ZA200610478B - Expression-enhanced polypeptides - Google Patents
Expression-enhanced polypeptides Download PDFInfo
- Publication number
- ZA200610478B ZA200610478B ZA200610478A ZA200610478A ZA200610478B ZA 200610478 B ZA200610478 B ZA 200610478B ZA 200610478 A ZA200610478 A ZA 200610478A ZA 200610478 A ZA200610478 A ZA 200610478A ZA 200610478 B ZA200610478 B ZA 200610478B
- Authority
- ZA
- South Africa
- Prior art keywords
- polypeptide
- cys2
- composite
- gly
- composite polypeptide
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
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- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04016890 | 2004-07-16 |
Publications (1)
| Publication Number | Publication Date |
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| ZA200610478B true ZA200610478B (en) | 2008-04-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ZA200610478A ZA200610478B (en) | 2004-07-16 | 2006-12-14 | Expression-enhanced polypeptides |
Country Status (12)
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| US (1) | US8518403B2 (es) |
| EP (1) | EP1769000B1 (es) |
| JP (2) | JP5014988B2 (es) |
| KR (1) | KR20070042967A (es) |
| CN (1) | CN101018809B (es) |
| AU (1) | AU2005263555B2 (es) |
| CA (1) | CA2570990C (es) |
| EA (1) | EA010374B1 (es) |
| MX (1) | MX2007000387A (es) |
| NZ (1) | NZ552745A (es) |
| WO (1) | WO2006008096A1 (es) |
| ZA (1) | ZA200610478B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| EP1996716B1 (en) | 2006-03-20 | 2011-05-11 | The Regents of the University of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| CN101245110B (zh) * | 2007-02-16 | 2010-09-15 | 鲁南制药集团股份有限公司 | 重组中性粒细胞抑制因子和水蛭原嵌合蛋白及其药物组合物 |
| WO2009032949A2 (en) | 2007-09-04 | 2009-03-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
| EP3714906A1 (en) * | 2007-10-03 | 2020-09-30 | Cornell University | Treatment of proliferative disorders using radiolabelled antibodies to psma |
| KR101678925B1 (ko) * | 2008-06-30 | 2016-11-24 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | 기능화 폴리펩티드 |
| US20100069616A1 (en) * | 2008-08-06 | 2010-03-18 | The Regents Of The University Of California | Engineered antibody-nanoparticle conjugates |
| PT2356153T (pt) * | 2008-10-01 | 2016-07-15 | Amgen Res (Munich) Gmbh | Anticorpo biespecífico, de cadeia única, amepxcd3, específico interespécies |
| BRPI0919840B1 (pt) * | 2008-10-01 | 2023-02-28 | Amgen Research (Munich) Gmbh | Molécula de anticorpo de cadeia única biespecífica, seu uso, e composição farmacêutica que a compreende |
| EP2398504B1 (en) * | 2009-02-17 | 2018-11-28 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| JP2011026294A (ja) * | 2009-06-26 | 2011-02-10 | Canon Inc | 化合物 |
| CA2766409C (en) * | 2009-07-03 | 2023-04-25 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them |
| US8993715B2 (en) * | 2009-07-06 | 2015-03-31 | Canon Kabushiki Kaisha | Labeled protein and method for obtaining the same |
| MX354143B (es) | 2009-12-02 | 2018-02-14 | Imaginab Inc | Minicuerpos j591 y diacuerpos-cys para apuntar con especificidad de objetivo a un antígeno de membrana específico para próstata de humano (psma) y métodos para su uso. |
| KR101961495B1 (ko) * | 2009-12-23 | 2019-03-22 | 아비펩 피티와이 리미티트 | 면역-컨쥬게이트 및 그 제조방법 ２ |
| MY171343A (en) | 2011-04-22 | 2019-10-09 | Aptevo Res & Development Llc | Prostate-specific membrane antigen binding proteins and related composition and methods |
| BR112014022692A8 (pt) * | 2012-03-14 | 2021-07-20 | Regeneron Pharma | molécula de ligação de antígeno multiespecífica |
| JO3519B1 (ar) | 2013-01-25 | 2020-07-05 | Amgen Inc | تركيبات أجسام مضادة لأجل cdh19 و cd3 |
| US9212225B1 (en) | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
| MX2017015380A (es) | 2015-05-29 | 2018-03-28 | Amphivena Therapeutics Inc | Metodos para utilizar proteinas de enlace biespecificas cd3 y cd33. |
| KR20180050321A (ko) | 2015-08-07 | 2018-05-14 | 이미지냅 인코포레이티드 | 분자를 표적화하기 위한 항원 결합 구조체 |
| UA126278C2 (uk) | 2015-09-21 | 2022-09-14 | Аптево Рісьорч Енд Девелопмент Ллс | Поліпептиди, які зв'язують cd3 |
| US11352446B2 (en) | 2016-04-28 | 2022-06-07 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
| WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
| KR20190118172A (ko) | 2017-02-08 | 2019-10-17 | 드래곤플라이 쎄라퓨틱스, 인크. | 천연 킬러 세포의 활성화를 위한 다중-특이적 결합 단백질 및 암 치료에서의 그의 치료적 용도 |
| KR20190120782A (ko) | 2017-02-20 | 2019-10-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Her2, nkg2d 및 cd16에 결합하는 단백질 |
| MX2020008336A (es) | 2018-02-08 | 2020-09-21 | Dragonfly Therapeutics Inc | Dominios variables de anticuerpos que se dirigen al receptor nkg2d. |
| CN110668984B (zh) * | 2019-12-03 | 2020-04-10 | 凯莱英医药集团（天津）股份有限公司 | 一种依特卡肽中间体及依特卡肽的合成方法 |
| JP2023550148A (ja) | 2020-11-20 | 2023-11-30 | シンシア・イノベーション・インコーポレイテッド | がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法 |
| CN117285647A (zh) * | 2022-06-17 | 2023-12-26 | 南京北恒生物科技有限公司 | 靶向ccr8的嵌合抗原受体及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013653A (en) * | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
| US5932448A (en) * | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| US5739277A (en) * | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| AU6097100A (en) | 1999-07-13 | 2001-01-30 | Regents Of The University Of Michigan, The | Crosslinked dna condensate compositions and gene delivery methods |
| JP4873818B2 (ja) | 2000-05-16 | 2012-02-08 | ボルダー バイオテクノロジー， インコーポレイテッド | 遊離システイン残基を含有するタンパク質をリフォールディングする方法 |
| ATE275979T1 (de) * | 2000-06-09 | 2004-10-15 | Us Gov Health & Human Serv | Pegylation von linker verbessert die antitumor- aktivität und verringert die toxizität von immunkonjugaten |
| WO2001095919A2 (en) * | 2000-06-15 | 2001-12-20 | The Governement Of The United States Of America, As Represented By The Secretary Departement Of Hea Lth And Human Services | A recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses |
| ES2393733T3 (es) * | 2001-03-07 | 2012-12-27 | Merck Patent Gmbh | Tecnología de expresión para proteínas que contienen una fracción de anticuerpo de isotipo híbrido |
| CN1195779C (zh) * | 2001-05-24 | 2005-04-06 | 中国科学院遗传与发育生物学研究所 | 抗人卵巢癌抗人cd3双特异性抗体 |
| MXPA04004289A (es) * | 2001-11-08 | 2005-03-31 | William R Moyle | Proteina knobs. |
| TW200930407A (en) * | 2007-11-30 | 2009-07-16 | Medarex Inc | Conjugates of anti-RG-1 antibodies |
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- 2005-07-15 CN CN2005800240023A patent/CN101018809B/zh active Active
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- 2005-07-15 NZ NZ552745A patent/NZ552745A/en unknown
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- 2005-07-15 US US11/572,116 patent/US8518403B2/en active Active
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- 2005-07-15 AU AU2005263555A patent/AU2005263555B2/en active Active
- 2005-07-15 MX MX2007000387A patent/MX2007000387A/es not_active Application Discontinuation
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2006
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Also Published As
| Publication number | Publication date |
|---|---|
| EA200700292A1 (ru) | 2007-06-29 |
| AU2005263555B2 (en) | 2011-01-27 |
| EP1769000B1 (en) | 2014-12-24 |
| EP1769000A1 (en) | 2007-04-04 |
| CN101018809A (zh) | 2007-08-15 |
| AU2005263555A1 (en) | 2006-01-26 |
| US20090053223A1 (en) | 2009-02-26 |
| JP2012144552A (ja) | 2012-08-02 |
| EA010374B1 (ru) | 2008-08-29 |
| CA2570990C (en) | 2014-01-21 |
| CA2570990A1 (en) | 2006-01-26 |
| MX2007000387A (es) | 2007-03-28 |
| JP2008506659A (ja) | 2008-03-06 |
| KR20070042967A (ko) | 2007-04-24 |
| US8518403B2 (en) | 2013-08-27 |
| CN101018809B (zh) | 2012-07-18 |
| JP5014988B2 (ja) | 2012-08-29 |
| NZ552745A (en) | 2009-01-31 |
| WO2006008096A1 (en) | 2006-01-26 |
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