NO20055565L - Anvendelse av derivater av 2,4-dihydro-[1,2,4]triazol-3-thion som inhibitorer av enzymet myeloperoksidase (MPO) - Google Patents

Anvendelse av derivater av 2,4-dihydro-[1,2,4]triazol-3-thion som inhibitorer av enzymet myeloperoksidase (MPO)

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Publication number
NO20055565L
NO20055565L NO20055565A NO20055565A NO20055565L NO 20055565 L NO20055565 L NO 20055565L NO 20055565 A NO20055565 A NO 20055565A NO 20055565 A NO20055565 A NO 20055565A NO 20055565 L NO20055565 L NO 20055565L
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NO
Norway
Prior art keywords
mpo
inhibitors
thione
triazol
dihydro
Prior art date
Application number
NO20055565A
Other languages
English (en)
Norwegian (no)
Other versions
NO20055565D0 (no
Inventor
Anna-Karin Tiden
Mats Svensson
Dominika Turek
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20055565D0 publication Critical patent/NO20055565D0/no
Publication of NO20055565L publication Critical patent/NO20055565L/no

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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NO20055565A 2003-04-25 2005-11-24 Anvendelse av derivater av 2,4-dihydro-[1,2,4]triazol-3-thion som inhibitorer av enzymet myeloperoksidase (MPO) NO20055565L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0301232A SE0301232D0 (sv) 2003-04-25 2003-04-25 Novel use
PCT/SE2004/000618 WO2004096781A1 (en) 2003-04-25 2004-04-22 Use of derivatives of 2, 4-dihydro-[1,2,4]triazole-3-thione as inhibitors o fteh enzyme myeloperoxidase (mpo)

Publications (2)

Publication Number Publication Date
NO20055565D0 NO20055565D0 (no) 2005-11-24
NO20055565L true NO20055565L (no) 2006-01-25

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ID=20291142

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055565A NO20055565L (no) 2003-04-25 2005-11-24 Anvendelse av derivater av 2,4-dihydro-[1,2,4]triazol-3-thion som inhibitorer av enzymet myeloperoksidase (MPO)

Country Status (13)

Country Link
US (1) US20070093483A1 (enExample)
EP (1) EP1620410A1 (enExample)
JP (1) JP2006524686A (enExample)
KR (1) KR20060006064A (enExample)
CN (1) CN1780822A (enExample)
AU (1) AU2004234320A1 (enExample)
BR (1) BRPI0409498A (enExample)
CA (1) CA2523020A1 (enExample)
MX (1) MXPA05011207A (enExample)
NO (1) NO20055565L (enExample)
SE (1) SE0301232D0 (enExample)
WO (1) WO2004096781A1 (enExample)
ZA (1) ZA200508623B (enExample)

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SE0302756D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel Compounds
SE0402591D0 (sv) * 2004-10-25 2004-10-25 Astrazeneca Ab Novel use
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WO2011133581A1 (en) 2010-04-19 2011-10-27 General Atomics Methods and compositions for assaying enzymatic activity of myeloperoxidase in blood samples
EP2560640A1 (en) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
WO2013067162A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
JP2014534228A (ja) 2011-11-02 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 白金含有剤とｈｓｐ９０阻害剤の組合せ療法
BR112014011254A2 (pt) * 2011-11-11 2017-05-16 Pfizer 2-tiopirimidinonas
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FR2988000A1 (fr) * 2012-03-16 2013-09-20 Thomas Wandji Composition pharmaceutique active dans la therapie des affections virales humaines et animales
CN111372579B (zh) * 2017-10-30 2023-08-22 神经孔疗法股份有限公司 取代的苯基磺酰基苯基三唑硫酮和其用途
KR20200083843A (ko) 2018-12-31 2020-07-09 공주대학교 산학협력단 4-(2-플루오로페닐)-3-(3-메톡시벤질)-1h-1,2,4-트리아졸-5(4h)-온 및 이의 퇴행성 뇌질환 및 대사성 질환 치료제로서의 용도
CN110313401A (zh) * 2019-07-12 2019-10-11 华南农业大学 一种促进企剑白墨墨兰组织培养过程中芽分化的方法
WO2021226161A1 (en) * 2020-05-06 2021-11-11 Biohaven Therapeutics Ltd. Process for the preparation of verdiperstat
PL444904A1 (pl) * 2023-05-15 2024-11-18 Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu Nowe pochodne 4,6-dimetylo-2-sulfanylopirydyny sprzężone z pierścieniem 1,2,4-triazolu, sposób syntezy pochodnych oraz zastosowanie pochodnych
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WO2004089415A2 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST

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US20070093483A1 (en) 2007-04-26
BRPI0409498A (pt) 2006-05-02
CA2523020A1 (en) 2004-11-11
AU2004234320A1 (en) 2004-11-11
CN1780822A (zh) 2006-05-31
WO2004096781A1 (en) 2004-11-11
KR20060006064A (ko) 2006-01-18
NO20055565D0 (no) 2005-11-24
ZA200508623B (en) 2007-07-25
SE0301232D0 (sv) 2003-04-25
JP2006524686A (ja) 2006-11-02
EP1620410A1 (en) 2006-02-01

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