ZA200405140B - Hepatitus B virus surface antigen as a mucosal immunostimulator andthe resulting formulations - Google Patents
Hepatitus B virus surface antigen as a mucosal immunostimulator andthe resulting formulations Download PDFInfo
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- ZA200405140B ZA200405140B ZA200405140A ZA200405140A ZA200405140B ZA 200405140 B ZA200405140 B ZA 200405140B ZA 200405140 A ZA200405140 A ZA 200405140A ZA 200405140 A ZA200405140 A ZA 200405140A ZA 200405140 B ZA200405140 B ZA 200405140B
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- hbsag
- antigens
- nasal
- nasal administration
- vaccine formulation
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- AIHDCSAXVMAMJH-GFBKWZILSA-N levan Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@@H]1[C@@H](O)[C@H](O)[C@](CO)(CO[C@@H]2[C@H]([C@H](O)[C@@](O)(CO)O2)O)O1 AIHDCSAXVMAMJH-GFBKWZILSA-N 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 230000001589 lymphoproliferative effect Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 208000037941 meningococcal disease Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229940074096 monoolein Drugs 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940046166 oligodeoxynucleotide Drugs 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229940126578 oral vaccine Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229960005030 other vaccine in atc Drugs 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 229940066827 pertussis vaccine Drugs 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 229920001432 poly(L-lactide) Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009696 proliferative response Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 210000005122 simple epithelium Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000005127 stratified epithelium Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 229940118376 tetanus toxin Drugs 0.000 description 1
- 210000002978 thoracic duct Anatomy 0.000 description 1
- 230000036964 tight binding Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 208000028110 viral sexually transmitted disease Diseases 0.000 description 1
- 229960004854 viral vaccine Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20020019A CU23031A1 (es) | 2002-01-24 | 2002-01-24 | Antigeno de superficie del virus de la hepatitis b como inmunopotenciador mucosal, formulaciones resultantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200405140B true ZA200405140B (en) | 2006-07-26 |
Family
ID=27587819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200405140A ZA200405140B (en) | 2002-01-24 | 2004-06-28 | Hepatitus B virus surface antigen as a mucosal immunostimulator andthe resulting formulations |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050025780A1 (zh) |
| EP (1) | EP1493447A2 (zh) |
| KR (1) | KR20040081469A (zh) |
| CN (1) | CN1703241A (zh) |
| AR (1) | AR038311A1 (zh) |
| BR (1) | BR0307121A (zh) |
| CA (1) | CA2471727A1 (zh) |
| CU (1) | CU23031A1 (zh) |
| MY (1) | MY141983A (zh) |
| WO (1) | WO2003061692A2 (zh) |
| ZA (1) | ZA200405140B (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU23405A1 (es) * | 2003-10-20 | 2009-08-04 | Ct Ingenieria Genetica Biotech | Composiciones farmacéuticas para uso terapéutico |
| GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| KR20130122810A (ko) * | 2005-06-27 | 2013-11-08 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 제조 방법 |
| CN104958759B (zh) * | 2015-06-24 | 2018-04-27 | 康希诺生物股份公司 | 多价脑膜炎球菌制剂盒、疫苗制剂及其制备方法 |
| FI3506935T3 (fi) | 2016-09-02 | 2024-04-17 | Sanofi Pasteur Inc | Neisseria meningitidis -rokote |
| RU2020108205A (ru) * | 2017-08-10 | 2021-09-10 | Йишенг Байофарма (Сингапур) Пте Лтд | Композиция для лечения и/или профилактики вирусной инфекции гепатита b и ее применение |
| CA3075423A1 (en) * | 2017-10-05 | 2019-04-11 | Toko Yakuhin Kogyo Co., Ltd. | Nasal hepatitis b vaccine composition and method for producing same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4547368A (en) * | 1983-12-20 | 1985-10-15 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Hepatitis B core antigen vaccine made by recombinant DNA |
| CA2136429C (en) * | 1992-05-23 | 2001-12-11 | Jean Petre | Combined vaccines comprising hepatitis b surface antigen and other antigens |
| US6153201A (en) * | 1993-03-09 | 2000-11-28 | University Of Rochester | Oral immunization with papillomavirus virus-like particles |
| GB9503863D0 (en) * | 1995-02-25 | 1995-04-19 | Smithkline Beecham Biolog | Vaccine compositions |
| CU22629A1 (es) * | 1997-03-06 | 2000-12-22 | Ct Ingenieria Genetica Biotech | Formulaciones inmunopotenciadoras para uso vacunal |
| CU22871A1 (es) * | 1998-12-02 | 2003-10-21 | Ct Ingenieria Genetica Biotech | Formulaciones conteniendo partículas semejantes a virus como inmunopotenciadores por vía mucosal |
-
2002
- 2002-01-24 CU CU20020019A patent/CU23031A1/es unknown
-
2003
- 2003-01-22 EP EP03731653A patent/EP1493447A2/en not_active Withdrawn
- 2003-01-22 BR BRPI0307121-9A patent/BR0307121A/pt not_active IP Right Cessation
- 2003-01-22 CN CNA038026260A patent/CN1703241A/zh active Pending
- 2003-01-22 KR KR10-2004-7011504A patent/KR20040081469A/ko not_active Application Discontinuation
- 2003-01-22 US US10/501,570 patent/US20050025780A1/en not_active Abandoned
- 2003-01-22 WO PCT/CU2003/000001 patent/WO2003061692A2/es active IP Right Grant
- 2003-01-22 CA CA002471727A patent/CA2471727A1/en not_active Abandoned
- 2003-01-23 AR ARP030100201A patent/AR038311A1/es not_active Application Discontinuation
- 2003-01-24 MY MYPI20030252A patent/MY141983A/en unknown
-
2004
- 2004-06-28 ZA ZA200405140A patent/ZA200405140B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1703241A (zh) | 2005-11-30 |
| KR20040081469A (ko) | 2004-09-21 |
| MY141983A (en) | 2010-08-16 |
| CA2471727A1 (en) | 2003-07-31 |
| BR0307121A (pt) | 2006-04-11 |
| WO2003061692A2 (es) | 2003-07-31 |
| EP1493447A2 (en) | 2005-01-05 |
| WO2003061692A3 (es) | 2004-10-21 |
| AR038311A1 (es) | 2005-01-12 |
| US20050025780A1 (en) | 2005-02-03 |
| CU23031A1 (es) | 2005-02-23 |
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