ZA200700683B - Piperidine derivatives as histamine H3 receptor ligands - Google Patents
Piperidine derivatives as histamine H3 receptor ligandsInfo
- Publication number
- ZA200700683B ZA200700683B ZA200700683A ZA200700683A ZA200700683B ZA 200700683 B ZA200700683 B ZA 200700683B ZA 200700683 A ZA200700683 A ZA 200700683A ZA 200700683 A ZA200700683 A ZA 200700683A ZA 200700683 B ZA200700683 B ZA 200700683B
- Authority
- ZA
- South Africa
- Prior art keywords
- histamine
- receptor ligands
- piperidine derivatives
- piperidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401971A SE0401971D0 (sv) | 2004-08-02 | 2004-08-02 | Piperidne derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200700683B true ZA200700683B (en) | 2008-08-27 |
Family
ID=32906883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200700683A ZA200700683B (en) | 2004-08-02 | 2007-01-24 | Piperidine derivatives as histamine H3 receptor ligands |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080064706A1 (fr) |
| EP (1) | EP1781613A1 (fr) |
| JP (1) | JP2008508353A (fr) |
| KR (1) | KR20070043998A (fr) |
| CN (1) | CN1993325A (fr) |
| AU (1) | AU2005267932A1 (fr) |
| BR (1) | BRPI0514035A (fr) |
| CA (1) | CA2576112A1 (fr) |
| IL (1) | IL180548A0 (fr) |
| MX (1) | MX2007001226A (fr) |
| RU (1) | RU2007105970A (fr) |
| SE (1) | SE0401971D0 (fr) |
| WO (1) | WO2006014136A1 (fr) |
| ZA (1) | ZA200700683B (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004228028B2 (en) | 2003-04-03 | 2009-12-10 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| CA2559665A1 (fr) | 2004-03-16 | 2005-09-29 | The Regents Of The University Of California | Reduction de la nephropathie au moyen d'inhibiteurs d'hydrolase d'epoxyde soluble et d'epoxyeicosanoides |
| EP1814875A4 (fr) | 2004-10-20 | 2010-02-17 | Univ California | Inhibiteurs ameliores de l'epoxyde hydrolase soluble |
| WO2006074025A1 (fr) | 2004-12-30 | 2006-07-13 | Janssen Pharmaceutica N.V. | Urees piperazinyle et piperidinyle en tant que modulateurs de l’amide hydrolase d’acides gras |
| EP1909797A4 (fr) | 2005-08-02 | 2013-02-27 | Neurogen Corp | Dipipérazinyl cétones et analogues apparentés |
| AR059826A1 (es) | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
| CN101784529A (zh) * | 2007-06-22 | 2010-07-21 | 弗·哈夫曼-拉罗切有限公司 | 作为非核苷逆转录酶抑制剂的脲和氨基甲酸酯衍生物 |
| MX2010005225A (es) | 2007-11-13 | 2010-05-27 | Taisho Pharmaceutical Co Ltd | Derivados de fenilpirazol. |
| US8598356B2 (en) | 2008-11-25 | 2013-12-03 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| WO2010068453A1 (fr) | 2008-11-25 | 2010-06-17 | Janssen Pharmaceutica Nv | Modulateurs d'urée substitués par hétéroaryle d'amide d'acide gras hydrolase |
| TW201039822A (en) | 2009-02-06 | 2010-11-16 | Taisho Pharmaceutical Co Ltd | Dihydroquinolinone derivatives |
| KR101855471B1 (ko) | 2009-12-04 | 2018-05-09 | 선오비온 파마슈티컬스 인코포레이티드 | 다환형 화합물 및 이의 사용 방법 |
| WO2012054093A2 (fr) | 2010-01-29 | 2012-04-26 | The Regents Of The University Of California | Inhibiteurs d'acyl pipéridine d'époxyde hydrolase soluble |
| UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
| WO2011153359A1 (fr) | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Inhibiteurs du transporteur 1 de la glycine, procédés de fabrication associés, et utilisations associées |
| WO2012113103A1 (fr) * | 2011-02-25 | 2012-08-30 | Helsinn Healthcare S.A. | Urées asymétriques et leurs utilisations médicales |
| TW201321353A (zh) | 2011-10-08 | 2013-06-01 | Novartis Ag | 胺基甲酸酯／尿素衍生物 |
| MX345145B (es) | 2011-12-08 | 2017-01-17 | Taisho Pharmaceutical Co Ltd | Derivado de fenilpirrol. |
| US20150045553A1 (en) | 2011-12-27 | 2015-02-12 | Taisho Pharmaceutical Co., Ltd | Phenyltriazole derivative |
| US9034874B2 (en) | 2012-07-20 | 2015-05-19 | Novartis Ag | Carbamate/urea derivatives |
| TWI690512B (zh) * | 2014-03-07 | 2020-04-11 | 瑞士商赫爾辛保健股份有限公司 | 對位取代的不對稱脲及其醫療用途 |
| WO2015179414A1 (fr) * | 2014-05-19 | 2015-11-26 | Merial, Inc. | Composés anthelmintiques |
| EP3383853B1 (fr) | 2015-12-01 | 2020-11-04 | Merck Sharp & Dohme Corp. | Dérivés homobispipéridinyl en tant qu'agonistes du récepteur nuclélaire des oxystérols (lxr) bêta pour le traitement p.e. de la maladie d´alzheimer |
| BR112018014788B1 (pt) | 2016-03-22 | 2022-03-22 | Helsinn Healthcare Sa | Composto e uso de um composto |
| AU2017275657B2 (en) | 2016-06-02 | 2021-08-19 | Novartis Ag | Potassium channel modulators |
| UA125519C2 (uk) | 2016-07-29 | 2022-04-13 | Суновіон Фармасьютікалз Інк. | Сполуки і композиції і їх застосування |
| SG11201900687VA (en) | 2016-07-29 | 2019-02-27 | Sunovion Pharmaceuticals Inc | Compounds and compositions and uses thereof |
| CN110198935B (zh) | 2017-01-23 | 2022-05-31 | 卡登特治疗公司 | 钾通道调节剂 |
| JP7146782B2 (ja) | 2017-02-16 | 2022-10-04 | サノビオン ファーマシューティカルズ インク | 統合失調症を処置する方法 |
| CA3070993A1 (fr) | 2017-08-02 | 2019-02-07 | Sunovion Pharmaceuticals Inc. | Composes d'isochromane et leurs utilisations |
| SG11202007823PA (en) | 2018-02-16 | 2020-09-29 | Sunovion Pharmaceuticals Inc | Salts, crystal forms, and production methods thereof |
| UA127357C2 (uk) | 2018-04-18 | 2023-07-26 | Констеллатіон Фармацеутікалс, Інк. | Модулятори метилмодифікуючих ферментів, композиції та їх використання |
| CA3100977A1 (fr) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulateurs d'enzymes de modification de methyle, compositions et utilisations de ceux-ci |
| MA53978A (fr) | 2018-10-22 | 2021-09-01 | Cadent Therapeutics Inc | Formes cristallines de modulateurs des canaux potassiques |
| CN111349609A (zh) * | 2018-12-21 | 2020-06-30 | 泰州医药城国科化物生物医药科技有限公司 | 一种无标记组胺受体h3的细胞筛选模型 |
| AU2020236225A1 (en) | 2019-03-14 | 2021-09-16 | Sunovion Pharmaceuticals Inc. | Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
| ES2819309B2 (es) * | 2019-10-14 | 2021-11-17 | Fundacion Para La Investigacion Biomedica Del Hospital Univ De La Princesa | Compuestos agonistas nicotínicos y antioxidantes para el tratamiento de enfermedades neurodegenerativas |
| IL297248A (en) | 2020-04-14 | 2022-12-01 | Sunovion Pharmaceuticals Inc | (s)-(5,4-dihydro-7h-thiano[3,2-c]pyran-7-yl)-n-methylmethanamine for the treatment of neurological and psychiatric disorders |
| CN113549006B (zh) * | 2020-04-26 | 2023-07-21 | 江苏恩华药业股份有限公司 | 一种酰胺衍生物及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0343307A1 (fr) * | 1988-05-26 | 1989-11-29 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | Dérivés de 4-pipéridinealcanamine |
| DE19614204A1 (de) * | 1996-04-10 | 1997-10-16 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| ATE450508T1 (de) * | 2001-09-14 | 2009-12-15 | High Point Pharmaceuticals Llc | Substituierte piperidinen mit selektiver bindungsfähigkeit zu histamin h3-rezeptoren |
| US6673829B2 (en) * | 2001-09-14 | 2004-01-06 | Novo Nordisk A/S | Aminoazetidine,-pyrrolidine and -piperidine derivatives |
| US7064135B2 (en) * | 2001-10-12 | 2006-06-20 | Novo Nordisk Inc. | Substituted piperidines |
| WO2004037800A1 (fr) * | 2002-10-22 | 2004-05-06 | Glaxo Group Limited | Derives d'aryloxyalkylamine tels que des ligands du recepteur h3 |
| US7332508B2 (en) * | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
| CA2551037A1 (fr) * | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | Nouveau derive de piperidine |
-
2004
- 2004-08-02 SE SE0401971A patent/SE0401971D0/xx unknown
-
2005
- 2005-07-27 WO PCT/SE2005/001189 patent/WO2006014136A1/fr active Application Filing
- 2005-07-27 BR BRPI0514035-8A patent/BRPI0514035A/pt not_active Application Discontinuation
- 2005-07-27 EP EP05761797A patent/EP1781613A1/fr not_active Withdrawn
- 2005-07-27 CA CA002576112A patent/CA2576112A1/fr not_active Abandoned
- 2005-07-27 AU AU2005267932A patent/AU2005267932A1/en not_active Abandoned
- 2005-07-27 MX MX2007001226A patent/MX2007001226A/es not_active Application Discontinuation
- 2005-07-27 CN CNA2005800262732A patent/CN1993325A/zh active Pending
- 2005-07-27 US US11/572,967 patent/US20080064706A1/en not_active Abandoned
- 2005-07-27 RU RU2007105970/04A patent/RU2007105970A/ru not_active Application Discontinuation
- 2005-07-27 JP JP2007524768A patent/JP2008508353A/ja not_active Abandoned
- 2005-07-27 KR KR1020077002643A patent/KR20070043998A/ko not_active Application Discontinuation
-
2007
- 2007-01-04 IL IL180548A patent/IL180548A0/en unknown
- 2007-01-24 ZA ZA200700683A patent/ZA200700683B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1781613A1 (fr) | 2007-05-09 |
| RU2007105970A (ru) | 2008-09-10 |
| CN1993325A (zh) | 2007-07-04 |
| SE0401971D0 (sv) | 2004-08-02 |
| MX2007001226A (es) | 2007-03-23 |
| IL180548A0 (en) | 2007-06-03 |
| AU2005267932A1 (en) | 2006-02-09 |
| KR20070043998A (ko) | 2007-04-26 |
| CA2576112A1 (fr) | 2006-02-09 |
| BRPI0514035A (pt) | 2008-05-27 |
| US20080064706A1 (en) | 2008-03-13 |
| JP2008508353A (ja) | 2008-03-21 |
| WO2006014136A1 (fr) | 2006-02-09 |
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