ZA200405446B - Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same. - Google Patents
Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same. Download PDFInfo
- Publication number
- ZA200405446B ZA200405446B ZA200405446A ZA200405446A ZA200405446B ZA 200405446 B ZA200405446 B ZA 200405446B ZA 200405446 A ZA200405446 A ZA 200405446A ZA 200405446 A ZA200405446 A ZA 200405446A ZA 200405446 B ZA200405446 B ZA 200405446B
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- South Africa
- Prior art keywords
- branched
- linear
- formula
- compound
- dihydroxy
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 54
- 238000000034 method Methods 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 27
- 125000003118 aryl group Chemical group 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 20
- 239000002253 acid Substances 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 19
- 125000001072 heteroaryl group Chemical group 0.000 claims description 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 16
- -1 benzhydryl group Chemical group 0.000 claims description 15
- 125000001624 naphthyl group Chemical group 0.000 claims description 14
- 125000002252 acyl group Chemical group 0.000 claims description 12
- 229940005561 1,4-benzoquinone Drugs 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 125000005843 halogen group Chemical group 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 6
- 125000005530 alkylenedioxy group Chemical group 0.000 claims description 6
- 125000004429 atom Chemical group 0.000 claims description 6
- 230000007717 exclusion Effects 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
- 125000006684 polyhaloalkyl group Polymers 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical group O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims description 5
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
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- PCMWVXNZRQRPBY-UHFFFAOYSA-N 2-(4-bromophenyl)-3,6-dihydroxy-5-phenylcyclohexa-2,5-diene-1,4-dione Chemical compound O=C1C(O)=C(C=2C=CC=CC=2)C(=O)C(O)=C1C1=CC=C(Br)C=C1 PCMWVXNZRQRPBY-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0201409A FR2835523B1 (fr) | 2002-02-06 | 2002-02-06 | Nouveaux derives de 3-aryl-2,5-dihydroxy-1,4-benzoquinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200405446B true ZA200405446B (en) | 2005-07-08 |
Family
ID=27619936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200405446A ZA200405446B (en) | 2002-02-06 | 2004-07-08 | Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20050085644A1 (fr) |
| EP (1) | EP1472208A1 (fr) |
| JP (1) | JP4098248B2 (fr) |
| KR (1) | KR100605805B1 (fr) |
| CN (1) | CN1274655C (fr) |
| AR (1) | AR038397A1 (fr) |
| AU (1) | AU2003226860B9 (fr) |
| BR (1) | BR0307465A (fr) |
| CA (1) | CA2474533A1 (fr) |
| EA (1) | EA006775B1 (fr) |
| FR (1) | FR2835523B1 (fr) |
| GE (1) | GEP20063900B (fr) |
| HK (1) | HK1078566A1 (fr) |
| MA (1) | MA27103A1 (fr) |
| MX (1) | MXPA04007684A (fr) |
| NO (1) | NO20043532L (fr) |
| NZ (1) | NZ534099A (fr) |
| PL (1) | PL370773A1 (fr) |
| UA (1) | UA79448C2 (fr) |
| WO (1) | WO2003066561A1 (fr) |
| ZA (1) | ZA200405446B (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103058846B (zh) * | 2013-01-17 | 2014-07-30 | 福州大学 | 一种源于棘孢曲霉的苯醌衍生物及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK34185A (da) * | 1984-01-26 | 1985-07-27 | Otsuka Pharma Co Ltd | 1,4-benzoquinon-derivater og benzen-derivater samt fremgangsmaade til fremstilling af saadanne derivater |
| US7057052B2 (en) * | 2002-09-26 | 2006-06-06 | Duke University | Heterocyclic quinones as pharmaceutical agents |
-
2002
- 2002-02-06 FR FR0201409A patent/FR2835523B1/fr not_active Expired - Fee Related
-
2003
- 2003-02-04 CN CNB038031779A patent/CN1274655C/zh not_active Expired - Fee Related
- 2003-02-04 CA CA002474533A patent/CA2474533A1/fr not_active Abandoned
- 2003-02-04 PL PL03370773A patent/PL370773A1/xx unknown
- 2003-02-04 JP JP2003565937A patent/JP4098248B2/ja not_active Expired - Fee Related
- 2003-02-04 EA EA200400992A patent/EA006775B1/ru not_active IP Right Cessation
- 2003-02-04 GE GEAP8395A patent/GEP20063900B/en unknown
- 2003-02-04 BR BR0307465-0A patent/BR0307465A/pt not_active IP Right Cessation
- 2003-02-04 MX MXPA04007684A patent/MXPA04007684A/es not_active Application Discontinuation
- 2003-02-04 EP EP03737340A patent/EP1472208A1/fr not_active Withdrawn
- 2003-02-04 NZ NZ534099A patent/NZ534099A/en unknown
- 2003-02-04 US US10/503,527 patent/US20050085644A1/en not_active Abandoned
- 2003-02-04 KR KR1020047012152A patent/KR100605805B1/ko not_active IP Right Cessation
- 2003-02-04 AU AU2003226860A patent/AU2003226860B9/en not_active Ceased
- 2003-02-04 WO PCT/FR2003/000331 patent/WO2003066561A1/fr active Application Filing
- 2003-02-06 AR ARP030100368A patent/AR038397A1/es not_active Application Discontinuation
- 2003-04-02 UA UA20040907252A patent/UA79448C2/uk unknown
-
2004
- 2004-07-08 ZA ZA200405446A patent/ZA200405446B/en unknown
- 2004-07-21 MA MA27795A patent/MA27103A1/fr unknown
- 2004-08-24 NO NO20043532A patent/NO20043532L/no not_active Application Discontinuation
-
2005
- 2005-11-21 HK HK05110489A patent/HK1078566A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ534099A (en) | 2006-09-29 |
| AU2003226860B9 (en) | 2008-08-14 |
| JP4098248B2 (ja) | 2008-06-11 |
| MA27103A1 (fr) | 2004-12-20 |
| JP2005517001A (ja) | 2005-06-09 |
| US20050085644A1 (en) | 2005-04-21 |
| UA79448C2 (en) | 2007-06-25 |
| AR038397A1 (es) | 2005-01-12 |
| EP1472208A1 (fr) | 2004-11-03 |
| FR2835523A1 (fr) | 2003-08-08 |
| FR2835523B1 (fr) | 2004-04-16 |
| NO20043532L (no) | 2004-08-24 |
| CA2474533A1 (fr) | 2003-08-14 |
| AU2003226860B2 (en) | 2008-06-26 |
| WO2003066561A1 (fr) | 2003-08-14 |
| HK1078566A1 (en) | 2006-03-17 |
| CN1628088A (zh) | 2005-06-15 |
| KR100605805B1 (ko) | 2006-08-01 |
| CN1274655C (zh) | 2006-09-13 |
| GEP20063900B (en) | 2006-08-10 |
| EA200400992A1 (ru) | 2005-02-24 |
| EA006775B1 (ru) | 2006-04-28 |
| AU2003226860B8 (en) | 2008-07-10 |
| KR20040086352A (ko) | 2004-10-08 |
| AU2003226860A1 (en) | 2003-09-02 |
| PL370773A1 (en) | 2005-05-30 |
| BR0307465A (pt) | 2004-11-09 |
| MXPA04007684A (es) | 2005-07-13 |
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