ZA200503237B - Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases - Google Patents
Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases Download PDFInfo
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- ZA200503237B ZA200503237B ZA200503237A ZA200503237A ZA200503237B ZA 200503237 B ZA200503237 B ZA 200503237B ZA 200503237 A ZA200503237 A ZA 200503237A ZA 200503237 A ZA200503237 A ZA 200503237A ZA 200503237 B ZA200503237 B ZA 200503237B
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- South Africa
- Prior art keywords
- retinal
- alkyl
- retinopathy
- heteroaryl
- heterocycloalkyl
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- AODPIQQILQLWGS-GXBDJPPSSA-N tetrahydrocortisol Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CC[C@@H]21 AODPIQQILQLWGS-GXBDJPPSSA-N 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
- 229930192474 thiophene Chemical group 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- YTZALCGQUPRCGW-ZSFNYQMMSA-N verteporfin Chemical compound N1C(C=C2C(=C(CCC(O)=O)C(C=C3C(CCC(=O)OC)=C(C)C(N3)=C3)=N2)C)=C(C=C)C(C)=C1C=C1C2=CC=C(C(=O)OC)[C@@H](C(=O)OC)[C@@]2(C)C3=N1 YTZALCGQUPRCGW-ZSFNYQMMSA-N 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 229940061392 visudyne Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42557402P | 2002-11-12 | 2002-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200503237B true ZA200503237B (en) | 2006-06-28 |
Family
ID=32313018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200503237A ZA200503237B (en) | 2002-11-12 | 2005-04-21 | Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases |
Country Status (12)
Country | Link |
---|---|
US (3) | US20040092558A1 (ja) |
EP (1) | EP1560583A4 (ja) |
JP (1) | JP2006512318A (ja) |
KR (1) | KR20050086526A (ja) |
CN (1) | CN1711087A (ja) |
AU (1) | AU2003287349B2 (ja) |
BR (1) | BR0316206A (ja) |
CA (1) | CA2504460A1 (ja) |
MX (1) | MXPA05004485A (ja) |
RU (1) | RU2352337C2 (ja) |
WO (1) | WO2004043352A2 (ja) |
ZA (1) | ZA200503237B (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004043352A2 (en) * | 2002-11-12 | 2004-05-27 | Alcon, Inc. | Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases |
AU2004228011A1 (en) * | 2003-04-01 | 2004-10-21 | Memorial Sloan-Kettering Cancer Center | Hydroxamic acid compounds and methods of use thereof |
US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
WO2006016680A1 (en) * | 2004-08-09 | 2006-02-16 | Astellas Pharma Inc. | Hydroxyamide compounds having activity as inhibitors of histone deacetylase (hdac) |
JP2008530136A (ja) | 2005-02-14 | 2008-08-07 | ミイカナ セラピューティクス インコーポレイテッド | ヒストンデアセチラーゼの阻害剤として有用な縮合複素環化合物 |
GB0509225D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of enzymatic activity |
EP1964577B1 (en) | 2005-05-05 | 2016-04-13 | GlaxoSmithKline Intellectual Property Development Limited | Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase |
AU2006270322A1 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
MX2008010035A (es) * | 2006-02-07 | 2008-10-17 | Astellas Pharma Inc | Compuestos de n-hidroxiacrilamida. |
WO2007113644A2 (en) * | 2006-04-05 | 2007-10-11 | Orchid Research Laboratories Limited | New hdac inhibitors |
WO2008053131A1 (en) * | 2006-10-30 | 2008-05-08 | Chroma Therapeutics Ltd. | Hydroxamates as inhibitors of histone deacetylase |
MX2009006129A (es) * | 2006-12-15 | 2009-06-18 | Astellas Pharma Inc | Compuestos de n-hidroxiacrilamida. |
CN101239929B (zh) * | 2007-02-09 | 2013-04-17 | 中国科学院上海药物研究所 | 曲古抑菌素a衍生物及其制备方法和用途 |
WO2008117861A1 (ja) * | 2007-03-28 | 2008-10-02 | Santen Pharmaceutical Co., Ltd. | フェニレンジアミン誘導体を有効成分とする眼圧下降剤 |
US11045435B2 (en) * | 2016-09-29 | 2021-06-29 | Naturewise Biotech & Medicals Corporation | Methods for treating ocular diseases |
WO2019089573A1 (en) * | 2017-10-30 | 2019-05-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Treatment of ocular conditions utilizing a histone/protein deacetylase inhibitor |
KR102236356B1 (ko) | 2017-11-24 | 2021-04-05 | 주식회사 종근당 | 루푸스의 예방 또는 치료를 위한 조성물 |
KR20190099952A (ko) * | 2018-02-20 | 2019-08-28 | 주식회사 종근당 | 포도막염의 예방 또는 치료를 위한 조성물 |
WO2019246509A1 (en) * | 2018-06-22 | 2019-12-26 | Mohan Rajiv R | Methods and compositions for promoting wound healing with decreased scar formation after glaucoma filtration surgery |
WO2020102599A1 (en) * | 2018-11-14 | 2020-05-22 | Vanderbilt University | Treating intraocular retinoblastoma with inhibitors of histone modification |
RU2769320C1 (ru) * | 2020-12-28 | 2022-03-30 | Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) | Способ получения производных N-гидроксибутанамида |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4975537A (en) * | 1985-10-23 | 1990-12-04 | The Upjohn Company | Δ9(11) -angiostatic steroids |
US4771042A (en) * | 1985-11-25 | 1988-09-13 | The Upjohn Company | Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments |
US5629327A (en) * | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
GB9804504D0 (en) * | 1998-03-03 | 1998-04-29 | Leo Pharm Prod Ltd | Matrix metalloproteinase inhibitors |
AUPP505798A0 (en) * | 1998-08-04 | 1998-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Novel compound fr225497 substance |
EP1123309A2 (en) * | 1998-10-13 | 2001-08-16 | Fujisawa Pharmaceutical Co., Ltd. | Cyclic tetrapeptides and their use as histone deacetylase inhibitor |
US6953783B1 (en) * | 1998-10-19 | 2005-10-11 | Methylgene, Inc. | Modulation of gene expression by combination therapy |
US6569899B1 (en) * | 1999-04-06 | 2003-05-27 | Ono Pharmaceuticals Co., Ltd. | 4-aminobutanoic acid derivatives and drugs containing these derivatives as the active ingredient |
EP1231919B1 (en) * | 1999-09-08 | 2015-09-30 | Sloan-Kettering Institute For Cancer Research | Derivatives of 1-amino-1-(hetero)arylaminocarbonyl-6-hydroxyaminocarbonylhexane useful in the treatment of tumors |
US6544957B2 (en) * | 2000-01-04 | 2003-04-08 | The Johns Hopkins University | Methods and reagents for facilitating transcription |
AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
GB0023983D0 (en) * | 2000-09-29 | 2000-11-15 | Prolifix Ltd | Therapeutic compounds |
US20050119305A1 (en) * | 2001-03-21 | 2005-06-02 | Masao Naka | Il-6 production inhibitors |
WO2003032921A2 (en) * | 2001-10-16 | 2003-04-24 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
US7154002B1 (en) * | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
WO2004043352A2 (en) * | 2002-11-12 | 2004-05-27 | Alcon, Inc. | Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases |
RU2324483C2 (ru) * | 2002-11-12 | 2008-05-20 | Алькон, Инк. | Ингибиторы гистондеацетилазы для лечения дегенеративных заболеваний глаз |
US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
-
2003
- 2003-10-30 WO PCT/US2003/034617 patent/WO2004043352A2/en active Application Filing
- 2003-10-30 EP EP03781581A patent/EP1560583A4/en not_active Withdrawn
- 2003-10-30 BR BR0316206-0A patent/BR0316206A/pt not_active Application Discontinuation
- 2003-10-30 KR KR1020057008413A patent/KR20050086526A/ko not_active Application Discontinuation
- 2003-10-30 US US10/697,135 patent/US20040092558A1/en not_active Abandoned
- 2003-10-30 RU RU2005118107/14A patent/RU2352337C2/ru not_active IP Right Cessation
- 2003-10-30 CA CA002504460A patent/CA2504460A1/en not_active Abandoned
- 2003-10-30 CN CNA2003801030038A patent/CN1711087A/zh active Pending
- 2003-10-30 MX MXPA05004485A patent/MXPA05004485A/es active IP Right Grant
- 2003-10-30 AU AU2003287349A patent/AU2003287349B2/en not_active Ceased
- 2003-10-30 JP JP2004551638A patent/JP2006512318A/ja active Pending
- 2003-10-30 US US10/531,754 patent/US20060074100A1/en not_active Abandoned
-
2005
- 2005-04-21 ZA ZA200503237A patent/ZA200503237B/en unknown
-
2009
- 2009-10-30 US US12/609,873 patent/US20100048608A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2352337C2 (ru) | 2009-04-20 |
US20040092558A1 (en) | 2004-05-13 |
RU2005118107A (ru) | 2006-01-20 |
WO2004043352A2 (en) | 2004-05-27 |
KR20050086526A (ko) | 2005-08-30 |
MXPA05004485A (es) | 2005-11-23 |
EP1560583A2 (en) | 2005-08-10 |
WO2004043352A3 (en) | 2004-07-15 |
JP2006512318A (ja) | 2006-04-13 |
WO2004043352A8 (en) | 2005-06-30 |
US20100048608A1 (en) | 2010-02-25 |
AU2003287349A1 (en) | 2004-06-03 |
EP1560583A4 (en) | 2010-09-22 |
CN1711087A (zh) | 2005-12-21 |
BR0316206A (pt) | 2005-09-27 |
US20060074100A1 (en) | 2006-04-06 |
CA2504460A1 (en) | 2004-05-27 |
AU2003287349B2 (en) | 2009-04-23 |
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