ZA200200673B - Inhibitors of the integrin avbeta6. - Google Patents

Inhibitors of the integrin avbeta6. Download PDF

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Publication number
ZA200200673B
ZA200200673B ZA200200673A ZA200200673A ZA200200673B ZA 200200673 B ZA200200673 B ZA 200200673B ZA 200200673 A ZA200200673 A ZA 200200673A ZA 200200673 A ZA200200673 A ZA 200200673A ZA 200200673 B ZA200200673 B ZA 200200673B
Authority
ZA
South Africa
Prior art keywords
leu
asp
arg
ser
thr
Prior art date
Application number
ZA200200673A
Other languages
English (en)
Inventor
Alfred Jonczyk
Ulrich Groth
Beate Diefenbach
Gunther Zischinsky
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200200673B publication Critical patent/ZA200200673B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA200200673A 1999-06-26 2002-01-24 Inhibitors of the integrin avbeta6. ZA200200673B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19929410A DE19929410A1 (de) 1999-06-26 1999-06-26 Inhibitoren des Integrins avß6

Publications (1)

Publication Number Publication Date
ZA200200673B true ZA200200673B (en) 2003-04-24

Family

ID=7912712

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200200673A ZA200200673B (en) 1999-06-26 2002-01-24 Inhibitors of the integrin avbeta6.

Country Status (17)

Country Link
EP (1) EP1189930A1 (ko)
JP (1) JP2003503422A (ko)
KR (1) KR20020015704A (ko)
CN (1) CN1358195A (ko)
AR (1) AR024472A1 (ko)
AU (1) AU771099B2 (ko)
BR (1) BR0011954A (ko)
CA (1) CA2377224A1 (ko)
CZ (1) CZ20014484A3 (ko)
DE (1) DE19929410A1 (ko)
HU (1) HUP0201729A3 (ko)
MX (1) MXPA01013247A (ko)
NO (1) NO20016341L (ko)
PL (1) PL352374A1 (ko)
SK (1) SK18722001A3 (ko)
WO (1) WO2001000660A1 (ko)
ZA (1) ZA200200673B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
AU2004208865B2 (en) 2003-02-06 2010-06-17 Merck Patent Gmbh Peptidic sulfonamides
GB0520068D0 (en) 2005-10-03 2005-11-09 Cancer Res Technology av peptide ligand
KR20090039739A (ko) 2006-08-03 2009-04-22 아스트라제네카 아베 αVβ6에 대해 작용하는 항체 및 그의 용도
KR102634762B1 (ko) * 2016-11-01 2024-02-06 애로우헤드 파마슈티컬스 인코포레이티드 알파-v 베타-6 인테그린 리간드 및 그의 용도
KR20200083523A (ko) 2017-11-01 2020-07-08 애로우헤드 파마슈티컬스 인코포레이티드 인테그린 리간드 및 그의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2103139A1 (en) * 1991-05-14 1992-11-15 George A. Heavner Peptide inhibitors of inflammation
US20020004482A1 (en) * 1997-08-08 2002-01-10 Xiaozhu Huang Treatment of acute lung injury and fibrosis with antagonists of avbeta6
CN1335853A (zh) * 1998-12-19 2002-02-13 默克专利股份公司 整联蛋白αvβb的抑制剂

Also Published As

Publication number Publication date
PL352374A1 (en) 2003-08-25
JP2003503422A (ja) 2003-01-28
DE19929410A1 (de) 2000-12-28
CA2377224A1 (en) 2001-01-04
SK18722001A3 (sk) 2002-05-09
CZ20014484A3 (cs) 2002-04-17
HUP0201729A2 (en) 2002-08-28
NO20016341L (no) 2002-02-25
CN1358195A (zh) 2002-07-10
HUP0201729A3 (en) 2005-01-28
AU6263000A (en) 2001-01-31
KR20020015704A (ko) 2002-02-28
WO2001000660A1 (de) 2001-01-04
AR024472A1 (es) 2002-10-02
BR0011954A (pt) 2002-05-07
EP1189930A1 (de) 2002-03-27
AU771099B2 (en) 2004-03-11
NO20016341D0 (no) 2001-12-21
MXPA01013247A (es) 2002-07-02

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