ZA200701583B - Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 - Google Patents
Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1Info
- Publication number
- ZA200701583B ZA200701583B ZA200701583A ZA200701583A ZA200701583B ZA 200701583 B ZA200701583 B ZA 200701583B ZA 200701583 A ZA200701583 A ZA 200701583A ZA 200701583 A ZA200701583 A ZA 200701583A ZA 200701583 B ZA200701583 B ZA 200701583B
- Authority
- ZA
- South Africa
- Prior art keywords
- thiazolo
- inhibitors
- plasminogen activator
- activator inhibitor
- naphthyl acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60373904P | 2004-08-23 | 2004-08-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200701583B true ZA200701583B (en) | 2009-08-26 |
Family
ID=35968262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200701583A ZA200701583B (en) | 2004-08-23 | 2007-02-22 | Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 |
Country Status (15)
Country | Link |
---|---|
US (2) | US7605172B2 (xx) |
EP (1) | EP1794138A2 (xx) |
JP (1) | JP2008510816A (xx) |
KR (1) | KR20070045353A (xx) |
CN (1) | CN101044127A (xx) |
AU (1) | AU2005277139A1 (xx) |
BR (1) | BRPI0514572A (xx) |
CA (1) | CA2577846A1 (xx) |
CR (1) | CR8926A (xx) |
EC (1) | ECSP077270A (xx) |
IL (1) | IL181330A0 (xx) |
NO (1) | NO20071378L (xx) |
RU (1) | RU2007106869A (xx) |
WO (1) | WO2006023866A2 (xx) |
ZA (1) | ZA200701583B (xx) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE331709T1 (de) * | 2002-12-10 | 2006-07-15 | Wyeth Corp | Substituierte 3-carbonyl-1-yl essigsäure derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren |
US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
CA2577782A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as pai-1 inhibitors |
AU2006279496A1 (en) * | 2005-08-17 | 2007-02-22 | Wyeth | Substituted indoles and use thereof |
KR20080108407A (ko) * | 2006-02-27 | 2008-12-15 | 와이어쓰 | 근육 상태의 치료를 위한 pai-1 억제제 |
EP2706852B1 (en) | 2011-05-10 | 2018-08-22 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as syk inhibitors |
KR20140028062A (ko) * | 2011-05-10 | 2014-03-07 | 머크 샤프 앤드 돔 코포레이션 | Syk 억제제로서의 아미노피리미딘 |
EP2707357B1 (en) | 2011-05-10 | 2017-01-18 | Merck Sharp & Dohme Corp. | Pyridyl aminopyridines as syk inhibitors |
US9045466B2 (en) | 2011-07-29 | 2015-06-02 | Taisho Pharmaceutical Co., Ltd | Amidine compound or salt thereof |
CN105418527A (zh) * | 2015-12-28 | 2016-03-23 | 青岛友诚高新技术有限公司 | 一种具有抗乳腺导管癌活性的化合物及其制备方法、用途 |
CN107162999B (zh) * | 2017-06-30 | 2022-06-10 | 淮海工学院 | 2-苯基-4-对羟基苯基噻唑的合成方法 |
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TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
US7291639B2 (en) | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
JP4399253B2 (ja) | 2001-06-20 | 2010-01-13 | ワイス | プラスミノゲンアクチベーターインヒビター−1(pai−1)のインヒビターとしての、置換されたインドール酸誘導体 |
TW591020B (en) * | 2001-06-20 | 2004-06-11 | Wyeth Corp | 6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
TWI240723B (en) | 2001-06-20 | 2005-10-01 | Wyeth Corp | Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
KR100810468B1 (ko) | 2001-10-10 | 2008-03-07 | 씨제이제일제당 (주) | 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난1h-인돌 유도체 |
UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
US7056943B2 (en) | 2002-12-10 | 2006-06-06 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
EP1569901B1 (en) | 2002-12-10 | 2008-10-15 | Wyeth | ARYL, ARYLOXY, AND ALKYLOXY SUBSTITUTED i 1H /i -INDOL-3-YL GLYOXYLIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) |
DE60306547T2 (de) | 2002-12-10 | 2007-06-28 | Wyeth | Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen-aktivator |
ATE331709T1 (de) | 2002-12-10 | 2006-07-15 | Wyeth Corp | Substituierte 3-carbonyl-1-yl essigsäure derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren |
JP4330353B2 (ja) | 2003-02-21 | 2009-09-16 | 株式会社静岡カフェイン工業所 | ピリミジン誘導体 |
JP4390460B2 (ja) | 2003-02-21 | 2009-12-24 | 株式会社静岡カフェイン工業所 | オキサゾール誘導体 |
US20050215626A1 (en) | 2003-09-25 | 2005-09-29 | Wyeth | Substituted benzofuran oximes |
US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
CA2577782A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as pai-1 inhibitors |
US7754747B2 (en) | 2004-08-23 | 2010-07-13 | Wyeth Llc | Oxazolo-naphthyl acids |
-
2005
- 2005-08-22 US US11/208,772 patent/US7605172B2/en not_active Expired - Fee Related
- 2005-08-22 KR KR1020077006735A patent/KR20070045353A/ko not_active Application Discontinuation
- 2005-08-22 EP EP05792721A patent/EP1794138A2/en not_active Withdrawn
- 2005-08-22 BR BRPI0514572-4A patent/BRPI0514572A/pt not_active IP Right Cessation
- 2005-08-22 CN CNA2005800355900A patent/CN101044127A/zh active Pending
- 2005-08-22 AU AU2005277139A patent/AU2005277139A1/en not_active Abandoned
- 2005-08-22 JP JP2007530023A patent/JP2008510816A/ja not_active Withdrawn
- 2005-08-22 WO PCT/US2005/029824 patent/WO2006023866A2/en active Application Filing
- 2005-08-22 CA CA002577846A patent/CA2577846A1/en not_active Abandoned
- 2005-08-22 RU RU2007106869/04A patent/RU2007106869A/ru not_active Application Discontinuation
-
2007
- 2007-02-14 IL IL181330A patent/IL181330A0/en unknown
- 2007-02-15 CR CR8926A patent/CR8926A/es not_active Application Discontinuation
- 2007-02-22 ZA ZA200701583A patent/ZA200701583B/xx unknown
- 2007-02-23 EC EC2007007270A patent/ECSP077270A/es unknown
- 2007-03-14 NO NO20071378A patent/NO20071378L/no not_active Application Discontinuation
-
2009
- 2009-09-04 US US12/554,131 patent/US20090326021A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ECSP077270A (es) | 2007-03-29 |
KR20070045353A (ko) | 2007-05-02 |
EP1794138A2 (en) | 2007-06-13 |
CR8926A (es) | 2007-08-28 |
IL181330A0 (en) | 2007-07-04 |
NO20071378L (no) | 2007-03-23 |
US7605172B2 (en) | 2009-10-20 |
JP2008510816A (ja) | 2008-04-10 |
RU2007106869A (ru) | 2008-09-27 |
US20060052420A1 (en) | 2006-03-09 |
CA2577846A1 (en) | 2006-03-02 |
AU2005277139A1 (en) | 2006-03-02 |
US20090326021A1 (en) | 2009-12-31 |
WO2006023866A2 (en) | 2006-03-02 |
WO2006023866A3 (en) | 2006-06-01 |
BRPI0514572A (pt) | 2008-06-17 |
CN101044127A (zh) | 2007-09-26 |
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