YU76403A - Sintetski peptidi i postupak za preventivnu i terapeutsku upotrebu kod širenja kancera i metastaza - Google Patents
Sintetski peptidi i postupak za preventivnu i terapeutsku upotrebu kod širenja kancera i metastazaInfo
- Publication number
- YU76403A YU76403A YU76403A YUP76403A YU76403A YU 76403 A YU76403 A YU 76403A YU 76403 A YU76403 A YU 76403A YU P76403 A YUP76403 A YU P76403A YU 76403 A YU76403 A YU 76403A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- metastasis
- synthetic peptides
- therapy
- prevention
- cancer invasion
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Ovaj pronalazak se odnosi na sintetske peptide koji pokazuju inhibitorno delovanje na širenje kancera i metastaze. Peptidi pronalaska uključuju PRKPKWDK (SEQ ID:2) peptid koji odgovara amino kiselinama 85 do 92 metaloproteinaze matriksa (MMP-2) i fragmentima, analozima i homolozima SEQ ID:2). Ovaj pronalazak se takodje odnosi na upotrebu ovih peptida za inhibiciju napredovanja kancera kod ljudi i metastaza, a zatim na terapeutsku upotrebu u prevenciji i lečenju kancera i ostalih patoloških stanja koja su u vezi sa degradacijom ekstracelularnog matriksa sa MMPs.[The present invention relates to synthetic peptides of the invention comprises PRKPKWDK (SEQ ID: 2) peptide corresponding to amino acids of 85 to 92 of the matrix metalloproteinase (MMP-2), and fragments, analogs and homologs to SEQ ID:2). The invention also relates to the uses of such peptides as inhibitory of human cancer invasion and metastasis and further to the therapeutic use in preventing and and treating cancer and other pathological conditions related to the degradation of extracellular matrix by MMPs.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35131702P | 2002-01-23 | 2002-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU76403A true YU76403A (sh) | 2006-05-25 |
Family
ID=27613485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU76403A YU76403A (sh) | 2002-01-23 | 2003-01-23 | Sintetski peptidi i postupak za preventivnu i terapeutsku upotrebu kod širenja kancera i metastaza |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8012935B2 (sh) |
| EP (1) | EP1468085B1 (sh) |
| JP (1) | JP2005515262A (sh) |
| KR (1) | KR20040077764A (sh) |
| CN (2) | CN1622992A (sh) |
| AT (1) | ATE425247T1 (sh) |
| BR (1) | BR0302819A (sh) |
| CA (1) | CA2472775A1 (sh) |
| DE (1) | DE60326539D1 (sh) |
| EE (1) | EE200400030A (sh) |
| ES (1) | ES2324027T3 (sh) |
| HR (1) | HRP20040732A2 (sh) |
| IL (1) | IL162714A0 (sh) |
| LV (2) | LV13289B (sh) |
| MX (1) | MXPA04007170A (sh) |
| NO (1) | NO20034146L (sh) |
| NZ (1) | NZ533738A (sh) |
| PL (1) | PL209827B1 (sh) |
| RU (1) | RU2346043C2 (sh) |
| WO (1) | WO2003062413A1 (sh) |
| YU (1) | YU76403A (sh) |
| ZA (1) | ZA200405328B (sh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2856598B1 (fr) * | 2003-06-25 | 2005-10-28 | Inst Nat Sante Rech Med | Peptides derives de la proteine mmp-2 et leur utilisation en immunotherapie antitumorale |
| JP4911950B2 (ja) * | 2005-11-07 | 2012-04-04 | 晃 伊東 | Ｍｍｐ−１の部分ペプチドを用いた癌浸潤・転移阻害薬 |
| EP2403508B1 (en) * | 2009-03-06 | 2015-10-28 | Université Paris Descartes | Method of treating cancer employing gingival fibroblast conditioned medium |
| US8593732B1 (en) * | 2010-01-23 | 2013-11-26 | Lightsmyth Technologies, Inc. | Partially metallized total internal reflection immersion grating |
| US8003110B1 (en) * | 2011-01-24 | 2011-08-23 | Matthias W. Rath | Metalloproteinase oligopeptides and their therapeutic use |
| EP2649985A1 (en) * | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
| US20140017267A1 (en) * | 2012-07-13 | 2014-01-16 | Matthias W Rath | Metalloproteinase oligopeptides and their therapeutic use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5280106A (en) * | 1988-05-20 | 1994-01-18 | Liotta Lance A | Matrix metalloproteinase peptides: role in diagnosis and therapy |
| GB8817075D0 (en) * | 1988-07-18 | 1988-08-24 | Raychem Ltd | Oscillation suppressor |
| US5646027A (en) * | 1994-09-08 | 1997-07-08 | Warner-Lambert Company | Process for the production of gelatinase catalytic domain protein |
| CN101613397A (zh) * | 1999-10-29 | 2009-12-30 | 启龙股份公司 | 奈瑟球菌的抗原性肽 |
-
2003
- 2003-01-23 NZ NZ533738A patent/NZ533738A/xx unknown
- 2003-01-23 JP JP2003562281A patent/JP2005515262A/ja active Pending
- 2003-01-23 US US10/350,258 patent/US8012935B2/en not_active Expired - Fee Related
- 2003-01-23 AT AT03702506T patent/ATE425247T1/de active
- 2003-01-23 PL PL371254A patent/PL209827B1/pl not_active IP Right Cessation
- 2003-01-23 RU RU2004125599/13A patent/RU2346043C2/ru not_active IP Right Cessation
- 2003-01-23 EP EP03702506A patent/EP1468085B1/en not_active Expired - Lifetime
- 2003-01-23 WO PCT/EP2003/000659 patent/WO2003062413A1/en active IP Right Grant
- 2003-01-23 CN CNA038026899A patent/CN1622992A/zh active Pending
- 2003-01-23 EE EEP200400030A patent/EE200400030A/xx unknown
- 2003-01-23 BR BR0302819-4A patent/BR0302819A/pt not_active IP Right Cessation
- 2003-01-23 CA CA002472775A patent/CA2472775A1/en not_active Abandoned
- 2003-01-23 IL IL16271403A patent/IL162714A0/xx unknown
- 2003-01-23 KR KR10-2004-7011323A patent/KR20040077764A/ko not_active Application Discontinuation
- 2003-01-23 CN CNA2007100054389A patent/CN101007844A/zh active Pending
- 2003-01-23 YU YU76403A patent/YU76403A/sh unknown
- 2003-01-23 MX MXPA04007170A patent/MXPA04007170A/es not_active Application Discontinuation
- 2003-01-23 DE DE60326539T patent/DE60326539D1/de not_active Expired - Lifetime
- 2003-01-23 ES ES03702506T patent/ES2324027T3/es not_active Expired - Lifetime
- 2003-09-17 NO NO20034146A patent/NO20034146L/no not_active Application Discontinuation
-
2004
- 2004-07-05 ZA ZA200405328A patent/ZA200405328B/en unknown
- 2004-08-13 HR HR20040732A patent/HRP20040732A2/hr not_active Application Discontinuation
- 2004-09-17 LV LVP-04-102A patent/LV13289B/en unknown
-
2005
- 2005-10-17 LV LVP-05-134A patent/LV13419B/lv unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1622992A (zh) | 2005-06-01 |
| KR20040077764A (ko) | 2004-09-06 |
| BR0302819A (pt) | 2004-04-27 |
| US20030139345A1 (en) | 2003-07-24 |
| IL162714A0 (en) | 2005-11-20 |
| DE60326539D1 (de) | 2009-04-23 |
| PL371254A1 (en) | 2005-06-13 |
| NZ533738A (en) | 2006-03-31 |
| EP1468085A1 (en) | 2004-10-20 |
| CA2472775A1 (en) | 2003-07-31 |
| ATE425247T1 (de) | 2009-03-15 |
| EP1468085B1 (en) | 2009-03-11 |
| LV13419B (en) | 2006-09-20 |
| ES2324027T3 (es) | 2009-07-29 |
| JP2005515262A (ja) | 2005-05-26 |
| WO2003062413A1 (en) | 2003-07-31 |
| ZA200405328B (en) | 2006-03-29 |
| EE200400030A (et) | 2004-04-15 |
| HRP20040732A2 (en) | 2005-06-30 |
| US8012935B2 (en) | 2011-09-06 |
| CN101007844A (zh) | 2007-08-01 |
| MXPA04007170A (es) | 2004-10-29 |
| PL209827B1 (pl) | 2011-10-31 |
| NO20034146D0 (no) | 2003-09-17 |
| RU2004125599A (ru) | 2005-07-10 |
| RU2346043C2 (ru) | 2009-02-10 |
| NO20034146L (no) | 2003-10-28 |
| LV13289B (en) | 2005-11-20 |
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