ZA200410407B - Cyclothiocarbamative derivatives as PR modulators and use thereof for treatment of skin disorders - Google Patents
Cyclothiocarbamative derivatives as PR modulators and use thereof for treatment of skin disorders Download PDFInfo
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- ZA200410407B ZA200410407B ZA200410407A ZA200410407A ZA200410407B ZA 200410407 B ZA200410407 B ZA 200410407B ZA 200410407 A ZA200410407 A ZA 200410407A ZA 200410407 A ZA200410407 A ZA 200410407A ZA 200410407 B ZA200410407 B ZA 200410407B
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- ZA
- South Africa
- Prior art keywords
- substituted
- dihydro
- alkyl
- dimethyl
- group
- Prior art date
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- 208000017520 skin disease Diseases 0.000 title claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 146
- 229910052799 carbon Inorganic materials 0.000 claims description 125
- 125000003545 alkoxy group Chemical group 0.000 claims description 64
- 229910052739 hydrogen Inorganic materials 0.000 claims description 64
- 239000000203 mixture Substances 0.000 claims description 54
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 50
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 50
- 125000000623 heterocyclic group Chemical group 0.000 claims description 48
- 150000001875 compounds Chemical class 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 38
- 125000003118 aryl group Chemical group 0.000 claims description 26
- 125000003107 substituted aryl group Chemical group 0.000 claims description 26
- 125000004001 thioalkyl group Chemical group 0.000 claims description 25
- 206010000496 acne Diseases 0.000 claims description 23
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- 208000002874 Acne Vulgaris Diseases 0.000 claims description 21
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- 125000001424 substituent group Chemical group 0.000 claims description 19
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims description 18
- 150000002367 halogens Chemical class 0.000 claims description 16
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- 241000124008 Mammalia Species 0.000 claims description 13
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- 239000002207 metabolite Substances 0.000 claims description 12
- 239000000651 prodrug Substances 0.000 claims description 12
- 229940002612 prodrug Drugs 0.000 claims description 12
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- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 6
- 150000001555 benzenes Chemical group 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
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- FXVPGONKQHRTRT-UHFFFAOYSA-N 6-[3-bromo-5-(trifluoromethoxy)phenyl]-4,4-dimethyl-1h-3,1-benzoxazine-2-thione Chemical compound C1=C2C(C)(C)OC(=S)NC2=CC=C1C1=CC(Br)=CC(OC(F)(F)F)=C1 FXVPGONKQHRTRT-UHFFFAOYSA-N 0.000 claims 1
- KWEKPTTVUMVEHM-UHFFFAOYSA-N 6-[3-fluoro-5-(trifluoromethyl)phenyl]-4,4-dimethyl-1h-3,1-benzoxazine-2-thione Chemical compound C1=C2C(C)(C)OC(=S)NC2=CC=C1C1=CC(F)=CC(C(F)(F)F)=C1 KWEKPTTVUMVEHM-UHFFFAOYSA-N 0.000 claims 1
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Natural products N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims 1
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- 208000035475 disorder Diseases 0.000 description 3
- 208000031513 cyst Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003780 hair follicle Anatomy 0.000 description 2
- 230000003779 hair growth Effects 0.000 description 2
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
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- 206010065701 Dermatillomania Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010016936 Folliculitis Diseases 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 208000009675 Perioral Dermatitis Diseases 0.000 description 1
- 208000001818 Pseudofolliculitis barbae Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 206010040849 Skin fissures Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000002430 laser surgery Methods 0.000 description 1
- 238000002647 laser therapy Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
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- 230000037390 scarring Effects 0.000 description 1
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- 150000003384 small molecules Chemical class 0.000 description 1
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Birds (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39188502P | 2002-06-25 | 2002-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200410407B true ZA200410407B (en) | 2007-07-25 |
Family
ID=30000769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200410407A ZA200410407B (en) | 2002-06-25 | 2004-12-23 | Cyclothiocarbamative derivatives as PR modulators and use thereof for treatment of skin disorders |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7268149B2 (no) |
| EP (1) | EP1531824A4 (no) |
| JP (1) | JP2005535628A (no) |
| KR (1) | KR20050013627A (no) |
| CN (1) | CN1665510A (no) |
| AR (1) | AR040644A1 (no) |
| AU (1) | AU2003245657A1 (no) |
| BR (1) | BR0312039A (no) |
| CA (1) | CA2489815A1 (no) |
| CO (1) | CO5680439A2 (no) |
| CR (1) | CR7608A (no) |
| EC (1) | ECSP055572A (no) |
| IL (1) | IL165397A0 (no) |
| MX (1) | MXPA04012420A (no) |
| NO (1) | NO20045214L (no) |
| RU (1) | RU2005101625A (no) |
| TW (1) | TW200400950A (no) |
| WO (1) | WO2004000230A2 (no) |
| ZA (1) | ZA200410407B (no) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
| US6391907B1 (en) * | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| JP2005535623A (ja) * | 2002-06-25 | 2005-11-24 | ワイス | ホルモン関連症状の治療における、チオ−オキシインドール誘導体の使用 |
| DK1732922T3 (da) * | 2004-04-08 | 2009-01-12 | Wyeth Corp | Fremgangsmåde til minimering af thioamidurenheder |
| MXPA06011696A (es) | 2004-04-08 | 2006-12-14 | Wyeth Corp | Derivados de tioamida como moduladores del receptor de progesterona. |
| EP1756072A2 (en) * | 2004-04-27 | 2007-02-28 | Wyeth | Purification of progesterone receptor modulators |
| MXPA06012402A (es) * | 2004-04-27 | 2007-01-17 | Wyeth Corp | Carbamato y tiocarbamato biarilos ciclicos que contienen cianopirrol y metodos para preparar los mismos. |
| PE20060378A1 (es) * | 2004-07-07 | 2006-06-02 | Wyeth Corp | Regimenes y kits de progestina ciclica |
| PL1778710T3 (pl) | 2004-08-13 | 2012-06-29 | Wyeth Llc | Pochodne tanaprogetu, metabolity i ich zastosowania |
| US7496489B2 (en) | 2004-08-20 | 2009-02-24 | Wyeth | Design of progesterone receptor ligands |
| PL1877059T3 (pl) * | 2005-04-28 | 2010-07-30 | Wyeth Llc | Mikroniozowany tanaproget i zawierające go kompozycje |
| BRPI0610433A2 (pt) * | 2005-04-28 | 2010-11-23 | Wyeth Corp | forma polimórfica ii de tanaproget, processos para preparar a mesma, e para preparar forma micronizada de um composto, composição farmacêutica, método de preparação de uma composição farmacêutica, e, uso da forma polimórfica ii de tanaproget ou da forma micronizada |
| AR053595A1 (es) * | 2005-04-28 | 2007-05-09 | Wyeth Corp | Forma purificada de tanaproget |
| EP1896034B8 (en) | 2005-04-28 | 2010-05-19 | Wyeth a Corporation of the State of Delaware | Micronized tanaproget compositions and methods of preparing the same |
| JP5149161B2 (ja) | 2005-04-28 | 2013-02-20 | ワイス・エルエルシー | ミクロ化タナプロゲットを含む組成物 |
| US20060280800A1 (en) | 2005-06-09 | 2006-12-14 | Wyeth | Tanaproget compositions containing ethinyl estradiol |
| BRPI0720849A2 (pt) * | 2006-12-22 | 2014-03-11 | Hoffmann La Roche | Processos para a preparação de (3r,4r)-n-(4-clorofenil)-1-(2,2-difluoretil)-n'-(2-flúor-4- (2-oxo-1-(2h)-piridinil)fenil]-3,4-pirrolidinadicarboxam ida |
| EA201070715A1 (ru) * | 2007-12-20 | 2011-02-28 | Тева Вимен'С Хелс, Инк. | Режимы дозирования, фармацевтические композиции и упаковки для экстренной контрацепции |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| EP2664325A1 (en) * | 2012-05-16 | 2013-11-20 | PregLem S.A. | Methods for preventing or treating androgen mediated diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0155934B1 (en) * | 1983-07-29 | 1989-12-06 | Duke University | Pharmaceutical compositions for treating androgen-related disorders in humans |
| GB2310660A (en) * | 1996-03-01 | 1997-09-03 | Merck & Co Inc | Benzoxazinone oxytocin receptor antagonists |
| IL142598A0 (en) * | 1998-10-23 | 2002-03-10 | Aventis Pharma Gmbh | Preparations for topical application of substances having antiandrogenic effect |
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
| US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| EP1206761B1 (en) | 1999-08-26 | 2007-10-03 | Automotive Systems Laboratory Inc. | Magnetic sensor |
| US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| CZ2002711A3 (cs) * | 1999-08-27 | 2003-11-12 | Ligand Pharmaceuticals Incorporated | Modulátory androgenních receptorů, způsoby jejich výroby a způsoby jejich použití |
| KR20020087134A (ko) | 2000-04-10 | 2002-11-21 | 화이자 프로덕츠 인크. | 벤조아미드 피페리딘 함유 화합물 및 관련 화합물 |
| US7119207B2 (en) * | 2000-04-10 | 2006-10-10 | Pfizer Inc | Benzoamide piperidine containing compounds and related compounds |
| UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
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2003
- 2003-06-23 EP EP03739286A patent/EP1531824A4/en not_active Withdrawn
- 2003-06-23 WO PCT/US2003/019860 patent/WO2004000230A2/en not_active Application Discontinuation
- 2003-06-23 CN CN038151944A patent/CN1665510A/zh active Pending
- 2003-06-23 TW TW092116986A patent/TW200400950A/zh unknown
- 2003-06-23 KR KR10-2004-7021150A patent/KR20050013627A/ko not_active Application Discontinuation
- 2003-06-23 JP JP2004516187A patent/JP2005535628A/ja active Pending
- 2003-06-23 RU RU2005101625/04A patent/RU2005101625A/ru not_active Application Discontinuation
- 2003-06-23 CA CA002489815A patent/CA2489815A1/en not_active Abandoned
- 2003-06-23 US US10/601,968 patent/US7268149B2/en not_active Expired - Fee Related
- 2003-06-23 AR AR20030102239A patent/AR040644A1/es not_active Application Discontinuation
- 2003-06-23 IL IL16539703A patent/IL165397A0/xx unknown
- 2003-06-23 BR BR0312039-2A patent/BR0312039A/pt not_active IP Right Cessation
- 2003-06-23 AU AU2003245657A patent/AU2003245657A1/en not_active Abandoned
- 2003-06-23 MX MXPA04012420A patent/MXPA04012420A/es unknown
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2004
- 2004-11-29 NO NO20045214A patent/NO20045214L/no not_active Application Discontinuation
- 2004-12-08 CR CR7608A patent/CR7608A/es not_active Application Discontinuation
- 2004-12-23 ZA ZA200410407A patent/ZA200410407B/en unknown
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2005
- 2005-01-20 CO CO05004456A patent/CO5680439A2/es not_active Application Discontinuation
- 2005-01-25 EC EC2005005572A patent/ECSP055572A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7268149B2 (en) | 2007-09-11 |
| CA2489815A1 (en) | 2003-12-31 |
| US20040014798A1 (en) | 2004-01-22 |
| IL165397A0 (en) | 2006-01-15 |
| MXPA04012420A (es) | 2005-04-19 |
| AR040644A1 (es) | 2005-04-13 |
| RU2005101625A (ru) | 2005-06-27 |
| ECSP055572A (es) | 2005-04-18 |
| KR20050013627A (ko) | 2005-02-04 |
| TW200400950A (en) | 2004-01-16 |
| EP1531824A2 (en) | 2005-05-25 |
| NO20045214L (no) | 2005-03-17 |
| CR7608A (es) | 2006-07-14 |
| WO2004000230A3 (en) | 2004-04-29 |
| JP2005535628A (ja) | 2005-11-24 |
| AU2003245657A1 (en) | 2004-01-06 |
| CO5680439A2 (es) | 2006-09-29 |
| CN1665510A (zh) | 2005-09-07 |
| WO2004000230A2 (en) | 2003-12-31 |
| EP1531824A4 (en) | 2005-09-21 |
| BR0312039A (pt) | 2005-06-28 |
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