ZA200508623B - Use of derivatives of 2,4-dihydro-[1,2,4]triazole-3-thione as inhibitors of the enzyme myeloperoxidase (MPO) - Google Patents

Use of derivatives of 2,4-dihydro-[1,2,4]triazole-3-thione as inhibitors of the enzyme myeloperoxidase (MPO) Download PDF

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ZA200508623B
ZA200508623B ZA200508623A ZA200508623A ZA200508623B ZA 200508623 B ZA200508623 B ZA 200508623B ZA 200508623 A ZA200508623 A ZA 200508623A ZA 200508623 A ZA200508623 A ZA 200508623A ZA 200508623 B ZA200508623 B ZA 200508623B
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thione
dihydro
triazole
phenyl
chlorobenzyl
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ZA200508623A
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English (en)
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Svensson Mats
Turek Dominika
Tidun Anna-Karin
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Astrazeneca Ab
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Publication of ZA200508623B publication Critical patent/ZA200508623B/en

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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ZA200508623A 2003-04-25 2005-10-24 Use of derivatives of 2,4-dihydro-[1,2,4]triazole-3-thione as inhibitors of the enzyme myeloperoxidase (MPO) ZA200508623B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0301232A SE0301232D0 (sv) 2003-04-25 2003-04-25 Novel use

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ZA200508623A ZA200508623B (en) 2003-04-25 2005-10-24 Use of derivatives of 2,4-dihydro-[1,2,4]triazole-3-thione as inhibitors of the enzyme myeloperoxidase (MPO)

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Country Link
US (1) US20070093483A1 (enExample)
EP (1) EP1620410A1 (enExample)
JP (1) JP2006524686A (enExample)
KR (1) KR20060006064A (enExample)
CN (1) CN1780822A (enExample)
AU (1) AU2004234320A1 (enExample)
BR (1) BRPI0409498A (enExample)
CA (1) CA2523020A1 (enExample)
MX (1) MXPA05011207A (enExample)
NO (1) NO20055565L (enExample)
SE (1) SE0301232D0 (enExample)
WO (1) WO2004096781A1 (enExample)
ZA (1) ZA200508623B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039385A1 (es) 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
SE0302756D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel Compounds
SE0402591D0 (sv) * 2004-10-25 2004-10-25 Astrazeneca Ab Novel use
EP1817295B1 (en) 2004-11-18 2012-11-07 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
TW200804383A (en) * 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
NZ598548A (en) * 2006-08-15 2013-09-27 Novartis Ag Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level
EP1921073A1 (en) 2006-11-10 2008-05-14 Laboratorios del Dr. Esteve S.A. 1,2,4-Triazole derivatives as sigma receptor inhibitors
US20090053176A1 (en) * 2007-08-23 2009-02-26 Astrazeneca Ab New Combination 937
AU2008345573B2 (en) 2007-12-20 2013-12-19 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
UA107917C2 (ru) * 2008-10-21 2015-03-10 Сімабей Терапьютікс, Інк. Арильный агонист рецептора gpr120 и его применение
CN101723909B (zh) * 2008-10-29 2011-12-28 天津药物研究院 三唑酮类化合物、其制备方法和用途
US20110287468A1 (en) 2010-04-19 2011-11-24 General Atomics Methods and compositions for assaying enzymatic activity of myeloperoxidase in blood samples
EP2560640A1 (en) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
CA2853799A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
AU2012332424A1 (en) 2011-11-02 2014-06-05 Synta Pharmaceuticals Corp. Combination therapy of Hsp90 inhibitors with platinum-containing agents
EP2776405A1 (en) * 2011-11-11 2014-09-17 Pfizer Inc 2-thiopyrimidinones
WO2013074594A1 (en) 2011-11-14 2013-05-23 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors
FR2988000A1 (fr) * 2012-03-16 2013-09-20 Thomas Wandji Composition pharmaceutique active dans la therapie des affections virales humaines et animales
BR112020008727A2 (pt) * 2017-10-30 2020-10-20 Neuropore Therapies, Inc. fenil sulfonil fenil triazol tionas substituídas e usos destas
KR20200083843A (ko) 2018-12-31 2020-07-09 공주대학교 산학협력단 4-(2-플루오로페닐)-3-(3-메톡시벤질)-1h-1,2,4-트리아졸-5(4h)-온 및 이의 퇴행성 뇌질환 및 대사성 질환 치료제로서의 용도
CN110313401A (zh) * 2019-07-12 2019-10-11 华南农业大学 一种促进企剑白墨墨兰组织培养过程中芽分化的方法
IL297857A (en) * 2020-05-06 2023-01-01 Biohaven Therapeutics Ltd Process for the preparation of verdiperstat
PL444904A1 (pl) * 2023-05-15 2024-11-18 Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu Nowe pochodne 4,6-dimetylo-2-sulfanylopirydyny sprzężone z pierścieniem 1,2,4-triazolu, sposób syntezy pochodnych oraz zastosowanie pochodnych
US11926602B1 (en) * 2023-08-23 2024-03-12 King Faisal University 4-amino-5-(4-fluoro-3-phenoxyphenyl)-4H-1,2,4-triazole-3-thiol derivatives as antifungal agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ231534A (en) * 1988-11-29 1992-02-25 Warner Lambert Co 3,5-di-t-butyl-4-hydroxyphenyl-triazoles, oxadiazoles and thiadiazoles; anti-inflammatory compositions
US5100906A (en) * 1990-04-19 1992-03-31 Merrell Dow Pharmaceuticals Inc. 5-aryl-4-alkyl-3h-1,2,4-triazole-3-thiones useful as memory enhancers
US5498720A (en) * 1993-08-26 1996-03-12 Lee; An-Rong Certain triazole compounds and their pharmaceutical uses
US5489598A (en) * 1994-06-08 1996-02-06 Warner-Lambert Company Cytoprotection utilizing aryltriazol-3-thiones
JPH10147568A (ja) * 1996-11-19 1998-06-02 Mitsui Chem Inc ナフタレン誘導体およびそれを有効成分として含有する医薬品
JPH10175970A (ja) * 1996-12-19 1998-06-30 Mitsui Chem Inc ベンゾチオフェン誘導体およびそれを有効成分として含有する医薬品
WO2001053331A2 (en) * 2000-01-24 2001-07-26 Adherex Technologies, Inc. Peptidomimetic modulators of cell adhesion
GB2362101A (en) * 2000-05-12 2001-11-14 Astrazeneca Ab Treatment of chronic obstructive pulmonary disease
WO2002066447A1 (en) * 2001-02-21 2002-08-29 Ono Pharmaceutical Co., Ltd. 4h-1,2,4-triazole-3(2h)-thione deratives as sphingomyelinase inhibitors
US6727241B2 (en) * 2002-06-12 2004-04-27 Chemocentryx Anti-inflammatory compositions and methods of use
JP2006522744A (ja) * 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ グルココルチコイド受容体アゴニスト療法に伴う副作用を最小化するための、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤およびグルココルチコイド受容体アゴニストを使用する併用療法

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CN1780822A (zh) 2006-05-31
JP2006524686A (ja) 2006-11-02
AU2004234320A1 (en) 2004-11-11
US20070093483A1 (en) 2007-04-26
WO2004096781A1 (en) 2004-11-11
NO20055565D0 (no) 2005-11-24
CA2523020A1 (en) 2004-11-11
MXPA05011207A (es) 2005-12-14
NO20055565L (no) 2006-01-25
BRPI0409498A (pt) 2006-05-02
EP1620410A1 (en) 2006-02-01
KR20060006064A (ko) 2006-01-18
SE0301232D0 (sv) 2003-04-25

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