ZA200108820B - Prucalopride oral solution. - Google Patents
Prucalopride oral solution. Download PDFInfo
- Publication number
- ZA200108820B ZA200108820B ZA200108820A ZA200108820A ZA200108820B ZA 200108820 B ZA200108820 B ZA 200108820B ZA 200108820 A ZA200108820 A ZA 200108820A ZA 200108820 A ZA200108820 A ZA 200108820A ZA 200108820 B ZA200108820 B ZA 200108820B
- Authority
- ZA
- South Africa
- Prior art keywords
- prucalopride
- addition salt
- oral
- solution according
- oral solution
- Prior art date
Links
- ZPMNHBXQOOVQJL-UHFFFAOYSA-N prucalopride Chemical compound C1CN(CCCOC)CCC1NC(=O)C1=CC(Cl)=C(N)C2=C1OCC2 ZPMNHBXQOOVQJL-UHFFFAOYSA-N 0.000 title claims description 28
- 229960003863 prucalopride Drugs 0.000 title claims description 26
- 229940100688 oral solution Drugs 0.000 title claims description 13
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 23
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 18
- 239000000796 flavoring agent Substances 0.000 claims description 16
- 235000019634 flavors Nutrition 0.000 claims description 16
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 15
- 239000000600 sorbitol Substances 0.000 claims description 15
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 13
- 239000005711 Benzoic acid Substances 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 12
- 235000010233 benzoic acid Nutrition 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 11
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 9
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 9
- 235000003599 food sweetener Nutrition 0.000 claims description 8
- 239000003765 sweetening agent Substances 0.000 claims description 8
- 239000001384 succinic acid Substances 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 6
- 239000008213 purified water Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 235000013615 non-nutritive sweetener Nutrition 0.000 claims description 4
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 2
- 240000009088 Fragaria x ananassa Species 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 26
- 238000009472 formulation Methods 0.000 description 19
- AYGJDUHQRFKLBG-UHFFFAOYSA-M sodium;1,1-dioxo-1,2-benzothiazol-3-olate;dihydrate Chemical compound O.O.[Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 AYGJDUHQRFKLBG-UHFFFAOYSA-M 0.000 description 9
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- 230000000694 effects Effects 0.000 description 3
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- 229960002216 methylparaben Drugs 0.000 description 3
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- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99201335 | 1999-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200108820B true ZA200108820B (en) | 2003-01-27 |
Family
ID=8240160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200108820A ZA200108820B (en) | 1999-04-29 | 2001-10-25 | Prucalopride oral solution. |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6413988B1 (ar) |
| EP (1) | EP1176982B1 (ar) |
| JP (1) | JP4773619B2 (ar) |
| KR (1) | KR100669175B1 (ar) |
| CN (1) | CN1165345C (ar) |
| AR (1) | AR023815A1 (ar) |
| AT (1) | ATE254929T1 (ar) |
| AU (1) | AU770073B2 (ar) |
| BG (1) | BG65061B1 (ar) |
| BR (1) | BRPI0010150B8 (ar) |
| CA (1) | CA2371178C (ar) |
| CZ (1) | CZ294070B6 (ar) |
| DE (1) | DE60006799T2 (ar) |
| DK (1) | DK1176982T3 (ar) |
| EA (1) | EA003904B1 (ar) |
| EE (1) | EE05264B1 (ar) |
| ES (1) | ES2211546T3 (ar) |
| HK (1) | HK1045950B (ar) |
| HR (1) | HRP20010764B1 (ar) |
| HU (1) | HU228924B1 (ar) |
| ID (1) | ID30397A (ar) |
| IL (2) | IL146152A0 (ar) |
| JO (1) | JO2181B1 (ar) |
| MX (1) | MXPA01010953A (ar) |
| MY (1) | MY119880A (ar) |
| NO (1) | NO331448B1 (ar) |
| NZ (1) | NZ515119A (ar) |
| PL (1) | PL195674B1 (ar) |
| PT (1) | PT1176982E (ar) |
| SI (1) | SI1176982T1 (ar) |
| SK (1) | SK284847B6 (ar) |
| TR (1) | TR200103121T2 (ar) |
| TW (1) | TW592709B (ar) |
| UA (1) | UA68426C2 (ar) |
| WO (1) | WO2000066170A1 (ar) |
| ZA (1) | ZA200108820B (ar) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050063998A1 (en) * | 1999-10-26 | 2005-03-24 | Francois Marc Karel Jozef | Oral solution containing galantamine and a sweetening agent |
| US20040096423A1 (en) * | 2000-11-24 | 2004-05-20 | Megens Antonius Adrianus Hendrikus Petrus | Use of a triple combination comprising a 5ht3 antagonist, a 5ht4agonist and a laxative for promoting intestinal lavage |
| CN1330646C (zh) | 2002-01-16 | 2007-08-08 | 詹森药业有限公司 | 普卢卡必利－n－氧化物 |
| JP4526247B2 (ja) * | 2002-07-08 | 2010-08-18 | 第一三共株式会社 | 経口用セファロスポリン製剤 |
| FI20022007A0 (fi) * | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
| AU2005272598B2 (en) | 2004-08-12 | 2011-11-17 | Helsinn Therapeutics (U.S.), Inc. | Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues |
| GB201103397D0 (ar) * | 2011-02-28 | 2011-04-13 | Shire Movetis N V | |
| US8568747B1 (en) | 2012-10-05 | 2013-10-29 | Silvergate Pharmaceuticals, Inc. | Enalapril compositions |
| US9463183B1 (en) | 2015-10-30 | 2016-10-11 | Silvergate Pharmaceuticals, Inc. | Lisinopril formulations |
| US9669008B1 (en) | 2016-03-18 | 2017-06-06 | Silvergate Pharmaceuticals, Inc. | Enalapril formulations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
| GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
| JPH05163154A (ja) * | 1991-12-13 | 1993-06-29 | Kanebo Ltd | 経口液剤 |
| TW490465B (en) | 1994-11-24 | 2002-06-11 | Janssen Pharmaceutica Nv | Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof |
| WO2000030640A1 (en) | 1998-11-23 | 2000-06-02 | Janssen Pharmaceutica N.V. | Use of prucalopride for the manufacture of a medicament for the treatment of dyspepsia |
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2000
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- 2000-04-20 PT PT00931072T patent/PT1176982E/pt unknown
- 2000-04-20 TR TR2001/03121T patent/TR200103121T2/xx unknown
- 2000-04-20 CZ CZ20013735A patent/CZ294070B6/cs not_active IP Right Cessation
- 2000-04-20 DK DK00931072T patent/DK1176982T3/da active
- 2000-04-20 EP EP00931072A patent/EP1176982B1/en not_active Expired - Lifetime
- 2000-04-20 SI SI200030294T patent/SI1176982T1/xx unknown
- 2000-04-20 UA UA2001107369A patent/UA68426C2/uk unknown
- 2000-04-20 ID IDW00200102322A patent/ID30397A/id unknown
- 2000-04-20 AT AT00931072T patent/ATE254929T1/de active
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