ZA200507067B - Antibodies against human IL-21 receptor and uses therefor - Google Patents
Antibodies against human IL-21 receptor and uses thereforInfo
- Publication number
- ZA200507067B ZA200507067B ZA200507067A ZA200507067A ZA200507067B ZA 200507067 B ZA200507067 B ZA 200507067B ZA 200507067 A ZA200507067 A ZA 200507067A ZA 200507067 A ZA200507067 A ZA 200507067A ZA 200507067 B ZA200507067 B ZA 200507067B
- Authority
- ZA
- South Africa
- Prior art keywords
- receptor
- antibodies against
- against human
- uses therefor
- therefor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45433603P | 2003-03-14 | 2003-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200507067B true ZA200507067B (en) | 2006-12-27 |
Family
ID=33029874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200507067A ZA200507067B (en) | 2003-03-14 | 2005-09-02 | Antibodies against human IL-21 receptor and uses therefor |
Country Status (20)
Country | Link |
---|---|
US (2) | US7495085B2 (no) |
EP (2) | EP1603949B9 (no) |
JP (1) | JP4914209B2 (no) |
KR (1) | KR20050119120A (no) |
CN (2) | CN102040662A (no) |
AR (1) | AR043616A1 (no) |
AT (1) | ATE456581T1 (no) |
AU (1) | AU2004221876B2 (no) |
BR (1) | BRPI0408315A (no) |
CA (1) | CA2518371A1 (no) |
CL (1) | CL2004000534A1 (no) |
CO (1) | CO5660297A2 (no) |
DE (1) | DE602004025332D1 (no) |
ES (1) | ES2340280T3 (no) |
MX (1) | MXPA05009556A (no) |
NO (1) | NO20054170L (no) |
NZ (1) | NZ542306A (no) |
RU (1) | RU2005131852A (no) |
WO (1) | WO2004083249A2 (no) |
ZA (1) | ZA200507067B (no) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057128A (en) | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
ZA200500480B (en) | 2002-07-15 | 2006-10-25 | Wyeth Corp | Methods and compositions for modulating T helper (TH) cell development and function |
RU2005131852A (ru) | 2003-03-14 | 2006-04-20 | Уайт (Us) | Антитела против человеческого рецептора il-21 и их применение |
BRPI0408523A (pt) * | 2003-03-21 | 2006-03-21 | Wyeth Corp | métodos para melhorar um sintoma de esclerose múltipla em um indivìduo, para melhorar esclerose múltipla em um indivìduo mamìfero, para modular uma deficiência de il-10, ou um distúrbio associado com uma deficiência de il-10 em um indivìduo mamìfero, para tratar ou prevenir um distúrbio imunológico em um indivìduo mamìfero e para avaliar o tratamento de esclerose múltipla em um indivìduo mamìfero, composição farmacêutica, e, artigo de manufatura |
ATE395083T1 (de) | 2003-11-21 | 2008-05-15 | Ucb Pharma Sa | Verfahren zur behandlung von multipler sklerose durch hemmung der il-17-aktivität |
CN1980698A (zh) * | 2004-05-19 | 2007-06-13 | 惠氏公司 | 免疫球蛋白产生和特应性疾病的调节 |
KR20070057789A (ko) * | 2004-08-05 | 2007-06-07 | 와이어쓰 | 인터루킨-21 수용체 활성의 상쇄 |
EP2368995A3 (en) | 2005-03-25 | 2012-01-18 | National Research Council of Canada | Method for isolation of soluble polypeptides |
GT200600148A (es) | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis | |
US20070122413A1 (en) * | 2005-11-28 | 2007-05-31 | Sivakumar Pallavur V | Il-21 antagonists |
AU2006341398B9 (en) * | 2005-11-28 | 2012-02-02 | Zymogenetics, Inc. | IL-21 receptor antagonists |
WO2007067032A1 (en) | 2005-12-09 | 2007-06-14 | Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
AU2006323315B2 (en) * | 2005-12-09 | 2014-02-20 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of antibody producing cells |
WO2007109749A2 (en) * | 2006-03-21 | 2007-09-27 | Wyeth | Methods for preventing and treating amyloidogenic diseases |
US20090022727A1 (en) * | 2007-01-26 | 2009-01-22 | Alza Corp. | Injectable, nonaqueous suspension with high concentration of therapeutic agent |
SI2167540T1 (en) | 2007-06-29 | 2018-05-31 | F. Hoffmann-La Roche Ag | A mutant heavy chain that enables improved production of immunoglobulins |
US20110212100A1 (en) * | 2007-08-15 | 2011-09-01 | Tracy Keller | Methods for modulating development and expansion of il-17 expressing cells |
DK2217268T3 (en) * | 2007-12-07 | 2016-08-15 | Zymogenetics Inc | MONOCLONAL ANTI-HUMAN IL-21 ANTIBODIES |
WO2009111889A1 (en) * | 2008-03-13 | 2009-09-17 | The Hospital For Sick Children | Lymphocyte control of obesity and insulin resistance |
PE20100141A1 (es) * | 2008-05-23 | 2010-02-22 | Wyeth Corp | Proteina de union al receptor de interleuquina 21 |
WO2009143526A1 (en) * | 2008-05-23 | 2009-11-26 | Wyeth | Methods of treatment utilizing binding proteins of the interleukin-21 receptor |
JP2012504939A (ja) * | 2008-09-23 | 2012-03-01 | ワイス・エルエルシー | 架橋結合タンパク質による活性化シグナルの産生を予測するための方法 |
US8877199B2 (en) | 2009-05-15 | 2014-11-04 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | B cell surface reactive antibodies |
CA2768207C (en) | 2009-07-15 | 2019-12-03 | Aimm Therapeutics B.V. | Means and methods for producing high affinity antibodies |
US20130224109A1 (en) * | 2010-07-20 | 2013-08-29 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods featuring il-6 and il-21 antagonists |
DK2646466T3 (en) | 2010-12-02 | 2017-06-06 | Aimm Therapeutics Bv | METHODS AND METHODS FOR MANUFACTURING HIGH EFFICIENCY ANTIBODIES |
CA2834619A1 (en) * | 2011-04-29 | 2012-11-01 | Selecta Biosciences, Inc. | Controlled release of immunosuppressants from synthetic nanocarriers |
US9309318B2 (en) * | 2012-10-17 | 2016-04-12 | Amgen, Inc. | Compositions relating to anti-IL-21 receptor antibodies |
CN105229033B (zh) | 2013-03-14 | 2019-04-23 | 拜尔健康护理有限责任公司 | 针对与肝素复合的抗凝血酶β的单克隆抗体 |
AU2015211480B2 (en) | 2014-01-31 | 2020-05-14 | Kling Biotherapeutics B.V. | Means and methods for producing stable antibodies |
AR099625A1 (es) * | 2014-03-21 | 2016-08-03 | Lilly Co Eli | Anticuerpos de il-21 |
SG10201913627TA (en) | 2014-04-08 | 2020-03-30 | Boston Pharmaceuticals Inc | Binding molecules specific for il-21 and uses thereof |
JP2018532801A (ja) * | 2015-10-30 | 2018-11-08 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 標的化がん療法 |
JP7010833B2 (ja) * | 2016-03-31 | 2022-02-10 | イーライ リリー アンド カンパニー | Il-21抗体及びその使用 |
JP6989138B2 (ja) * | 2016-06-17 | 2022-01-05 | メディジーン イミュノテラピーズ ゲーエムベーハー | T細胞受容体及びその使用 |
US20190185559A1 (en) * | 2016-09-02 | 2019-06-20 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating neoplasias |
WO2019052562A1 (zh) * | 2017-09-15 | 2019-03-21 | 科济生物医药(上海)有限公司 | Il-4r的融合蛋白及其应用 |
MX2022000191A (es) * | 2019-06-26 | 2022-05-06 | Univ Johns Hopkins | Metodos y materiales para la expansión dirigida de celulas t reguladoras. |
WO2021129656A1 (en) * | 2019-12-24 | 2021-07-01 | Dizal (Jiangsu) Pharmaceutical Co., Ltd. | Novel anti-fgfr2b antibodies |
US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
WO2023023150A2 (en) * | 2021-08-18 | 2023-02-23 | Hifibio (Hk) Limited | Methods and compositions related to neutralizing antibodies against human coronavirus |
WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4496689A (en) * | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
DE3675588D1 (de) * | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
US5011912A (en) * | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
DE3883899T3 (de) * | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
GB8905669D0 (en) | 1989-03-13 | 1989-04-26 | Celltech Ltd | Modified antibodies |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
ES2136092T3 (es) * | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
AU3382595A (en) | 1994-07-29 | 1996-03-04 | Smithkline Beecham Corporation | Novel compounds |
FR2724182B1 (fr) * | 1994-09-02 | 1996-12-13 | Pasteur Institut | Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations |
BRPI9715219B8 (pt) * | 1996-02-09 | 2015-07-07 | Abbvie Biotechnology Ltd | Vetor recombinante de expressão, e célula hospedeira procariótica. |
GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
AU6450196A (en) | 1996-06-12 | 1998-01-07 | Human Genome Sciences, Inc. | Hr-1 receptor |
EP0812913A3 (en) | 1996-06-12 | 1999-08-04 | Smithkline Beecham Corporation | HR-1 receptor, a receptor of the cytokine receptors family |
WO1997047741A1 (en) | 1996-06-12 | 1997-12-18 | Smithkline Beecham Corporation | Hr-1 receptor |
AUPO224696A0 (en) | 1996-09-11 | 1996-10-03 | Amrad Operations Pty. Limited | A novel haemopoietin receptor and genetic sequences encoding same |
EP1005552A1 (en) | 1997-01-16 | 2000-06-07 | Genetics Institute, Inc. | Member of the hematopoietin receptor superfamily |
US6350892B1 (en) | 1997-09-23 | 2002-02-26 | Bristol-Myers Squibb Company | Trifluoromethyl ketone analogs as selective cPLA2 inhibitors |
US20010025022A1 (en) | 1997-11-26 | 2001-09-27 | Kikly Kristine Kay | Hnovilr |
US7198789B2 (en) * | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
US7189400B2 (en) * | 1998-03-17 | 2007-03-13 | Genetics Institute, Llc | Methods of treatment with antagonists of MU-1 |
US6057128A (en) | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
EP1088831A4 (en) | 1998-06-24 | 2003-01-02 | Chugai Pharmaceutical Co Ltd | HEMOPOIETIN RECEPTOR PROTEINS |
WO2000008152A1 (en) * | 1998-08-04 | 2000-02-17 | Regeneron Pharmaceuticals, Inc. | Novel orphan cytokine receptors |
ES2329741T3 (es) | 1998-09-23 | 2009-11-30 | Zymogenetics, Inc. | Receptor de citoquinas zalpha11. |
US6803451B2 (en) * | 1998-09-23 | 2004-10-12 | Zymogenetics, Inc. | Cytokine receptor zalpha11 polypeptides |
US6576744B1 (en) * | 1998-09-23 | 2003-06-10 | Zymogenetics, Inc. | Cytokine receptor zalpha11 |
US6355788B1 (en) * | 1998-10-15 | 2002-03-12 | Zymogenetics, Inc. | Follistatin-related protein zfsta2 |
WO2000027882A1 (en) | 1998-11-06 | 2000-05-18 | Smithkline Beecham Corporation | Hnovilr |
HU229148B1 (en) | 1999-03-09 | 2013-09-30 | Zymogenetics Inc Seattle | Human cytokine as ligand of the zalpha receptor and uses thereof |
US6307024B1 (en) * | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
CA2796140A1 (en) | 1999-03-25 | 2000-09-28 | Jochen Salfeld | Human antibodies that bind human il-12 and methods for producing |
US20020090680A1 (en) | 1999-05-18 | 2002-07-11 | Millennium Pharmaceuticals, Inc. | Novel IL-9/IL-2 receptor-like molecules and uses thereof |
WO2000069880A1 (en) | 1999-05-18 | 2000-11-23 | Millennium Pharmaceuticals, Inc. | Il-9/il-2 receptor-like molecules and uses thereof |
KR100942863B1 (ko) | 1999-08-24 | 2010-02-17 | 메다렉스, 인코포레이티드 | 인간 씨티엘에이-4 항체 및 그의 용도 |
AU7676300A (en) | 1999-10-12 | 2001-04-23 | Cambridge Antibody Technology Limited | Human anti-adipocyte monoclonal antibodies and their use |
CA2392109A1 (en) | 1999-11-18 | 2001-05-25 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
JP2003520852A (ja) | 2000-01-27 | 2003-07-08 | アメリカン・サイアナミド・カンパニー | α−スルホニルヒドロキサム酸誘導体を製造する方法 |
ES2279809T3 (es) * | 2000-04-05 | 2007-09-01 | Zymogenetics, Inc. | Receptores de citoquina zalfa11 solubles. |
PT1353953E (pt) | 2000-05-11 | 2007-02-28 | Genetics Inst Llc | Mu-1, membro da família dos receptores de citocina |
WO2002002641A1 (en) * | 2000-06-16 | 2002-01-10 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to blys |
NZ532021A (en) * | 2001-10-04 | 2008-05-30 | Genetics Inst Llc | Methods and compositions for modulating interleukin-21 receptor activity |
CA2465156C (en) | 2001-11-05 | 2011-10-18 | Zymogenetics, Inc. | Il-21 antagonists |
US20040016010A1 (en) | 2002-04-17 | 2004-01-22 | Marion Kasaian | IL-21 receptor knockout animal and methods of use thereof |
ZA200500480B (en) | 2002-07-15 | 2006-10-25 | Wyeth Corp | Methods and compositions for modulating T helper (TH) cell development and function |
RU2005131852A (ru) | 2003-03-14 | 2006-04-20 | Уайт (Us) | Антитела против человеческого рецептора il-21 и их применение |
BRPI0408523A (pt) | 2003-03-21 | 2006-03-21 | Wyeth Corp | métodos para melhorar um sintoma de esclerose múltipla em um indivìduo, para melhorar esclerose múltipla em um indivìduo mamìfero, para modular uma deficiência de il-10, ou um distúrbio associado com uma deficiência de il-10 em um indivìduo mamìfero, para tratar ou prevenir um distúrbio imunológico em um indivìduo mamìfero e para avaliar o tratamento de esclerose múltipla em um indivìduo mamìfero, composição farmacêutica, e, artigo de manufatura |
CN1980698A (zh) | 2004-05-19 | 2007-06-13 | 惠氏公司 | 免疫球蛋白产生和特应性疾病的调节 |
KR20070057789A (ko) | 2004-08-05 | 2007-06-07 | 와이어쓰 | 인터루킨-21 수용체 활성의 상쇄 |
GT200600148A (es) | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis | |
WO2009100035A2 (en) | 2008-02-01 | 2009-08-13 | Wyeth | Interleukin-21 (il-21) and il-21 receptor (il-21r) modulation of regulatory t cells and forkhead box p3 (foxp3) |
-
2004
- 2004-03-12 RU RU2005131852/13A patent/RU2005131852A/ru not_active Application Discontinuation
- 2004-03-12 BR BRPI0408315-6A patent/BRPI0408315A/pt not_active IP Right Cessation
- 2004-03-12 AT AT04720349T patent/ATE456581T1/de not_active IP Right Cessation
- 2004-03-12 KR KR1020057017254A patent/KR20050119120A/ko not_active Application Discontinuation
- 2004-03-12 CA CA002518371A patent/CA2518371A1/en not_active Abandoned
- 2004-03-12 EP EP04720349A patent/EP1603949B9/en not_active Revoked
- 2004-03-12 DE DE602004025332T patent/DE602004025332D1/de not_active Expired - Lifetime
- 2004-03-12 AU AU2004221876A patent/AU2004221876B2/en not_active Ceased
- 2004-03-12 EP EP09178337A patent/EP2184298A1/en not_active Withdrawn
- 2004-03-12 CN CN2010101657309A patent/CN102040662A/zh active Pending
- 2004-03-12 MX MXPA05009556A patent/MXPA05009556A/es active IP Right Grant
- 2004-03-12 US US10/798,380 patent/US7495085B2/en not_active Expired - Fee Related
- 2004-03-12 WO PCT/US2004/007444 patent/WO2004083249A2/en active Application Filing
- 2004-03-12 ES ES04720349T patent/ES2340280T3/es not_active Expired - Lifetime
- 2004-03-12 JP JP2006507081A patent/JP4914209B2/ja not_active Expired - Fee Related
- 2004-03-12 NZ NZ542306A patent/NZ542306A/en unknown
- 2004-03-12 CN CNA2004800105188A patent/CN1777621A/zh active Pending
- 2004-03-15 CL CL200400534A patent/CL2004000534A1/es unknown
- 2004-03-15 AR ARP040100859A patent/AR043616A1/es unknown
-
2005
- 2005-09-02 ZA ZA200507067A patent/ZA200507067B/xx unknown
- 2005-09-07 NO NO20054170A patent/NO20054170L/no not_active Application Discontinuation
- 2005-09-14 CO CO05093185A patent/CO5660297A2/es not_active Application Discontinuation
-
2009
- 2009-01-14 US US12/353,812 patent/US8143385B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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NZ542306A (en) | 2008-04-30 |
NO20054170L (no) | 2005-12-05 |
AU2004221876B2 (en) | 2011-05-26 |
US20040265960A1 (en) | 2004-12-30 |
NO20054170D0 (no) | 2005-09-07 |
CL2004000534A1 (es) | 2005-03-04 |
US7495085B2 (en) | 2009-02-24 |
AR043616A1 (es) | 2005-08-03 |
RU2005131852A (ru) | 2006-04-20 |
WO2004083249A2 (en) | 2004-09-30 |
CN1777621A (zh) | 2006-05-24 |
EP1603949B9 (en) | 2011-02-02 |
JP4914209B2 (ja) | 2012-04-11 |
CN102040662A (zh) | 2011-05-04 |
ATE456581T1 (de) | 2010-02-15 |
JP2007525159A (ja) | 2007-09-06 |
DE602004025332D1 (de) | 2010-03-18 |
EP1603949A2 (en) | 2005-12-14 |
EP1603949B8 (en) | 2010-03-10 |
EP1603949B1 (en) | 2010-01-27 |
ES2340280T3 (es) | 2010-06-01 |
CO5660297A2 (es) | 2006-07-31 |
EP2184298A1 (en) | 2010-05-12 |
KR20050119120A (ko) | 2005-12-20 |
AU2004221876A1 (en) | 2004-09-30 |
MXPA05009556A (es) | 2005-11-16 |
US8143385B2 (en) | 2012-03-27 |
CA2518371A1 (en) | 2004-09-30 |
WO2004083249A3 (en) | 2004-12-09 |
US20100297151A1 (en) | 2010-11-25 |
BRPI0408315A (pt) | 2006-03-07 |
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