ZA200602690B - Drug containing (2R)-2-propyloctanoic acid as the active ingredient - Google Patents

Info

Publication number

ZA200602690B

ZA200602690B ZA200602690A ZA200602690A ZA200602690B ZA 200602690 B ZA200602690 B ZA 200602690B ZA 200602690 A ZA200602690 A ZA 200602690A ZA 200602690 A ZA200602690 A ZA 200602690A ZA 200602690 B ZA200602690 B ZA 200602690B

Authority

ZA

South Africa

Prior art keywords

salt

sodium

medicament

acid

propyloctanoic acid

Prior art date

2003-10-03

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003814 drug Substances 0.000 title claims description 272
• YCYMCMYLORLIJX-SNVBAGLBSA-N (2r)-2-propyloctanoic acid Chemical compound CCCCCC[C@H](C(O)=O)CCC YCYMCMYLORLIJX-SNVBAGLBSA-N 0.000 title claims description 172
• 239000004480 active ingredient Substances 0.000 title description 10
• 229940079593 drug Drugs 0.000 title description 8
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 189
• 150000003839 salts Chemical class 0.000 claims description 148
• -1 basic metal ion Chemical class 0.000 claims description 116
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 106
• 239000000243 solution Substances 0.000 claims description 86
• 229910052751 metal Inorganic materials 0.000 claims description 62
• 239000002184 metal Substances 0.000 claims description 62
• 229910052728 basic metal Inorganic materials 0.000 claims description 54
• 239000007788 liquid Substances 0.000 claims description 44
• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 39
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 34
• 230000001954 sterilising effect Effects 0.000 claims description 34
• 239000004033 plastic Substances 0.000 claims description 29
• 229920003023 plastic Polymers 0.000 claims description 29
• 229910000000 metal hydroxide Inorganic materials 0.000 claims description 28
• 150000004692 metal hydroxides Chemical class 0.000 claims description 28
• 239000007787 solid Substances 0.000 claims description 27
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 24
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 24
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 23
• 238000000034 method Methods 0.000 claims description 22
• 239000007864 aqueous solution Substances 0.000 claims description 21
• 239000011521 glass Substances 0.000 claims description 21
• 239000003795 chemical substances by application Substances 0.000 claims description 20
• 239000000693 micelle Substances 0.000 claims description 20
• AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 20
• 239000001488 sodium phosphate Substances 0.000 claims description 20
• GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 20
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 20
• 238000001802 infusion Methods 0.000 claims description 19
• 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 19
• 235000019801 trisodium phosphate Nutrition 0.000 claims description 19
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
• DGLRDKLJZLEJCY-UHFFFAOYSA-L disodium hydrogenphosphate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O DGLRDKLJZLEJCY-UHFFFAOYSA-L 0.000 claims description 17
• 235000019799 monosodium phosphate Nutrition 0.000 claims description 17
• 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 17
• 239000004743 Polypropylene Substances 0.000 claims description 16
• 229920001155 polypropylene Polymers 0.000 claims description 16
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 15
• 210000005036 nerve Anatomy 0.000 claims description 14
• 229910001415 sodium ion Inorganic materials 0.000 claims description 14
• DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims description 12
• 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 12
• 235000017557 sodium bicarbonate Nutrition 0.000 claims description 12
• 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 12
• 229940079827 sodium hydrogen sulfite Drugs 0.000 claims description 12
• 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims description 12
• 238000004659 sterilization and disinfection Methods 0.000 claims description 12
• 201000010099 disease Diseases 0.000 claims description 11
• 230000004770 neurodegeneration Effects 0.000 claims description 11
• 208000015122 neurodegenerative disease Diseases 0.000 claims description 11
• 229920001296 polysiloxane Polymers 0.000 claims description 11
• LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 11
• LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims description 10
• BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 10
• 229910000029 sodium carbonate Inorganic materials 0.000 claims description 10
• 235000017550 sodium carbonate Nutrition 0.000 claims description 10
• 159000000000 sodium salts Chemical class 0.000 claims description 10
• 239000004698 Polyethylene Substances 0.000 claims description 9
• FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 claims description 9
• 239000003708 ampul Substances 0.000 claims description 9
• 125000004122 cyclic group Chemical group 0.000 claims description 9
• 238000002156 mixing Methods 0.000 claims description 9
• 229920000573 polyethylene Polymers 0.000 claims description 9
• 229920000098 polyolefin Polymers 0.000 claims description 9
• 235000010265 sodium sulphite Nutrition 0.000 claims description 9
• 229910052783 alkali metal Inorganic materials 0.000 claims description 8
• ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 8
• 239000006185 dispersion Substances 0.000 claims description 8
• 235000019796 monopotassium phosphate Nutrition 0.000 claims description 8
• 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 8
• PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 8
• 230000008569 process Effects 0.000 claims description 8
• 208000035475 disorder Diseases 0.000 claims description 7
• 230000008929 regeneration Effects 0.000 claims description 7
• 238000011069 regeneration method Methods 0.000 claims description 7
• 239000000377 silicon dioxide Substances 0.000 claims description 7
• 235000012239 silicon dioxide Nutrition 0.000 claims description 7
• UTCWLXGGADHOGW-HNCPQSOCSA-M sodium;(2r)-2-propyloctanoate Chemical compound [Na+].CCCCCC[C@H](C([O-])=O)CCC UTCWLXGGADHOGW-HNCPQSOCSA-M 0.000 claims description 7
• 235000015497 potassium bicarbonate Nutrition 0.000 claims description 6
• 239000011736 potassium bicarbonate Substances 0.000 claims description 6
• 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 6
• DJEHXEMURTVAOE-UHFFFAOYSA-M potassium bisulfite Chemical compound [K+].OS([O-])=O DJEHXEMURTVAOE-UHFFFAOYSA-M 0.000 claims description 6
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 6
• 235000010259 potassium hydrogen sulphite Nutrition 0.000 claims description 6
• TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 6
• 229940086066 potassium hydrogencarbonate Drugs 0.000 claims description 6
• 239000002904 solvent Substances 0.000 claims description 5
• 235000019798 tripotassium phosphate Nutrition 0.000 claims description 5
• 229910000404 tripotassium phosphate Inorganic materials 0.000 claims description 5
• BHZRJJOHZFYXTO-UHFFFAOYSA-L potassium sulfite Chemical compound [K+].[K+].[O-]S([O-])=O BHZRJJOHZFYXTO-UHFFFAOYSA-L 0.000 claims description 4
• 235000019252 potassium sulphite Nutrition 0.000 claims description 4
• YCYMCMYLORLIJX-UHFFFAOYSA-N 2-propyloctanoic acid Chemical compound CCCCCCC(C(O)=O)CCC YCYMCMYLORLIJX-UHFFFAOYSA-N 0.000 claims description 3
• 238000011049 filling Methods 0.000 claims description 3
• 238000004519 manufacturing process Methods 0.000 claims description 3
• 229910000027 potassium carbonate Inorganic materials 0.000 claims description 3
• 229940093956 potassium carbonate Drugs 0.000 claims description 3
• 235000011181 potassium carbonates Nutrition 0.000 claims description 3
• 235000002639 sodium chloride Nutrition 0.000 description 149
• 239000008215 water for injection Substances 0.000 description 65
• 235000011121 sodium hydroxide Nutrition 0.000 description 59
• 239000007924 injection Substances 0.000 description 46
• 238000002347 injection Methods 0.000 description 46
• 239000002253 acid Substances 0.000 description 37
• 239000000203 mixture Substances 0.000 description 36
• 238000002360 preparation method Methods 0.000 description 35
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 24
• 239000012528 membrane Substances 0.000 description 24
• 239000011734 sodium Substances 0.000 description 24
• 229910052708 sodium Inorganic materials 0.000 description 24
• 229940083542 sodium Drugs 0.000 description 24
• 239000012456 homogeneous solution Substances 0.000 description 22
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 17
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
• 239000000463 material Substances 0.000 description 15
• 229940024606 amino acid Drugs 0.000 description 14
• 235000001014 amino acid Nutrition 0.000 description 14
• 238000007865 diluting Methods 0.000 description 13
• 238000011282 treatment Methods 0.000 description 13
• 239000011780 sodium chloride Substances 0.000 description 12
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 10
• 150000001413 amino acids Chemical class 0.000 description 10
• 238000000465 moulding Methods 0.000 description 10
• 239000011591 potassium Substances 0.000 description 10
• 229960003975 potassium Drugs 0.000 description 10
• 229910052700 potassium Inorganic materials 0.000 description 10
• 238000007789 sealing Methods 0.000 description 10
• 239000000126 substance Substances 0.000 description 10
• 239000000654 additive Substances 0.000 description 9
• 238000010790 dilution Methods 0.000 description 9
• 239000012895 dilution Substances 0.000 description 9
• 239000001257 hydrogen Substances 0.000 description 9
• 229910052739 hydrogen Inorganic materials 0.000 description 9
• 150000007513 acids Chemical class 0.000 description 8
• 150000002736 metal compounds Chemical class 0.000 description 8
• QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 7
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
• 229910052782 aluminium Inorganic materials 0.000 description 7
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 7
• 206010008118 cerebral infarction Diseases 0.000 description 7
• 208000026106 cerebrovascular disease Diseases 0.000 description 7
• 229910021645 metal ion Inorganic materials 0.000 description 7
• BTRXYXNWHKNMAB-UHFFFAOYSA-N phosphoric acid;dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.OP(O)(O)=O BTRXYXNWHKNMAB-UHFFFAOYSA-N 0.000 description 7
• WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 6
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
• 230000015572 biosynthetic process Effects 0.000 description 6
• 150000001720 carbohydrates Chemical class 0.000 description 6
• 238000004090 dissolution Methods 0.000 description 6
• 230000000694 effects Effects 0.000 description 6
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 5
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
• FHNINJWBTRXEBC-UHFFFAOYSA-N Sudan III Chemical compound OC1=CC=C2C=CC=CC2=C1N=NC(C=C1)=CC=C1N=NC1=CC=CC=C1 FHNINJWBTRXEBC-UHFFFAOYSA-N 0.000 description 5
• 230000003139 buffering effect Effects 0.000 description 5
• 235000014633 carbohydrates Nutrition 0.000 description 5
• 239000004359 castor oil Substances 0.000 description 5
• 235000019438 castor oil Nutrition 0.000 description 5
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 5
• 150000001875 compounds Chemical class 0.000 description 5
• 238000007796 conventional method Methods 0.000 description 5
• 239000003792 electrolyte Substances 0.000 description 5
• 239000012530 fluid Substances 0.000 description 5
• 239000008103 glucose Substances 0.000 description 5
• ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 5
• 229940001447 lactate Drugs 0.000 description 5
• 230000007774 longterm Effects 0.000 description 5
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• 229940099373 sudan iii Drugs 0.000 description 5
• 229940124597 therapeutic agent Drugs 0.000 description 5
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 5
• ASTWEMOBIXQPPV-UHFFFAOYSA-K trisodium;phosphate;dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O ASTWEMOBIXQPPV-UHFFFAOYSA-K 0.000 description 5
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 4
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 4
• 239000004472 Lysine Substances 0.000 description 4
• 208000006011 Stroke Diseases 0.000 description 4
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
• 238000002835 absorbance Methods 0.000 description 4
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• 229940021013 electrolyte solution Drugs 0.000 description 4
• 239000008151 electrolyte solution Substances 0.000 description 4
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
• 238000001914 filtration Methods 0.000 description 4
• 230000006870 function Effects 0.000 description 4
• 150000004677 hydrates Chemical class 0.000 description 4
• CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 4
• 229940102223 injectable solution Drugs 0.000 description 4
• 235000018977 lysine Nutrition 0.000 description 4
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• CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 4
• JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 4
• OOSZCNKVJAVHJI-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]piperazine Chemical compound C1=CC(F)=CC=C1CN1CCNCC1 OOSZCNKVJAVHJI-UHFFFAOYSA-N 0.000 description 3
• HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 3
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• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
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• 108010010803 Gelatin Proteins 0.000 description 3
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
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• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
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• 235000019262 disodium citrate Nutrition 0.000 description 3
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• CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 3
• QELUYTUMUWHWMC-UHFFFAOYSA-N edaravone Chemical compound O=C1CC(C)=NN1C1=CC=CC=C1 QELUYTUMUWHWMC-UHFFFAOYSA-N 0.000 description 3
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• 238000004809 thin layer chromatography Methods 0.000 description 3
• SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 3
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• JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 2
• VZZUJVDCIBINIT-YDALLXLXSA-N (2s)-2-acetamido-3-(1h-indol-3-yl)propanoic acid;sodium Chemical compound [Na].C1=CC=C2C(C[C@H](NC(=O)C)C(O)=O)=CNC2=C1 VZZUJVDCIBINIT-YDALLXLXSA-N 0.000 description 2
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