ZA200106973B - Method crystallising N-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide. - Google Patents

Method crystallising N-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide. Download PDF

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Publication number
ZA200106973B
ZA200106973B ZA200106973A ZA200106973A ZA200106973B ZA 200106973 B ZA200106973 B ZA 200106973B ZA 200106973 A ZA200106973 A ZA 200106973A ZA 200106973 A ZA200106973 A ZA 200106973A ZA 200106973 B ZA200106973 B ZA 200106973B
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ZA
South Africa
Prior art keywords
compound
mol
amount
formula
water
Prior art date
Application number
ZA200106973A
Other languages
English (en)
Inventor
Hans-Hermann Lau
Udo Hedtmann
Holger Faasch
Andreas Gappisch
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of ZA200106973B publication Critical patent/ZA200106973B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200106973A 1999-02-26 2001-08-23 Method crystallising N-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide. ZA200106973B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19908527A DE19908527C2 (de) 1999-02-26 1999-02-26 Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid

Publications (1)

Publication Number Publication Date
ZA200106973B true ZA200106973B (en) 2002-08-22

Family

ID=7899073

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200106973A ZA200106973B (en) 1999-02-26 2001-08-23 Method crystallising N-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide.

Country Status (22)

Country Link
US (1) US6303792B1 (pl)
EP (1) EP1155004B1 (pl)
JP (1) JP4625187B2 (pl)
KR (1) KR100626110B1 (pl)
CN (1) CN1127491C (pl)
AR (1) AR022737A1 (pl)
AT (1) ATE257828T1 (pl)
AU (1) AU762394B2 (pl)
BR (1) BR0008566B1 (pl)
CA (1) CA2363875C (pl)
DE (2) DE19908527C2 (pl)
DK (1) DK1155004T3 (pl)
ES (1) ES2214259T3 (pl)
HK (1) HK1043787B (pl)
HU (1) HU228918B1 (pl)
IL (2) IL144867A0 (pl)
NO (1) NO319830B1 (pl)
NZ (1) NZ513777A (pl)
PL (1) PL199365B1 (pl)
PT (1) PT1155004E (pl)
WO (1) WO2000050411A1 (pl)
ZA (1) ZA200106973B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19610955A1 (de) * 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
DK0987256T3 (da) * 1997-08-08 2002-02-11 Aventis Pharma Gmbh Krystalform af N-(4-trifluormethylphenyl)-5-methylisoxazol-4-carboxylsyreamid
IL149792A0 (en) * 1999-12-16 2002-11-10 Teva Pharma Novel processes for making and a new crystalline form of leflunomide
ES2237553T3 (es) * 2000-02-15 2005-08-01 Teva Pharmaceutical Industries Ltd. Procedimiento para la sintesis de leflunomida.
CN107311954B (zh) * 2017-05-17 2020-04-07 力赛生物医药科技（厦门）有限公司 来氟米特晶型化合物、制备方法及其应用
CN114436894A (zh) * 2020-11-04 2022-05-06 欣凯医药化工中间体（上海）有限公司 泰瑞米特钠晶型及制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2854439A1 (de) 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
DE3534440A1 (de) 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
RU2142937C1 (ru) * 1990-05-18 1999-12-20 Хехст АГ Амиды органических кислот, способ их получения и фармацевтическая композиция
DE4127737A1 (de) * 1991-08-22 1993-02-25 Hoechst Ag Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
DK0987256T3 (da) 1997-08-08 2002-02-11 Aventis Pharma Gmbh Krystalform af N-(4-trifluormethylphenyl)-5-methylisoxazol-4-carboxylsyreamid
DE19734438A1 (de) * 1997-08-08 1999-02-11 Hoechst Marion Roussel De Gmbh Kristallform von N-(4-Trifluormethylphenyl)-5-methyl-isoxazole-4-carboxamid

Also Published As

Publication number Publication date
IL144867A (en) 2006-12-31
CN1127491C (zh) 2003-11-12
JP4625187B2 (ja) 2011-02-02
DK1155004T3 (da) 2004-04-13
EP1155004A1 (de) 2001-11-21
ATE257828T1 (de) 2004-01-15
DE19908527A1 (de) 2000-08-31
BR0008566A (pt) 2002-01-22
NZ513777A (en) 2004-01-30
NO20014077L (no) 2001-10-24
WO2000050411A1 (de) 2000-08-31
EP1155004B1 (de) 2004-01-14
IL144867A0 (en) 2002-06-30
KR100626110B1 (ko) 2006-09-20
HU228918B1 (en) 2013-06-28
ES2214259T3 (es) 2004-09-16
PL350422A1 (en) 2002-12-16
CA2363875C (en) 2008-04-29
NO20014077D0 (no) 2001-08-22
HK1043787B (zh) 2004-03-05
HK1043787A1 (en) 2002-09-27
BR0008566B1 (pt) 2011-03-22
HUP0200058A3 (en) 2004-07-28
CN1341106A (zh) 2002-03-20
CA2363875A1 (en) 2000-08-31
PT1155004E (pt) 2004-05-31
AU762394B2 (en) 2003-06-26
JP2002537388A (ja) 2002-11-05
KR20010103774A (ko) 2001-11-23
AR022737A1 (es) 2002-09-04
US6303792B1 (en) 2001-10-16
HUP0200058A2 (hu) 2002-05-29
NO319830B1 (no) 2005-09-19
AU3803800A (en) 2000-09-14
DE19908527C2 (de) 2001-08-30
PL199365B1 (pl) 2008-09-30
DE50005025D1 (de) 2004-02-19

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