AR054047A1 - Derivados de fenilquinazolina - Google Patents

Derivados de fenilquinazolina

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Publication number
AR054047A1
AR054047A1 ARP060102035A ARP060102035A AR054047A1 AR 054047 A1 AR054047 A1 AR 054047A1 AR P060102035 A ARP060102035 A AR P060102035A AR P060102035 A ARP060102035 A AR P060102035A AR 054047 A1 AR054047 A1 AR 054047A1
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Argentina
Prior art keywords
hal
atoms
nhcoa
mono
so2naa
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ARP060102035A
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English (en)
Inventor
Hans-Michael Eggenweiler
Michael Wolf
Hans-Peter Buchstaller
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Merck Patent Gmbh
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Publication of AR054047A1 publication Critical patent/AR054047A1/es

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
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Abstract

Nuevos derivados de fenilquinazolinas de la formula (1) en donde R1 es Hal, OH; OA, SH, SA, H o A, R2 y R3 son en cada caso, de modo independiente entre sí, -O-(X)s-Q,-S-(X)s-Q, -NHCO- (X) s -Q, -CONH- (X)s -Q, -CONA-(X)s-Q, NH(CO)NH-(X)s-Q, - NH(CO)O-(X)s-Q, -NHSO2-(X)s-Q, -SO2NH-(X)s-Q, -SO2NA-(X)s-Q, NHCOA, Hal, Het o H, en donde, en el caso de que R2 = H, entonces R3 es distinto H, o en caso de que R3 = H, entonces R2 es distinto de H, R4, R5 son en cada caso, de modo independiente entre sí, H, Hal, CN, NO2, A, OH, OA, SH, SA, (CH2)nCOOH, (CH2)nCOOA, O(CH2)0CONH2, CONHA, CONNA', NH2, NHA, NAA', NHCOOA, NHCO(CH2)nNH2, NHCONHA, SOA, SO2A; SO2NH2, SO2NHA, SO2NAA' u O(CH2)0Het1, dos radicales adyacentes, seleccionados del grupo R1, R2, R3, también son juntos metilendioxi o etilendioxi, A, A' son en cada caso, de modo independiente entre sí alquilo no ramificado o ramificado con 1-10 átomos de C, en donde 1-5 átomos de H pueden estar reemplazados por F, Cl y/o Br, Alk o alquilo cíclico con 3-7 átomos de C, A y A' también son juntos una cadena alquileno con 2, 3, 4, 5 o 6 átomos de C, en donde uno o dos grupos CH2, pueden estar reemplazados por O, S, SO, SO2; NH, NA y/o N-COOA, Alk es alquenilo con 2-6 átomos de C, X es alquileno C1-10 o alquenileno C2-C10 no ramificado o ramificado no sustituido o mono-, di-, tri - tetrasustituido con A, OA, OH, SH, SA, Hal, NO2, CN, Ar, O ar, COOH, COOA, CHO, C(=O)A, C(=O)Ar, SO2A, CONH2, SO2NH2, CONHA, XONNA', SO2NHA, SO2NAA?,NH2, NHA, NAA'OCONH2, OCONHA, OCONAA', NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONH2, NHCONHA, NACONHA; NHCONAA', NACONAA', y/u =O, en donde también uno, dos o tres grupos C pueden estar reemplazados por O, S, SO, SO2, NCO, NACO, CONH, CONA, SO2NH, SO2NA, NHSO2, NASO2 y/o por grupos NH, Q es H, Carb, Ar o Het, Carb es cicloalquilo con 3-7 átomos de C o cicloalquenilo con 3-7 átomos de C no sustituido o mono-, di, tri-, tetra- o pentasustituido con A, OA, OH, SH, SA, Hal, NO2; CN, (CH2)nAr', (CH2)nCOOH, (CH2)nCOOA, CHO, COA, SO2A, CONH2, SO2NH2, CONHA, CONAA', SO2NHA, SO2NAA', NH2, NHA, NAA', OCONH2, OCONHA, OCONAA', NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH, NACONH2, NHCONHA, NACONHA, NHCONAA' y/o NACONAA', Ar es fenilo, naftilo o bifenilo no sustituido o mono-, di-, tri-, tetra- o pentasustituido con A, OA, OH, SH, SA, Hal, NO2, CN (CH2)nAr', (CH2)nCOOA, CHO, COA, SO2A, CONH2, SO2NH2, CONHA, CONAA', SO2NHA, SO2NAA', NH2, NHA, NAA', OCoN2; OCONHA, OCONAA', NHCOA, NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONHA; NACONHA, NHCONAA', NACONAA', y/o tetraazol, Ar' es fenilo, naftilo o bifenilo no sustituido o mono-, di- o trisustituido con A, OA, OH, SH, SA, Hal, NO2, CH, (CH2)n fenilo, (CH2)nCOOH, (CH2)nCOOA, CHO, COA, SO2A, CONH2, SO2NH2, CONHA, CONAA', SO2NHA, SO2NAA', NH2, NHA, NAA', OCONH2, OCONHA, OCONAA', NHCOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONHA, NACONHA, NHCONAA' y/o NACONAA', Het es un heterociclo mono-, o bicíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S, que puede estar mono-, di o trisustituido con A, OA, OH, SH,SA, Hal, NO2, CN, (CH2)nAr', (CH2)nCOOH, (CH2)nCOOA, CHO, COA, SO2A, CONH2, SO2nH2, CONHA, CONNA', SO2NHA, SO2NAA', NH2, NHA, NAA', OCONH2, OCONHA, OCONAA, NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONHA, NACONHA, NHCONAA', NACONAA', SO2A, =S, =NH, =NA y/u =O (oxígeno del carbonilo),,Het1 un heterociclo monocíclico saturado, insaturado o aromático con 1 a 2 átomos de N y/u O, que puede estar mono- o disustituido con A, OA, OH, Hal y/u =O (oxígeno el carbonilo), Hal es F Cl, Br, o I, n es 0, 1, 2, 3, o 4, o es 1, 2, o 3, s es 0, 1 o 2, así como sus derivados, sales, ,solvatos, tautomeros y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones. Son inhibidores de HSP90 y pueden ser utilizados para preparar un medicamento para el tratamiento de enfermedades en las que la inhibicion, la regulacion y/o la modulacion de la HSP90 desempana un papel importante
ARP060102035A 2005-05-19 2006-05-19 Derivados de fenilquinazolina AR054047A1 (es)

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DE102005022977A DE102005022977A1 (de) 2005-05-19 2005-05-19 Phenylchinazolinderivate

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US (1) US7947696B2 (es)
EP (1) EP1881965A1 (es)
JP (1) JP5075117B2 (es)
KR (1) KR20080016651A (es)
CN (1) CN101180278B (es)
AR (1) AR054047A1 (es)
AU (1) AU2006246744B2 (es)
BR (1) BRPI0610134A2 (es)
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE541844T1 (de) * 2005-12-21 2012-02-15 Abbott Lab Antivirale verbindungen
AR061185A1 (es) * 2006-05-26 2008-08-13 Chugai Pharmaceutical Co Ltd Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas.
EP2109612B1 (en) 2007-02-01 2010-11-10 AstraZeneca AB 5,6,7,8-tetrahydropteridine derivatives as hsp90 inhibitors
CL2008000629A1 (es) * 2007-03-01 2008-08-29 Chugai Pharmaceutical Co Ltd Compuestos macrociclicos derivados de 6-aril-4-mercapto-[1.3.5]triazina/[1.3]pirimidin-2-amina; composicion farmaceutica, utiles en el tratamiento del cancer.
ES2395114T3 (es) * 2007-03-27 2013-02-08 Synta Pharmaceuticals Corporation Derivados de triazinona y de diazinona útiles como inhibidores de Hsp90
AU2008242983B2 (en) * 2007-04-16 2013-07-11 Abbvie Inc. 7-substituted indole Mcl-1 inhibitors
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
DE102007032739A1 (de) * 2007-07-13 2009-01-15 Merck Patent Gmbh Chinazolinamidderivate
GB0722680D0 (en) * 2007-11-19 2007-12-27 Topotarget As Therapeutic compounds and their use
US20110281908A1 (en) * 2008-10-06 2011-11-17 Emory University Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
DE102008061214A1 (de) 2008-12-09 2010-06-10 Merck Patent Gmbh Chinazolinamidderivate
RU2015144653A (ru) 2009-03-25 2018-12-29 Эббви Инк. Противовирусные соединения и их применения
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
DE102010046837A1 (de) * 2010-09-29 2012-03-29 Merck Patent Gmbh Phenylchinazolinderivate
MX2013007938A (es) * 2011-01-07 2013-11-01 Taiho Pharmaceutical Co Ltd Compuesto biciclico novedoso o sal del mismo.
AR091858A1 (es) 2012-07-25 2015-03-04 Sova Pharmaceuticals Inc INHIBIDORES DE CISTATIONIN-g-LIASA (CSE)
CA2952230C (en) * 2014-06-13 2023-03-21 Yuma Therapeutics, Inc. Pyrimidine compounds and methods using the same
CA3015417A1 (en) 2016-03-01 2017-09-08 Propellon Therapeutics Inc. Inhibitors of wdr5 protein-protein binding
EP3423451B1 (en) 2016-03-01 2022-08-17 Propellon Therapeutics Inc. Inhibitors of wdr5 protein-protein binding
KR101990669B1 (ko) * 2016-05-31 2019-06-19 전남대학교산학협력단 퀴나졸린 유도체, 이의 제조방법 및 이를 함유하는 인플루엔자 바이러스 치료용 약학적 조성물
CN113286785A (zh) * 2019-01-04 2021-08-20 贝尔布鲁克实验室有限责任公司 作为治疗剂的cGAS活性的抑制剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06192099A (ja) * 1992-10-07 1994-07-12 Sumitomo Pharmaceut Co Ltd 腫瘍壊死因子産生阻害剤
US5646154A (en) 1992-10-07 1997-07-08 Sumitomo Pharmaceuticals Co., Ltd. Pharmaceutical compositions for inhibiting the formation of tumor necrosis factor
JPH11209350A (ja) * 1998-01-26 1999-08-03 Eisai Co Ltd 含窒素複素環誘導体およびその医薬
AU2001293826A1 (en) * 2000-09-25 2002-04-02 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors
AR038658A1 (es) 2001-06-15 2005-01-26 Novartis Ag Derivados de 4-aril-2(1h) quinazolinona y 4-aril-quinazolina 2-sustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de un medicamento
DE10163991A1 (de) * 2001-12-24 2003-07-03 Merck Patent Gmbh Pyrrolo-pyrimidine
KR101139314B1 (ko) 2003-08-29 2012-04-26 베르날리스(캠브리지)리미티드 피리미도티오펜 화합물
EP1685115A1 (en) * 2003-11-03 2006-08-02 Warner-Lambert Company LLC Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders

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DE102005022977A1 (de) 2006-12-07
JP5075117B2 (ja) 2012-11-14
BRPI0610134A2 (pt) 2010-06-01
ZA200710966B (en) 2008-12-31
CN101180278B (zh) 2011-05-04
HK1119690A1 (es) 2009-03-13
CN101180278A (zh) 2008-05-14
US20080214586A1 (en) 2008-09-04
AU2006246744A1 (en) 2006-11-23
MX2007014264A (es) 2008-01-22
AU2006246744B2 (en) 2011-11-03
EP1881965A1 (de) 2008-01-30
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RU2007146388A (ru) 2009-06-27
US7947696B2 (en) 2011-05-24

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