ZA200406010B - 2-oxazolamines and their use as a 5-HT2B receptor antagonists. - Google Patents
2-oxazolamines and their use as a 5-HT2B receptor antagonists. Download PDFInfo
- Publication number
- ZA200406010B ZA200406010B ZA200406010A ZA200406010A ZA200406010B ZA 200406010 B ZA200406010 B ZA 200406010B ZA 200406010 A ZA200406010 A ZA 200406010A ZA 200406010 A ZA200406010 A ZA 200406010A ZA 200406010 B ZA200406010 B ZA 200406010B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- optionally substituted
- group
- compound according
- cycloalkyl
- Prior art date
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- 229940044551 receptor antagonist Drugs 0.000 title description 4
- 239000002464 receptor antagonist Substances 0.000 title description 4
- 102000006969 5-HT2B Serotonin Receptor Human genes 0.000 title description 2
- 108010072584 5-HT2B Serotonin Receptor Proteins 0.000 title description 2
- ACTKAGSPIFDCMF-UHFFFAOYSA-N 1,3-oxazol-2-amine Chemical class NC1=NC=CO1 ACTKAGSPIFDCMF-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims description 61
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 32
- 150000001875 compounds Chemical class 0.000 claims description 30
- -1 cyano, amino Chemical group 0.000 claims description 24
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 23
- 125000003118 aryl group Chemical group 0.000 claims description 21
- 125000000623 heterocyclic group Chemical group 0.000 claims description 19
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 125000003368 amide group Chemical group 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000005488 carboaryl group Chemical group 0.000 claims description 7
- 125000001475 halogen functional group Chemical group 0.000 claims description 7
- 230000008485 antagonism Effects 0.000 claims description 5
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- 238000000034 method Methods 0.000 claims description 4
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- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
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- 239000012453 solvate Substances 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 description 16
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 14
- 125000003342 alkenyl group Chemical group 0.000 description 11
- 125000000304 alkynyl group Chemical group 0.000 description 9
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0203412.2A GB0203412D0 (en) | 2002-02-13 | 2002-02-13 | 5-HT 2B receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200406010B true ZA200406010B (en) | 2005-06-08 |
Family
ID=9930999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200406010A ZA200406010B (en) | 2002-02-13 | 2004-07-28 | 2-oxazolamines and their use as a 5-HT2B receptor antagonists. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7429607B2 (de) |
| EP (1) | EP1474140B1 (de) |
| JP (1) | JP4439266B2 (de) |
| KR (1) | KR20040084905A (de) |
| CN (1) | CN1633291A (de) |
| AU (1) | AU2003207297B2 (de) |
| CA (1) | CA2472762A1 (de) |
| DE (1) | DE60317632T2 (de) |
| EA (1) | EA200401077A1 (de) |
| GB (1) | GB0203412D0 (de) |
| IL (1) | IL163110A (de) |
| MX (1) | MXPA04007738A (de) |
| NO (1) | NO327465B1 (de) |
| NZ (1) | NZ534539A (de) |
| PL (1) | PL370221A1 (de) |
| WO (1) | WO2003068226A1 (de) |
| ZA (1) | ZA200406010B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050176791A1 (en) * | 2002-02-13 | 2005-08-11 | Oxford Alexander W. | 5-HT2B receptor antagonists |
| CA2532505A1 (en) * | 2003-07-24 | 2005-02-10 | Pharmagene Laboratories Limited | 5-ht2b receptor antagonists |
| WO2005079845A1 (ja) | 2004-02-20 | 2005-09-01 | Astellas Pharma Inc. | 片頭痛予防薬 |
| SE0400850D0 (sv) * | 2004-03-30 | 2004-03-31 | Astrazeneca Ab | Novel Compounds |
| WO2005097113A2 (en) * | 2004-04-08 | 2005-10-20 | Pharmagene Laboratories Limited | 5-ht2b receptor antagonists |
| UA91520C2 (en) | 2004-09-29 | 2010-08-10 | Баер Шеринг Фарма Акциенгезельшафт | Thermodynamically stable form of tosylate |
| WO2014085413A1 (en) * | 2012-11-28 | 2014-06-05 | Temple University - Of The Commonwealth System Of Higher Education | Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2b activity modulators |
| KR101592068B1 (ko) | 2013-11-08 | 2016-02-05 | 순천향대학교 산학협력단 | 플라즈마 아포리포프로테인 h를 포함하는 아스피린 과민성 호흡계 질환 및 아스피린 내성 천식 구별 진단용 마커 및 구별 진단용 키트 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0658559A1 (de) * | 1993-12-14 | 1995-06-21 | Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. | Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren |
| US5663178A (en) | 1995-02-06 | 1997-09-02 | Eli Lilly And Company | Tetrahydro-beta carbolines |
| HUT75522A (en) | 1994-03-11 | 1997-05-28 | Lilly Co Eli | Indole-, pyrido-indole-, indolo-quinoline- and benzo-pyrido-indole-derivatives, method for treating 5ht2b receptor related conditions, pharmaceutical compositions containing them |
| ES2182054T3 (es) * | 1996-04-03 | 2003-03-01 | Takeda Chemical Industries Ltd | Derivados de oxazol, su produccion y uso. |
| TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| US5952331A (en) | 1996-05-23 | 1999-09-14 | Syntex (Usa) Inc. | Aryl pyrimidine derivatives |
| US5958934A (en) | 1996-05-23 | 1999-09-28 | Syntex (U.S.A.) Inc. | Aryl pyrimidine derivatives and uses thereof |
| WO2000023444A1 (en) * | 1998-10-21 | 2000-04-27 | Abbott Laboratories | 5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
| ATE250417T1 (de) | 1999-07-30 | 2003-10-15 | Pharmagene Lab Ltd | Verwendung von 2-amino-4-(4-fluoronaphth-1-yl)-6- isopropylpyrimidine zur behandlung von erkrankungen des magen-darm-traktes |
| AR035016A1 (es) * | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
-
2002
- 2002-02-13 GB GBGB0203412.2A patent/GB0203412D0/en not_active Ceased
-
2003
- 2003-02-11 AU AU2003207297A patent/AU2003207297B2/en not_active Ceased
- 2003-02-11 MX MXPA04007738A patent/MXPA04007738A/es active IP Right Grant
- 2003-02-11 EP EP03704768A patent/EP1474140B1/de not_active Expired - Lifetime
- 2003-02-11 KR KR10-2004-7012479A patent/KR20040084905A/ko not_active Application Discontinuation
- 2003-02-11 NZ NZ534539A patent/NZ534539A/en not_active IP Right Cessation
- 2003-02-11 CA CA002472762A patent/CA2472762A1/en not_active Abandoned
- 2003-02-11 CN CNA038039532A patent/CN1633291A/zh active Pending
- 2003-02-11 EA EA200401077A patent/EA200401077A1/ru unknown
- 2003-02-11 JP JP2003567408A patent/JP4439266B2/ja not_active Expired - Fee Related
- 2003-02-11 DE DE60317632T patent/DE60317632T2/de not_active Expired - Lifetime
- 2003-02-11 PL PL03370221A patent/PL370221A1/xx not_active IP Right Cessation
- 2003-02-11 WO PCT/GB2003/000552 patent/WO2003068226A1/en active IP Right Grant
- 2003-02-12 US US10/364,672 patent/US7429607B2/en not_active Expired - Fee Related
-
2004
- 2004-07-20 IL IL163110A patent/IL163110A/en not_active IP Right Cessation
- 2004-07-28 ZA ZA200406010A patent/ZA200406010B/en unknown
- 2004-09-10 NO NO20043799A patent/NO327465B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003068226A1 (en) | 2003-08-21 |
| DE60317632T2 (de) | 2008-10-30 |
| EA200401077A1 (ru) | 2005-06-30 |
| AU2003207297A2 (en) | 2003-09-04 |
| NO20043799L (no) | 2004-09-10 |
| CA2472762A1 (en) | 2003-08-21 |
| IL163110A (en) | 2010-12-30 |
| GB0203412D0 (en) | 2002-04-03 |
| US7429607B2 (en) | 2008-09-30 |
| NO327465B1 (no) | 2009-07-06 |
| EP1474140A1 (de) | 2004-11-10 |
| US20040010022A1 (en) | 2004-01-15 |
| AU2003207297A1 (en) | 2003-09-04 |
| AU2003207297B2 (en) | 2008-11-06 |
| NZ534539A (en) | 2006-02-24 |
| MXPA04007738A (es) | 2004-10-15 |
| CN1633291A (zh) | 2005-06-29 |
| JP4439266B2 (ja) | 2010-03-24 |
| EP1474140B1 (de) | 2007-11-21 |
| KR20040084905A (ko) | 2004-10-06 |
| JP2005528341A (ja) | 2005-09-22 |
| DE60317632D1 (de) | 2008-01-03 |
| PL370221A1 (en) | 2005-05-16 |
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