ZA200503024B - Selective cytokine inhibitory drugs for treating myelodysplastic syndrome - Google Patents

Selective cytokine inhibitory drugs for treating myelodysplastic syndrome Download PDF

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Publication number
ZA200503024B
ZA200503024B ZA200503024A ZA200503024A ZA200503024B ZA 200503024 B ZA200503024 B ZA 200503024B ZA 200503024 A ZA200503024 A ZA 200503024A ZA 200503024 A ZA200503024 A ZA 200503024A ZA 200503024 B ZA200503024 B ZA 200503024B
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South Africa
Prior art keywords
carbon atoms
active ingredient
cytokine inhibitory
selective cytokine
stereoisomer
Prior art date
Application number
ZA200503024A
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English (en)
Inventor
Jerome B Zeldis
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Celgene Corp
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Publication of ZA200503024B publication Critical patent/ZA200503024B/en

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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203Retinoic acids ; Salts thereof
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035Isoindoles, e.g. phthalimide
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K38/1816Erythropoietin [EPO]
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    • A61K38/19Cytokines; Lymphokines; Interferons
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ZA200503024A 2002-10-15 2003-04-13 Selective cytokine inhibitory drugs for treating myelodysplastic syndrome ZA200503024B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41847002P 2002-10-15 2002-10-15

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ZA200503024B true ZA200503024B (en) 2006-11-29

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ZA200503024A ZA200503024B (en) 2002-10-15 2003-04-13 Selective cytokine inhibitory drugs for treating myelodysplastic syndrome

Country Status (13)

Country Link
US (1) US7842691B2 (ko)
EP (1) EP1551385A4 (ko)
JP (1) JP2006510606A (ko)
KR (1) KR20050056247A (ko)
CN (1) CN1713905A (ko)
AU (1) AU2003228509B2 (ko)
BR (1) BR0315316A (ko)
CA (1) CA2501936A1 (ko)
IL (1) IL168060A0 (ko)
MX (1) MXPA05003889A (ko)
NZ (1) NZ539534A (ko)
WO (1) WO2004034962A2 (ko)
ZA (1) ZA200503024B (ko)

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EA017775B1 (ru) * 2008-01-24 2013-03-29 Мерк Патент Гмбх ПРОИЗВОДНЫЕ β-АМИНОКИСЛОТ ДЛЯ ЛЕЧЕНИЯ ДИАБЕТА
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RU2678117C2 (ru) 2012-11-02 2019-01-23 Селджин Корпорейшн Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений
HUE062189T2 (hu) 2014-12-03 2023-09-28 Celgene Corp Aktivin-ACTRII-antagonisták és alkalmazások mielodiszpláziás szindróma kezelésére
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JP2006510606A (ja) 2006-03-30
CN1713905A (zh) 2005-12-28
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AU2003228509B2 (en) 2008-06-26
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