ZA200602072B - Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-HT1F agonists - Google Patents

Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-HT1F agonists Download PDF

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Publication number
ZA200602072B
ZA200602072B ZA200602072A ZA200602072A ZA200602072B ZA 200602072 B ZA200602072 B ZA 200602072B ZA 200602072 A ZA200602072 A ZA 200602072A ZA 200602072 A ZA200602072 A ZA 200602072A ZA 200602072 B ZA200602072 B ZA 200602072B
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Prior art keywords
substituted
alkyl
hydrogen
mammal
compound according
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ZA200602072A
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English (en)
Inventor
Blanco-Pillado Maria Jesus
Filla Sandra Ann
Kohlman Daniel Timothy
Victor Frantz
Ying Bai-Ping
Zhang Deyi
Cohen Michael Philip
Hudziak Kevin John
Benesh Dana Rae
Xu Yao-Chang
Zacherl De Anna Piatt
Mathes Brian Michael
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Lilly Co Eli
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Publication of ZA200602072B publication Critical patent/ZA200602072B/en

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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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ZA200602072A 2003-09-12 2006-03-10 Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-HT1F agonists ZA200602072B (en)

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US50278003P 2003-09-12 2003-09-12

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ZA200602072B true ZA200602072B (en) 2007-09-26

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ZA200602072A ZA200602072B (en) 2003-09-12 2006-03-10 Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-HT1F agonists

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US (3) US7291632B2 (fr)
EP (1) EP1663971B1 (fr)
JP (1) JP4700614B2 (fr)
KR (1) KR100777875B1 (fr)
CN (1) CN1849307B (fr)
AR (1) AR045619A1 (fr)
AT (1) ATE538093T1 (fr)
AU (1) AU2004280320B2 (fr)
BR (1) BRPI0414241A (fr)
CA (1) CA2537936C (fr)
CR (1) CR8275A (fr)
CY (1) CY1112475T1 (fr)
DK (1) DK1663971T3 (fr)
EA (1) EA011274B1 (fr)
EC (1) ECSP066415A (fr)
ES (1) ES2379665T3 (fr)
IL (1) IL173521A (fr)
MA (1) MA28212A1 (fr)
MX (1) MXPA06002767A (fr)
MY (1) MY144623A (fr)
NO (1) NO20061584L (fr)
NZ (1) NZ545049A (fr)
PE (1) PE20050350A1 (fr)
PL (1) PL1663971T3 (fr)
PT (1) PT1663971E (fr)
SI (1) SI1663971T1 (fr)
TW (1) TWI340740B (fr)
UA (1) UA82711C2 (fr)
WO (1) WO2005035499A1 (fr)
ZA (1) ZA200602072B (fr)

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UA82711C2 (en) * 2003-09-12 2008-05-12 Эли Лилли Энд Компани Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists
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WO2011030537A1 (fr) * 2009-09-08 2011-03-17 杏林製薬株式会社 Procédé de production de dérivés de l'acide 4-(5-méthylpyridine-2-ylamino)pipéridine-1-carboxylique
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CN109596521A (zh) * 2018-02-11 2019-04-09 中国科学院海洋研究所 磷钼蓝分光光度法中还原剂的保存方法
AU2019323450A1 (en) * 2018-08-24 2021-02-11 Sunshine Lake Pharma Co., Ltd. Pyridinylmethylenepiperidine derivatives and uses thereof
TWI776175B (zh) 2019-07-09 2022-09-01 美商美國禮來大藥廠 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備
CN110845402B (zh) * 2019-11-22 2023-05-09 广东东阳光药业有限公司 吡啶亚甲基哌嗪衍生物及其用途
CN111004214B (zh) * 2019-11-22 2021-06-08 广东东阳光药业有限公司 吡啶酰基哌啶衍生物及其用途
CN114728929A (zh) * 2019-11-22 2022-07-08 广东东阳光药业有限公司 吡啶亚甲基哌啶衍生物及其用途
CN113045540B (zh) * 2019-12-27 2024-02-13 上海天慈国际药业有限公司 一种拉司米地坦的制备方法

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UA82711C2 (en) * 2003-09-12 2008-05-12 Эли Лилли Энд Компани Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists

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ECSP066415A (es) 2006-09-18
KR20060087554A (ko) 2006-08-02
UA82711C2 (en) 2008-05-12
SI1663971T1 (sl) 2012-05-31
MXPA06002767A (es) 2006-06-14
US7803813B2 (en) 2010-09-28
US7291632B2 (en) 2007-11-06
CY1112475T1 (el) 2015-12-09
PL1663971T3 (pl) 2012-05-31
EP1663971B1 (fr) 2011-12-21
JP4700614B2 (ja) 2011-06-15
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