BR0011954A - Inibidores da integrina alfavbeta6 - Google Patents
Inibidores da integrina alfavbeta6Info
- Publication number
- BR0011954A BR0011954A BR0011954-7A BR0011954A BR0011954A BR 0011954 A BR0011954 A BR 0011954A BR 0011954 A BR0011954 A BR 0011954A BR 0011954 A BR0011954 A BR 0011954A
- Authority
- BR
- Brazil
- Prior art keywords
- asp
- arg
- leu
- aia
- phe
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Patente de Invenção: "INIBIDORES DA INTEGRINA ALFA~ v~BETA~ 6~". A invenção refere-se a novos peptídeos da fórmula (I), Ac-Arg-X^ 1^-Asp-X^ 2^-X^ 3^-X^ 4^-X^ 5^-X^ 6^-NH~ 2~, os quais são biologicamente ativos como ligantes da integrina <244>~ v~<225>~ 6~, em que: Ac representa acetila, X^ 1^ representa Ser, Gly, Thr, Asp, Arg, Val, Tyr, His ou Ala; X^ 2^ representa Leu, IIe, NIe, VaI ou Phe; X^ 3^ representa Asp, GIu, Lys, Phe, AIb, NaI, GIy, AIa, BgI ou Phg; X^ 4^ representa GIy, AIa, Ser, <225>-AIa ou <sym>-Abu; X^ 5^ representa Leu, IIe, NIe, VaI ou Phe; e X^ 6^ representa Arg, Har, Lys, Leu, Om, Phe, AIa, Tyr, GIy, Ser ou Asp, onde os aminoácidos mencionados podem ser derivatizados. Os radicais de aminoácido são ligados uns aos outros de um modo em peptídeo via os grupos <244>-amino e <244>-carbóxi. As formas dextro-rotatórias e as formas levo-rotatórias dos radicais de aminoácido opticamente ativos estão contidas, bem como os sais dos referidos peptídeos. Ac-Arg-Thr-Asp-Leu-Asp-Ser-Leu-Arg-NH~ 2~ está excluído. Os peptídeos da invenção também podem ser usados como inibidores eficazes do receptor de integrina <244>~ v~<225>~ 6~ e, assim, para o tratamento de diferentes doenças e achados patológicos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19929410A DE19929410A1 (de) | 1999-06-26 | 1999-06-26 | Inhibitoren des Integrins avß6 |
| PCT/EP2000/005404 WO2001000660A1 (de) | 1999-06-26 | 2000-06-13 | INHIBITOREN DES INTEGRINS αv$(g)b¿6? |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0011954A true BR0011954A (pt) | 2002-05-07 |
Family
ID=7912712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0011954-7A BR0011954A (pt) | 1999-06-26 | 2000-06-13 | Inibidores da integrina alfavbeta6 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1189930A1 (pt) |
| JP (1) | JP2003503422A (pt) |
| KR (1) | KR20020015704A (pt) |
| CN (1) | CN1358195A (pt) |
| AR (1) | AR024472A1 (pt) |
| AU (1) | AU771099B2 (pt) |
| BR (1) | BR0011954A (pt) |
| CA (1) | CA2377224A1 (pt) |
| CZ (1) | CZ20014484A3 (pt) |
| DE (1) | DE19929410A1 (pt) |
| HU (1) | HUP0201729A3 (pt) |
| MX (1) | MXPA01013247A (pt) |
| NO (1) | NO20016341L (pt) |
| PL (1) | PL352374A1 (pt) |
| SK (1) | SK18722001A3 (pt) |
| WO (1) | WO2001000660A1 (pt) |
| ZA (1) | ZA200200673B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| MXPA05008313A (es) * | 2003-02-06 | 2005-09-20 | Merck Patent Gmbh | Sulfonamidas peptidicas. |
| GB0520068D0 (en) | 2005-10-03 | 2005-11-09 | Cancer Res Technology | av peptide ligand |
| BRPI0715141A2 (pt) | 2006-08-03 | 2013-06-04 | Astrazeneca Ab | agente de ligaÇço alvejante, anticorpo isolado, fragmento de anticorpo isolado, molÉcula de Ácido nucleico, vetor, cÉlula hospedeira, mÉtodos para produzir um agente de ligaÇço alvejado, para produzir um anticorpo, para produzir um fragmento de anticorpo, para tratar um tumor maligno em um animal, para tratar inflamaÇço, e para inibir a interaÇço de alfabeta6 com seu ligando, e, conjugado |
| WO2018085415A1 (en) * | 2016-11-01 | 2018-05-11 | Arrowhead Pharmaceuticals, Inc. | Alpha-v beta-6 integrin ligands and uses thereof |
| AU2018359515B2 (en) | 2017-11-01 | 2024-09-19 | Arrowhead Pharmaceuticals, Inc. | Integrin ligands and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06511477A (ja) * | 1991-05-14 | 1994-12-22 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ オクラホマ | 炎症のペプチド阻害剤 |
| KR100586202B1 (ko) * | 1997-08-08 | 2006-06-07 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | ανβ6 길항제로의 급성 폐 상해 및 섬유증의 치료방법 |
| JP2002533064A (ja) * | 1998-12-19 | 2002-10-08 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | インテグリンαｖβ６阻害剤 |
-
1999
- 1999-06-26 DE DE19929410A patent/DE19929410A1/de not_active Withdrawn
-
2000
- 2000-06-13 CZ CZ20014484A patent/CZ20014484A3/cs unknown
- 2000-06-13 CA CA002377224A patent/CA2377224A1/en not_active Abandoned
- 2000-06-13 CN CN00809493A patent/CN1358195A/zh active Pending
- 2000-06-13 BR BR0011954-7A patent/BR0011954A/pt not_active IP Right Cessation
- 2000-06-13 EP EP00949177A patent/EP1189930A1/de not_active Withdrawn
- 2000-06-13 HU HU0201729A patent/HUP0201729A3/hu unknown
- 2000-06-13 KR KR1020017016580A patent/KR20020015704A/ko not_active Application Discontinuation
- 2000-06-13 PL PL00352374A patent/PL352374A1/xx unknown
- 2000-06-13 MX MXPA01013247A patent/MXPA01013247A/es unknown
- 2000-06-13 JP JP2001507066A patent/JP2003503422A/ja active Pending
- 2000-06-13 WO PCT/EP2000/005404 patent/WO2001000660A1/de not_active Application Discontinuation
- 2000-06-13 SK SK1872-2001A patent/SK18722001A3/sk unknown
- 2000-06-13 AU AU62630/00A patent/AU771099B2/en not_active Ceased
- 2000-06-23 AR ARP000103177A patent/AR024472A1/es not_active Application Discontinuation
-
2001
- 2001-12-21 NO NO20016341A patent/NO20016341L/no not_active Application Discontinuation
-
2002
- 2002-01-24 ZA ZA200200673A patent/ZA200200673B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20016341D0 (no) | 2001-12-21 |
| EP1189930A1 (de) | 2002-03-27 |
| DE19929410A1 (de) | 2000-12-28 |
| NO20016341L (no) | 2002-02-25 |
| AU6263000A (en) | 2001-01-31 |
| AR024472A1 (es) | 2002-10-02 |
| CA2377224A1 (en) | 2001-01-04 |
| WO2001000660A1 (de) | 2001-01-04 |
| PL352374A1 (en) | 2003-08-25 |
| CN1358195A (zh) | 2002-07-10 |
| JP2003503422A (ja) | 2003-01-28 |
| MXPA01013247A (es) | 2002-07-02 |
| AU771099B2 (en) | 2004-03-11 |
| SK18722001A3 (sk) | 2002-05-09 |
| HUP0201729A3 (en) | 2005-01-28 |
| ZA200200673B (en) | 2003-04-24 |
| KR20020015704A (ko) | 2002-02-28 |
| HUP0201729A2 (en) | 2002-08-28 |
| CZ20014484A3 (cs) | 2002-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1927 DE 11/12/2007. |