ZA200602077B - Combinations comprising alpha-2-delta ligands and serotonin/noradrenaline re-up-take inhibitors - Google Patents

Combinations comprising alpha-2-delta ligands and serotonin/noradrenaline re-up-take inhibitors Download PDF

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Publication number
ZA200602077B
ZA200602077B ZA200602077A ZA200602077A ZA200602077B ZA 200602077 B ZA200602077 B ZA 200602077B ZA 200602077 A ZA200602077 A ZA 200602077A ZA 200602077 A ZA200602077 A ZA 200602077A ZA 200602077 B ZA200602077 B ZA 200602077B
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South Africa
Prior art keywords
combination
pain
snri
pharmaceutically acceptable
alpha
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ZA200602077A
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English (en)
Inventor
David J Dooley
Williams Richard Griffith
Field Mark John
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Pfizer
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Publication of ZA200602077B publication Critical patent/ZA200602077B/en

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
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ZA200602077A 2003-09-12 2006-03-10 Combinations comprising alpha-2-delta ligands and serotonin/noradrenaline re-up-take inhibitors ZA200602077B (en)

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US50255603P 2003-09-12 2003-09-12

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ZA200602077B true ZA200602077B (en) 2007-06-27

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ZA200602077A ZA200602077B (en) 2003-09-12 2006-03-10 Combinations comprising alpha-2-delta ligands and serotonin/noradrenaline re-up-take inhibitors

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US (4) US20050059715A1 (de)
EP (2) EP1663398B1 (de)
JP (2) JP2007505097A (de)
KR (1) KR100828218B1 (de)
CN (1) CN1849153A (de)
AR (1) AR045634A1 (de)
AT (1) ATE449633T1 (de)
AU (2) AU2004271800A1 (de)
BR (1) BRPI0414343A (de)
CA (1) CA2537402C (de)
CO (1) CO5660280A2 (de)
DE (1) DE602004024317D1 (de)
ES (1) ES2334673T3 (de)
IL (1) IL173904A0 (de)
MX (1) MXPA06002789A (de)
NO (1) NO20061083L (de)
NZ (1) NZ545494A (de)
RU (1) RU2320369C2 (de)
TW (1) TW200526249A (de)
WO (1) WO2005025675A1 (de)
ZA (1) ZA200602077B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001876A (en) 1996-07-24 1999-12-14 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
US7704527B2 (en) * 2002-10-25 2010-04-27 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
EP1763354A2 (de) * 2004-06-09 2007-03-21 Pfizer Limited Verwendung von reboxetin zur schmerzbehandlung
US20090306050A1 (en) * 2006-02-03 2009-12-10 Timothy Dinan Treatment and prevention of depression with pain, depression secondary to pain, and of neuropathic pain
TW200914457A (en) * 2007-05-31 2009-04-01 Kyowa Hakko Kogyo Kk Pyrimidodiazepinone derivative
WO2009136375A1 (en) * 2008-05-08 2009-11-12 Pfizer Inc Treatment of interstitial cystitis
EP2123626A1 (de) 2008-05-21 2009-11-25 Laboratorios del Dr. Esteve S.A. Duloxetin-Kokristalle und Kokristallbildner für Schmerzbehandlung
WO2011008885A1 (en) 2009-07-15 2011-01-20 Portola Pharmaceuticals, Inc. Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same
WO2012015027A1 (ja) 2010-07-30 2012-02-02 東レ株式会社 神経障害性疼痛の治療剤又は予防剤
US10576045B2 (en) 2011-02-16 2020-03-03 Nir Barak Low dosage combinations of fluoxetine and reboxetine for treating obesity
EP2946777B1 (de) 2013-01-18 2023-10-04 Kemphys Ltd. Arzneimittel zur behandlung neuropathischer erkrankungen
AU2014364693B2 (en) * 2013-12-18 2018-12-06 Novassay Sa Gamma-aminobutyric acid (GABA) analogues for the treatment of pain and other disorders
MD3364975T2 (ro) 2015-10-22 2021-09-30 Acraf Combinație de trazodonă și gabapentină pentru tratamentul durerii
IT201900006602A1 (it) 2019-05-07 2020-11-07 Acraf Composizione farmaceutica per il trattamento del dolore neuropatico

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3454554A (en) 1960-10-14 1969-07-08 Colgate Palmolive Co Aminoalkyliminodibenzyl compounds
NL127069C (de) 1961-10-10
US3198834A (en) 1964-07-27 1965-08-03 Snc Science Union Et Compagnie Optical isomers of trifluoromethylated phenethylamines
NL129434C (de) 1966-03-12
GB1177525A (en) 1967-04-13 1970-01-14 Leo Ab New Heterocyclic Aminoketones of Therapeutic Interest
BE759838A (fr) 1969-12-04 1971-06-03 Wellcome Found Cetones a activite biologique
US3885046A (en) 1969-12-04 1975-05-20 Burroughs Wellcome Co Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression
GB1422263A (en) 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US4194009A (en) 1974-01-10 1980-03-18 Eli Lilly And Company Aryloxyphenylpropylamines for obtaining a psychotropic effect
US4626549A (en) 1974-01-10 1986-12-02 Eli Lilly And Company Treatment of obesity with aryloxyphenylpropylamines
US4018895A (en) 1974-01-10 1977-04-19 Eli Lilly And Company Aryloxyphenylpropylamines in treating depression
US4314081A (en) 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
DE2460891C2 (de) 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
NL7503310A (nl) 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
US4062843A (en) 1976-12-29 1977-12-13 G. D. Searle & Co. 23-Hydroxy-3-oxo-24-norchola-4,17(20)-dien-21-oic acid γ-lactone and intermediates thereto
IL56369A (en) 1978-01-20 1984-05-31 Erba Farmitalia Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4535186A (en) 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
DK149624C (da) 1983-03-07 1987-02-02 Ferrosan As Fremgangsmaade til fremstilling af (+)-trans-3-((4-methoxyphenoxy)-methyl)-1-methyl-4-phenylpiperidin eller et farmaceutisk acceptabelt salt heraf ud fra en blanding af enantiomererne
US4611078A (en) 1983-10-26 1986-09-09 American Home Products Corporation Substituted phenylacetonitriles
US4761501A (en) 1983-10-26 1988-08-02 American Home Products Corporation Substituted phenylacetamides
GB8419683D0 (en) 1984-08-02 1984-09-05 Erba Farmitalia 3-substituted derivatives of 1-amino-2-hydroxy-propane
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
DK0641330T3 (da) 1992-05-20 2001-12-03 Univ Northwestern Gaba- og L-glutaminsyreanaloger til antikrampeanfaldsbehandling
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
ES2176668T3 (es) 1996-02-07 2002-12-01 Warner Lambert Co Aminoacidos ciclicos novedosos como agentes farmaceuticos.
KR100512506B1 (ko) 1996-03-14 2005-12-21 워너-램버트 캄파니 엘엘씨 제약제제로서신규한치환시클릭아미노산
CZ287598A3 (cs) 1996-03-14 1999-02-17 Warner-Lambert Company Přemostěné cyklické aminokyseliny
US6372792B1 (en) * 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
US6001876A (en) 1996-07-24 1999-12-14 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
AU733896B2 (en) 1996-10-23 2001-05-31 Warner-Lambert Company Substituted gamma aminobutyric acids as pharmaceutical agents
WO1998046601A1 (en) * 1997-04-11 1998-10-22 Eli Lilly And Company Composition for treating pain
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US5942530A (en) * 1997-08-28 1999-08-24 Eli Lilly And Company Method for treating pain
US6635673B1 (en) 1997-10-27 2003-10-21 Warner-Lambert Company Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
EP1047678B1 (de) 1997-12-16 2004-09-08 Warner-Lambert Company LLC 1-substituierte-1-aminomethyl-cycloalkan derivate (= gabapentin analoga), deren herstellung und deren verwendung bei der behandlung von neurologischen erkrankungen
TR200001800T2 (tr) 1997-12-16 2001-03-21 Warner-Lambert Company -4(3)-İkameli -4(3)- aminometil-(tio) piran veya- piperidin türevleri (=Gabapentin analogları), hazırlanmaları ve nörolojik hastalıkların tedavisinde kullanımları
KR20010033154A (ko) 1997-12-16 2001-04-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 제약물로서의 신규한 아민
EP1089976B1 (de) * 1998-06-22 2003-09-24 Neurosearch A/S Synthese von 5- oder 8-bromoisoquinolin derivaten
NZ512910A (en) 1999-02-23 2003-11-28 Pfizer Prod Inc Monoamine reuptake inhibitors for treatment of CNS disorders
JP3547360B2 (ja) 1999-03-30 2004-07-28 株式会社東芝 フィールドエミッション型表示装置及びその駆動方法
JP2002541224A (ja) * 1999-04-09 2002-12-03 ワーナー−ランバート・カンパニー うつ病の治療のためのgaba類縁体と三環系化合物の組合わせ
ES2317839T3 (es) 1999-06-10 2009-05-01 Warner-Lambert Company Llc Acidos 3-propil gamma-aminobutiricos monosustituidos.
US20020022662A1 (en) * 1999-06-15 2002-02-21 American Home Products Corporation Enantiomers of O-desmethyl venlafaxine
DE60022916T2 (de) * 1999-07-01 2006-07-06 Pharmacia & Upjohn Co. Llc, Kalamazoo Reboxetin zur Behandlung von peripheren Neuropathien
HN2000000224A (es) 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
GB2362646A (en) 2000-05-26 2001-11-28 Warner Lambert Co Cyclic amino acid derivatives useful as pharmaceutical agents
GB2365425A (en) 2000-08-01 2002-02-20 Parke Davis & Co Ltd Alkyl amino acid derivatives useful as pharmaceutical agents
NZ525143A (en) 2000-09-14 2005-12-23 Gruenenthal Chemie Beta-thio-amino acids
PE20021046A1 (es) 2000-09-30 2002-12-14 Gruenenthal Chemie Sulfonilguanidina que tiene afinidad al punto de fijacion de gabapentina
DE10048715A1 (de) 2000-09-30 2004-05-19 Grünenthal GmbH Verwendung von Aminosäure zur Behandlung von Schmerz
US6992076B2 (en) 2000-10-06 2006-01-31 Xenoport, Inc. Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration
GB2367869B (en) 2000-10-14 2004-10-06 Trw Ltd Rear-axle demand for use with front push-through in electrohydraulic (EHB) braking systems
GB2368579A (en) 2000-10-31 2002-05-08 Parke Davis & Co Ltd Azole pharmaceutical agents
WO2002042414A2 (en) 2000-11-17 2002-05-30 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
US6500972B2 (en) * 2001-01-03 2002-12-31 Chinese Petroleim Corp. Synthesis of TMBQ with transition metal-containing molecular sieve as catalysts
US6500955B1 (en) * 2001-02-02 2002-12-31 National Institute Of Pharmaceutical Education And Research One pot synthesis of [2,8-Bis (trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, a mefloquine intermediate
KR100618743B1 (ko) 2001-04-19 2006-08-31 워너-램버트 캄파니 엘엘씨 융합된 비사이클릭 또는 트리사이클릭 아미노산
AU783516B2 (en) * 2001-04-30 2005-11-03 Warner-Lambert Company Methods, kits and compositions for using pyrrole derivatives
ES2265040T3 (es) * 2001-05-25 2007-02-01 Warner-Lambert Company Llc Composicion farmaceutica liquida.
NZ567711A (en) 2001-06-11 2009-10-30 Xenoport Inc Orally administered dosage forms of GABA analog prodrugs having reduced toxicity
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
WO2003061656A1 (en) * 2002-01-16 2003-07-31 Endo Pharmaceuticals Inc. Pharmaceutical composition and method for treating disorders of the central nervous system
JP4428053B2 (ja) * 2002-02-05 2010-03-10 味の素株式会社 ガバペンチン若しくはプレガバリンおよびn型カルシウムチャンネル拮抗剤を含有する医薬組成物
BR0307906A (pt) * 2002-02-22 2004-12-21 Warner Lambert Co Combinações de um ligando alfa-2-delta com um inibidor seletivo de ciclooxigenase-2
KR20050085563A (ko) * 2002-12-13 2005-08-29 워너-램버트 캄파니 엘엘씨 하부요로증상을 치료하기 위한 알파-2-델타 리간드

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DE602004024317D1 (de) 2010-01-07
BRPI0414343A (pt) 2006-11-07
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US20050059715A1 (en) 2005-03-17
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EP2156863A2 (de) 2010-02-24
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RU2006107552A (ru) 2007-09-20
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KR100828218B1 (ko) 2008-05-07
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