ZA200710644B - Amylases for pharmaceutical use - Google Patents

Amylases for pharmaceutical use

Info

Publication number
ZA200710644B
ZA200710644B ZA200710644A ZA200710644A ZA200710644B ZA 200710644 B ZA200710644 B ZA 200710644B ZA 200710644 A ZA200710644 A ZA 200710644A ZA 200710644 A ZA200710644 A ZA 200710644A ZA 200710644 B ZA200710644 B ZA 200710644B
Authority
ZA
South Africa
Prior art keywords
amylases
pharmaceutical use
pharmaceutical
Prior art date
Application number
ZA200710644A
Other languages
English (en)
Inventor
Svendsen Allan
Gregory Peter Colin
Original Assignee
Novozymes As
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As, Solvay Pharm Gmbh filed Critical Novozymes As
Publication of ZA200710644B publication Critical patent/ZA200710644B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • C12N9/2408Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411Amylases
    • C12N9/2414Alpha-amylase (3.2.1.1.)
    • C12N9/2417Alpha-amylase (3.2.1.1.) from microbiological source
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200710644A 2005-06-24 2007-12-06 Amylases for pharmaceutical use ZA200710644B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200500931 2005-06-24

Publications (1)

Publication Number Publication Date
ZA200710644B true ZA200710644B (en) 2008-11-26

Family

ID=34956782

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710644A ZA200710644B (en) 2005-06-24 2007-12-06 Amylases for pharmaceutical use

Country Status (15)

Country Link
US (1) US8017351B2 (pt)
EP (1) EP1896057A2 (pt)
JP (1) JP2008546396A (pt)
KR (1) KR20080031868A (pt)
CN (1) CN101242853A (pt)
AU (1) AU2006261444A1 (pt)
BR (1) BRPI0611932A2 (pt)
CA (1) CA2612811A1 (pt)
IL (1) IL187635A0 (pt)
MX (1) MX2007015471A (pt)
NO (1) NO20080439L (pt)
NZ (1) NZ563737A (pt)
RU (1) RU2008102650A (pt)
WO (1) WO2006136161A2 (pt)
ZA (1) ZA200710644B (pt)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2440249T3 (es) * 2006-04-04 2014-01-28 Novozymes A/S Proceso de trituración
RU2009128067A (ru) 2006-12-21 2011-01-27 Новозимс А/С (Dk) Варианты липаз для их применения в фармацевтике
CN101889084A (zh) 2007-12-04 2010-11-17 诺维信公司 供药学应用的蛋白酶变体
GB2468629B (en) * 2008-06-08 2011-10-26 Tarig Sayed Mustafa Arbab Method, composition, device for the treatment of amylase malfunctions/inactivity in association with saccharides (mainly polysaccharides) based diseases
CN102438599B (zh) * 2009-03-04 2015-01-21 迈雅营养品有限公司 通过降低血糖水平来控制糖尿病的营养组合物和方法
WO2011000924A1 (en) 2009-07-03 2011-01-06 Abbott Products Gmbh Spray-dried amylase, pharmaceutical preparations comprising the same and use
CN102918149A (zh) 2010-01-04 2013-02-06 诺维信公司 α-淀粉酶
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
US20130273026A1 (en) * 2012-04-12 2013-10-17 Integrative Enzymatics, Inc. Composition and method for modulating inflammatory molecules with amylase
EP3004341B1 (en) 2013-05-29 2017-08-30 Danisco US Inc. Novel metalloproteases
EP3110833B1 (en) 2013-05-29 2020-01-08 Danisco US Inc. Novel metalloproteases
JP6367930B2 (ja) 2013-05-29 2018-08-01 ダニスコ・ユーエス・インク 新規メタロプロテアーゼ
US20160160202A1 (en) 2013-05-29 2016-06-09 Danisco Us Inc. Novel metalloproteases
ES2723948T3 (es) 2013-12-13 2019-09-04 Danisco Us Inc Serina proteasas procedentes de especies de Bacillus
EP3553173B1 (en) 2013-12-13 2021-05-19 Danisco US Inc. Serine proteases of the bacillus gibsonii-clade
US10005850B2 (en) 2013-12-16 2018-06-26 E I Du Pont De Nemours And Company Use of poly alpha-1,3-glucan ethers as viscosity modifiers
CN106029700B (zh) 2013-12-18 2019-04-12 纳幕尔杜邦公司 阳离子聚α-1,3-葡聚糖醚
CN105992796A (zh) 2014-02-14 2016-10-05 纳幕尔杜邦公司 用于粘度调节的聚-α-1,3-1,6-葡聚糖
CN103789285B (zh) * 2014-02-19 2016-01-20 江南大学 一种热稳定性提高的淀粉酶突变体及其构建方法和应用
JP2017515921A (ja) 2014-03-11 2017-06-15 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company 酸化されたポリα−1,3−グルカン
US20170096653A1 (en) 2014-03-21 2017-04-06 Danisco Us Inc. Serine proteases of bacillus species
CN106661564A (zh) 2014-04-25 2017-05-10 巴斯夫欧洲公司 淀粉酶变体
EP3919599A1 (en) 2014-06-19 2021-12-08 Nutrition & Biosciences USA 4, Inc. Compositions containing one or more poly alpha-1,3-glucan ether compounds
US9714403B2 (en) 2014-06-19 2017-07-25 E I Du Pont De Nemours And Company Compositions containing one or more poly alpha-1,3-glucan ether compounds
CN104212780A (zh) * 2014-09-02 2014-12-17 华东理工大学 一种α-淀粉酶及其编码基因与应用
WO2016036834A1 (en) * 2014-09-02 2016-03-10 Danisco Us Inc. Dp5-enriched syrups
US20170233710A1 (en) 2014-10-17 2017-08-17 Danisco Us Inc. Serine proteases of bacillus species
WO2016069557A1 (en) 2014-10-27 2016-05-06 Danisco Us Inc. Serine proteases of bacillus species
EP3550017B1 (en) 2014-10-27 2021-07-14 Danisco US Inc. Serine proteases
EP3212781B1 (en) 2014-10-27 2019-09-18 Danisco US Inc. Serine proteases
EP3212783B1 (en) 2014-10-27 2024-06-26 Danisco US Inc. Serine proteases
EP3212662B1 (en) 2014-10-27 2020-04-08 Danisco US Inc. Serine proteases
WO2016106011A1 (en) 2014-12-23 2016-06-30 E. I. Du Pont De Nemours And Company Enzymatically produced cellulose
EP3872174B1 (en) 2015-05-13 2023-03-01 Danisco US Inc. Aprl-clade protease variants and uses thereof
ES2962329T3 (es) 2015-06-09 2024-03-18 Danisco Us Inc Encapsulados de estallido osmótico
WO2016201069A1 (en) 2015-06-09 2016-12-15 Danisco Us Inc Low-density enzyme-containing particles
WO2016201040A1 (en) 2015-06-09 2016-12-15 Danisco Us Inc. Water-triggered enzyme suspension
CN107849549B (zh) 2015-06-17 2024-04-05 丹尼斯科美国公司 吉氏芽孢杆菌进化枝丝氨酸蛋白酶
WO2017052455A1 (en) 2015-09-23 2017-03-30 Anara Ab Amylase fragments for blood glucose control
WO2017079751A1 (en) 2015-11-05 2017-05-11 Danisco Us Inc Paenibacillus sp. mannanases
EP3371307A1 (en) 2015-11-05 2018-09-12 Danisco US Inc. Paenibacillus and bacillus spp. mannanases
JP7045313B2 (ja) 2015-11-13 2022-03-31 ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー,インコーポレイテッド 洗濯ケアおよび織物ケアにおいて使用するためのグルカン繊維組成物
JP2019504932A (ja) 2015-11-13 2019-02-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company 洗濯ケアおよび織物ケアにおいて使用するためのグルカン繊維組成物
US10876074B2 (en) 2015-11-13 2020-12-29 Dupont Industrial Biosciences Usa, Llc Glucan fiber compositions for use in laundry care and fabric care
BR112018011755A2 (pt) 2015-12-09 2018-12-04 Danisco Us Inc variantes combinatórias de alfa-amilase
WO2017106676A1 (en) 2015-12-18 2017-06-22 Danisco Us Inc Polypeptides with endoglucanase activity and uses thereof
EP3452585A1 (en) 2016-05-03 2019-03-13 Danisco US Inc. Protease variants and uses thereof
EP3452497B1 (en) * 2016-05-03 2021-02-17 Novozymes A/S Alpha-amylase variants and polynucleotides encoding the same
BR112018072586A2 (pt) 2016-05-05 2019-02-19 Danisco Us Inc variantes de protease e usos das mesmas
CN109477112A (zh) 2016-05-31 2019-03-15 丹尼斯科美国公司 蛋白酶变体及其用途
EP3251687A1 (en) 2016-06-01 2017-12-06 Centrum Innowacji Edoradca Sp. z o.o. Spolka Komandytowa Bioactive peptides for blood glucose control
BR112018075933A2 (pt) 2016-06-17 2019-10-01 Danisco Us Inc variantes de protease e usos das mesmas
GB201614415D0 (en) * 2016-08-24 2016-10-05 Pepsis Ltd Enzymes for the treatment of human enterometabolic dysfunction
EP3535365A2 (en) 2016-11-07 2019-09-11 Danisco US Inc. Laundry detergent composition
EP4212622A3 (en) 2016-12-21 2023-11-29 Danisco US Inc. Bacillus gibsonii-clade serine proteases
WO2018118917A1 (en) 2016-12-21 2018-06-28 Danisco Us Inc. Protease variants and uses thereof
EP3583210B1 (en) 2017-03-15 2021-07-07 Danisco US Inc. Trypsin-like serine proteases and uses thereof
US20200040283A1 (en) 2017-03-31 2020-02-06 Danisco Us Inc Delayed release enzyme formulations for bleach-containing detergents
JP2020527339A (ja) 2017-06-30 2020-09-10 ダニスコ・ユーエス・インク 低凝集の酵素含有粒子
EP3717643A1 (en) 2017-11-29 2020-10-07 Danisco US Inc. Subtilisin variants having improved stability
CA3086202A1 (en) 2017-12-21 2019-06-27 Danisco Us Inc. Enzyme-containing, hot-melt granules comprising a thermotolerant desiccant
US20200359656A1 (en) 2018-02-08 2020-11-19 Danisco Us Inc. Thermally-resistant wax matrix particles for enzyme encapsulation
WO2019204486A1 (en) * 2018-04-18 2019-10-24 Baylor College Of Medicine Development of amyloglucosidase as a medicinal food or dietary supplement
US20210214703A1 (en) 2018-06-19 2021-07-15 Danisco Us Inc Subtilisin variants
WO2019245705A1 (en) 2018-06-19 2019-12-26 Danisco Us Inc Subtilisin variants
US20210189295A1 (en) 2018-08-30 2021-06-24 Danisco Us Inc Enzyme-containing granules
CN113166682A (zh) 2018-09-27 2021-07-23 丹尼斯科美国公司 用于医疗器械清洁的组合物
US20230028935A1 (en) 2018-11-28 2023-01-26 Danisco Us Inc Subtilisin variants having improved stability
CN114174504A (zh) 2019-05-24 2022-03-11 丹尼斯科美国公司 枯草杆菌蛋白酶变体和使用方法
EP3980517A1 (en) 2019-06-06 2022-04-13 Danisco US Inc. Methods and compositions for cleaning
US20240034960A1 (en) 2020-08-27 2024-02-01 Danisco Us Inc Enzymes and enzyme compositions for cleaning
US20240117275A1 (en) 2021-01-29 2024-04-11 Danisco Us Inc. Compositions for cleaning and methods related thereto
EP4363565A1 (en) 2021-06-30 2024-05-08 Danisco US Inc. Variant lipases and uses thereof
WO2023034486A2 (en) 2021-09-03 2023-03-09 Danisco Us Inc. Laundry compositions for cleaning
WO2023039270A2 (en) 2021-09-13 2023-03-16 Danisco Us Inc. Bioactive-containing granules
WO2023114936A2 (en) 2021-12-16 2023-06-22 Danisco Us Inc. Subtilisin variants and methods of use
WO2023114939A2 (en) 2021-12-16 2023-06-22 Danisco Us Inc. Subtilisin variants and methods of use
WO2023114932A2 (en) 2021-12-16 2023-06-22 Danisco Us Inc. Subtilisin variants and methods of use
WO2023168234A1 (en) 2022-03-01 2023-09-07 Danisco Us Inc. Enzymes and enzyme compositions for cleaning
WO2023250301A1 (en) 2022-06-21 2023-12-28 Danisco Us Inc. Methods and compositions for cleaning comprising a polypeptide having thermolysin activity
WO2024050339A1 (en) 2022-09-02 2024-03-07 Danisco Us Inc. Mannanase variants and methods of use
WO2024050343A1 (en) 2022-09-02 2024-03-07 Danisco Us Inc. Subtilisin variants and methods related thereto
WO2024050346A1 (en) 2022-09-02 2024-03-07 Danisco Us Inc. Detergent compositions and methods related thereto
WO2024102698A1 (en) 2022-11-09 2024-05-16 Danisco Us Inc. Subtilisin variants and methods of use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK173590D0 (da) 1990-06-06 1990-07-19 Novo Nordisk As Rekombinante terapeutiske lipaser
US5281526A (en) * 1992-10-20 1994-01-25 Solvay Enzymes, Inc. Method of purification of amylase by precipitation with a metal halide and 4-hydroxybenzic acid or a derivative thereof
AU6221496A (en) 1995-05-31 1996-12-18 Simon Lodewijk Scharpe Composition to improve digestibility and utilisation of nutr ients
AU2692897A (en) * 1996-04-30 1997-11-19 Novo Nordisk A/S Alpha-amylase mutants
EP1023439B1 (en) 1997-10-13 2009-02-18 Novozymes A/S alpha-AMYLASE MUTANTS
PT1162995E (pt) * 1999-03-17 2003-08-29 Solvay Pharm Gmbh Enzimas para o tratamento da diabetes mellitus do tipo i
US6410295B1 (en) * 1999-03-30 2002-06-25 Novozymes A/S Alpha-amylase variants
US20010046493A1 (en) * 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
AR032392A1 (es) * 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
RU2201763C1 (ru) 2001-12-29 2003-04-10 Закрытое акционерное общество "Брынцалов-А" Полиферментное средство ферестал
DE10260903A1 (de) * 2002-12-20 2004-07-08 Henkel Kgaa Neue Perhydrolasen
EP1597363B1 (en) * 2003-02-26 2015-07-15 Danisco US Inc. Amylases producing an altered immunogenic response and methods of making and using the same
BRPI0611936A2 (pt) * 2005-06-24 2011-02-22 Solvay Pharm Gmbh protease, uso de uma protease, composição farmacêutica, e, método para o tratamento de doença
US20090047266A1 (en) * 2005-06-24 2009-02-19 Novozymes A/S Lipases for Pharmaceutical Use

Also Published As

Publication number Publication date
US8017351B2 (en) 2011-09-13
CA2612811A1 (en) 2006-12-28
CN101242853A (zh) 2008-08-13
NO20080439L (no) 2008-03-04
RU2008102650A (ru) 2009-07-27
AU2006261444A1 (en) 2006-12-28
US20090035293A1 (en) 2009-02-05
NZ563737A (en) 2010-08-27
WO2006136161A3 (en) 2007-07-05
IL187635A0 (en) 2008-03-20
MX2007015471A (es) 2008-04-04
BRPI0611932A2 (pt) 2011-01-04
WO2006136161A2 (en) 2006-12-28
EP1896057A2 (en) 2008-03-12
KR20080031868A (ko) 2008-04-11
JP2008546396A (ja) 2008-12-25

Similar Documents

Publication Publication Date Title
IL187635A0 (en) Amylases for pharmaceutical use
IL187511A0 (en) Lipases for pharmaceutical use
GB0501999D0 (en) Pharmaceutical compounds
GB0520657D0 (en) Pharmaceutical compounds
GB0520656D0 (en) Pharmaceutical compounds
AP2008004533A0 (en) Pharmaceutical combination
IL187510A0 (en) Proteases for pharmaceutical use
ZA200708705B (en) Pharmaceutical composition
IL188438A0 (en) New pharmaceutical compounds
EP1937255A4 (en) PHARMACEUTICAL COMPOSITION
EP1852117A4 (en) PHARMACEUTICAL AGENT COMPRISING SOLIFENACIN
EP1862184A4 (en) PHARMACEUTICAL COMPOSITION
GB0512643D0 (en) Pharmaceutical compounds
ZA200804666B (en) Pharmaceutical combination
ZA200710642B (en) Proteases for pharmaceutical use
GB0512246D0 (en) Novel pharmaceutical
ZA200705612B (en) Pharmaceutical compounds
GB0501475D0 (en) Pharmaceutical compounds
GB0500826D0 (en) Pharmaceutical use
GB0515315D0 (en) Pharmaceutical agents
GB0514530D0 (en) Pharmaceutical agent
GB0512681D0 (en) Pharmaceutical compounds
GB0512654D0 (en) Pharmaceutical compounds
GB0526607D0 (en) Pharmaceutical compounds
GB0507474D0 (en) Pharmaceutical compounds