BR0302819A - Peptìdeos sintéticos que exibem atividade inibidora contra invasão de câncer e metástases - Google Patents
Peptìdeos sintéticos que exibem atividade inibidora contra invasão de câncer e metástasesInfo
- Publication number
- BR0302819A BR0302819A BR0302819-4A BR0302819A BR0302819A BR 0302819 A BR0302819 A BR 0302819A BR 0302819 A BR0302819 A BR 0302819A BR 0302819 A BR0302819 A BR 0302819A
- Authority
- BR
- Brazil
- Prior art keywords
- metastasis
- cancer invasion
- inhibitory activity
- activity against
- synthetic peptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PEPTìDEOS SINTéTICOS QUE EXIBEM ATIVIDADE INIBIDORA CONTRA INVASãO DE CâNCER E METáSTASES". A presente invenção se relaciona a peptídeos sintéticos que exibem atividade inibidora contra a invasão de câncer e metástases. Os peptídeos da invenção compreendem o peptídeo PRKPKWDK (ID. DE SEQ.:2) que corresponde aos aminoácidos de 85 a 92 da metaloproteinase da matriz (MMP-2), e fragmentos, análogos e homólogos da ID. DE SEQ. :2. A invenção também se relaciona aos usos de tais peptídeos como inibidores da invasão de câncer e metástases humanas e ainda ao seu uso terapêutico na prevenção e tratamento de câncer e outras condições patológicas relacionadas à degradação da matriz extracelular por MMPS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35131702P | 2002-01-23 | 2002-01-23 | |
PCT/EP2003/000659 WO2003062413A1 (en) | 2002-01-23 | 2003-01-23 | Synthetic peptides and uses thereof for the prevention and therapy of cancer invasion and metastasis |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0302819A true BR0302819A (pt) | 2004-04-27 |
Family
ID=27613485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0302819-4A BR0302819A (pt) | 2002-01-23 | 2003-01-23 | Peptìdeos sintéticos que exibem atividade inibidora contra invasão de câncer e metástases |
Country Status (22)
Country | Link |
---|---|
US (1) | US8012935B2 (pt) |
EP (1) | EP1468085B1 (pt) |
JP (1) | JP2005515262A (pt) |
KR (1) | KR20040077764A (pt) |
CN (2) | CN101007844A (pt) |
AT (1) | ATE425247T1 (pt) |
BR (1) | BR0302819A (pt) |
CA (1) | CA2472775A1 (pt) |
DE (1) | DE60326539D1 (pt) |
EE (1) | EE200400030A (pt) |
ES (1) | ES2324027T3 (pt) |
HR (1) | HRP20040732A2 (pt) |
IL (1) | IL162714A0 (pt) |
LV (2) | LV13289B (pt) |
MX (1) | MXPA04007170A (pt) |
NO (1) | NO20034146L (pt) |
NZ (1) | NZ533738A (pt) |
PL (1) | PL209827B1 (pt) |
RU (1) | RU2346043C2 (pt) |
WO (1) | WO2003062413A1 (pt) |
YU (1) | YU76403A (pt) |
ZA (1) | ZA200405328B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2856598B1 (fr) * | 2003-06-25 | 2005-10-28 | Inst Nat Sante Rech Med | Peptides derives de la proteine mmp-2 et leur utilisation en immunotherapie antitumorale |
JP4911950B2 (ja) * | 2005-11-07 | 2012-04-04 | 晃 伊東 | Mmp−1の部分ペプチドを用いた癌浸潤・転移阻害薬 |
WO2010100282A1 (en) * | 2009-03-06 | 2010-09-10 | Universite Paris Descartes | Method for treating cancer |
US8593732B1 (en) * | 2010-01-23 | 2013-11-26 | Lightsmyth Technologies, Inc. | Partially metallized total internal reflection immersion grating |
US8003110B1 (en) * | 2011-01-24 | 2011-08-23 | Matthias W. Rath | Metalloproteinase oligopeptides and their therapeutic use |
EP2649985A1 (en) * | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
US20140017267A1 (en) * | 2012-07-13 | 2014-01-16 | Matthias W Rath | Metalloproteinase oligopeptides and their therapeutic use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5280106A (en) * | 1988-05-20 | 1994-01-18 | Liotta Lance A | Matrix metalloproteinase peptides: role in diagnosis and therapy |
GB8817075D0 (en) * | 1988-07-18 | 1988-08-24 | Raychem Ltd | Oscillation suppressor |
US5646027A (en) * | 1994-09-08 | 1997-07-08 | Warner-Lambert Company | Process for the production of gelatinase catalytic domain protein |
EP2275553B1 (en) * | 1999-10-29 | 2015-05-13 | Novartis Vaccines and Diagnostics S.r.l. | Neisserial antigenic peptides |
-
2003
- 2003-01-23 EE EEP200400030A patent/EE200400030A/xx unknown
- 2003-01-23 DE DE60326539T patent/DE60326539D1/de not_active Expired - Lifetime
- 2003-01-23 NZ NZ533738A patent/NZ533738A/xx unknown
- 2003-01-23 CA CA002472775A patent/CA2472775A1/en not_active Abandoned
- 2003-01-23 BR BR0302819-4A patent/BR0302819A/pt not_active IP Right Cessation
- 2003-01-23 ES ES03702506T patent/ES2324027T3/es not_active Expired - Lifetime
- 2003-01-23 KR KR10-2004-7011323A patent/KR20040077764A/ko not_active Application Discontinuation
- 2003-01-23 JP JP2003562281A patent/JP2005515262A/ja active Pending
- 2003-01-23 US US10/350,258 patent/US8012935B2/en not_active Expired - Fee Related
- 2003-01-23 YU YU76403A patent/YU76403A/sh unknown
- 2003-01-23 PL PL371254A patent/PL209827B1/pl not_active IP Right Cessation
- 2003-01-23 RU RU2004125599/13A patent/RU2346043C2/ru not_active IP Right Cessation
- 2003-01-23 CN CNA2007100054389A patent/CN101007844A/zh active Pending
- 2003-01-23 EP EP03702506A patent/EP1468085B1/en not_active Expired - Lifetime
- 2003-01-23 AT AT03702506T patent/ATE425247T1/de active
- 2003-01-23 MX MXPA04007170A patent/MXPA04007170A/es not_active Application Discontinuation
- 2003-01-23 WO PCT/EP2003/000659 patent/WO2003062413A1/en active IP Right Grant
- 2003-01-23 IL IL16271403A patent/IL162714A0/xx unknown
- 2003-01-23 CN CNA038026899A patent/CN1622992A/zh active Pending
- 2003-09-17 NO NO20034146A patent/NO20034146L/no not_active Application Discontinuation
-
2004
- 2004-07-05 ZA ZA200405328A patent/ZA200405328B/en unknown
- 2004-08-13 HR HR20040732A patent/HRP20040732A2/hr not_active Application Discontinuation
- 2004-09-17 LV LVP-04-102A patent/LV13289B/en unknown
-
2005
- 2005-10-17 LV LVP-05-134A patent/LV13419B/lv unknown
Also Published As
Publication number | Publication date |
---|---|
YU76403A (sh) | 2006-05-25 |
PL371254A1 (en) | 2005-06-13 |
LV13419B (en) | 2006-09-20 |
ATE425247T1 (de) | 2009-03-15 |
CA2472775A1 (en) | 2003-07-31 |
WO2003062413A1 (en) | 2003-07-31 |
JP2005515262A (ja) | 2005-05-26 |
CN101007844A (zh) | 2007-08-01 |
CN1622992A (zh) | 2005-06-01 |
EP1468085B1 (en) | 2009-03-11 |
RU2004125599A (ru) | 2005-07-10 |
US20030139345A1 (en) | 2003-07-24 |
ES2324027T3 (es) | 2009-07-29 |
MXPA04007170A (es) | 2004-10-29 |
DE60326539D1 (de) | 2009-04-23 |
KR20040077764A (ko) | 2004-09-06 |
EP1468085A1 (en) | 2004-10-20 |
LV13289B (en) | 2005-11-20 |
IL162714A0 (en) | 2005-11-20 |
RU2346043C2 (ru) | 2009-02-10 |
HRP20040732A2 (en) | 2005-06-30 |
US8012935B2 (en) | 2011-09-06 |
NO20034146L (no) | 2003-10-28 |
EE200400030A (et) | 2004-04-15 |
NO20034146D0 (no) | 2003-09-17 |
ZA200405328B (en) | 2006-03-29 |
PL209827B1 (pl) | 2011-10-31 |
NZ533738A (en) | 2006-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A(S) 7A E 8A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011. |