ZA200302636B - Arylpiperazine derivatives and their use as psychotropic agents. - Google Patents

Arylpiperazine derivatives and their use as psychotropic agents. Download PDF

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Publication number
ZA200302636B
ZA200302636B ZA200302636A ZA200302636A ZA200302636B ZA 200302636 B ZA200302636 B ZA 200302636B ZA 200302636 A ZA200302636 A ZA 200302636A ZA 200302636 A ZA200302636 A ZA 200302636A ZA 200302636 B ZA200302636 B ZA 200302636B
Authority
ZA
South Africa
Prior art keywords
compounds
formula
cha
solvates
cehaf
Prior art date
Application number
ZA200302636A
Other languages
English (en)
Inventor
Rudolf Gottschlich
Gerd Bartoszyk
Christoph Syfried
Dieter Dorsch
Juergen Harting
Christoph Van Amsterdam
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200302636B publication Critical patent/ZA200302636B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/40Nitrogen atoms attached in position 8
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200302636A 2000-09-05 2003-04-03 Arylpiperazine derivatives and their use as psychotropic agents. ZA200302636B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10043659A DE10043659A1 (de) 2000-09-05 2000-09-05 Arylpiperazinderivate

Publications (1)

Publication Number Publication Date
ZA200302636B true ZA200302636B (en) 2004-09-08

Family

ID=7655009

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200302636A ZA200302636B (en) 2000-09-05 2003-04-03 Arylpiperazine derivatives and their use as psychotropic agents.

Country Status (15)

Country Link
US (1) US20040014972A1 (cs)
EP (1) EP1326842A1 (cs)
KR (1) KR20030024913A (cs)
CN (1) CN1452614A (cs)
AU (1) AU2001291744A1 (cs)
BR (1) BR0113581A (cs)
CA (1) CA2421219A1 (cs)
CZ (1) CZ2003809A3 (cs)
DE (1) DE10043659A1 (cs)
MX (1) MXPA03001826A (cs)
NO (1) NO20030998D0 (cs)
PL (1) PL360289A1 (cs)
SK (1) SK3612003A3 (cs)
WO (1) WO2002020491A1 (cs)
ZA (1) ZA200302636B (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
WO2004082570A2 (en) * 2003-03-17 2004-09-30 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with dopamine receptor d2 (drd2)
WO2004113333A1 (ja) * 2003-06-23 2004-12-29 Dainippon Sumitomo Pharma Co., Ltd. 老人性痴呆症治療剤
ES2250000B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Procedimiento para la preparacion de ziprasidona.
ES2250001B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Proceso para la purificacion de ziprasidona.
KR100660142B1 (ko) * 2005-01-24 2006-12-20 이명섭 건식 모래 생산 방법 및 그 시스템
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
TW200800959A (en) * 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
TW200808730A (en) * 2006-06-09 2008-02-16 Wyeth Corp Process for synthesizing piperazine-piperidine compounds
TW200831096A (en) * 2006-11-28 2008-08-01 Wyeth Corp Metabolites of 5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl} quinoline and methods of preparation and uses thereof
PE20090188A1 (es) 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
WO1998031679A1 (fr) * 1997-01-21 1998-07-23 Yoshitomi Pharmaceutical Industries, Ltd. Composes de thiophene et leur application medicinale
ES2128266B1 (es) * 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists

Also Published As

Publication number Publication date
CA2421219A1 (en) 2003-03-03
SK3612003A3 (en) 2003-07-01
BR0113581A (pt) 2003-07-15
CZ2003809A3 (cs) 2003-06-18
DE10043659A1 (de) 2002-03-14
EP1326842A1 (de) 2003-07-16
NO20030998L (no) 2003-03-04
US20040014972A1 (en) 2004-01-22
WO2002020491A1 (de) 2002-03-14
KR20030024913A (ko) 2003-03-26
CN1452614A (zh) 2003-10-29
MXPA03001826A (es) 2003-06-04
NO20030998D0 (no) 2003-03-04
AU2001291744A1 (en) 2002-03-22
PL360289A1 (en) 2004-09-06

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