ZA200509944B - Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid - Google Patents

Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid Download PDF

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Publication number
ZA200509944B
ZA200509944B ZA200509944A ZA200509944A ZA200509944B ZA 200509944 B ZA200509944 B ZA 200509944B ZA 200509944 A ZA200509944 A ZA 200509944A ZA 200509944 A ZA200509944 A ZA 200509944A ZA 200509944 B ZA200509944 B ZA 200509944B
Authority
ZA
South Africa
Prior art keywords
ethyl
thio
methylsulfonyl
phenyl
hydroxyphenyl
Prior art date
Application number
ZA200509944A
Other languages
English (en)
Inventor
Andersson Kjell
Sorensen Henrik
Lindstedt-Alstermark Eva-Lotte
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200509944B publication Critical patent/ZA200509944B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA200509944A 2003-06-19 2005-12-07 Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid ZA200509944B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0314260.1A GB0314260D0 (en) 2003-06-19 2003-06-19 Therapeutic agents

Publications (1)

Publication Number Publication Date
ZA200509944B true ZA200509944B (en) 2006-12-27

Family

ID=27636892

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200509944A ZA200509944B (en) 2003-06-19 2005-12-07 Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid

Country Status (14)

Country Link
US (1) US7429675B2 (cg-RX-API-DMAC7.html)
EP (1) EP1638929A1 (cg-RX-API-DMAC7.html)
JP (1) JP2006527751A (cg-RX-API-DMAC7.html)
KR (1) KR20060010840A (cg-RX-API-DMAC7.html)
CN (1) CN1835918A (cg-RX-API-DMAC7.html)
AU (1) AU2004249487A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0411450A (cg-RX-API-DMAC7.html)
CA (1) CA2529252A1 (cg-RX-API-DMAC7.html)
GB (1) GB0314260D0 (cg-RX-API-DMAC7.html)
IL (1) IL172376A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA05013716A (cg-RX-API-DMAC7.html)
NO (1) NO20055883L (cg-RX-API-DMAC7.html)
WO (1) WO2004113285A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200509944B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0104333D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
CN1319938C (zh) 2002-06-20 2007-06-06 阿斯特拉曾尼卡有限公司 治疗胰岛素抵抗的邻位取代的苯甲酸衍生物
GB0314075D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0427524D0 (en) 2004-12-16 2005-01-19 Astrazeneca Ab Chemical process
KR101558005B1 (ko) * 2007-03-08 2015-10-06 알비레오 에이비 2-치환-3-페닐프로피온산 유도체 및 염증성 장 질환 치료에서의 그의 용도
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61197530A (ja) 1985-02-25 1986-09-01 Mitsubishi Gas Chem Co Inc ラセミ化法
DE3683512D1 (de) 1985-02-25 1992-03-05 Mitsubishi Gas Chemical Co Verfahren zur optischen isomerisierung von optisch aktiver aminosaeure und verfahren zur herstellung von optisch aktiver aminosaeure.
TW472047B (en) 1994-02-04 2002-01-11 Merck & Co Inc Process for making HIV protease inhibitors
SE9801992D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl-2-hydroxypropionic acid derivative I
MA26634A1 (fr) 1998-06-04 2004-12-20 Astra Ab Nouveaux derives de l'acide 3-aryl propionique et analogues
SE0104333D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents

Also Published As

Publication number Publication date
CN1835918A (zh) 2006-09-20
WO2004113285A1 (en) 2004-12-29
US20060167309A1 (en) 2006-07-27
NO20055883L (no) 2006-01-09
AU2004249487A1 (en) 2004-12-29
KR20060010840A (ko) 2006-02-02
IL172376A0 (en) 2009-02-11
US7429675B2 (en) 2008-09-30
CA2529252A1 (en) 2004-12-29
BRPI0411450A (pt) 2006-07-18
MXPA05013716A (es) 2006-03-08
EP1638929A1 (en) 2006-03-29
GB0314260D0 (en) 2003-07-23
JP2006527751A (ja) 2006-12-07

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