ZA200307411B - Process for the industrial synthesis of tetraesters of 5-[Bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates. - Google Patents

Process for the industrial synthesis of tetraesters of 5-[Bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates.

Info

Publication number
ZA200307411B
ZA200307411B ZA200307411A ZA200307411A ZA200307411B ZA 200307411 B ZA200307411 B ZA 200307411B ZA 200307411 A ZA200307411 A ZA 200307411A ZA 200307411 A ZA200307411 A ZA 200307411A ZA 200307411 B ZA200307411 B ZA 200307411B
Authority
ZA
South Africa
Prior art keywords
carboxymethyl
synthesis
acid
tetraesters
hydrates
Prior art date
Application number
ZA200307411A
Other languages
English (en)
Inventor
Lucile Vaysse-Ludot
Jean-Pierre Lecouve
Pascal Langlois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of ZA200307411B publication Critical patent/ZA200307411B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
ZA200307411A 2002-09-24 2003-09-23 Process for the industrial synthesis of tetraesters of 5-[Bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates. ZA200307411B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0211765A FR2844797B1 (fr) 2002-09-24 2002-09-24 Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Publications (1)

Publication Number Publication Date
ZA200307411B true ZA200307411B (en) 2004-07-07

Family

ID=29415191

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200307411A ZA200307411B (en) 2002-09-24 2003-09-23 Process for the industrial synthesis of tetraesters of 5-[Bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates.

Country Status (39)

Country Link
US (1) US7091364B2 (ko)
EP (1) EP1403265B1 (ko)
JP (1) JP4136866B2 (ko)
KR (1) KR100551502B1 (ko)
CN (1) CN1280286C (ko)
AP (1) AP1972A (ko)
AR (1) AR041357A1 (ko)
AT (1) ATE449767T1 (ko)
AU (2) AU2003248280B2 (ko)
BR (1) BR0304203A (ko)
CA (1) CA2442881C (ko)
CY (1) CY1109831T1 (ko)
DE (1) DE60330213D1 (ko)
DK (1) DK1403265T3 (ko)
EA (1) EA007108B1 (ko)
EC (1) ECSP055743A (ko)
ES (1) ES2337348T3 (ko)
FR (1) FR2844797B1 (ko)
GE (1) GEP20074139B (ko)
HK (1) HK1061846A1 (ko)
HR (1) HRP20050361B1 (ko)
IL (1) IL167315A (ko)
IS (1) IS2728B (ko)
MA (1) MA26100A1 (ko)
ME (1) ME00453B (ko)
MX (1) MXPA03008647A (ko)
MY (1) MY134924A (ko)
NO (1) NO328626B1 (ko)
NZ (1) NZ528401A (ko)
OA (1) OA12932A (ko)
PL (1) PL215879B1 (ko)
PT (1) PT1403265E (ko)
RS (1) RS51551B (ko)
SG (1) SG110069A1 (ko)
SI (1) SI1403265T1 (ko)
TN (1) TNSN05088A1 (ko)
UA (1) UA79157C2 (ko)
WO (1) WO2004029034A1 (ko)
ZA (1) ZA200307411B (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2844796A1 (fr) * 2002-09-24 2004-03-26 Servier Lab Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844795B1 (fr) * 2002-09-24 2004-10-22 Servier Lab Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
JP4354984B2 (ja) * 2003-05-07 2009-10-28 オステオロジックス エイ／エス 水溶性ストロンチウム塩を用いる軟骨／骨症状の治療
SI1622630T1 (sl) * 2003-05-07 2012-12-31 Osteologix A/S Stroncijeva kombinacije za profilakso/zdravljenje patologij hrustanca in/ali kosti
US20050085531A1 (en) * 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
AU2005216596B2 (en) * 2004-02-26 2011-03-24 Osteologix A/S Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
MXPA06015187A (es) 2004-06-25 2007-09-27 Strontin Aps Composiciones que comprenden estroncio y vitamina d y usos de las mismas.
FR2875807B1 (fr) * 2004-09-30 2006-11-17 Servier Lab Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN100391955C (zh) * 2005-04-30 2008-06-04 河北医科大学 一种雷尼酸锶中间体的合成方法
US20070292529A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating osteoporotic conditions
US20070292535A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating arthritic and or osteoporitic conditions
FR2921367B1 (fr) 2007-09-26 2009-10-30 Servier Lab Nouveau procede de synthese du ranelate de strontium et de ses hydrates
US20120123131A1 (en) * 2008-08-22 2012-05-17 Koilpillai Joseph Prabahar Process for the preparation of strontium ranelate
CN101665483B (zh) * 2008-09-01 2013-01-23 河北医科大学 一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011124992A1 (en) * 2010-03-24 2011-10-13 Actavis Group Ptc Ehf Substantially pure strontium ranelate
CN101812048B (zh) * 2010-04-06 2012-11-14 浙江东亚药业有限公司 雷尼酸锶及其水合物的合成方法
EP2602248A1 (en) 2011-12-05 2013-06-12 University Of Leicester Novel pyrrole compounds
WO2013113319A1 (en) 2012-01-31 2013-08-08 Pharmathen S.A. Process for the preparation of strontium ranelate, intermediate or hydrates thereof
ES2505716T3 (es) 2013-01-21 2015-09-04 Galenicum Health S.L. Composiciones farmacéuticas que comprenden una sal de ácido
GB201310126D0 (en) * 2013-06-06 2013-07-24 Univ Leicester Novel pyrrole derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3624304A1 (de) 1986-07-18 1988-01-28 Bayer Ag Fungizide verwendung von substituierten thienylaminen
GB8715925D0 (en) * 1987-07-07 1987-08-12 Shell Int Research Thiapentanamide derivatives
FR2651497B1 (fr) * 1989-09-01 1991-10-25 Adir Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE19528380A1 (de) * 1995-08-02 1997-02-06 Hoechst Ag Heterogene Vinylacetat/Ethylen-Dispersion
FR2749759B1 (fr) * 1996-06-17 1999-11-26 Adir Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
DE19650196A1 (de) * 1996-12-04 1998-06-10 Bayer Ag Thienylsulfonylamino(thio)carbonylverbindungen
US6835745B2 (en) * 2002-01-15 2004-12-28 Wyeth Phenyl substituted thiophenes as estrogenic agents

Also Published As

Publication number Publication date
NO328626B1 (no) 2010-04-12
ES2337348T3 (es) 2010-04-23
CA2442881C (fr) 2010-06-29
GEP20074139B (en) 2007-06-25
AU2003248280B2 (en) 2009-01-08
HK1061846A1 (en) 2004-10-08
DE60330213D1 (de) 2010-01-07
KR20040026626A (ko) 2004-03-31
DK1403265T3 (da) 2010-04-06
ECSP055743A (es) 2005-07-06
IS2728B (is) 2011-04-15
MXPA03008647A (es) 2005-04-19
IS7803A (is) 2005-04-18
BR0304203A (pt) 2004-08-24
CA2442881A1 (fr) 2004-03-24
KR100551502B1 (ko) 2006-02-13
JP4136866B2 (ja) 2008-08-20
HRP20050361A2 (en) 2005-06-30
FR2844797B1 (fr) 2004-10-22
MY134924A (en) 2008-01-31
HRP20050361B1 (hr) 2014-03-14
RS51551B (en) 2011-06-30
PT1403265E (pt) 2009-12-16
SI1403265T1 (sl) 2010-01-29
PL362366A1 (en) 2004-04-05
FR2844797A1 (fr) 2004-03-26
US20040059134A1 (en) 2004-03-25
AU2003299095A1 (en) 2004-04-19
AP1972A (en) 2009-03-12
EP1403265A1 (fr) 2004-03-31
EP1403265B1 (fr) 2009-11-25
CN1280286C (zh) 2006-10-18
AP2005003255A0 (en) 2005-03-31
NZ528401A (en) 2004-05-28
NO20034236L (no) 2004-03-25
TNSN05088A1 (fr) 2007-05-14
US7091364B2 (en) 2006-08-15
SG110069A1 (en) 2005-04-28
RS20050241A (en) 2007-06-04
JP2004269496A (ja) 2004-09-30
EA007108B1 (ru) 2006-06-30
MA26100A1 (fr) 2004-04-01
IL167315A (en) 2009-08-03
NO20034236D0 (no) 2003-09-23
ATE449767T1 (de) 2009-12-15
CN1500784A (zh) 2004-06-02
EA200300927A1 (ru) 2004-04-29
AU2003248280A1 (en) 2004-04-08
PL215879B1 (pl) 2014-02-28
OA12932A (en) 2006-10-13
ME00453B (me) 2011-10-10
WO2004029034A1 (fr) 2004-04-08
CY1109831T1 (el) 2014-09-10
UA79157C2 (en) 2007-05-25
AR041357A1 (es) 2005-05-11

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