ZA200710966B - 2-Amino-4-Phenylquinazoline derivatives and their use as HSP90 modulators - Google Patents

2-Amino-4-Phenylquinazoline derivatives and their use as HSP90 modulators

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Publication number
ZA200710966B
ZA200710966B ZA200710966A ZA200710966A ZA200710966B ZA 200710966 B ZA200710966 B ZA 200710966B ZA 200710966 A ZA200710966 A ZA 200710966A ZA 200710966 A ZA200710966 A ZA 200710966A ZA 200710966 B ZA200710966 B ZA 200710966B
Authority
ZA
South Africa
Prior art keywords
amino
hsp90 modulators
phenylquinazoline
derivatives
phenylquinazoline derivatives
Prior art date
Application number
ZA200710966A
Other languages
English (en)
Inventor
Eggenweiler Hans-Michael
Buchstaller Hans-Peter
Wolf Michael
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200710966B publication Critical patent/ZA200710966B/xx

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
ZA200710966A 2005-05-19 2007-12-18 2-Amino-4-Phenylquinazoline derivatives and their use as HSP90 modulators ZA200710966B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005022977A DE102005022977A1 (de) 2005-05-19 2005-05-19 Phenylchinazolinderivate

Publications (1)

Publication Number Publication Date
ZA200710966B true ZA200710966B (en) 2008-12-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710966A ZA200710966B (en) 2005-05-19 2007-12-18 2-Amino-4-Phenylquinazoline derivatives and their use as HSP90 modulators

Country Status (15)

Country Link
US (1) US7947696B2 (de)
EP (1) EP1881965A1 (de)
JP (1) JP5075117B2 (de)
KR (1) KR20080016651A (de)
CN (1) CN101180278B (de)
AR (1) AR054047A1 (de)
AU (1) AU2006246744B2 (de)
BR (1) BRPI0610134A2 (de)
CA (1) CA2608766A1 (de)
DE (1) DE102005022977A1 (de)
HK (1) HK1119690A1 (de)
MX (1) MX2007014264A (de)
RU (1) RU2421449C2 (de)
WO (1) WO2006122631A1 (de)
ZA (1) ZA200710966B (de)

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KR20080080395A (ko) * 2005-12-21 2008-09-03 아보트 러보러터리즈 항바이러스 화합물
AR061185A1 (es) * 2006-05-26 2008-08-13 Chugai Pharmaceutical Co Ltd Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas.
RU2009132605A (ru) 2007-02-01 2011-03-10 Астразенека Аб (Se) Производные 5,6,7,8-тетрагидроптеридина в качестве ингибиторов hsp90
CA2679126A1 (en) 2007-03-01 2008-09-04 Chugai Seiyaku Kabushiki Kaisha Macrocyclic compound
AU2008232354B9 (en) * 2007-03-27 2012-07-26 Synta Pharmaceuticals Corp. Triazinone and diazinone derivatives useful as Hsp90 inhibitors
EP2134684B1 (de) * 2007-04-16 2017-08-02 AbbVie Inc. 7-substituierte indole als mcl-1-hemmer
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
DE102007032739A1 (de) * 2007-07-13 2009-01-15 Merck Patent Gmbh Chinazolinamidderivate
GB0722680D0 (en) * 2007-11-19 2007-12-27 Topotarget As Therapeutic compounds and their use
WO2010042489A2 (en) * 2008-10-06 2010-04-15 Emory University Aminoquinoline derived heat shock protein 90 inhibitors, methods of preparing same, and methods for their use
DE102008061214A1 (de) 2008-12-09 2010-06-10 Merck Patent Gmbh Chinazolinamidderivate
MX2011010058A (es) 2009-03-25 2011-10-11 Abbott Lab Compuestos antivirales y usos de los mismos.
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
DE102010046837A1 (de) * 2010-09-29 2012-03-29 Merck Patent Gmbh Phenylchinazolinderivate
MX2013007938A (es) 2011-01-07 2013-11-01 Taiho Pharmaceutical Co Ltd Compuesto biciclico novedoso o sal del mismo.
AR091858A1 (es) 2012-07-25 2015-03-04 Sova Pharmaceuticals Inc INHIBIDORES DE CISTATIONIN-g-LIASA (CSE)
EP3154547B1 (de) * 2014-06-13 2023-06-07 Yuma Therapeutics, Inc. Pyrimidinverbindungen und verfahren zur verwendung davon
EA038109B1 (ru) 2016-03-01 2021-07-07 Пропеллон Терапьютикс Инк. Ингибиторы связывания белка wdr5 с белками
US11174250B2 (en) 2016-03-01 2021-11-16 Propellon Therapeutics Inc. Substituted carboxamides as inhibitors of WDR5 protein-protein binding
KR101990669B1 (ko) * 2016-05-31 2019-06-19 전남대학교산학협력단 퀴나졸린 유도체, 이의 제조방법 및 이를 함유하는 인플루엔자 바이러스 치료용 약학적 조성물
US20220073470A1 (en) * 2019-01-04 2022-03-10 Bellbrook Labs, Llc Inhibitors of cgas activity as therapeutic agents

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JPH06192099A (ja) * 1992-10-07 1994-07-12 Sumitomo Pharmaceut Co Ltd 腫瘍壊死因子産生阻害剤
EP0664128A4 (de) * 1992-10-07 1997-12-17 Sumitomo Pharma Pharmazeutisches mittel zur hemmung der tumornekrosefaktorproduktion.
JPH11209350A (ja) * 1998-01-26 1999-08-03 Eisai Co Ltd 含窒素複素環誘導体およびその医薬
WO2002024682A1 (en) * 2000-09-25 2002-03-28 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors
AR038658A1 (es) 2001-06-15 2005-01-26 Novartis Ag Derivados de 4-aril-2(1h) quinazolinona y 4-aril-quinazolina 2-sustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de un medicamento
DE10163991A1 (de) * 2001-12-24 2003-07-03 Merck Patent Gmbh Pyrrolo-pyrimidine
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CA2543710A1 (en) * 2003-11-03 2005-05-12 Warner-Lambert Company Llc Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders

Also Published As

Publication number Publication date
CN101180278B (zh) 2011-05-04
HK1119690A1 (de) 2009-03-13
US20080214586A1 (en) 2008-09-04
RU2421449C2 (ru) 2011-06-20
KR20080016651A (ko) 2008-02-21
AU2006246744A1 (en) 2006-11-23
DE102005022977A1 (de) 2006-12-07
MX2007014264A (es) 2008-01-22
CN101180278A (zh) 2008-05-14
JP2008540587A (ja) 2008-11-20
WO2006122631A1 (de) 2006-11-23
US7947696B2 (en) 2011-05-24
AR054047A1 (es) 2007-05-30
BRPI0610134A2 (pt) 2010-06-01
JP5075117B2 (ja) 2012-11-14
RU2007146388A (ru) 2009-06-27
EP1881965A1 (de) 2008-01-30
AU2006246744B2 (en) 2011-11-03
CA2608766A1 (en) 2006-11-23

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