ZA200203434B - Novel apparatus and process for preparing crystalline particles. - Google Patents

Novel apparatus and process for preparing crystalline particles.

Info

Publication number
ZA200203434B
ZA200203434B ZA200203434A ZA200203434A ZA200203434B ZA 200203434 B ZA200203434 B ZA 200203434B ZA 200203434 A ZA200203434 A ZA 200203434A ZA 200203434 A ZA200203434 A ZA 200203434A ZA 200203434 B ZA200203434 B ZA 200203434B
Authority
ZA
South Africa
Prior art keywords
crystalline particles
mixing chamber
substance
liquid
reservoir
Prior art date
Application number
ZA200203434A
Other languages
English (en)
Inventor
Alan Ronald Ferrie
Andrew Patrick Savage
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ZA200203434B publication Critical patent/ZA200203434B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Steroid Compounds (AREA)
ZA200203434A 1999-11-03 2002-04-30 Novel apparatus and process for preparing crystalline particles. ZA200203434B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9925934.3A GB9925934D0 (en) 1999-11-03 1999-11-03 Novel apparatus and process

Publications (1)

Publication Number Publication Date
ZA200203434B true ZA200203434B (en) 2003-02-25

Family

ID=10863815

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200203434A ZA200203434B (en) 1999-11-03 2002-04-30 Novel apparatus and process for preparing crystalline particles.

Country Status (25)

Country Link
EP (2) EP1466595A1 (zh)
JP (1) JP4700247B2 (zh)
KR (1) KR20020047322A (zh)
CN (1) CN1409627A (zh)
AT (1) ATE271853T1 (zh)
AU (1) AU768915B2 (zh)
BR (1) BR0015271A (zh)
CA (1) CA2389908A1 (zh)
CZ (1) CZ20021555A3 (zh)
DE (1) DE60012558T2 (zh)
DK (1) DK1225875T3 (zh)
ES (1) ES2225247T3 (zh)
GB (2) GB9925934D0 (zh)
HK (1) HK1045268B (zh)
HU (1) HUP0203278A3 (zh)
IL (1) IL149366A0 (zh)
MX (1) MXPA02004394A (zh)
NO (1) NO20022059L (zh)
NZ (1) NZ518565A (zh)
PL (1) PL356746A1 (zh)
PT (1) PT1225875E (zh)
SI (1) SI1225875T1 (zh)
TR (1) TR200402709T4 (zh)
WO (1) WO2001032125A2 (zh)
ZA (1) ZA200203434B (zh)

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ATE410225T1 (de) 2001-08-02 2008-10-15 Lg Life Sciences Ltd Verfahren zur herstellung von amino-geschützten 4-aminomethylene-pyrrolidin-3-on-derivaten, gemifloxacin und deren salze
EP1423096B1 (en) * 2001-08-29 2006-08-16 Dow Global Technologies Inc. A process for preparing crystalline drug particles by means of precipitation
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
GB0202564D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process
JP3691459B2 (ja) * 2002-06-14 2005-09-07 久光メディカル株式会社 粉末状吸入剤組成物
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0300427D0 (en) * 2003-01-09 2003-02-05 Univ Strathclyde Pharmaceutical composition
WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
CA2516733C (en) * 2003-02-21 2011-09-27 The University Of Bath Process for the production of particles
MXPA05009413A (es) * 2003-03-04 2005-11-04 Five Star Technologies Inc Dispositivo y procedimiento para cristalizacion por cavitacion hidrodinamica.
US7278982B2 (en) 2003-03-27 2007-10-09 Bioactis Limited Powder medicine applicator for nasal cavity
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US7811606B2 (en) * 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
WO2005009375A2 (en) * 2003-07-22 2005-02-03 Baxter International Inc. Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
WO2006016530A1 (ja) 2004-08-10 2006-02-16 Translational Research, Ltd. 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
WO2006045795A2 (en) * 2004-10-29 2006-05-04 Akzo Nobel N.V. Processes involving the use of antisolvent crystallization
EP1837343A4 (en) * 2004-12-08 2009-07-29 Kuraray Co PROCESS FOR PRODUCING BENZOATE (5 ALPHA, 7 ALPHA) -3-SPIRO-2 '- (1', 3'-DIOXOLAN) -24-OXOCHOLEST-22-EN-7-YLE
WO2006086270A1 (en) 2005-02-10 2006-08-17 Glaxo Group Limited Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
JP5415769B2 (ja) 2006-12-26 2014-02-12 株式会社新日本科学 経鼻投与用製剤
GB0705159D0 (en) 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
GB0724498D0 (en) 2007-12-15 2008-01-30 Univ Strathclyde Slow release compositions
EP2321023B1 (en) * 2008-07-18 2016-06-15 Prosonix Limited Process for improving crystallinity of fluticasone particles
US9101539B2 (en) 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
US8827946B2 (en) 2009-07-31 2014-09-09 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
PT105058B (pt) * 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos
US10370402B2 (en) * 2011-07-08 2019-08-06 Pfizer Limited Process for the preparation of fluticasone propionate form 1
CN102366405A (zh) * 2011-10-21 2012-03-07 江阴长风医药科技有限公司 以氢氟烷烃为抛射剂的氟替卡松丙酸酯气雾剂制剂
EP4218740A1 (en) * 2012-01-13 2023-08-02 XSpray Pharma AB (publ) Novel compositions
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
EP3741772B1 (en) 2012-05-08 2024-06-19 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
AU2014261539A1 (en) * 2013-04-29 2015-12-10 Sanofi Sa Inhalable pharmaceutical compositions and the inhaler devices containing them
PT108368B (pt) * 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas
PT108885B (pt) * 2015-10-12 2019-02-13 Hovione Farm S A Método de produção de partículas compósitas inaláveis mediante a utilização de um atomizador de três fluidos
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
CN110960504A (zh) * 2019-10-31 2020-04-07 上海新黄河制药有限公司 中空颗粒制备方法及干粉吸入制剂
BR112023004247A2 (pt) * 2020-09-08 2023-04-11 Genentech Inc Kits de tubulação para formar uma mistura, sistemas para formar uma composição farmacêutica, métodos para transferir composições farmacêuticas e para fabricar uma composição farmacêutica e amortecedor de pulsação
CN112755301B (zh) * 2021-01-20 2022-03-29 孙洪坤 一种血液病造血干细胞移植用皮肤清洁器

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GB8404749D0 (en) 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor
CA1282405C (en) * 1984-05-21 1991-04-02 Michael R. Violante Method for making uniformly sized particles from water-insoluble organic compounds
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
US4826589A (en) * 1988-06-30 1989-05-02 Gene Hirs Bar screen filter
GB8911259D0 (en) * 1989-05-17 1989-07-05 Fisons Plc Inhalation medicament
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
GB9007027D0 (en) 1990-03-29 1990-05-30 Atomic Energy Authority Uk Precipitation apparatus and method
GB9101967D0 (en) 1991-01-30 1991-03-13 Atomic Energy Authority Uk Reagent mixing
GB9320455D0 (en) 1993-10-05 1993-11-24 Atomic Energy Authority Uk Vortex mixer
GB9620187D0 (en) * 1996-09-27 1996-11-13 Minnesota Mining & Mfg Medicinal aerosol formulations

Also Published As

Publication number Publication date
EP1225875B1 (en) 2004-07-28
WO2001032125A3 (en) 2002-05-16
AU1160401A (en) 2001-05-14
ATE271853T1 (de) 2004-08-15
PL356746A1 (en) 2004-06-28
TR200402709T4 (tr) 2004-11-22
GB0024511D0 (en) 2000-11-22
EP1466595A1 (en) 2004-10-13
JP2003512892A (ja) 2003-04-08
JP4700247B2 (ja) 2011-06-15
MXPA02004394A (es) 2002-09-02
HUP0203278A2 (hu) 2003-01-28
BR0015271A (pt) 2002-12-31
DE60012558T2 (de) 2005-07-28
IL149366A0 (en) 2002-11-10
NZ518565A (en) 2004-04-30
HK1045268A1 (en) 2002-11-22
NO20022059L (no) 2002-06-14
CN1409627A (zh) 2003-04-09
ES2225247T3 (es) 2005-03-16
AU768915B2 (en) 2004-01-08
NO20022059D0 (no) 2002-04-30
KR20020047322A (ko) 2002-06-21
CZ20021555A3 (cs) 2002-11-13
PT1225875E (pt) 2004-12-31
CA2389908A1 (en) 2001-05-10
DE60012558D1 (de) 2004-09-02
DK1225875T3 (da) 2004-11-22
GB9925934D0 (en) 1999-12-29
EP1225875A2 (en) 2002-07-31
HK1045268B (zh) 2005-02-18
WO2001032125A2 (en) 2001-05-10
SI1225875T1 (en) 2004-12-31
HUP0203278A3 (en) 2004-06-28

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