HK1126221A1 - Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group - Google Patents

Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group

Info

Publication number
HK1126221A1
HK1126221A1 HK09104518.6A HK09104518A HK1126221A1 HK 1126221 A1 HK1126221 A1 HK 1126221A1 HK 09104518 A HK09104518 A HK 09104518A HK 1126221 A1 HK1126221 A1 HK 1126221A1
Authority
HK
Hong Kong
Prior art keywords
pyrazolylaminoquinazoline
derivatives
preparation
phosphate group
phosphate
Prior art date
Application number
HK09104518.6A
Other languages
English (en)
Inventor
John David Pittam
George Joseph Sependa
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HK1126221A1 publication Critical patent/HK1126221A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK09104518.6A 2006-05-16 2009-05-18 Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group HK1126221A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0609617.6A GB0609617D0 (en) 2006-05-16 2006-05-16 Process & intermediate
PCT/GB2007/001748 WO2007132210A1 (en) 2006-05-16 2007-05-14 Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group

Publications (1)

Publication Number Publication Date
HK1126221A1 true HK1126221A1 (en) 2009-08-28

Family

ID=36637525

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09104518.6A HK1126221A1 (en) 2006-05-16 2009-05-18 Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group

Country Status (19)

Country Link
US (1) US8063210B2 (xx)
EP (1) EP2019832B1 (xx)
JP (1) JP5249927B2 (xx)
KR (1) KR101463633B1 (xx)
CN (1) CN101443339B (xx)
AR (1) AR060962A1 (xx)
AU (1) AU2007251395B2 (xx)
BR (1) BRPI0712787A2 (xx)
CA (1) CA2650518C (xx)
ES (1) ES2392996T3 (xx)
GB (1) GB0609617D0 (xx)
HK (1) HK1126221A1 (xx)
IL (1) IL194861A0 (xx)
MX (1) MX2008014551A (xx)
NO (1) NO20084631L (xx)
NZ (1) NZ572204A (xx)
TW (1) TWI387601B (xx)
WO (1) WO2007132210A1 (xx)
ZA (1) ZA200809171B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE446093T1 (de) * 2001-12-24 2009-11-15 Astrazeneca Ab Substituierte chinazolin-derivate als aurora- kinase inhibitoren
JP4939220B2 (ja) * 2003-05-15 2012-05-23 アークル インコーポレイテッド ｐ３８の阻害物質としてのイミダゾチアゾール類およびイミダゾオキサゾール誘導体
EP2258704A1 (en) * 2004-10-19 2010-12-08 ArQule, Inc. Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
EP2013218A2 (en) * 2006-04-17 2009-01-14 Arqule, Inc. Raf inhibitors and their uses
WO2010065893A1 (en) * 2008-12-05 2010-06-10 Arqule, Inc. Raf inhibitors and their uses
CN103664797A (zh) * 2012-09-25 2014-03-26 杨子娇 一类治疗房角狭窄的化合物及其用途
CN103435598B (zh) * 2013-07-25 2015-08-05 苏州明锐医药科技有限公司 巴拉塞替的制备方法
LT3046584T (lt) 2013-09-16 2017-10-10 Astrazeneca Ab Terapinės polimerinės nanodalelės ir jų gamybos būdai ir panaudojimas

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE446093T1 (de) 2001-12-24 2009-11-15 Astrazeneca Ab Substituierte chinazolin-derivate als aurora- kinase inhibitoren
US7022667B2 (en) * 2002-07-03 2006-04-04 Bristol-Myers Squibb Company O-derivatized nocathiacin derivatives
DE60315892T2 (de) 2002-12-24 2008-08-14 Astrazeneca Ab Phosphonooxy-chinazolin derivate und ihre pharmazeutische verwendung
AU2003290322A1 (en) 2002-12-24 2004-07-22 Astrazeneca Ab Quinazoline compounds
UA86470C2 (ru) * 2002-12-24 2009-04-27 Астразенека Аб Производные фосфонооксихиназолина и их фармацевтическое применение
RU2005135337A (ru) 2003-04-16 2006-06-10 Астразенека Аб (Se) Производные хиназолина для лечения злокачественного новообразования
DE602004015108D1 (de) * 2003-06-02 2008-08-28 Astrazeneca Ab (3-((chinazolin-4-yl)amino)-1h-pyrazol-1-yl)acetamid derivate und verwandte verbindungen als aurora kinase inhibitoren zur behandlung von proliferativen erkrankungen wie krebs
GB0609619D0 (en) * 2006-05-16 2006-06-21 Astrazeneca Ab Combination

Also Published As

Publication number Publication date
EP2019832B1 (en) 2012-09-12
WO2007132210A1 (en) 2007-11-22
TW200813080A (en) 2008-03-16
CN101443339B (zh) 2012-07-04
JP2009537496A (ja) 2009-10-29
MX2008014551A (es) 2008-11-27
GB0609617D0 (en) 2006-06-21
JP5249927B2 (ja) 2013-07-31
CA2650518C (en) 2014-12-02
CA2650518A1 (en) 2007-11-22
IL194861A0 (en) 2009-08-03
ES2392996T3 (es) 2012-12-17
KR20090008450A (ko) 2009-01-21
ZA200809171B (en) 2009-11-25
NO20084631L (no) 2008-12-03
NZ572204A (en) 2011-09-30
US8063210B2 (en) 2011-11-22
AU2007251395A1 (en) 2007-11-22
TWI387601B (zh) 2013-03-01
EP2019832A1 (en) 2009-02-04
US20070270384A1 (en) 2007-11-22
AU2007251395B2 (en) 2011-01-06
AR060962A1 (es) 2008-07-23
CN101443339A (zh) 2009-05-27
KR101463633B1 (ko) 2014-11-19
BRPI0712787A2 (pt) 2012-09-11

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170514