ZA200502867B - Methods of generating and screening for proteases with altered specificity - Google Patents
Methods of generating and screening for proteases with altered specificityInfo
- Publication number
- ZA200502867B ZA200502867B ZA200502867A ZA200502867A ZA200502867B ZA 200502867 B ZA200502867 B ZA 200502867B ZA 200502867 A ZA200502867 A ZA 200502867A ZA 200502867 A ZA200502867 A ZA 200502867A ZA 200502867 B ZA200502867 B ZA 200502867B
- Authority
- ZA
- South Africa
- Prior art keywords
- proteases
- screening
- generating
- methods
- altered specificity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6467—Granzymes, e.g. granzyme A (3.4.21.78); granzyme B (3.4.21.79)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41538802P | 2002-10-02 | 2002-10-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200502867B true ZA200502867B (en) | 2007-09-26 |
Family
ID=32069849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200502867A ZA200502867B (en) | 2002-10-02 | 2003-10-02 | Methods of generating and screening for proteases with altered specificity |
Country Status (13)
Country | Link |
---|---|
US (2) | US20040146938A1 (zh) |
EP (3) | EP2444810A3 (zh) |
JP (3) | JP5376747B2 (zh) |
KR (3) | KR101132555B1 (zh) |
CN (2) | CN101124484A (zh) |
AU (2) | AU2003282724B2 (zh) |
CA (1) | CA2501295A1 (zh) |
MX (1) | MXPA05003493A (zh) |
NO (1) | NO20052096L (zh) |
NZ (2) | NZ590187A (zh) |
SG (2) | SG166001A1 (zh) |
WO (1) | WO2004031733A2 (zh) |
ZA (1) | ZA200502867B (zh) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060024289A1 (en) * | 2002-10-02 | 2006-02-02 | Ruggles Sandra W | Cleavage of VEGF and VEGF receptor by wild-type and mutant proteases |
SG166001A1 (en) * | 2002-10-02 | 2010-11-29 | Catalyst Biosciences Inc | Methods of generating and screening for proteases with altered specificity |
US7939304B2 (en) * | 2002-10-02 | 2011-05-10 | Catalyst Biosciences, Inc. | Mutant MT-SP1 proteases with altered substrate specificity or activity |
WO2005017110A2 (en) * | 2003-08-06 | 2005-02-24 | University Of Maryland Biotechnology Institute | Engineered proteases for affinity purification and processing of fusion proteins |
EP1735438A2 (en) * | 2004-04-12 | 2006-12-27 | Catalyst Biosciences | Cleavage of vegf and vegf receptor by wild-type and mutant proteases |
DK1735439T3 (da) * | 2004-04-12 | 2012-02-06 | Catalyst Biosciences Inc | Spaltning af VEGF og VEGF receptor ved hjælp af vild-type og mutant MT-SP1 |
JP2006117594A (ja) * | 2004-10-22 | 2006-05-11 | Shiseido Co Ltd | 活性型カスパーゼ−14特異的抗体及びその作成方法 |
EP1866328B1 (en) | 2005-03-22 | 2011-01-12 | Rohto Pharmaceutical Co., Ltd. | Peptides which increase collagen or hyaluronic acid production |
AU2006304804B2 (en) | 2005-10-21 | 2011-06-02 | Vertex Pharmaceuticals Incorporated | Modified proteases that inhibit complement activation |
EP2423305A1 (en) * | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modified coagulation factor IX polypeptides and use thereof for treatment |
SG175602A1 (en) | 2006-07-05 | 2011-11-28 | Catalyst Biosciences Inc | Protease screening methods and proteases identified thereby |
EP2147096B1 (en) * | 2007-04-13 | 2015-03-25 | Catalyst Biosciences, Inc. | Modified factor VII polypeptides and uses thereof |
TWI538916B (zh) | 2008-04-11 | 2016-06-21 | 介控生化科技公司 | 經修飾的因子vii多肽和其用途 |
ES2940323T3 (es) | 2008-09-15 | 2023-05-05 | Uniqure Biopharma B V | Mutante de polipéptido factor IX, sus usos y un método para su producción |
US10577639B2 (en) | 2009-06-26 | 2020-03-03 | University Of Florida Research Foundation, Inc. | Rapid bed-side measurement of neutrophil elastase activity in biological fluids |
WO2011038114A1 (en) * | 2009-09-23 | 2011-03-31 | Potomac Affinity Proteins, Inc. | Systems and methods for evolving enzymes with desired activities |
WO2012038049A2 (en) * | 2010-09-22 | 2012-03-29 | Roche Diagnostics Gmbh | Amplification of distant nucleic acid targets using engineered primers |
TWI557135B (zh) | 2010-11-03 | 2016-11-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
JP5851092B2 (ja) * | 2010-12-24 | 2016-02-03 | 株式会社明治 | ペプチド組成物、およびその製造方法 |
EP2658971A1 (en) | 2010-12-28 | 2013-11-06 | XOMA Technology Ltd. | Cell surface display using pdz domains |
EP2758527B1 (en) | 2011-09-23 | 2016-11-09 | PharmedArtis GmbH | Novel serine protease variants |
ES2741723T5 (es) * | 2012-05-25 | 2023-01-23 | Chr Hansen As | Variantes de quimosina con propiedades mejoradas de coagulación de leche |
ES2704083T3 (es) | 2012-07-25 | 2019-03-14 | Catalyst Biosciences Inc | Polipéptidos de factor x modificados y usos de los mismos |
WO2014055836A2 (en) * | 2012-10-04 | 2014-04-10 | Research Development Foundation | Serine protease molecules and therapies |
UA121380C2 (uk) | 2014-02-26 | 2020-05-25 | Кр. Гансен А/С | Поліпептид хімозину з удосконаленими властивостями щодо згортання молока |
US11512335B2 (en) * | 2014-04-29 | 2022-11-29 | Novartis Ag | Vertebrate cells and methods for recombinantly expressing a polypeptide of interest |
JP6743022B2 (ja) | 2014-12-24 | 2020-08-19 | ネクシミューン インコーポレイテッド | 免疫療法のためのナノ粒子組成物及び方法 |
JP6856551B2 (ja) | 2015-06-22 | 2021-04-07 | セーホーエル.ハンセン アクティーゼルスカブ | 改善された特性を有するキモシン変異体 |
EP3344049A1 (en) | 2015-08-31 | 2018-07-11 | Chr. Hansen A/S | Variants of chymosin with improved properties |
US11702477B2 (en) | 2015-11-06 | 2023-07-18 | Orionis Biosciences BV | Bi-functional chimeric proteins and uses thereof |
AU2016358125A1 (en) | 2015-11-19 | 2018-07-05 | Asclepix Therapeutics, Llc. | Peptides with anti-angiogenic, anti-lymphangiogenic, and anti-edemic properties and nanoparticle formulations |
ES2877568T3 (es) | 2016-02-05 | 2021-11-17 | Orionis Biosciences Nv | Agentes de unión de Clec9A |
US11248057B2 (en) | 2016-03-07 | 2022-02-15 | Vib Vzw | CD20 binding single domain antibodies |
CN109689087B (zh) | 2016-05-13 | 2023-04-04 | 奥里尼斯生物科学私人有限公司 | 靶向性突变干扰素-β及其用途 |
CN109563141A (zh) | 2016-05-13 | 2019-04-02 | 奥里尼斯生物科学公司 | 对非细胞结构的治疗性靶向 |
CN109640677A (zh) | 2016-05-19 | 2019-04-16 | 科·汉森有限公司 | 具有改善的凝乳特性的凝乳酶的变体 |
AU2017267273B2 (en) | 2016-05-19 | 2021-10-21 | Chr. Hansen A/S | Variants of Chymosin with improved milk-clotting properties |
BR112019006735A2 (pt) | 2016-10-04 | 2019-06-25 | Asclepix Therapeutics Llc | compostos e métodos para ativação da sinalização de tie2 |
BR102017010169A2 (pt) * | 2017-05-15 | 2019-02-26 | Remer Consultores Assessoria Empresarial Ltda. | composto, intermediário de síntese, uso na preparação de anticonvulsivante, composição farmacêutica anticonvulsivante |
US11084859B2 (en) | 2016-10-24 | 2021-08-10 | Orionis Biosciences BV | Targeted mutant interferon-gamma and uses thereof |
GB201622422D0 (en) * | 2016-12-30 | 2017-02-15 | Dublin Inst Of Tech | Peptide prediction |
US10906985B2 (en) | 2017-02-06 | 2021-02-02 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
US11384154B2 (en) | 2017-02-06 | 2022-07-12 | Orionis Biosciences BV | Targeted chimeric proteins and uses thereof |
EP3580230A1 (en) | 2017-02-07 | 2019-12-18 | VIB vzw | Immune-cell targeted bispecific chimeric proteins and uses thereof |
SG11201912071QA (en) | 2017-06-22 | 2020-01-30 | Catalyst Biosciences Inc | Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use |
US11674959B2 (en) | 2017-08-03 | 2023-06-13 | The Johns Hopkins University | Methods for identifying and preparing pharmaceutical agents for activating Tie1 and/or Tie2 receptors |
CN108241054B (zh) * | 2017-12-26 | 2021-03-12 | 天津市中西医结合医院(天津市南开医院) | 检测g蛋白偶联受体18的试剂在制备败血症诊断及病程监测和预后判断试剂中表达的应用 |
GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
AU2019215440A1 (en) | 2018-02-05 | 2020-08-27 | Orionis Biosciences, Inc. | Fibroblast binding agents and use thereof |
US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
PE20211664A1 (es) | 2018-12-28 | 2021-08-26 | Catalyst Biosciences Inc | Polipeptidos de activador de plasminogeno, tipo urocinasa, modificados y metodos de uso |
EP3924379A4 (en) | 2019-02-15 | 2022-12-21 | Integral Molecular, Inc. | COMMON LIGHT CHAIN ANTIBODIES AND THEIR USES |
EA202192146A1 (ru) | 2019-02-15 | 2021-11-09 | Интиграл Молекьюлар, Инк. | Антитела к клаудину 6 и их применение |
WO2020210455A1 (en) * | 2019-04-09 | 2020-10-15 | University Of Houston System | Engineered chymotrypsins and uses thereof |
CN110079514A (zh) * | 2019-04-12 | 2019-08-02 | 江苏大学 | 一种制备蛋白酶3重组蛋白的方法 |
US20210069306A1 (en) | 2019-08-15 | 2021-03-11 | Catalyst Biosciences, Inc. | Modified factor vii polypeptides for subcutaneous administration and on-demand treatment |
GB202004514D0 (en) | 2020-03-27 | 2020-05-13 | Inst De Medicina Molecular Joaeo Lobo Antunes | Treatment of Immunosuppressive Cancer |
CN112322722B (zh) * | 2020-11-13 | 2021-11-12 | 上海宝藤生物医药科技股份有限公司 | 检测16p11.2微缺失的引物探针组合物、试剂盒及其应用 |
WO2024008755A1 (en) | 2022-07-04 | 2024-01-11 | Vib Vzw | Blood-cerebrospinal fluid barrier crossing antibodies |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5801038A (en) * | 1984-05-29 | 1998-09-01 | Genencor International Inc. | Modified subtilisins having amino acid alterations |
US5185258A (en) * | 1984-05-29 | 1993-02-09 | Genencor International, Inc. | Subtilisin mutants |
DK6488D0 (da) * | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5304482A (en) * | 1989-03-06 | 1994-04-19 | The Board Of Regents Of The University Of Texas System | Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors |
US5843693A (en) * | 1989-08-16 | 1998-12-01 | Chiron Corporation | Assay method for screening for inhibitors of proTNF conversion |
US6271012B1 (en) * | 1989-10-11 | 2001-08-07 | Genencor International, Inc. | Protease muteins and their use in detergents |
IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
US6335160B1 (en) * | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5766842A (en) * | 1994-09-16 | 1998-06-16 | Sepracor, Inc. | In vitro method for predicting the evolutionary response of a protein to a drug targeted thereagainst |
US6165794A (en) * | 1994-11-10 | 2000-12-26 | The Regents Of The University Of California | Suppression of proteolytic activity by dysfunctional protease formation |
GB9618960D0 (en) * | 1996-09-11 | 1996-10-23 | Medical Science Sys Inc | Proteases |
US6969601B2 (en) * | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
DE19743683A1 (de) * | 1997-10-02 | 1999-04-08 | Basf Ag | Verfahren zur Änderung der Substratspezifität von Enzymen |
US20030186329A1 (en) * | 1999-03-22 | 2003-10-02 | The Scripps Research Institute | Use of substrate subtraction libraries to distinguish enzyme specificities |
US20020068320A1 (en) * | 2000-03-14 | 2002-06-06 | Yanggu Shi | Serine protease polynucleotides, polypeptides, and antibodies |
DE19943177C2 (de) * | 1999-09-09 | 2002-10-24 | Dieter Jenne | Verfahren zur Herstellung von aktiven Serienproteasen und inaktiven Varianten |
US7030231B1 (en) * | 1999-09-30 | 2006-04-18 | Catalyst Biosciences, Inc. | Membrane type serine protease 1 (MT-SP1) and uses thereof |
US20030171252A9 (en) * | 2000-01-31 | 2003-09-11 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
WO2001059084A1 (en) * | 2000-02-11 | 2001-08-16 | Eli Lilly And Company | Protein c derivatives |
US20020031801A1 (en) * | 2000-03-24 | 2002-03-14 | Millennium Pharmaceuticals, Inc. | 18806, a novel trypsin serine protease-like molecule and uses thereof |
AU2001265092A1 (en) * | 2000-06-02 | 2001-12-17 | Regents Of The University Of California | Profiling of protease specificity using combinatorial fluorogenic substrate libraries |
US7157596B2 (en) * | 2000-09-08 | 2007-01-02 | Dendreon Corporation | Inhibitors of serine protease activity of matriptase or MTSP1 |
US6797461B2 (en) * | 2000-10-27 | 2004-09-28 | Promega Corporation | Tryptase substrates and assay for tryptase activity using same |
US20030049689A1 (en) * | 2000-12-14 | 2003-03-13 | Cynthia Edwards | Multifunctional polypeptides |
US20030068792A1 (en) * | 2000-12-14 | 2003-04-10 | Yiyou Chen | Targeted enzymes |
US20030104591A1 (en) * | 2000-12-14 | 2003-06-05 | Murray Christopher J. | Methods and compositions for grafting functional loops into a protein |
DE60331644D1 (de) * | 2002-04-22 | 2010-04-22 | Novozymes Inc | Verfahren zur herstellung von varianten einer dna-sequenz in filamentösen pilzen |
US20040072276A1 (en) * | 2002-05-10 | 2004-04-15 | Direvo BioTech AG. | Process for generating sequence-specific proteases by directed evolution and use thereof |
US20040081647A1 (en) * | 2002-08-27 | 2004-04-29 | Afeyan Noubar B. | Adzymes and uses thereof |
DE60332358D1 (de) * | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
US20060024289A1 (en) * | 2002-10-02 | 2006-02-02 | Ruggles Sandra W | Cleavage of VEGF and VEGF receptor by wild-type and mutant proteases |
US7939304B2 (en) * | 2002-10-02 | 2011-05-10 | Catalyst Biosciences, Inc. | Mutant MT-SP1 proteases with altered substrate specificity or activity |
SG166001A1 (en) * | 2002-10-02 | 2010-11-29 | Catalyst Biosciences Inc | Methods of generating and screening for proteases with altered specificity |
US20040115727A1 (en) * | 2002-12-11 | 2004-06-17 | Allergan, Inc., A Corporation | Evolved clostridial toxins with altered protease specificity |
US7335504B2 (en) * | 2003-06-18 | 2008-02-26 | Direvo Biotechnology Ag | Engineered enzymes and uses thereof |
CA2529589A1 (en) * | 2003-06-18 | 2004-12-29 | Direvo Biotech Ag | New biological entities and the pharmaceutical or diagnostic use thereof |
US7439226B2 (en) * | 2003-09-30 | 2008-10-21 | The United States Of America As Represented By The Department Of Health And Human Services | Serine protease inhibitors |
DK1735439T3 (da) * | 2004-04-12 | 2012-02-06 | Catalyst Biosciences Inc | Spaltning af VEGF og VEGF receptor ved hjælp af vild-type og mutant MT-SP1 |
EP1726643A1 (en) * | 2005-05-27 | 2006-11-29 | Direvo Biotech AG | Method for the provision, identification and selection of proteases with altered sensitivity to activity-modulating substances |
US7974395B2 (en) * | 2005-09-28 | 2011-07-05 | Avaya Inc. | Detection of telephone number spoofing |
AU2006304804B2 (en) * | 2005-10-21 | 2011-06-02 | Vertex Pharmaceuticals Incorporated | Modified proteases that inhibit complement activation |
WO2007064759A2 (en) * | 2005-11-29 | 2007-06-07 | The Scripps Research Institute | Inhibiting tumour cell invasion, metastasis and angiogenesis through targetting legumain |
SG175602A1 (en) * | 2006-07-05 | 2011-11-28 | Catalyst Biosciences Inc | Protease screening methods and proteases identified thereby |
EP2147096B1 (en) * | 2007-04-13 | 2015-03-25 | Catalyst Biosciences, Inc. | Modified factor VII polypeptides and uses thereof |
TWI557135B (zh) * | 2010-11-03 | 2016-11-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
-
2003
- 2003-10-02 SG SG200704897-8A patent/SG166001A1/en unknown
- 2003-10-02 ZA ZA200502867A patent/ZA200502867B/xx unknown
- 2003-10-02 KR KR1020057005800A patent/KR101132555B1/ko not_active IP Right Cessation
- 2003-10-02 JP JP2004541703A patent/JP5376747B2/ja not_active Expired - Fee Related
- 2003-10-02 SG SG2009070467A patent/SG188669A1/en unknown
- 2003-10-02 WO PCT/US2003/031719 patent/WO2004031733A2/en active Application Filing
- 2003-10-02 NZ NZ590187A patent/NZ590187A/en not_active IP Right Cessation
- 2003-10-02 US US10/677,977 patent/US20040146938A1/en not_active Abandoned
- 2003-10-02 AU AU2003282724A patent/AU2003282724B2/en not_active Ceased
- 2003-10-02 KR KR1020107018921A patent/KR20100109969A/ko not_active Application Discontinuation
- 2003-10-02 CA CA002501295A patent/CA2501295A1/en not_active Abandoned
- 2003-10-02 CN CNA2003801026530A patent/CN101124484A/zh active Pending
- 2003-10-02 KR KR1020127014802A patent/KR20120088836A/ko not_active Application Discontinuation
- 2003-10-02 EP EP11179703A patent/EP2444810A3/en not_active Withdrawn
- 2003-10-02 MX MXPA05003493A patent/MXPA05003493A/es active IP Right Grant
- 2003-10-02 EP EP03774608A patent/EP1608947A4/en not_active Withdrawn
- 2003-10-02 NZ NZ539242A patent/NZ539242A/en not_active IP Right Cessation
- 2003-10-02 EP EP11179700.7A patent/EP2444809A3/en not_active Withdrawn
- 2003-10-02 CN CN201510012744.XA patent/CN104630192A/zh active Pending
-
2005
- 2005-04-29 NO NO20052096A patent/NO20052096L/no not_active Application Discontinuation
-
2007
- 2007-12-28 US US12/005,949 patent/US20090136477A1/en not_active Abandoned
-
2009
- 2009-12-16 JP JP2009285529A patent/JP2010099082A/ja active Pending
-
2010
- 2010-03-25 AU AU2010201204A patent/AU2010201204B2/en not_active Ceased
-
2012
- 2012-07-10 JP JP2012154952A patent/JP2012254988A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NZ539242A (en) | 2009-07-31 |
JP2012254988A (ja) | 2012-12-27 |
NZ590187A (en) | 2012-07-27 |
AU2003282724B2 (en) | 2010-03-04 |
CN104630192A (zh) | 2015-05-20 |
EP1608947A4 (en) | 2009-06-17 |
JP5376747B2 (ja) | 2013-12-25 |
NO20052096D0 (no) | 2005-04-29 |
US20090136477A1 (en) | 2009-05-28 |
CN101124484A (zh) | 2008-02-13 |
EP1608947A2 (en) | 2005-12-28 |
JP2006518983A (ja) | 2006-08-24 |
SG188669A1 (en) | 2013-04-30 |
KR20100109969A (ko) | 2010-10-11 |
EP2444809A2 (en) | 2012-04-25 |
NO20052096L (no) | 2005-06-28 |
MXPA05003493A (es) | 2005-09-30 |
KR20050083717A (ko) | 2005-08-26 |
AU2010201204B2 (en) | 2012-09-20 |
JP2010099082A (ja) | 2010-05-06 |
CA2501295A1 (en) | 2004-04-15 |
WO2004031733A3 (en) | 2007-03-15 |
EP2444809A3 (en) | 2013-07-24 |
US20040146938A1 (en) | 2004-07-29 |
EP2444810A3 (en) | 2013-01-02 |
KR20120088836A (ko) | 2012-08-08 |
WO2004031733A2 (en) | 2004-04-15 |
AU2003282724A1 (en) | 2004-04-23 |
SG166001A1 (en) | 2010-11-29 |
AU2010201204A1 (en) | 2010-04-15 |
EP2444810A2 (en) | 2012-04-25 |
KR101132555B1 (ko) | 2012-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA200502867B (en) | Methods of generating and screening for proteases with altered specificity | |
PL375691A1 (en) | Imidazolopyridines and methods of making and using the same | |
HK1079789A1 (zh) | 血管靜態毒性試劑及其使用方法 | |
HK1084995A1 (en) | Rekeyable lock assembly and method of operation | |
EP1549756A4 (en) | RECOMBINANT MUTANTS OF RHABDOVIRUS AND METHODS OF USE | |
AU2003288902A8 (en) | Microcapsules and methods of use | |
AU2003213673A8 (en) | Pin1-modulating compounds and methods of use thereof | |
EP1497270A4 (en) | AMID COMPOUNDS AND METHOD FOR THEIR USE | |
GB2389410B (en) | Lighter and method of use | |
EP1476150A4 (en) | CARBOXY FULLERES AND USE METHOD THEREFOR | |
AU2003235506A8 (en) | Targeted enzymes and methods of making and using targeted enzymes. | |
EP1491091A4 (en) | MEANS OF PROTECTION AGAINST INSECTS AND METHODS OF PROTECTION AGAINST INSECTS | |
AU2003297612A8 (en) | 2-substituted-3-propenamide derivatives and methods of using the same | |
GB0208214D0 (en) | Receiver and method of operation thereof | |
EP1545287A4 (en) | VASOREGULATORY COMPOUNDS AND METHODS RELATING TO THEIR USE | |
AU2003216354A8 (en) | Modulators of paraptosis and related methods | |
AU2003209289A8 (en) | Transposable elements in rice and methods of use | |
PL362732A1 (en) | Latex and method of its manufacture | |
AU2003224694A8 (en) | Modified aequorins having enhanced glowing kinetics and methods of using same | |
AU2003261099A8 (en) | 4,7-disubstituted indoles and methods of making | |
AU2003279800A8 (en) | Sulfatases and methods of use thereof | |
AU2003209049A1 (en) | Methods of treating and diagnosing arthritis | |
AU2003228597A8 (en) | Antibodies for enzymes of the omega-oxidation pathway and methods relating thereto | |
AU2003212195A1 (en) | Protease screening and novel use of proteases | |
AU2003228532A8 (en) | Methods of use of the enzymes of mycothiol synthesis |