ZA200406154B - 1-[alkyl], 1-[heteroaryl)alkyl] and 1-[aryl)alkyl]-7-(pyrimidin-4-YL)-imidazo[1,2-A]pyrimidin-5(1H)-one derivatives. - Google Patents
1-[alkyl], 1-[heteroaryl)alkyl] and 1-[aryl)alkyl]-7-(pyrimidin-4-YL)-imidazo[1,2-A]pyrimidin-5(1H)-one derivatives. Download PDFInfo
- Publication number
- ZA200406154B ZA200406154B ZA200406154A ZA200406154A ZA200406154B ZA 200406154 B ZA200406154 B ZA 200406154B ZA 200406154 A ZA200406154 A ZA 200406154A ZA 200406154 A ZA200406154 A ZA 200406154A ZA 200406154 B ZA200406154 B ZA 200406154B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrimidin
- group
- imidazo
- phenyl
- ethyl
- Prior art date
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 239000012312 sodium hydride Substances 0.000 description 1
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- 125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 description 1
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02290487A EP1340759A1 (en) | 2002-02-28 | 2002-02-28 | 1-[alkyl], 1-[(heteroaryl)alkyl] and 1-[(aryl)alkyl]-7-(pyrimidin-4-yl)-imidazo[1,2-a]pyrimidin-5(1H)-one derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200406154B true ZA200406154B (en) | 2005-08-02 |
Family
ID=27675771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200406154A ZA200406154B (en) | 2002-02-28 | 2004-08-02 | 1-[alkyl], 1-[heteroaryl)alkyl] and 1-[aryl)alkyl]-7-(pyrimidin-4-YL)-imidazo[1,2-A]pyrimidin-5(1H)-one derivatives. |
Country Status (23)
Country | Link |
---|---|
US (2) | US7429663B2 (zh) |
EP (2) | EP1340759A1 (zh) |
JP (1) | JP4484524B2 (zh) |
KR (1) | KR100935262B1 (zh) |
CN (1) | CN100441581C (zh) |
AR (1) | AR038620A1 (zh) |
AT (1) | ATE309246T1 (zh) |
AU (1) | AU2003214127C1 (zh) |
BR (1) | BR0308106A (zh) |
CA (1) | CA2474875C (zh) |
DE (1) | DE60302220T2 (zh) |
DK (1) | DK1480981T3 (zh) |
EA (1) | EA007459B1 (zh) |
ES (1) | ES2250876T3 (zh) |
IL (1) | IL163288A (zh) |
MX (1) | MXPA04008365A (zh) |
NO (1) | NO329756B1 (zh) |
NZ (1) | NZ534467A (zh) |
PL (1) | PL372664A1 (zh) |
SI (1) | SI1480981T1 (zh) |
TW (1) | TWI305534B (zh) |
WO (1) | WO2003072580A1 (zh) |
ZA (1) | ZA200406154B (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007508290A (ja) * | 2003-10-10 | 2007-04-05 | ファイザー・プロダクツ・インク | GSK−3阻害剤としての置換2H−[1,2,4]トリアゾロ[4,3−a]ピラジン |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
AU2009260526A1 (en) * | 2008-05-30 | 2009-12-23 | Merck Sharp & Dohme Corp. | Novel substituted indoles |
EP2138494A1 (en) * | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted alkyl pyrimidin-4-one derivatives |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
PL2448939T3 (pl) * | 2009-07-02 | 2017-08-31 | Sanofi | Pochodne 2,3-dihydro-1h-imidazo {1,2-a} pirymidyn-5-onu, ich wytwarzanie i ich zastosowanie farmaceutyczne |
PL3143011T3 (pl) * | 2014-05-13 | 2021-07-19 | F. Hoffmann-La Roche Ag | Deuterowane związki heterocykliczne i ich zastosowanie jako środki obrazujące |
CN112574219A (zh) * | 2021-01-31 | 2021-03-30 | 湖北大学 | 一种苯并咪唑并嘧啶酮衍生物的合成方法 |
CN115448921B (zh) * | 2021-06-08 | 2023-08-01 | 四川大学 | 一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3571974D1 (en) * | 1984-12-06 | 1989-09-07 | Pfizer | Substituted dihydroquinolone carboxylic acids, anti-bacterial compositions containing them |
CZ296911B6 (cs) * | 1996-12-05 | 2006-07-12 | Amgen Inc. | Substituovaný pyrimidin, jeho pouzití a farmaceutický prostredek na jeho bázi |
TWI241298B (en) * | 1998-09-25 | 2005-10-11 | Mitsubishi Chem Corp | Pyrimidone derivatives |
EP1184384A1 (en) * | 2000-09-01 | 2002-03-06 | Sanofi-Synthelabo | 1-(Alkyl), 1-((heteroaryl)alkyl) and 1-((aryl)alkyl)-7-pyridin-4-ylimidazo(1,2a)pyrimidin-5(1H)-one derivatives |
EP1295884A1 (en) * | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives |
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2002
- 2002-02-28 EP EP02290487A patent/EP1340759A1/en not_active Withdrawn
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2003
- 2003-02-26 CN CNB038079380A patent/CN100441581C/zh not_active Expired - Fee Related
- 2003-02-26 EA EA200400937A patent/EA007459B1/ru not_active IP Right Cessation
- 2003-02-26 PL PL03372664A patent/PL372664A1/xx not_active IP Right Cessation
- 2003-02-26 NZ NZ534467A patent/NZ534467A/en not_active IP Right Cessation
- 2003-02-26 MX MXPA04008365A patent/MXPA04008365A/es active IP Right Grant
- 2003-02-26 DK DK03709786T patent/DK1480981T3/da active
- 2003-02-26 WO PCT/EP2003/002652 patent/WO2003072580A1/en active IP Right Grant
- 2003-02-26 KR KR1020047013439A patent/KR100935262B1/ko not_active IP Right Cessation
- 2003-02-26 EP EP03709786A patent/EP1480981B1/en not_active Expired - Lifetime
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- 2003-02-26 SI SI200330137T patent/SI1480981T1/sl unknown
- 2003-02-26 BR BR0308106-0A patent/BR0308106A/pt active Search and Examination
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- 2003-02-26 US US10/504,679 patent/US7429663B2/en not_active Expired - Fee Related
- 2003-02-26 AT AT03709786T patent/ATE309246T1/de active
- 2003-02-26 ES ES03709786T patent/ES2250876T3/es not_active Expired - Lifetime
- 2003-02-26 DE DE60302220T patent/DE60302220T2/de not_active Expired - Lifetime
- 2003-02-26 JP JP2003571286A patent/JP4484524B2/ja not_active Expired - Fee Related
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- 2003-02-28 AR ARP030100658A patent/AR038620A1/es unknown
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2004
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- 2004-08-02 ZA ZA200406154A patent/ZA200406154B/en unknown
- 2004-08-26 NO NO20043567A patent/NO329756B1/no not_active IP Right Cessation
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2008
- 2008-08-20 US US12/194,899 patent/US20080318980A1/en not_active Abandoned
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