ZA200602802B - Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors - Google Patents
Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors Download PDFInfo
- Publication number
- ZA200602802B ZA200602802B ZA200602802A ZA200602802A ZA200602802B ZA 200602802 B ZA200602802 B ZA 200602802B ZA 200602802 A ZA200602802 A ZA 200602802A ZA 200602802 A ZA200602802 A ZA 200602802A ZA 200602802 B ZA200602802 B ZA 200602802B
- Authority
- ZA
- South Africa
- Prior art keywords
- ylcarbamoyl
- methyl
- dibenzo
- dihydro
- azepin
- Prior art date
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- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title description 2
- 150000007655 dibenzoazepines Chemical class 0.000 title description 2
- 239000003540 gamma secretase inhibitor Substances 0.000 title description 2
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- -1 5H-dibenzo[b,d]azepin-7-ylcarbamoyl Chemical group 0.000 claims description 32
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 22
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- 150000003839 salts Chemical class 0.000 claims description 21
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
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- Organic Chemistry (AREA)
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- Health & Medical Sciences (AREA)
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- Hospice & Palliative Care (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP03022650 | 2003-10-06 |
Publications (1)
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ZA200602802B true ZA200602802B (en) | 2007-09-26 |
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ZA200602802A ZA200602802B (en) | 2003-10-06 | 2006-04-05 | Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors |
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EP (1) | EP1673347B1 (el) |
JP (1) | JP4503607B2 (el) |
KR (2) | KR100884872B1 (el) |
CN (1) | CN1894217B (el) |
AR (1) | AR045859A1 (el) |
AU (1) | AU2004283803B2 (el) |
BR (1) | BRPI0415070B8 (el) |
CA (1) | CA2541470C (el) |
CO (1) | CO5690560A2 (el) |
CY (1) | CY1116865T1 (el) |
DK (1) | DK1673347T3 (el) |
ES (1) | ES2548720T3 (el) |
HR (1) | HRP20151197T1 (el) |
HU (1) | HUE025548T2 (el) |
IL (1) | IL174513A (el) |
MX (1) | MXPA06003870A (el) |
MY (1) | MY143797A (el) |
NO (1) | NO20061469L (el) |
NZ (1) | NZ546036A (el) |
PL (1) | PL1673347T3 (el) |
PT (1) | PT1673347E (el) |
RU (1) | RU2356895C2 (el) |
SI (1) | SI1673347T1 (el) |
TW (1) | TWI293627B (el) |
WO (1) | WO2005040126A1 (el) |
ZA (1) | ZA200602802B (el) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
US7211573B2 (en) | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
WO2007029587A1 (ja) * | 2005-09-05 | 2007-03-15 | Dainippon Sumitomo Pharma Co., Ltd. | βセクレターゼ阻害剤 |
EP2018368B1 (en) * | 2006-03-27 | 2012-12-05 | F. Hoffmann-La Roche AG | Malonamide derivatives as gamma secretase inhibitors |
JP5001372B2 (ja) | 2006-09-20 | 2012-08-15 | エフ.ホフマン−ラ ロシュ アーゲー | 4−オキソ−2,3,4,5−テトラヒドロ−ベンゾ[b][1,4]ジアゼピン誘導体 |
JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての3−ヒドロキシ−1,5−ジヒドロ−ピロール−2−オン誘導体 |
JP5523107B2 (ja) | 2006-11-30 | 2014-06-18 | プロビオドルグ エージー | グルタミニルシクラーゼの新規阻害剤 |
CN101622232A (zh) | 2007-02-02 | 2010-01-06 | 弗·哈夫曼-拉罗切有限公司 | 6-氧代-6,7-二氢-5h-二苯并[b,d]氮杂䓬-7-基衍生物 |
ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
US7579464B2 (en) * | 2007-05-25 | 2009-08-25 | Hoffmann-La Roche Inc. | Process for preparation of enantiomerically pure compounds |
US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
KR101790806B1 (ko) | 2010-03-10 | 2017-11-20 | 프로비오드룩 아게 | 글루타미닐 사이클라제(qc, ec 2.3.2.5)의 헤테로사이클릭 억제제 |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
WO2011140213A1 (en) * | 2010-05-05 | 2011-11-10 | Amicus Therapeutics, Inc. | Method of treating alzheimer's disease using pharmacological chaperones to increase presenilin function and gamma-secretase activity |
ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
AR087107A1 (es) | 2011-07-27 | 2014-02-12 | Lilly Co Eli | Compuesto inhibidor de la señalizacion de la trayectoria notch |
WO2017075264A1 (en) * | 2015-10-30 | 2017-05-04 | Inception 3, Inc. | Dibenzo azepine compounds and their use in the treatment of otic diseases and disorders |
RU2757276C2 (ru) * | 2016-12-16 | 2021-10-12 | Пайплайн Терапьютикс, Инк. | Способы лечения кохлеарной синаптопатии |
DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
CA3100202A1 (en) * | 2018-05-15 | 2019-11-21 | Bristol-Myers Squibb Company | Compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds and methods of use thereof |
Family Cites Families (5)
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EP1313426A2 (en) * | 1998-12-24 | 2003-05-28 | Bristol-Myers Squibb Pharma Company | Succinoylamino benzodiazepines as inhibitors of a-beta protein production |
CA2404273A1 (en) * | 2000-04-11 | 2001-10-18 | Bristol-Myers Squibb Pharma Company | Substituted lactams as inhibitors of a.beta. protein production |
CA2379445C (en) * | 2000-06-01 | 2007-08-21 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production |
MXPA05008172A (es) | 2003-02-04 | 2005-10-05 | Hoffmann La Roche | Derivados de malonamida como inhibidores gamma-secretasa. |
NZ545538A (en) * | 2003-09-09 | 2008-12-24 | Hoffmann La Roche | Malonamide derivatives blocking the activity of gama-secretase |
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