrolidine inhibitors of iap |
US7517906B2 (en) | 2005-02-25 | 2009-04-14 | Tetralogic Pharmaceuticals Corporation | Dimeric IAP inhibitors |
US20070003535A1 (en) | 2005-03-17 | 2007-01-04 | Reed John C | Methods and compositions for derepression of IAP-inhibited caspase |
JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Birドメイン結合化合物 |
AU2006254538A1 (en) | 2005-05-25 | 2006-12-07 | 2Curex Aps | Compounds modifying apoptosis |
BRPI0611922A2 (pt) | 2005-06-08 | 2010-10-05 | Novartis Ag | compostos orgánicos |
WO2007021825A2 (en) | 2005-08-09 | 2007-02-22 | Tetralogic Pharmaceuticals Corporation | Treatment of proliferative disorders |
KR20080067357A (ko) | 2005-10-25 | 2008-07-18 | 에게라 쎄라퓨틱스 인코포레이티드 | Iap bir 도메인 결합 화합물 |
JP5155184B2 (ja) | 2005-12-19 | 2013-02-27 | ジェネンテック, インコーポレイテッド | Iapのインヒビター |
AU2006331964A1 (en) | 2005-12-20 | 2007-07-05 | Novartis Ag | Combination of an IAP-inhibitor and a taxane7 |
WO2007101347A1 (en) | 2006-03-07 | 2007-09-13 | Aegera Therapeutics Inc. | Bir domain binding compounds |
TWI543988B (zh) | 2006-03-16 | 2016-08-01 | 科學製藥股份有限公司 | 結合於細胞凋亡抑制蛋白(iap)之桿狀病毒iap重複序列(bir)區域之化合物 |
MX2008012053A (es) | 2006-03-21 | 2008-12-17 | Joyant Pharmaceuticals Inc | Promotores de apoptosis de molecula pequeña. |
EP2019671B1 (en) | 2006-05-05 | 2014-09-24 | The Regents Of The University Of Michigan | Intermediates for the preparation of bivalent smac mimetics |
US8202902B2 (en) | 2006-05-05 | 2012-06-19 | The Regents Of The University Of Michigan | Bivalent SMAC mimetics and the uses thereof |
EP2024362A4 (en) | 2006-05-16 | 2012-01-25 | Pharmascience Inc | IAP BIR DOMAIN BINDING COMPOUNDS |
PE20110218A1 (es) | 2006-08-02 | 2011-04-01 | Novartis Ag | DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS |
CA2665838A1 (en) | 2006-10-19 | 2008-05-15 | Novartis Ag | Organic compounds |
JP2010513561A (ja) | 2006-12-19 | 2010-04-30 | ジェネンテック, インコーポレイテッド | Iapのイミダゾピリジンインヒビター |
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MX2009011783A (es) | 2007-04-30 | 2009-12-04 | Genentech Inc | Inhibidores de iap. |
-
2007
- 2007-07-24 CN CNA2007800353552A patent/CN101516904A/zh active Pending
- 2007-07-24 NZ NZ574311A patent/NZ574311A/en not_active IP Right Cessation
- 2007-07-24 CL CL2007002167A patent/CL2007002167A1/es unknown
- 2007-07-24 KR KR1020097002257A patent/KR20090041391A/ko not_active Application Discontinuation
- 2007-07-24 BR BRPI0715195-0A patent/BRPI0715195A2/pt not_active IP Right Cessation
- 2007-07-24 EP EP07813293.3A patent/EP2049563B1/en not_active Not-in-force
- 2007-07-24 CA CA002657706A patent/CA2657706A1/en not_active Abandoned
- 2007-07-24 WO PCT/US2007/074225 patent/WO2008014263A2/en active Application Filing
- 2007-07-24 US US11/782,360 patent/US7985735B2/en not_active Expired - Fee Related
- 2007-07-24 AU AU2007276760A patent/AU2007276760B2/en not_active Ceased
- 2007-07-24 JP JP2009521954A patent/JP5228202B2/ja not_active Expired - Fee Related
- 2007-07-24 EP EP11179638A patent/EP2409984A1/en not_active Withdrawn
- 2007-07-24 MX MX2009000824A patent/MX2009000824A/es unknown
- 2007-07-24 AR ARP070103286A patent/AR063943A1/es not_active Application Discontinuation
-
2009
- 2009-01-11 IL IL196423A patent/IL196423A0/en unknown
- 2009-01-23 ZA ZA200900562A patent/ZA200900562B/xx unknown
-
2011
- 2011-06-09 US US13/156,661 patent/US20110305777A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7985735B2 (en) | 2011-07-26 |
US20110305777A1 (en) | 2011-12-15 |
AU2007276760B2 (en) | 2012-01-19 |
JP2009544728A (ja) | 2009-12-17 |
CN101516904A (zh) | 2009-08-26 |
WO2008014263A3 (en) | 2008-03-13 |
AR063943A1 (es) | 2009-03-04 |
WO2008014263A2 (en) | 2008-01-31 |
AU2007276760A1 (en) | 2008-01-31 |
KR20090041391A (ko) | 2009-04-28 |
NZ574311A (en) | 2011-12-22 |
EP2049563A2 (en) | 2009-04-22 |
EP2409984A1 (en) | 2012-01-25 |
BRPI0715195A2 (pt) | 2013-06-11 |
CL2007002167A1 (es) | 2009-01-23 |
US20080020986A1 (en) | 2008-01-24 |
CA2657706A1 (en) | 2008-01-31 |
MX2009000824A (es) | 2009-02-04 |
IL196423A0 (en) | 2011-08-01 |
JP5228202B2 (ja) | 2013-07-03 |
EP2049563B1 (en) | 2014-03-12 |
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