ZA200509970B - Novel spacer moiety for poly (ethylene glycol) modified peptide based compounds - Google Patents

Novel spacer moiety for poly (ethylene glycol) modified peptide based compounds Download PDF

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Publication number
ZA200509970B
ZA200509970B ZA200509970A ZA200509970A ZA200509970B ZA 200509970 B ZA200509970 B ZA 200509970B ZA 200509970 A ZA200509970 A ZA 200509970A ZA 200509970 A ZA200509970 A ZA 200509970A ZA 200509970 B ZA200509970 B ZA 200509970B
Authority
ZA
South Africa
Prior art keywords
peptide
moiety
poly
compound
peg
Prior art date
Application number
ZA200509970A
Other languages
English (en)
Inventor
Christopher P Holmes
Tumelty David
Yin Qun
Original Assignee
Affymax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymax Inc filed Critical Affymax Inc
Publication of ZA200509970B publication Critical patent/ZA200509970B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
ZA200509970A 2003-05-12 2005-12-08 Novel spacer moiety for poly (ethylene glycol) modified peptide based compounds ZA200509970B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46999603P 2003-05-12 2003-05-12

Publications (1)

Publication Number Publication Date
ZA200509970B true ZA200509970B (en) 2006-11-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200509970A ZA200509970B (en) 2003-05-12 2005-12-08 Novel spacer moiety for poly (ethylene glycol) modified peptide based compounds

Country Status (16)

Country Link
US (2) US7919118B2 (zh)
EP (2) EP2204193A3 (zh)
JP (2) JP2007500218A (zh)
KR (1) KR101160611B1 (zh)
CN (1) CN1849141A (zh)
AU (1) AU2004238364A1 (zh)
BR (1) BRPI0411166A (zh)
CA (1) CA2525399A1 (zh)
EA (1) EA010015B1 (zh)
IL (1) IL171885A0 (zh)
IS (1) IS8168A (zh)
MX (1) MXPA05012314A (zh)
NO (1) NO20055848L (zh)
NZ (2) NZ543934A (zh)
WO (1) WO2004100997A2 (zh)
ZA (1) ZA200509970B (zh)

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Also Published As

Publication number Publication date
IL171885A0 (en) 2006-04-10
BRPI0411166A (pt) 2006-07-18
JP2012140466A (ja) 2012-07-26
MXPA05012314A (es) 2006-04-18
WO2004100997A3 (en) 2005-05-19
CA2525399A1 (en) 2004-11-25
EA010015B1 (ru) 2008-06-30
EA200501800A1 (ru) 2006-08-25
NO20055848L (no) 2006-02-13
US20120115796A1 (en) 2012-05-10
US20070032408A1 (en) 2007-02-08
EP2204193A3 (en) 2010-08-18
EP2204193A2 (en) 2010-07-07
NZ543934A (en) 2008-06-30
CN1849141A (zh) 2006-10-18
EP1628686A2 (en) 2006-03-01
IS8168A (is) 2005-12-02
NZ563042A (en) 2008-09-26
US7919118B2 (en) 2011-04-05
KR101160611B1 (ko) 2012-06-28
WO2004100997A2 (en) 2004-11-25
AU2004238364A1 (en) 2004-11-25
KR20060023123A (ko) 2006-03-13
US8592365B2 (en) 2013-11-26
JP2007500218A (ja) 2007-01-11

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