ZA200609595B - Novel CIS-Imidazolines - Google Patents
Novel CIS-ImidazolinesInfo
- Publication number
- ZA200609595B ZA200609595B ZA200609595A ZA200609595A ZA200609595B ZA 200609595 B ZA200609595 B ZA 200609595B ZA 200609595 A ZA200609595 A ZA 200609595A ZA 200609595 A ZA200609595 A ZA 200609595A ZA 200609595 B ZA200609595 B ZA 200609595B
- Authority
- ZA
- South Africa
- Prior art keywords
- imidazolines
- novel cis
- cis
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57227504P | 2004-05-18 | 2004-05-18 | |
| US61553404P | 2004-10-01 | 2004-10-01 | |
| US66877205P | 2005-04-06 | 2005-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200609595B true ZA200609595B (en) | 2008-06-25 |
Family
ID=35058746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200609595A ZA200609595B (en) | 2004-05-18 | 2006-11-17 | Novel CIS-Imidazolines |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7964724B2 (xx) |
| EP (1) | EP1753727B1 (xx) |
| JP (1) | JP4814228B2 (xx) |
| KR (3) | KR20110033964A (xx) |
| CN (1) | CN1953965B (xx) |
| AR (1) | AR049545A1 (xx) |
| AT (1) | ATE414693T1 (xx) |
| AU (1) | AU2005243465B2 (xx) |
| BR (1) | BRPI0511328A (xx) |
| CA (1) | CA2565189A1 (xx) |
| DE (1) | DE602005011132D1 (xx) |
| ES (1) | ES2314660T3 (xx) |
| IL (1) | IL178884A (xx) |
| MX (1) | MXPA06013246A (xx) |
| MY (1) | MY143800A (xx) |
| NO (1) | NO20065730L (xx) |
| PE (1) | PE20060679A1 (xx) |
| RU (1) | RU2006144811A (xx) |
| TW (1) | TW200600501A (xx) |
| WO (1) | WO2005110996A1 (xx) |
| ZA (1) | ZA200609595B (xx) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7893278B2 (en) | 2004-06-17 | 2011-02-22 | Hoffman-La Roche Inc. | CIS-imidazolines |
| KR20100031783A (ko) * | 2005-03-16 | 2010-03-24 | 에프. 호프만-라 로슈 아게 | 시스-２，４，５-트리아릴-이미다졸린 및 항암 약제로서의 그의 용도 |
| AU2006319248B2 (en) | 2005-12-01 | 2012-09-27 | F.Hoffman-La Roche Ag | 2,4,5-triphenyl imidazoline derivatives as inhibitors of the interaction between P53 and MDM2 proteins for use as anticancer agents |
| KR101015073B1 (ko) * | 2006-01-18 | 2011-02-16 | 에프. 호프만-라 로슈 아게 | Ｍｄｍ2 억제제로서의시스-4,5-비아릴-2-헤테로시클릭-이미다졸린 |
| MX2009000285A (es) | 2006-06-30 | 2009-06-08 | Schering Corp | Piperidinas sustituidas que incrementan la actividad de p53 y usos de las mismas. |
| CA2670105A1 (en) * | 2006-11-27 | 2008-06-05 | Novartis Ag | Substituted dihydroimidazoles and their use in the treatment of tumors |
| BRPI0720546A2 (pt) | 2006-12-14 | 2015-06-23 | Daiichi Sankyo Co Ltd | Composto, inibidor, medicamento, agente antitumor, composição farmacêutica, método para tratar câncer, e, uso do composto |
| PL2118123T3 (pl) * | 2007-01-31 | 2016-06-30 | Dana Farber Cancer Inst Inc | Stabilizowane peptydy p53 i ich zastosowania |
| CA2682174C (en) | 2007-03-28 | 2021-04-06 | President And Fellows Of Harvard College | Stitched polypeptides |
| US7625895B2 (en) * | 2007-04-12 | 2009-12-01 | Hoffmann-Le Roche Inc. | Diphenyl-dihydro-imidazopyridinones |
| RU2487127C2 (ru) | 2007-10-09 | 2013-07-10 | Ф.Хоффманн-Ля Рош Аг | Хиральные цис-имидазолины |
| WO2009151069A1 (ja) | 2008-06-12 | 2009-12-17 | 第一三共株式会社 | ４，７－ジアザスピロ［２．５］オクタン環構造を有するイミダゾチアゾール誘導体 |
| DE102008047128A1 (de) * | 2008-09-15 | 2010-04-15 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Verwendung von cis-Imidazolinen, insbesondere Nutlinen, zur Behandlung von chemoresistenten Krebserkrankungen |
| CN102356085A (zh) | 2009-01-16 | 2012-02-15 | 第一三共株式会社 | 具有脯氨酸环结构的咪唑并噻唑衍生物 |
| EP2488028B1 (en) | 2009-10-14 | 2020-08-19 | Merck Sharp & Dohme Corp. | Substituted piperidines that increase p53 activity and the uses thereof |
| AU2010319595B2 (en) | 2009-11-12 | 2015-09-17 | The Regents Of The University Of Michigan | Spiro-oxindole MDM2 antagonists |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| WO2011106650A2 (en) * | 2010-02-27 | 2011-09-01 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Novel p53-mdm2/p53-mdm4 antagonists to treat proliferative disease |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| KR20130099938A (ko) | 2010-08-13 | 2013-09-06 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| US9266860B2 (en) | 2010-09-30 | 2016-02-23 | St. Jude Children's Research Hospital | Aryl-substituted imidazoles |
| US8680132B2 (en) | 2010-11-12 | 2014-03-25 | The Regents Of The University Of Michigan | Spiro-oxindole MDM2 antagonists |
| RS57158B1 (sr) | 2011-03-10 | 2018-07-31 | Daiichi Sankyo Co Ltd | Dispiropirolidinski derivat |
| US8629141B2 (en) | 2011-05-11 | 2014-01-14 | The Regents Of The University Of Michigan | Spiro-oxindole MDM2 antagonists |
| JP6093770B2 (ja) | 2011-09-27 | 2017-03-08 | アムジエン・インコーポレーテツド | 癌の治療のためのｍｄｍ２阻害剤としての複素環化合物 |
| WO2013054153A1 (en) | 2011-10-11 | 2013-04-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nutlin compounds for use in he treatment of pulmonary hypertension |
| CN108929375A (zh) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
| EP2771008A4 (en) | 2011-10-28 | 2015-04-08 | Merck Sharp & Dohme | MACROCYCLES INCREASING P53 ACTIVITY AND USES THEREOF |
| US8969341B2 (en) | 2011-11-29 | 2015-03-03 | Novartis Ag | Pyrazolopyrrolidine compounds |
| EP2793890B1 (en) | 2011-12-21 | 2016-09-07 | Merck Sharp & Dohme Corp. | Substituted piperidines as hdm2 inhibitors |
| UY34591A (es) | 2012-01-26 | 2013-09-02 | Novartis Ag | Compuestos de imidazopirrolidinona |
| ES2817877T3 (es) | 2012-02-15 | 2021-04-08 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| CN104321325B (zh) | 2012-05-24 | 2016-11-16 | 诺华股份有限公司 | 吡咯并吡咯烷酮化合物 |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| AU2013337388B2 (en) | 2012-11-01 | 2018-08-02 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| AU2013361694B2 (en) | 2012-12-20 | 2017-10-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as HDM2 inhibitors |
| US9556180B2 (en) | 2013-01-22 | 2017-01-31 | Novartis Ag | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction |
| US9403827B2 (en) | 2013-01-22 | 2016-08-02 | Novartis Ag | Substituted purinone compounds |
| WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| CA2902856C (en) | 2013-02-28 | 2021-02-16 | Amgen Inc. | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
| CA2906538C (en) | 2013-03-14 | 2021-02-02 | Ana Gonzalez Buenrostro | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
| US10005720B2 (en) | 2013-04-05 | 2018-06-26 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
| EA029312B1 (ru) | 2013-05-27 | 2018-03-30 | Новартис Аг | Производные имидазопирролидинона и их применение при лечении заболеваний |
| US8975417B2 (en) | 2013-05-27 | 2015-03-10 | Novartis Ag | Pyrazolopyrrolidine derivatives and their use in the treatment of disease |
| CA2912991A1 (en) | 2013-05-28 | 2014-12-04 | Novartis Ag | Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease |
| JP2016520118A (ja) | 2013-05-28 | 2016-07-11 | ノバルティス アーゲー | Ｂｅｔ阻害剤としてのピラゾロ−ピロリジン−４−オン誘導体および疾患の処置におけるその使用 |
| CN104208066B (zh) * | 2013-06-03 | 2016-06-15 | 中国科学院遗传与发育生物学研究所 | 哌嗪衍生物作为p53分子调节剂的用途 |
| JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| JP2016537384A (ja) | 2013-11-21 | 2016-12-01 | ノバルティス アーゲー | ピロロピロロン誘導体およびｂｅｔ阻害剤としてのその使用 |
| CN107106642B (zh) | 2014-09-24 | 2021-02-26 | 艾瑞朗医疗公司 | 拟肽大环化合物及其制剂 |
| JP2017533889A (ja) | 2014-09-24 | 2017-11-16 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ペプチド模倣大環状分子およびその使用 |
| PL3247699T3 (pl) | 2015-01-22 | 2019-11-29 | Sanofi Aventis Deutschland | Sposób wytwarzania 2-[4-(cyklopropanokarbonylo)fenylo]-2-metylo-propanonitrylu |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| EP3347372A4 (en) | 2015-09-10 | 2019-09-04 | Aileron Therapeutics, Inc. | PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1 |
| EP3440082A1 (en) | 2016-04-06 | 2019-02-13 | The Regents of The University of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| AU2017246452C1 (en) | 2016-04-06 | 2021-06-03 | The Regents Of The University Of Michigan | MDM2 protein degraders |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| WO2019079677A1 (en) * | 2017-10-20 | 2019-04-25 | Corbus Pharmaceuticals, Inc. | METHODS AND COMPOSITIONS RELATING TO 5- (1,1-DIMETHYLHEPTYL) -ORRESORCINOL ULTRAPUR |
| SG11202103282YA (en) | 2018-10-08 | 2021-04-29 | Univ Michigan Regents | Small molecule mdm2 protein degraders |
| CA3171258A1 (en) | 2020-03-19 | 2021-09-23 | Nan JI | Mdm2 degraders and uses thereof |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| US11548866B1 (en) | 2021-11-22 | 2023-01-10 | Ligature Therapeutics Pte. Ltd. | Therapeutic compounds and methods of use thereof |
| US11504381B1 (en) * | 2021-11-22 | 2022-11-22 | Ligature Therapeutics Pte. Ltd. | Therapeutic compounds and methods of use thereof |
| KR20230087856A (ko) | 2021-12-10 | 2023-06-19 | 교촌 에프 앤 비(주) | 생체이용율과 이미다졸 펩타이드가 증가된 수용성 닭가슴살 가수분해물 및 그 제조방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02101065A (ja) | 1988-10-06 | 1990-04-12 | Tanabe Seiyaku Co Ltd | イミダゾリン誘導体及びその製法 |
| DE4203547A1 (de) * | 1992-02-07 | 1993-08-12 | Knoll Ag | Verfahren zur racemattrennung von verapamil |
| FR2756560A1 (fr) * | 1996-12-04 | 1998-06-05 | Adir | Nouveaux derives de l'imidazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB2351082A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
| US6653501B2 (en) * | 2001-06-27 | 2003-11-25 | Napro Biotherapeutics, Inc. | Chiral resolution method for producing compounds useful in the synthesis of taxanes |
| RU2305095C2 (ru) * | 2001-12-18 | 2007-08-27 | Ф.Хоффманн-Ля Рош Аг | Цис-2,4,5-трифенилимидазолины и фармацевтическая композиция на их основе |
| MXPA04005880A (es) * | 2001-12-18 | 2004-09-13 | Hoffmann La Roche | Cis-imidazolinas como inhibidores de la mdm2. |
-
2005
- 2005-05-10 KR KR1020117006619A patent/KR20110033964A/ko not_active IP Right Cessation
- 2005-05-10 AT AT05742255T patent/ATE414693T1/de active
- 2005-05-10 JP JP2007517027A patent/JP4814228B2/ja not_active Expired - Fee Related
- 2005-05-10 CN CN200580015663XA patent/CN1953965B/zh not_active Expired - Fee Related
- 2005-05-10 KR KR1020067024089A patent/KR100832277B1/ko not_active IP Right Cessation
- 2005-05-10 BR BRPI0511328-8A patent/BRPI0511328A/pt not_active IP Right Cessation
- 2005-05-10 AU AU2005243465A patent/AU2005243465B2/en not_active Ceased
- 2005-05-10 CA CA002565189A patent/CA2565189A1/en not_active Abandoned
- 2005-05-10 KR KR1020087005155A patent/KR20080027969A/ko not_active Application Discontinuation
- 2005-05-10 MX MXPA06013246A patent/MXPA06013246A/es active IP Right Grant
- 2005-05-10 ES ES05742255T patent/ES2314660T3/es active Active
- 2005-05-10 EP EP05742255A patent/EP1753727B1/en active Active
- 2005-05-10 DE DE602005011132T patent/DE602005011132D1/de active Active
- 2005-05-10 RU RU2006144811/04A patent/RU2006144811A/ru not_active Application Discontinuation
- 2005-05-10 WO PCT/EP2005/005046 patent/WO2005110996A1/en active Application Filing
- 2005-05-13 US US11/129,621 patent/US7964724B2/en not_active Expired - Fee Related
- 2005-05-16 PE PE2005000539A patent/PE20060679A1/es not_active Application Discontinuation
- 2005-05-16 MY MYPI20052212A patent/MY143800A/en unknown
- 2005-05-16 TW TW094115741A patent/TW200600501A/zh unknown
- 2005-05-16 AR ARP050101998A patent/AR049545A1/es not_active Application Discontinuation
-
2006
- 2006-10-26 IL IL178884A patent/IL178884A/en not_active IP Right Cessation
- 2006-11-17 ZA ZA200609595A patent/ZA200609595B/xx unknown
- 2006-12-12 NO NO20065730A patent/NO20065730L/no not_active Application Discontinuation
-
2009
- 2009-02-05 US US12/366,381 patent/US20090143364A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06013246A (es) | 2007-02-08 |
| AU2005243465A1 (en) | 2005-11-24 |
| CN1953965B (zh) | 2012-07-04 |
| ATE414693T1 (de) | 2008-12-15 |
| US7964724B2 (en) | 2011-06-21 |
| NO20065730L (no) | 2007-01-19 |
| PE20060679A1 (es) | 2006-08-11 |
| MY143800A (en) | 2011-07-15 |
| KR100832277B1 (ko) | 2008-05-26 |
| AU2005243465B2 (en) | 2011-08-25 |
| ES2314660T3 (es) | 2009-03-16 |
| IL178884A0 (en) | 2007-03-08 |
| EP1753727B1 (en) | 2008-11-19 |
| EP1753727A1 (en) | 2007-02-21 |
| DE602005011132D1 (de) | 2009-01-02 |
| US20090143364A1 (en) | 2009-06-04 |
| IL178884A (en) | 2010-12-30 |
| BRPI0511328A (pt) | 2007-12-04 |
| KR20070011516A (ko) | 2007-01-24 |
| CN1953965A (zh) | 2007-04-25 |
| KR20110033964A (ko) | 2011-04-01 |
| JP4814228B2 (ja) | 2011-11-16 |
| KR20080027969A (ko) | 2008-03-28 |
| TW200600501A (en) | 2006-01-01 |
| WO2005110996A1 (en) | 2005-11-24 |
| RU2006144811A (ru) | 2008-06-27 |
| US20050288287A1 (en) | 2005-12-29 |
| AR049545A1 (es) | 2006-08-16 |
| JP2007538022A (ja) | 2007-12-27 |
| CA2565189A1 (en) | 2005-11-24 |
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| GB0408862D0 (en) | Novel benzoxazocines | |
| GB0408863D0 (en) | Novel benzoxazocines | |
| GB0420312D0 (en) | Novel uses | |
| GB0422684D0 (en) | Novel uses | |
| GB0420274D0 (en) | Novel uses | |
| GB0420275D0 (en) | Novel uses | |
| GB0420279D0 (en) | Novel uses | |
| GB0420289D0 (en) | Novel uses | |
| GB0420302D0 (en) | Novel uses | |
| GB0420304D0 (en) | Novel uses | |
| GB0420310D0 (en) | Novel uses | |
| GB0420262D0 (en) | Novel uses | |
| GB0420313D0 (en) | Novel uses | |
| GB0420316D0 (en) | Novel uses |