MX2009006003A - Composicion que contiene derivados de aurona con fines de diagnostico. - Google Patents

Composicion que contiene derivados de aurona con fines de diagnostico.

Info

Publication number
MX2009006003A
MX2009006003A MX2009006003A MX2009006003A MX2009006003A MX 2009006003 A MX2009006003 A MX 2009006003A MX 2009006003 A MX2009006003 A MX 2009006003A MX 2009006003 A MX2009006003 A MX 2009006003A MX 2009006003 A MX2009006003 A MX 2009006003A
Authority
MX
Mexico
Prior art keywords
sup
diagnosis
amyloid
containing composition
compound
Prior art date
Application number
MX2009006003A
Other languages
English (en)
Inventor
Masahiro Ono
Original Assignee
Univ Nagasaki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nagasaki filed Critical Univ Nagasaki
Publication of MX2009006003A publication Critical patent/MX2009006003A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0419—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Furan Compounds (AREA)

Abstract

Una composición para el diagnóstico de una enfermedad relacionada con amiloides, que comprende un compuesto representado por la fórmula general (I): (ver fórmula (I)) en donde X representa O o semejantes; R1, R3, R4, R5, R6, R8 y R9 representan un átomo de hidrógeno o semejantes; R2 representa un átomo de halógeno o semejantes; y R7 representa un grupo dimetilamino o semejantes; o el compuesto marcado con un radionúclido, o una sal farmacéuticamente aceptable del compuesto o del compuesto marcado. El compuesto representado por la fórmula general (I) presenta todas las siguientes propiedades: gran especificidad de unión a la proteína ß-amiloide, gran permeabilidad a través de la barrera hematoencefálica y depuración rápida de los sitios sin placas seniles en el cerebro.A2.
MX2009006003A 2006-12-05 2007-10-26 Composicion que contiene derivados de aurona con fines de diagnostico. MX2009006003A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006328131 2006-12-05
JP2007081602 2007-03-27
PCT/JP2007/070930 WO2008068974A1 (ja) 2006-12-05 2007-10-26 オーロン誘導体含有診断用組成物

Publications (1)

Publication Number Publication Date
MX2009006003A true MX2009006003A (es) 2009-06-17

Family

ID=39491885

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006003A MX2009006003A (es) 2006-12-05 2007-10-26 Composicion que contiene derivados de aurona con fines de diagnostico.

Country Status (11)

Country Link
US (1) US20100003191A1 (es)
EP (1) EP2113258A1 (es)
JP (1) JPWO2008068974A1 (es)
KR (1) KR20090087037A (es)
AU (1) AU2007330190A1 (es)
BR (1) BRPI0719689A2 (es)
CA (1) CA2671596A1 (es)
IL (1) IL198918A0 (es)
MX (1) MX2009006003A (es)
RU (1) RU2009125612A (es)
WO (1) WO2008068974A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8193363B2 (en) * 2008-08-29 2012-06-05 Astrazeneca Ab Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
AU2016279330B2 (en) 2015-06-16 2020-05-14 Jiangsu Hengrui Medicine Co., Ltd. Piperidine derivative and preparation method and pharmaceutical use thereof
US10899727B2 (en) 2016-04-11 2021-01-26 Middle Tennessee State University Therapeutic aurones
JP7300460B2 (ja) 2018-03-09 2023-06-29 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー 置換１，２－ジヒドロ－３Ｈ－ピラゾロ［３，４－ｄ］ピリミジン－３－オン
JP7204568B2 (ja) * 2018-04-04 2023-01-16 株式会社Cics アミロイドβ疾患のホウ素中性子捕捉療法用化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130305D0 (en) * 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
CN100537559C (zh) * 2006-06-14 2009-09-09 浙江大学 类黄酮衍生物及其制备方法和用途

Also Published As

Publication number Publication date
IL198918A0 (en) 2011-08-01
US20100003191A1 (en) 2010-01-07
AU2007330190A1 (en) 2008-06-12
CA2671596A1 (en) 2008-12-06
RU2009125612A (ru) 2011-01-20
KR20090087037A (ko) 2009-08-14
BRPI0719689A2 (pt) 2013-12-24
WO2008068974A1 (ja) 2008-06-12
EP2113258A1 (en) 2009-11-04
JPWO2008068974A1 (ja) 2010-03-18

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal