ZA200809171B - Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group - Google Patents

Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group

Info

Publication number
ZA200809171B
ZA200809171B ZA200809171A ZA200809171A ZA200809171B ZA 200809171 B ZA200809171 B ZA 200809171B ZA 200809171 A ZA200809171 A ZA 200809171A ZA 200809171 A ZA200809171 A ZA 200809171A ZA 200809171 B ZA200809171 B ZA 200809171B
Authority
ZA
South Africa
Prior art keywords
pyrazolylaminoquinazoline
derivatives
preparation
phosphate group
phosphate
Prior art date
Application number
ZA200809171A
Other languages
English (en)
Inventor
Pittam John David
Sependa George Joseph
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200809171B publication Critical patent/ZA200809171B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200809171A 2006-05-16 2008-10-24 Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group ZA200809171B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0609617.6A GB0609617D0 (en) 2006-05-16 2006-05-16 Process & intermediate

Publications (1)

Publication Number Publication Date
ZA200809171B true ZA200809171B (en) 2009-11-25

Family

ID=36637525

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200809171A ZA200809171B (en) 2006-05-16 2008-10-24 Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group

Country Status (19)

Country Link
US (1) US8063210B2 (xx)
EP (1) EP2019832B1 (xx)
JP (1) JP5249927B2 (xx)
KR (1) KR101463633B1 (xx)
CN (1) CN101443339B (xx)
AR (1) AR060962A1 (xx)
AU (1) AU2007251395B2 (xx)
BR (1) BRPI0712787A2 (xx)
CA (1) CA2650518C (xx)
ES (1) ES2392996T3 (xx)
GB (1) GB0609617D0 (xx)
HK (1) HK1126221A1 (xx)
IL (1) IL194861A0 (xx)
MX (1) MX2008014551A (xx)
NO (1) NO20084631L (xx)
NZ (1) NZ572204A (xx)
TW (1) TWI387601B (xx)
WO (1) WO2007132210A1 (xx)
ZA (1) ZA200809171B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0215312B8 (pt) * 2001-12-24 2021-05-25 Astrazeneca Ab composto, uso de um composto, composição farmacêutica, e processo para a preparação de um composto
CA2526285A1 (en) * 2003-05-15 2004-12-23 Arqule, Inc. Inhibitors of p38 and methods of using the same
JP2008517064A (ja) * 2004-10-19 2008-05-22 アークル インコーポレイテッド Ｐ３８ｍａｐキナーゼのイミダゾオキサゾールおよびイミダゾチアゾール阻害剤の合成
US7501430B2 (en) * 2006-04-17 2009-03-10 Arqule, Inc. RAF inhibitors and their uses
JP2012511021A (ja) * 2008-12-05 2012-05-17 アークル インコーポレイテッド Ｒａｆの阻害剤およびその使用
CN103664797A (zh) * 2012-09-25 2014-03-26 杨子娇 一类治疗房角狭窄的化合物及其用途
CN103435598B (zh) * 2013-07-25 2015-08-05 苏州明锐医药科技有限公司 巴拉塞替的制备方法
RS56362B1 (sr) 2013-09-16 2017-12-29 Astrazeneca Ab Terapeutske polimerne nanočestice i postupci njihove pripreme i primene

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0215312B8 (pt) 2001-12-24 2021-05-25 Astrazeneca Ab composto, uso de um composto, composição farmacêutica, e processo para a preparação de um composto
US7022667B2 (en) * 2002-07-03 2006-04-04 Bristol-Myers Squibb Company O-derivatized nocathiacin derivatives
UA86470C2 (ru) * 2002-12-24 2009-04-27 Астразенека Аб Производные фосфонооксихиназолина и их фармацевтическое применение
US7407946B2 (en) 2002-12-24 2008-08-05 Astrazeneca Ab Quinazoline compounds
SI1847539T1 (sl) 2002-12-24 2010-01-29 Astrazeneca Ab Kinazolinski derivati
CL2004000797A1 (es) * 2003-04-16 2005-05-27 Astrazeneca Ab Compuestos derivados de quinazolina, inhibidores de aurora quinasa; procedimiento de preparacion; composicion farmaceutica; y su uso para preparar un medicamento para tratar cancer colorrectal, de mama, de pulmon, de prostata, de vejiga, renal o panc
JP2006526599A (ja) 2003-06-02 2006-11-24 アストラゼネカ アクチボラグ 癌のような増殖性疾患の治療のためのオーロラキナーゼインヒビターとしての（３−（（キナゾリン−４−イル）アミノ）−１ｈ−ピラゾール−１−イル）アセトアミド誘導体及び関連化合物
GB0609619D0 (en) * 2006-05-16 2006-06-21 Astrazeneca Ab Combination

Also Published As

Publication number Publication date
JP2009537496A (ja) 2009-10-29
NO20084631L (no) 2008-12-03
AR060962A1 (es) 2008-07-23
JP5249927B2 (ja) 2013-07-31
AU2007251395A1 (en) 2007-11-22
CN101443339B (zh) 2012-07-04
KR20090008450A (ko) 2009-01-21
CA2650518A1 (en) 2007-11-22
TW200813080A (en) 2008-03-16
CN101443339A (zh) 2009-05-27
EP2019832A1 (en) 2009-02-04
GB0609617D0 (en) 2006-06-21
US8063210B2 (en) 2011-11-22
TWI387601B (zh) 2013-03-01
EP2019832B1 (en) 2012-09-12
BRPI0712787A2 (pt) 2012-09-11
US20070270384A1 (en) 2007-11-22
NZ572204A (en) 2011-09-30
KR101463633B1 (ko) 2014-11-19
HK1126221A1 (en) 2009-08-28
ES2392996T3 (es) 2012-12-17
CA2650518C (en) 2014-12-02
AU2007251395B2 (en) 2011-01-06
IL194861A0 (en) 2009-08-03
MX2008014551A (es) 2008-11-27
WO2007132210A1 (en) 2007-11-22

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