ZA200306792B - Novel amides, preparation and therapeutic use as modulators of CCR-receptor activity. - Google Patents
Novel amides, preparation and therapeutic use as modulators of CCR-receptor activity. Download PDFInfo
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- ZA200306792B ZA200306792B ZA200306792A ZA200306792A ZA200306792B ZA 200306792 B ZA200306792 B ZA 200306792B ZA 200306792 A ZA200306792 A ZA 200306792A ZA 200306792 A ZA200306792 A ZA 200306792A ZA 200306792 B ZA200306792 B ZA 200306792B
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- South Africa
- Prior art keywords
- compound
- formula
- composition
- pharmaceutically acceptable
- solvate
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- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 230000000694 effects Effects 0.000 title claims description 7
- 230000001225 therapeutic effect Effects 0.000 title description 4
- 150000001408 amides Chemical class 0.000 title description 2
- 102000005674 CCR Receptors Human genes 0.000 title 1
- 108010059983 CCR Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 81
- 238000000034 method Methods 0.000 claims abstract description 36
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- 150000003839 salts Chemical class 0.000 claims description 36
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 35
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 25
- 229920006395 saturated elastomer Polymers 0.000 claims description 25
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101038A SE0101038D0 (sv) | 2001-03-23 | 2001-03-23 | Novel compounds |
Publications (1)
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|---|---|
| ZA200306792B true ZA200306792B (en) | 2004-11-29 |
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Family Applications (1)
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| ZA200306792A ZA200306792B (en) | 2001-03-23 | 2003-08-29 | Novel amides, preparation and therapeutic use as modulators of CCR-receptor activity. |
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|---|---|
| US (1) | US7345063B2 (ko) |
| EP (1) | EP1372651B1 (ko) |
| JP (1) | JP2004524345A (ko) |
| KR (1) | KR20030085030A (ko) |
| CN (1) | CN1538844A (ko) |
| AT (1) | ATE355842T1 (ko) |
| BR (1) | BR0208336A (ko) |
| CA (1) | CA2441933A1 (ko) |
| DE (1) | DE60218641T2 (ko) |
| DK (1) | DK1372651T3 (ko) |
| ES (1) | ES2280511T3 (ko) |
| IL (1) | IL157653A0 (ko) |
| MX (1) | MXPA03008443A (ko) |
| NO (1) | NO20034215L (ko) |
| NZ (1) | NZ528296A (ko) |
| PT (1) | PT1372651E (ko) |
| SE (1) | SE0101038D0 (ko) |
| SI (1) | SI1372651T1 (ko) |
| WO (1) | WO2002076457A1 (ko) |
| ZA (1) | ZA200306792B (ko) |
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| CO5300399A1 (es) | 2000-02-25 | 2003-07-31 | Astrazeneca Ab | Heterocicliocs que contienen nitrogeno, proceso para su preparacion y composiciones farmaceuticas que los contienen |
| US7005439B2 (en) * | 2000-06-20 | 2006-02-28 | Astrazeneca Ab | Compounds |
| AR028948A1 (es) * | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| WO2005023771A1 (ja) * | 2003-09-05 | 2005-03-17 | Ono Pharmaceutical Co., Ltd. | ケモカインレセプターアンタゴニストおよびその医薬用途 |
| CN101213187B (zh) | 2005-06-28 | 2012-06-06 | 塞诺菲-安万特股份有限公司 | 作为rho-激酶抑制剂的异喹啉衍生物 |
| KR101373535B1 (ko) | 2005-07-26 | 2014-03-12 | 사노피 | Ｒｈｏ-키나제 억제제로서의 피페리디닐-치환된 이소퀴놀론유도체 |
| NZ565669A (en) | 2005-07-26 | 2010-05-28 | Sanofi Aventis | Cyclohexylamin isoquinolone derivatives as Rho-kinase inhibitors |
| TW200738634A (en) * | 2005-08-02 | 2007-10-16 | Astrazeneca Ab | New salt |
| CA2673917C (en) | 2006-12-27 | 2015-01-27 | Sanofi-Aventis | Cycloalkylamine substituted isoquinolone derivatives |
| ATE554072T1 (de) | 2006-12-27 | 2012-05-15 | Sanofi Sa | Cycloalkylaminsubstituierte isochinolinderivate |
| NZ577984A (en) | 2006-12-27 | 2011-03-31 | Sanofi Aventis | Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives |
| AU2007338408B2 (en) | 2006-12-27 | 2012-07-26 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives |
| WO2008077550A1 (en) | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase |
| CA2673921C (en) | 2006-12-27 | 2015-10-20 | Sanofi-Aventis | New substituted isoquinoline and isoquinolinone derivatives |
| RU2532481C2 (ru) | 2008-06-24 | 2014-11-10 | Санофи-Авентис | Би- и полициклические замещенные производные изохинолина и изохинолинона, полезные в качестве ингибиторов rho-киназы |
| PT2303846E (pt) | 2008-06-24 | 2015-09-04 | Sanofi Sa | Isoquinolinas e isoquinolinonas substituídas como inibidores de rho-quinase |
| AU2009262516B8 (en) | 2008-06-24 | 2014-01-30 | Sanofi | 6-substituted isoquinolines and isoquinolinones |
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| JPS5511670B1 (ko) | 1971-07-13 | 1980-03-26 | ||
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| SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
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| GB0011838D0 (en) | 2000-05-17 | 2000-07-05 | Astrazeneca Ab | Chemical compounds |
-
2001
- 2001-03-23 SE SE0101038A patent/SE0101038D0/xx unknown
-
2002
- 2002-03-19 US US10/472,017 patent/US7345063B2/en not_active Expired - Fee Related
- 2002-03-19 IL IL15765302A patent/IL157653A0/xx unknown
- 2002-03-19 DE DE60218641T patent/DE60218641T2/de not_active Expired - Fee Related
- 2002-03-19 DK DK02708893T patent/DK1372651T3/da active
- 2002-03-19 BR BR0208336-1A patent/BR0208336A/pt not_active IP Right Cessation
- 2002-03-19 NZ NZ528296A patent/NZ528296A/en unknown
- 2002-03-19 SI SI200230517T patent/SI1372651T1/sl unknown
- 2002-03-19 PT PT02708893T patent/PT1372651E/pt unknown
- 2002-03-19 CA CA002441933A patent/CA2441933A1/en not_active Abandoned
- 2002-03-19 CN CNA028070968A patent/CN1538844A/zh active Pending
- 2002-03-19 WO PCT/SE2002/000541 patent/WO2002076457A1/en active IP Right Grant
- 2002-03-19 EP EP02708893A patent/EP1372651B1/en not_active Expired - Lifetime
- 2002-03-19 MX MXPA03008443A patent/MXPA03008443A/es active IP Right Grant
- 2002-03-19 JP JP2002574972A patent/JP2004524345A/ja active Pending
- 2002-03-19 ES ES02708893T patent/ES2280511T3/es not_active Expired - Lifetime
- 2002-03-19 AT AT02708893T patent/ATE355842T1/de not_active IP Right Cessation
- 2002-03-19 KR KR10-2003-7012302A patent/KR20030085030A/ko not_active Application Discontinuation
-
2003
- 2003-08-29 ZA ZA200306792A patent/ZA200306792B/en unknown
- 2003-09-22 NO NO20034215A patent/NO20034215L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SE0101038D0 (sv) | 2001-03-23 |
| JP2004524345A (ja) | 2004-08-12 |
| DE60218641D1 (de) | 2007-04-19 |
| US7345063B2 (en) | 2008-03-18 |
| WO2002076457A1 (en) | 2002-10-03 |
| NO20034215L (no) | 2003-11-24 |
| PT1372651E (pt) | 2007-05-31 |
| EP1372651B1 (en) | 2007-03-07 |
| BR0208336A (pt) | 2004-03-23 |
| US20040122020A1 (en) | 2004-06-24 |
| KR20030085030A (ko) | 2003-11-01 |
| ES2280511T3 (es) | 2007-09-16 |
| SI1372651T1 (sl) | 2007-06-30 |
| DE60218641T2 (de) | 2007-11-29 |
| IL157653A0 (en) | 2004-03-28 |
| MXPA03008443A (es) | 2004-01-29 |
| CN1538844A (zh) | 2004-10-20 |
| CA2441933A1 (en) | 2002-10-03 |
| EP1372651A1 (en) | 2004-01-02 |
| NZ528296A (en) | 2005-03-24 |
| ATE355842T1 (de) | 2007-03-15 |
| DK1372651T3 (da) | 2007-05-29 |
| NO20034215D0 (no) | 2003-09-22 |
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