AU771099B2 - Inhibitors of the integrin alphavbeta6 - Google Patents

Inhibitors of the integrin alphavbeta6 Download PDF

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Publication number
AU771099B2
AU771099B2 AU62630/00A AU6263000A AU771099B2 AU 771099 B2 AU771099 B2 AU 771099B2 AU 62630/00 A AU62630/00 A AU 62630/00A AU 6263000 A AU6263000 A AU 6263000A AU 771099 B2 AU771099 B2 AU 771099B2
Authority
AU
Australia
Prior art keywords
leu
asp
arg
ser
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU62630/00A
Other languages
English (en)
Other versions
AU6263000A (en
Inventor
Beate Diefenbach
Ulrich Groth
Alfred Jonczyk
Gunther Zischinsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU6263000A publication Critical patent/AU6263000A/en
Application granted granted Critical
Publication of AU771099B2 publication Critical patent/AU771099B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU62630/00A 1999-06-26 2000-06-13 Inhibitors of the integrin alphavbeta6 Ceased AU771099B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19929410 1999-06-26
DE19929410A DE19929410A1 (de) 1999-06-26 1999-06-26 Inhibitoren des Integrins avß6
PCT/EP2000/005404 WO2001000660A1 (de) 1999-06-26 2000-06-13 INHIBITOREN DES INTEGRINS αv$(g)b¿6?

Publications (2)

Publication Number Publication Date
AU6263000A AU6263000A (en) 2001-01-31
AU771099B2 true AU771099B2 (en) 2004-03-11

Family

ID=7912712

Family Applications (1)

Application Number Title Priority Date Filing Date
AU62630/00A Ceased AU771099B2 (en) 1999-06-26 2000-06-13 Inhibitors of the integrin alphavbeta6

Country Status (17)

Country Link
EP (1) EP1189930A1 (ko)
JP (1) JP2003503422A (ko)
KR (1) KR20020015704A (ko)
CN (1) CN1358195A (ko)
AR (1) AR024472A1 (ko)
AU (1) AU771099B2 (ko)
BR (1) BR0011954A (ko)
CA (1) CA2377224A1 (ko)
CZ (1) CZ20014484A3 (ko)
DE (1) DE19929410A1 (ko)
HU (1) HUP0201729A3 (ko)
MX (1) MXPA01013247A (ko)
NO (1) NO20016341L (ko)
PL (1) PL352374A1 (ko)
SK (1) SK18722001A3 (ko)
WO (1) WO2001000660A1 (ko)
ZA (1) ZA200200673B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004208865B2 (en) * 2003-02-06 2010-06-17 Merck Patent Gmbh Peptidic sulfonamides

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
GB0520068D0 (en) 2005-10-03 2005-11-09 Cancer Res Technology av peptide ligand
KR20090039739A (ko) 2006-08-03 2009-04-22 아스트라제네카 아베 αＶβ６에 대해 작용하는 항체 및 그의 용도
KR102634762B1 (ko) * 2016-11-01 2024-02-06 애로우헤드 파마슈티컬스 인코포레이티드 알파-v 베타-6 인테그린 리간드 및 그의 용도
KR20200083523A (ko) 2017-11-01 2020-07-08 애로우헤드 파마슈티컬스 인코포레이티드 인테그린 리간드 및 그의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2103139A1 (en) * 1991-05-14 1992-11-15 George A. Heavner Peptide inhibitors of inflammation
US20020004482A1 (en) * 1997-08-08 2002-01-10 Xiaozhu Huang Treatment of acute lung injury and fibrosis with antagonists of avbeta6
CN1335853A (zh) * 1998-12-19 2002-02-13 默克专利股份公司 整联蛋白αvβb的抑制剂

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004208865B2 (en) * 2003-02-06 2010-06-17 Merck Patent Gmbh Peptidic sulfonamides

Also Published As

Publication number Publication date
PL352374A1 (en) 2003-08-25
JP2003503422A (ja) 2003-01-28
DE19929410A1 (de) 2000-12-28
ZA200200673B (en) 2003-04-24
CA2377224A1 (en) 2001-01-04
SK18722001A3 (sk) 2002-05-09
CZ20014484A3 (cs) 2002-04-17
HUP0201729A2 (en) 2002-08-28
NO20016341L (no) 2002-02-25
CN1358195A (zh) 2002-07-10
HUP0201729A3 (en) 2005-01-28
AU6263000A (en) 2001-01-31
KR20020015704A (ko) 2002-02-28
WO2001000660A1 (de) 2001-01-04
AR024472A1 (es) 2002-10-02
BR0011954A (pt) 2002-05-07
EP1189930A1 (de) 2002-03-27
NO20016341D0 (no) 2001-12-21
MXPA01013247A (es) 2002-07-02

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)