BRPI0507334A - processo para a preparação de -1(2s,3s)-2-benzidril-n-(5-terc-butil-2-metoxibenzila)q uinuclidin-3-amina - Google Patents

processo para a preparação de -1(2s,3s)-2-benzidril-n-(5-terc-butil-2-metoxibenzila)q uinuclidin-3-amina

Info

Publication number
BRPI0507334A
BRPI0507334A BRPI0507334-0A BRPI0507334A BRPI0507334A BR PI0507334 A BRPI0507334 A BR PI0507334A BR PI0507334 A BRPI0507334 A BR PI0507334A BR PI0507334 A BRPI0507334 A BR PI0507334A
Authority
BR
Brazil
Prior art keywords
amine
benzhydryl
methoxybenzyl
tert
butyl
Prior art date
Application number
BRPI0507334-0A
Other languages
English (en)
Inventor
Patricia Ann Basford
Ronald James Post
Julian Duncan Smith
Geraldine Patricia Taber
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0507334A publication Critical patent/BRPI0507334A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCESSO PARA A PREPARAçãO DE 1-(2S,3S)-2-BENZIDRIL-N-(5-TERC-BUTI-2-METOXIBENZILA)QUI NUCLIDIN-3-AMINA. A presente invenção refere-se a um processo aperfeiçoado para a preparação de (2S,3S)-2-benzidril-N-(5-terc-butil-2-metoxibenzila) quinucli-din-3-amina (a partir daqui, nesta exposição "composto da fómula l") e os seus sais farmaceuticamente aceitáveis. Especificamente, a invenção é direcionada a uma síntese aperfeiçoada do sal de citrato do monoidrato do composto da fórmula la.
BRPI0507334-0A 2004-02-02 2005-01-26 processo para a preparação de -1(2s,3s)-2-benzidril-n-(5-terc-butil-2-metoxibenzila)q uinuclidin-3-amina BRPI0507334A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54132304P 2004-02-02 2004-02-02
PCT/IB2005/000221 WO2005075473A1 (en) 2004-02-02 2005-01-26 Process for preparation of 1-(2s,3s)-2-benzhydr yl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine

Publications (1)

Publication Number Publication Date
BRPI0507334A true BRPI0507334A (pt) 2007-07-03

Family

ID=34837478

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507334-0A BRPI0507334A (pt) 2004-02-02 2005-01-26 processo para a preparação de -1(2s,3s)-2-benzidril-n-(5-terc-butil-2-metoxibenzila)q uinuclidin-3-amina

Country Status (22)

Country Link
US (1) US20090099364A1 (pt)
EP (1) EP1713801B1 (pt)
JP (1) JP2007519710A (pt)
KR (1) KR100812046B1 (pt)
CN (1) CN1914202A (pt)
AR (1) AR047523A1 (pt)
AT (1) ATE380811T1 (pt)
AU (1) AU2005210259A1 (pt)
BR (1) BRPI0507334A (pt)
CA (1) CA2554360A1 (pt)
CY (1) CY1107141T1 (pt)
DE (1) DE602005003791T2 (pt)
DK (1) DK1713801T3 (pt)
ES (1) ES2296131T3 (pt)
IL (1) IL176817A0 (pt)
NO (1) NO20063268L (pt)
PL (1) PL1713801T3 (pt)
PT (1) PT1713801E (pt)
RU (1) RU2320659C9 (pt)
SI (1) SI1713801T1 (pt)
WO (1) WO2005075473A1 (pt)
ZA (1) ZA200605784B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100834232B1 (ko) 2004-01-30 2008-05-30 화이자 프로덕츠 인크. 액체 투여형용 베타-시클로덱스트린을 사용하는 다수회투여 제형을 얻기 위한 항균 방부제
CA2798007C (en) 2010-05-19 2018-10-23 Sandoz Ag Preparation of posaconazole intermediates
EP2571847B1 (en) 2010-05-19 2016-09-21 Sandoz AG Process for the preparation of chiral hydrazides
WO2011144657A1 (en) * 2010-05-19 2011-11-24 Sandoz Ag Purification of posaconazole and posaconazole intermediates
US9446029B2 (en) 2010-07-27 2016-09-20 Colorado State University Research Foundation Use of NK-1 receptor antagonists in management of visceral pain
DE102011100534A1 (de) 2011-05-05 2012-11-08 Howaldtswerke-Deutsche Werft Gmbh Verfahren zum Betreiben einer Reformer-Brennstoffzellenanlage
WO2012172015A1 (en) 2011-06-16 2012-12-20 Sandoz Ag Process for the preparation of a chiral compound
CN108341812A (zh) * 2017-01-23 2018-07-31 科贝源(北京)生物医药科技有限公司 一种含奎宁环化合物的制备方法
CN108341811A (zh) * 2017-01-23 2018-07-31 科贝源(北京)生物医药科技有限公司 马罗皮坦杂质的制备方法
CN106977512B (zh) * 2017-05-04 2019-01-01 海门慧聚药业有限公司 制备马罗匹坦游离碱的方法
CN110577522B (zh) * 2018-06-07 2022-12-27 东莞市东阳光动物保健药品有限公司 马罗匹坦柠檬酸盐新晶型及其制备方法
CN109320510B (zh) * 2018-11-27 2021-04-27 江苏慧聚药业有限公司 一种马罗匹坦游离碱的制备方法
KR102666745B1 (ko) * 2023-09-06 2024-05-17 주식회사 에스아이켐 시선 유도봉 및 표지병의 노면부착용 에폭시계 접착제 조성물 및 이를 이용한 시선 유도봉 및 표지병의 시공방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL171379B1 (en) * 1991-05-31 1997-04-30 Pfizer Method of obtaining novel derivatives of quinuclidine
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
PE8798A1 (es) * 1995-07-17 1998-03-02 Pfizer Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]
US6255320B1 (en) * 1999-06-01 2001-07-03 Pfizer Inc. Polymorphs of a crystalline azo-bicyclo (2,2,2) octan-3-amine citrate and their pharmaceutical compositions
US6861526B2 (en) * 2002-10-16 2005-03-01 Pfizer Inc. Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine

Also Published As

Publication number Publication date
SI1713801T1 (sl) 2008-04-30
KR100812046B1 (ko) 2008-03-10
DK1713801T3 (da) 2008-03-17
US20090099364A1 (en) 2009-04-16
AR047523A1 (es) 2006-01-25
KR20060127966A (ko) 2006-12-13
JP2007519710A (ja) 2007-07-19
WO2005075473A1 (en) 2005-08-18
DE602005003791T2 (de) 2008-05-29
ATE380811T1 (de) 2007-12-15
AU2005210259A1 (en) 2005-08-18
RU2320659C9 (ru) 2008-07-20
NO20063268L (no) 2006-08-15
EP1713801A1 (en) 2006-10-25
RU2320659C1 (ru) 2008-03-27
PT1713801E (pt) 2008-02-11
ES2296131T3 (es) 2008-04-16
CY1107141T1 (el) 2012-10-24
DE602005003791D1 (de) 2008-01-24
PL1713801T3 (pl) 2008-04-30
EP1713801B1 (en) 2007-12-12
IL176817A0 (en) 2006-10-31
CA2554360A1 (en) 2005-08-18
ZA200605784B (en) 2007-11-28
CN1914202A (zh) 2007-02-14

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011.