ZA200206841B - Memno peptides, a process for their preparation and their use. - Google Patents
Memno peptides, a process for their preparation and their use. Download PDFInfo
- Publication number
- ZA200206841B ZA200206841B ZA200206841A ZA200206841A ZA200206841B ZA 200206841 B ZA200206841 B ZA 200206841B ZA 200206841 A ZA200206841 A ZA 200206841A ZA 200206841 A ZA200206841 A ZA 200206841A ZA 200206841 B ZA200206841 B ZA 200206841B
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- South Africa
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- compound
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- 238000000034 method Methods 0.000 title claims description 13
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 13
- 230000008569 process Effects 0.000 title claims description 12
- 102000004196 processed proteins & peptides Human genes 0.000 title claims description 9
- 238000002360 preparation method Methods 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 18
- 229910052799 carbon Inorganic materials 0.000 claims description 15
- 206010019280 Heart failures Diseases 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 7
- 238000011282 treatment Methods 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000002609 medium Substances 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 108010055874 memnopeptide A Proteins 0.000 claims description 4
- GRBLBISGALXJDT-LHTGWLQBSA-N memnopeptide a Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(CC(C)C)NC(=O)C1CCCN1C(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C1N(CCC1)C(=O)C(CCC(N)=O)NC(=O)C(CC=1NC=NC=1)NC(=O)C(CCS(C)=O)N1C(C2=CC(O)=C3C[C@]4(OC3=C2C1)[C@]1(CC[C@@H](O)C(C)(C)[C@@H]1CC[C@H]4C)C)=O)CC1=CNC=N1 GRBLBISGALXJDT-LHTGWLQBSA-N 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- 241001598067 Memnoniella echinata Species 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 239000001963 growth medium Substances 0.000 claims description 3
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims description 3
- 150000003462 sulfoxides Chemical class 0.000 claims description 3
- GZCGUPFRVQAUEE-UHFFFAOYSA-N 2,3,4,5,6-pentahydroxyhexanal Chemical compound OCC(O)C(O)C(O)C(O)C=O GZCGUPFRVQAUEE-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- BEPSGCXDIVACBU-IUCAKERBSA-N Pro-His Chemical compound C([C@@H](C(=O)O)NC(=O)[C@H]1NCCC1)C1=CN=CN1 BEPSGCXDIVACBU-IUCAKERBSA-N 0.000 claims description 2
- MCWHYUWXVNRXFV-RWMBFGLXSA-N Pro-Leu-Pro Chemical compound CC(C)C[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@@H]2CCCN2 MCWHYUWXVNRXFV-RWMBFGLXSA-N 0.000 claims description 2
- 150000001412 amines Chemical group 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- 108010077112 prolyl-proline Proteins 0.000 claims description 2
- 108010027345 wheylin-1 peptide Proteins 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 108010009004 proteose-peptone Proteins 0.000 claims 2
- 108010076119 Caseins Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 239000005018 casein Substances 0.000 claims 1
- 235000021240 caseins Nutrition 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 1
- 235000019341 magnesium sulphate Nutrition 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 239000011575 calcium Substances 0.000 description 13
- 102000005681 phospholamban Human genes 0.000 description 8
- 108010059929 phospholamban Proteins 0.000 description 8
- 150000003505 terpenes Chemical group 0.000 description 8
- 235000007586 terpenes Nutrition 0.000 description 8
- 230000026731 phosphorylation Effects 0.000 description 5
- 238000006366 phosphorylation reaction Methods 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 230000000747 cardiac effect Effects 0.000 description 4
- 210000003365 myofibril Anatomy 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- -1 nitrogen-containing terpenes Chemical class 0.000 description 3
- 125000000830 polyketide group Chemical group 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 108091006112 ATPases Proteins 0.000 description 2
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 2
- 108010055297 Sterol Esterase Proteins 0.000 description 2
- 102000000019 Sterol Esterase Human genes 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000002107 myocardial effect Effects 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 239000005445 natural material Substances 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 210000003660 reticulum Anatomy 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 102000000584 Calmodulin Human genes 0.000 description 1
- 108010041952 Calmodulin Proteins 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 102000008130 Cyclic AMP-Dependent Protein Kinases Human genes 0.000 description 1
- 108010049894 Cyclic AMP-Dependent Protein Kinases Proteins 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 102000010180 Endothelin receptor Human genes 0.000 description 1
- 108050001739 Endothelin receptor Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241001071795 Gentiana Species 0.000 description 1
- 108010016183 Human immunodeficiency virus 1 p16 protease Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 101710144867 Inositol monophosphatase Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 101710154541 Modulator protein Proteins 0.000 description 1
- 238000007126 N-alkylation reaction Methods 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 241001279361 Stachybotrys Species 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000037020 contractile activity Effects 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 125000004855 decalinyl group Chemical group C1(CCCC2CCCCC12)* 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 229930004069 diterpene Natural products 0.000 description 1
- 125000000567 diterpene group Chemical group 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000002329 esterase inhibitor Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- ZINJLDJMHCUBIP-UHFFFAOYSA-N ethametsulfuron-methyl Chemical compound CCOC1=NC(NC)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CC=2)C(=O)OC)=N1 ZINJLDJMHCUBIP-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 102000006029 inositol monophosphatase Human genes 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000003835 ketolide antibiotic agent Substances 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 229930003658 monoterpene Natural products 0.000 description 1
- 150000002773 monoterpene derivatives Chemical class 0.000 description 1
- 235000002577 monoterpenes Nutrition 0.000 description 1
- 229930191129 nakijiquinone Natural products 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
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- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000003836 peripheral circulation Effects 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 230000009894 physiological stress Effects 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229930188593 spirodihydrobenzofuranlactam Natural products 0.000 description 1
- 229930187239 stachybocin Natural products 0.000 description 1
- ZSDLLDNVSGVBTP-UHFFFAOYSA-N stachybotrin Natural products CC1CCC2C(C)(C)C(O)CCC2(C)C13Cc4c(O)cc(C5=NCCO5)c(CO)c4O3 ZSDLLDNVSGVBTP-UHFFFAOYSA-N 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00104114A EP1130027A1 (de) | 2000-02-29 | 2000-02-29 | Memno-Peptide, Verfahren zu ihrer Herstellung und Verwendung derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200206841B true ZA200206841B (en) | 2003-07-03 |
Family
ID=8167973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200206841A ZA200206841B (en) | 2000-02-29 | 2002-08-27 | Memno peptides, a process for their preparation and their use. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6627604B2 (cs) |
| EP (2) | EP1130027A1 (cs) |
| JP (1) | JP4787449B2 (cs) |
| KR (1) | KR100997073B1 (cs) |
| CN (1) | CN1274715C (cs) |
| AR (1) | AR029808A1 (cs) |
| AT (1) | ATE313556T1 (cs) |
| AU (2) | AU5031801A (cs) |
| BR (1) | BR0108757A (cs) |
| CA (1) | CA2401032C (cs) |
| CY (1) | CY1105550T1 (cs) |
| CZ (1) | CZ303552B6 (cs) |
| DE (1) | DE60116063T2 (cs) |
| DK (1) | DK1261625T3 (cs) |
| EE (1) | EE05406B1 (cs) |
| ES (1) | ES2254394T3 (cs) |
| HK (1) | HK1052712B (cs) |
| HR (1) | HRP20020703B1 (cs) |
| HU (1) | HU228067B1 (cs) |
| IL (2) | IL151458A0 (cs) |
| ME (1) | ME00379B (cs) |
| MX (1) | MXPA02007845A (cs) |
| NO (1) | NO329082B1 (cs) |
| NZ (1) | NZ521036A (cs) |
| PL (1) | PL206818B1 (cs) |
| RU (1) | RU2261254C2 (cs) |
| SI (1) | SI1261625T1 (cs) |
| SK (1) | SK287310B6 (cs) |
| WO (1) | WO2001064715A2 (cs) |
| ZA (1) | ZA200206841B (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1308613B1 (it) * | 1999-02-17 | 2002-01-09 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella prevenzione di eventi cardiovascolari. |
| EP1130027A1 (de) * | 2000-02-29 | 2001-09-05 | Aventis Pharma Deutschland GmbH | Memno-Peptide, Verfahren zu ihrer Herstellung und Verwendung derselben |
| DE10050091A1 (de) * | 2000-10-09 | 2002-04-25 | Biotechnolog Forschung Gmbh | Casein-Peptidfragmente mit wachstumsbeeinflußender Aktivität auf Zellkulturen |
| ITMI20010129A1 (it) * | 2001-01-25 | 2002-07-25 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco |
| DE10258650A1 (de) * | 2002-12-13 | 2004-06-24 | Aventis Pharma Deutschland Gmbh | Neue Spirobenzofuranlactame und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben |
| US7160917B2 (en) * | 2002-12-13 | 2007-01-09 | Sanofi-Aventis Deutschland Gmbh | Spirobenzofuran lactams and their derivatives, processes for their preparation and use thereof |
| DE102012016127A1 (de) | 2011-08-31 | 2013-02-28 | Daniel Elias | Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels |
| US11030144B2 (en) * | 2018-12-14 | 2021-06-08 | Texas Instruments Incorporated | Peripheral component interconnect (PCI) backplane connectivity system on chip (SoC) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3442815B2 (ja) * | 1992-05-13 | 2003-09-02 | 第一製薬株式会社 | ジアザビシクロアルケン誘導体 |
| WO1995004530A1 (en) * | 1993-08-06 | 1995-02-16 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| JPH07330622A (ja) * | 1994-06-06 | 1995-12-19 | Asahi Chem Ind Co Ltd | 新規生理活性物質スタキボシンｄ及びその製法 |
| RU2083585C1 (ru) * | 1994-12-13 | 1997-07-10 | Волгоградское акционерное общество открытого типа "Химпром" | Способ получения метилового эфира n-бензилоксикарбонил-l-аспартил-l-фенилаланина |
| JPH08283118A (ja) * | 1995-04-07 | 1996-10-29 | Kao Corp | 美白剤 |
| JPH10251262A (ja) * | 1997-01-13 | 1998-09-22 | Mercian Corp | プロテアーゼ阻害物質およびその製造方法 |
| DE19731571A1 (de) * | 1997-07-23 | 1999-01-28 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| DE19754082A1 (de) * | 1997-12-05 | 1999-06-10 | Knoll Ag | Methode zur Bekämpfung der Fettleibigkeit |
| WO1999031255A2 (en) * | 1997-12-16 | 1999-06-24 | Genencor International, Inc. | Novel egiii-like enzymes, dna encoding such enzymes and methods for producing such enzymes |
| EP1130027A1 (de) * | 2000-02-29 | 2001-09-05 | Aventis Pharma Deutschland GmbH | Memno-Peptide, Verfahren zu ihrer Herstellung und Verwendung derselben |
-
2000
- 2000-02-29 EP EP00104114A patent/EP1130027A1/de not_active Withdrawn
-
2001
- 2001-02-15 SK SK1226-2002A patent/SK287310B6/sk not_active IP Right Cessation
- 2001-02-15 CN CNB018057144A patent/CN1274715C/zh not_active Expired - Fee Related
- 2001-02-15 HK HK03104943.7A patent/HK1052712B/zh not_active IP Right Cessation
- 2001-02-15 RU RU2002125877/04A patent/RU2261254C2/ru not_active IP Right Cessation
- 2001-02-15 WO PCT/EP2001/001661 patent/WO2001064715A2/en active IP Right Grant
- 2001-02-15 SI SI200130491T patent/SI1261625T1/sl unknown
- 2001-02-15 HR HR20020703A patent/HRP20020703B1/xx not_active IP Right Cessation
- 2001-02-15 JP JP2001564208A patent/JP4787449B2/ja not_active Expired - Fee Related
- 2001-02-15 EE EEP200200480A patent/EE05406B1/xx not_active IP Right Cessation
- 2001-02-15 IL IL15145801A patent/IL151458A0/xx active IP Right Grant
- 2001-02-15 BR BR0108757-6A patent/BR0108757A/pt active Search and Examination
- 2001-02-15 MX MXPA02007845A patent/MXPA02007845A/es active IP Right Grant
- 2001-02-15 KR KR1020027011092A patent/KR100997073B1/ko not_active Expired - Fee Related
- 2001-02-15 PL PL358300A patent/PL206818B1/pl unknown
- 2001-02-15 CA CA2401032A patent/CA2401032C/en not_active Expired - Fee Related
- 2001-02-15 AU AU5031801A patent/AU5031801A/xx active Pending
- 2001-02-15 ME MEP-2008-591A patent/ME00379B/me unknown
- 2001-02-15 AT AT01923574T patent/ATE313556T1/de active
- 2001-02-15 DK DK01923574T patent/DK1261625T3/da active
- 2001-02-15 CZ CZ20022904A patent/CZ303552B6/cs not_active IP Right Cessation
- 2001-02-15 NZ NZ521036A patent/NZ521036A/en not_active IP Right Cessation
- 2001-02-15 HU HU0204584A patent/HU228067B1/hu not_active IP Right Cessation
- 2001-02-15 AU AU2001250318A patent/AU2001250318B2/en not_active Ceased
- 2001-02-15 EP EP01923574A patent/EP1261625B1/en not_active Expired - Lifetime
- 2001-02-15 DE DE60116063T patent/DE60116063T2/de not_active Expired - Lifetime
- 2001-02-15 ES ES01923574T patent/ES2254394T3/es not_active Expired - Lifetime
- 2001-02-27 AR ARP010100884A patent/AR029808A1/es active IP Right Grant
- 2001-02-28 US US09/794,346 patent/US6627604B2/en not_active Expired - Lifetime
-
2002
- 2002-08-25 IL IL151458A patent/IL151458A/en not_active IP Right Cessation
- 2002-08-27 ZA ZA200206841A patent/ZA200206841B/en unknown
- 2002-08-28 NO NO20024105A patent/NO329082B1/no not_active IP Right Cessation
-
2006
- 2006-02-13 CY CY20061100199T patent/CY1105550T1/el unknown
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