ZA200108291B - Diaminothiazoles and their use for inhibiting protein kinases. - Google Patents

Diaminothiazoles and their use for inhibiting protein kinases.

Info

Publication number
ZA200108291B
ZA200108291B ZA200108291A ZA200108291A ZA200108291B ZA 200108291 B ZA200108291 B ZA 200108291B ZA 200108291 A ZA200108291 A ZA 200108291A ZA 200108291 A ZA200108291 A ZA 200108291A ZA 200108291 B ZA200108291 B ZA 200108291B
Authority
ZA
South Africa
Prior art keywords
diaminothiazoles
protein kinases
inhibiting protein
inhibiting
kinases
Prior art date
Application number
ZA200108291A
Other languages
English (en)
Inventor
Shao Song Chu
Larry Andrew Alegria
Steven Lee Bender
Suzanne Pritchett Benedict
Allen J Borchardt
Robert Steven Kania
Mitchell David Nambu
Anna Marie Tempczyk-Russell
Sepehr Sarshar
Dilip Bhumralkar
Zhengwei Peng
Yi Michelle Yang
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of ZA200108291B publication Critical patent/ZA200108291B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200108291A 1999-06-04 2001-10-09 Diaminothiazoles and their use for inhibiting protein kinases. ZA200108291B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13781099P 1999-06-04 1999-06-04

Publications (1)

Publication Number Publication Date
ZA200108291B true ZA200108291B (en) 2002-12-24

Family

ID=22479135

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200108291A ZA200108291B (en) 1999-06-04 2001-10-09 Diaminothiazoles and their use for inhibiting protein kinases.

Country Status (34)

Country Link
US (1) US6620828B2 (hu)
EP (1) EP1181283B1 (hu)
JP (1) JP2003501420A (hu)
KR (1) KR20020015333A (hu)
CN (1) CN1359380A (hu)
AP (1) AP2001002341A0 (hu)
AT (1) ATE288424T1 (hu)
AU (1) AU778071B2 (hu)
BG (1) BG106276A (hu)
BR (1) BR0011585A (hu)
CA (1) CA2371158A1 (hu)
CZ (1) CZ20014213A3 (hu)
DE (1) DE60017894T2 (hu)
EA (1) EA200101268A1 (hu)
EE (1) EE200100659A (hu)
ES (1) ES2234628T3 (hu)
HR (1) HRP20020008A2 (hu)
HU (1) HUP0202897A3 (hu)
IL (1) IL146094A0 (hu)
IS (1) IS6183A (hu)
MA (1) MA25530A1 (hu)
MX (1) MXPA01012483A (hu)
NO (1) NO20015045L (hu)
NZ (1) NZ514881A (hu)
OA (1) OA11959A (hu)
PE (1) PE20010211A1 (hu)
PL (1) PL352714A1 (hu)
SK (1) SK17302001A3 (hu)
SV (1) SV2002000096A (hu)
UA (1) UA71971C2 (hu)
UY (1) UY26190A1 (hu)
WO (1) WO2000075120A1 (hu)
YU (1) YU85601A (hu)
ZA (1) ZA200108291B (hu)

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Also Published As

Publication number Publication date
KR20020015333A (ko) 2002-02-27
EP1181283B1 (en) 2005-02-02
IS6183A (is) 2001-11-29
UA71971C2 (en) 2005-01-17
NZ514881A (en) 2003-10-31
CN1359380A (zh) 2002-07-17
HRP20020008A2 (en) 2004-02-29
AP2001002341A0 (en) 2001-12-31
DE60017894D1 (de) 2005-03-10
ES2234628T3 (es) 2005-07-01
EP1181283A1 (en) 2002-02-27
SK17302001A3 (sk) 2004-01-08
MXPA01012483A (es) 2002-07-30
UY26190A1 (es) 2000-12-29
WO2000075120A1 (en) 2000-12-14
AU5725400A (en) 2000-12-28
OA11959A (en) 2006-04-17
IL146094A0 (en) 2002-07-25
CZ20014213A3 (cs) 2002-04-17
YU85601A (sh) 2004-09-03
US6620828B2 (en) 2003-09-16
AU778071B2 (en) 2004-11-11
MA25530A1 (fr) 2002-10-01
JP2003501420A (ja) 2003-01-14
HUP0202897A2 (hu) 2002-12-28
CA2371158A1 (en) 2000-12-14
DE60017894T2 (de) 2005-12-29
ATE288424T1 (de) 2005-02-15
HUP0202897A3 (en) 2004-12-28
BR0011585A (pt) 2002-03-19
PE20010211A1 (es) 2001-03-16
PL352714A1 (en) 2003-09-08
EA200101268A1 (ru) 2002-06-27
US20020025976A1 (en) 2002-02-28
NO20015045D0 (no) 2001-10-17
EE200100659A (et) 2003-02-17
NO20015045L (no) 2002-02-04
SV2002000096A (es) 2002-06-07
BG106276A (bg) 2002-10-31

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