ZA200804498B - N4-phenyl-quinazoline-4 -amine derivatives and related compounds as ERBB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases - Google Patents

N4-phenyl-quinazoline-4 -amine derivatives and related compounds as ERBB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases

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Publication number
ZA200804498B
ZA200804498B ZA200804498A ZA200804498A ZA200804498B ZA 200804498 B ZA200804498 B ZA 200804498B ZA 200804498 A ZA200804498 A ZA 200804498A ZA 200804498 A ZA200804498 A ZA 200804498A ZA 200804498 B ZA200804498 B ZA 200804498B
Authority
ZA
South Africa
Prior art keywords
treatment
tyrosine kinase
kinase inhibitors
quinazoline
receptor tyrosine
Prior art date
Application number
ZA200804498A
Other languages
English (en)
Inventor
Joseph P Lyssikatos
Fredrik P Marmsater
Zhao Qian
Greschuk Julie Marie
Liu Weidong
Hennings D David
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of ZA200804498B publication Critical patent/ZA200804498B/xx

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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
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  • Hematology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
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ZA200804498A 2005-11-15 2006-11-15 N4-phenyl-quinazoline-4 -amine derivatives and related compounds as ERBB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases ZA200804498B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73628905P 2005-11-15 2005-11-15
US81701906P 2006-06-28 2006-06-28

Publications (1)

Publication Number Publication Date
ZA200804498B true ZA200804498B (en) 2009-07-29

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ZA200804498A ZA200804498B (en) 2005-11-15 2006-11-15 N4-phenyl-quinazoline-4 -amine derivatives and related compounds as ERBB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases

Country Status (29)

Country Link
US (6) US8648087B2 (no)
EP (2) EP2090575B1 (no)
JP (2) JP5134548B2 (no)
KR (1) KR101086967B1 (no)
CN (2) CN102887891B (no)
AT (2) ATE507224T1 (no)
AU (2) AU2006315383B2 (no)
BR (2) BRPI0618668B1 (no)
CA (2) CA2632194C (no)
CY (2) CY1110583T1 (no)
DE (2) DE602006021645D1 (no)
DK (2) DK1971601T3 (no)
ES (2) ES2335535T3 (no)
FI (1) FIC20210022I1 (no)
FR (1) FR21C1031I2 (no)
HK (2) HK1119174A1 (no)
HU (1) HUS2100028I1 (no)
IL (2) IL239149A (no)
LT (1) LTC1971601I2 (no)
LU (1) LUC00217I2 (no)
NL (1) NL301113I2 (no)
NO (1) NO342413B1 (no)
PL (2) PL2090575T3 (no)
PT (2) PT2090575E (no)
RU (2) RU2592703C9 (no)
SG (1) SG152230A1 (no)
SI (2) SI1971601T1 (no)
WO (1) WO2007059257A2 (no)
ZA (1) ZA200804498B (no)

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SG174774A1 (en) * 2006-09-11 2011-10-28 Curis Inc Quinazoline based egfr inhibitors containing a zinc binding moiety
EP2061772A4 (en) * 2006-09-11 2011-06-29 Curis Inc MULTIFUNCTIONAL SMALL MOLECULES AS PROLIFERATION-ACTIVE ACTIVE SUBSTANCES
US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
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UA100126C2 (en) 2007-09-14 2012-11-26 Аддекс Фарма С.А. 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones
JP5433579B2 (ja) 2007-09-14 2014-03-05 ジャンセン ファーマシューティカルズ， インコーポレイテッド． １，３−二置換−４−フェニル−１ｈ−ピリジン−２−オン
CN101861316B (zh) 2007-11-14 2013-08-21 奥梅-杨森制药有限公司 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
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BRPI0921333A2 (pt) 2008-11-28 2015-12-29 Addex Pharmaceuticals Sa derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos
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