ZA200710311B - Oligonucleotides or their functional homologues, a composition comprising the same and a method of treating B cell neoplasm - Google Patents

Oligonucleotides or their functional homologues, a composition comprising the same and a method of treating B cell neoplasm

Info

Publication number
ZA200710311B
ZA200710311B ZA200710311A ZA200710311A ZA200710311B ZA 200710311 B ZA200710311 B ZA 200710311B ZA 200710311 A ZA200710311 A ZA 200710311A ZA 200710311 A ZA200710311 A ZA 200710311A ZA 200710311 B ZA200710311 B ZA 200710311B
Authority
ZA
South Africa
Prior art keywords
oligonucleotides
treating
composition
same
cell neoplasm
Prior art date
Application number
ZA200710311A
Other languages
English (en)
Inventor
Wang Li-Ying
Bao Mu-Sheng
Yu Yong-Li
Original Assignee
Changchun Huapu Biotechnology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Changchun Huapu Biotechnology filed Critical Changchun Huapu Biotechnology
Publication of ZA200710311B publication Critical patent/ZA200710311B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/313—Phosphorodithioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
ZA200710311A 2005-05-17 2006-02-13 Oligonucleotides or their functional homologues, a composition comprising the same and a method of treating B cell neoplasm ZA200710311B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2005100695764A CN1865275B (zh) 2005-05-17 2005-05-17 对人b细胞肿瘤有治疗作用的人工合成的单链脱氧核苷酸

Publications (1)

Publication Number Publication Date
ZA200710311B true ZA200710311B (en) 2009-08-26

Family

ID=37424439

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA200710311A ZA200710311B (en) 2005-05-17 2006-02-13 Oligonucleotides or their functional homologues, a composition comprising the same and a method of treating B cell neoplasm
ZA200710312A ZA200710312B (en) 2005-05-17 2006-02-13 An oligonucleotide or its functional homologue, a composition comprising the same and a method for treating B Cell neoplasm

Family Applications After (1)

Application Number Title Priority Date Filing Date
ZA200710312A ZA200710312B (en) 2005-05-17 2006-02-13 An oligonucleotide or its functional homologue, a composition comprising the same and a method for treating B Cell neoplasm

Country Status (22)

Country Link
US (3) US8133874B2 (pt)
EP (2) EP1883411B1 (pt)
JP (2) JP4837033B2 (pt)
KR (2) KR101294131B1 (pt)
CN (1) CN1865275B (pt)
AU (2) AU2006246897B2 (pt)
BR (2) BRPI0609885A2 (pt)
CA (2) CA2609067A1 (pt)
CY (1) CY1114844T1 (pt)
DK (2) DK1883411T3 (pt)
ES (2) ES2442462T3 (pt)
HK (2) HK1112745A1 (pt)
IL (2) IL187249A (pt)
MX (2) MX2007014146A (pt)
NZ (1) NZ563582A (pt)
PL (2) PL1883411T3 (pt)
PT (2) PT1883647E (pt)
RU (2) RU2413519C2 (pt)
SI (2) SI1883647T1 (pt)
UA (2) UA91057C2 (pt)
WO (2) WO2006122464A1 (pt)
ZA (2) ZA200710311B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110182880A1 (en) * 2008-06-18 2011-07-28 Oliver Von Stein Combination Therapies Against Cancer
CN101643496B (zh) * 2008-08-07 2015-09-09 长春华普生物技术有限公司 一种具有免疫抑制功能的寡核苷酸
WO2010053433A1 (en) * 2008-11-04 2010-05-14 Index Pharmaceuticals Ab Increased expression of specific antigens
US9157919B2 (en) * 2010-12-21 2015-10-13 Index Pharmaceuticals Ab Method for identifying biologically active oligonucleotides capable of modulating the immune system
WO2012084991A1 (en) * 2010-12-21 2012-06-28 Index Pharmaceuticals Ab Biologically active oligonucleotides capable of modulating the immune system ii
CN106893724B (zh) * 2015-12-17 2023-05-02 苏州派动生物技术有限公司 具有抗原增效作用和肿瘤治疗作用的寡核苷酸
WO2021249116A1 (en) 2020-06-10 2021-12-16 Sichuan Clover Biopharmaceuticals, Inc. Coronavirus vaccine compositions, methods, and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1775A (en) 1999-09-25 2007-08-28 Univ Iowa Res Found Immunostimulatory nucleic acids.
BR0109705A (pt) * 2000-03-31 2005-01-11 Idec Pharma Corp Uso combinado de anticorpos ou antagonistas anti-citocina e anticd20 para o tratamento de linfoma de célula b
AU2001270134B2 (en) 2000-06-22 2006-06-15 University Of Iowa Research Foundation Methods for enhancing antibody-induced cell lysis and treating cancer
US20040009156A1 (en) 2001-10-12 2004-01-15 Christoph Reinhard Antisense therapy using oligonucleotides that target human kinesin genes for treatment of cancer
EP1465634B1 (en) * 2001-12-12 2014-10-22 The Government of the United States of America, as represented by the Secretary Department of Health and Human Services Methods for using adenosine receptor inhibitors to enhance immune response and inflammation
US7576066B2 (en) * 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
DE10258677A1 (de) 2002-12-13 2004-06-24 Elez, Vera, Dr. Kombinations-antisense-Oligonukleotid-Krebstherapie
CN100439386C (zh) 2003-03-05 2008-12-03 长春华普生物技术有限公司 增强蛋白类疫苗免疫效果的含CpG单链脱氧寡核苷酸
CN100486987C (zh) * 2003-03-05 2009-05-13 长春华普生物技术有限公司 抗病毒和抗肿瘤的含CpG单链脱氧寡核苷酸
WO2005014611A1 (fr) 2003-07-25 2005-02-17 Changchun Huapu Biotechnology Co., Ltd. Oligodesoxyribonucleotide a simple brin cpg artificiel et utilisations antivirales
JP4513879B2 (ja) 2008-03-05 2010-07-28 ソニー株式会社 像ぶれ補正装置、レンズ鏡筒装置及びカメラ装置

Also Published As

Publication number Publication date
EP1883647A4 (en) 2010-10-06
EP1883411A1 (en) 2008-02-06
PL1883411T3 (pl) 2014-01-31
RU2413519C2 (ru) 2011-03-10
US20090162279A1 (en) 2009-06-25
CY1114844T1 (el) 2016-12-14
WO2006122463A1 (en) 2006-11-23
US20120142761A1 (en) 2012-06-07
ES2433129T3 (es) 2013-12-09
SI1883411T1 (sl) 2014-01-31
PT1883411E (pt) 2013-11-11
IL187281A0 (en) 2011-08-01
BRPI0609885A2 (pt) 2010-05-04
RU2007146705A (ru) 2009-06-27
JP2008539767A (ja) 2008-11-20
CA2609067A1 (en) 2006-11-23
MX2007014145A (es) 2008-03-07
CA2609062A1 (en) 2006-11-23
PL1883647T3 (pl) 2014-03-31
EP1883647A1 (en) 2008-02-06
IL187281A (en) 2012-04-30
BRPI0609882A2 (pt) 2010-05-04
US20090202567A1 (en) 2009-08-13
AU2006246898B2 (en) 2011-08-18
AU2006246897A1 (en) 2006-11-23
SI1883647T1 (sl) 2014-02-28
KR101346716B1 (ko) 2014-01-02
RU2007146706A (ru) 2009-06-27
JP4837033B2 (ja) 2011-12-14
EP1883411B1 (en) 2013-08-14
RU2409672C2 (ru) 2011-01-20
CN1865275A (zh) 2006-11-22
EP1883411A4 (en) 2010-10-06
UA94231C2 (ru) 2011-04-26
MX2007014146A (es) 2008-03-07
JP4837034B2 (ja) 2011-12-14
ES2442462T3 (es) 2014-02-11
UA91057C2 (ru) 2010-06-25
DK1883647T3 (da) 2014-01-27
NZ563582A (en) 2010-04-30
JP2008539768A (ja) 2008-11-20
CN1865275B (zh) 2011-06-15
KR20080011426A (ko) 2008-02-04
WO2006122464A1 (en) 2006-11-23
PT1883647E (pt) 2014-01-20
ZA200710312B (en) 2009-08-26
HK1113318A1 (en) 2008-10-03
HK1112745A1 (en) 2008-09-12
CA2609062C (en) 2013-11-19
AU2006246898A1 (en) 2006-11-23
US8133874B2 (en) 2012-03-13
IL187249A (en) 2012-03-29
KR101294131B1 (ko) 2013-08-07
DK1883411T3 (da) 2013-11-18
IL187249A0 (en) 2008-02-09
AU2006246897B2 (en) 2012-04-12
US8450292B2 (en) 2013-05-28
KR20080007655A (ko) 2008-01-22
EP1883647B1 (en) 2013-10-23

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