ZA200105040B - Sustained-release pharmaceutical preparation containing tilidine mesylate as active ingredient. - Google Patents
Sustained-release pharmaceutical preparation containing tilidine mesylate as active ingredient. Download PDFInfo
- Publication number
- ZA200105040B ZA200105040B ZA200105040A ZA200105040A ZA200105040B ZA 200105040 B ZA200105040 B ZA 200105040B ZA 200105040 A ZA200105040 A ZA 200105040A ZA 200105040 A ZA200105040 A ZA 200105040A ZA 200105040 B ZA200105040 B ZA 200105040B
- Authority
- ZA
- South Africa
- Prior art keywords
- sustained
- tilidine
- active ingredient
- agents
- pharmaceutical composition
- Prior art date
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- 229960001402 tilidine Drugs 0.000 title claims description 44
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- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- 150000005682 diethyl carbonates Chemical class 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000003401 opiate antagonist Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000019809 paraffin wax Nutrition 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 235000010269 sulphur dioxide Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19859636A DE19859636A1 (de) | 1998-12-23 | 1998-12-23 | Kontrolliert freisetzende pharmazeutische Zusammensetzung mit Tilidinmesylat als Wirkstoff |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200105040B true ZA200105040B (en) | 2002-05-22 |
Family
ID=7892368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200105040A ZA200105040B (en) | 1998-12-23 | 2001-06-20 | Sustained-release pharmaceutical preparation containing tilidine mesylate as active ingredient. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6579536B1 (tr) |
| EP (1) | EP1140031B1 (tr) |
| JP (1) | JP2002533381A (tr) |
| AT (1) | ATE252377T1 (tr) |
| AU (1) | AU770293B2 (tr) |
| BR (1) | BR9916575A (tr) |
| CA (1) | CA2355891A1 (tr) |
| CZ (1) | CZ301628B6 (tr) |
| DE (2) | DE19859636A1 (tr) |
| DK (1) | DK1140031T3 (tr) |
| ES (1) | ES2207334T3 (tr) |
| HK (1) | HK1039273A1 (tr) |
| HU (1) | HUP0104647A3 (tr) |
| MX (1) | MXPA01006493A (tr) |
| NO (1) | NO320022B1 (tr) |
| NZ (1) | NZ512079A (tr) |
| PL (1) | PL199024B1 (tr) |
| PT (1) | PT1140031E (tr) |
| SK (1) | SK284901B6 (tr) |
| TR (1) | TR200101864T2 (tr) |
| WO (1) | WO2000038656A1 (tr) |
| ZA (1) | ZA200105040B (tr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| HU1500214D0 (hu) | 1997-12-22 | 2002-03-28 | Euro Celtique Sa | Opioid agonista és antagonista hatóanyagot tartalmazó gyógyszerkészítmény |
| PL357158A1 (en) * | 2000-02-08 | 2004-07-12 | Euro-Celtique, S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| OA12215A (en) | 2000-02-08 | 2006-05-09 | Euro Celtique Sa | Tamper-resistant oral opioid agonist formulations. |
| ES2361148T3 (es) | 2001-05-11 | 2011-06-14 | Endo Pharmaceuticals Inc. | Forma de dosificación de opioides de liberación controlada resistente al abuso. |
| EP2425823A1 (en) | 2002-04-05 | 2012-03-07 | Euro-Celtique S.A. | Pharmaceutical preparation containing oxycodone and naloxone |
| JP4563642B2 (ja) * | 2002-05-31 | 2010-10-13 | ワトソン ラボラトリーズ、インコーポレイテッド | 医薬製剤 |
| DE10233108A1 (de) * | 2002-07-20 | 2004-01-29 | Krewel Meuselbach Gmbh | Retardiertes Schmerzmittel enthaltend Tilidin und ein Lichtschutzmittel |
| DE10250081A1 (de) * | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Vetmedica Gmbh | Wasserlösliche Meloxicam Granulate |
| EP1479381A1 (en) * | 2003-05-19 | 2004-11-24 | Euro-Celtique S.A. | Pharmaceutical dosage form comprising a solid solution |
| EP1604666A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
| JP2008507508A (ja) * | 2004-07-22 | 2008-03-13 | 株式會社アモーレパシフィック | トピラメート徐放性製剤及びその製造方法 |
| EP1702558A1 (en) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
| US20070048373A1 (en) * | 2005-08-30 | 2007-03-01 | Cima Labs Inc. | Dried milled granulate and methods |
| EP2168945A1 (en) * | 2008-09-26 | 2010-03-31 | Hexal Ag | Crystalline forms of Tilidine Mesylate |
| US20120065221A1 (en) | 2009-02-26 | 2012-03-15 | Theraquest Biosciences, Inc. | Extended Release Oral Pharmaceutical Compositions of 3-Hydroxy-N-Methylmorphinan and Method of Use |
| MX347106B (es) | 2009-03-10 | 2017-04-12 | Euro-Celtique S A * | Coposiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona. |
| CN105517551A (zh) | 2013-07-23 | 2016-04-20 | 欧洲凯尔特公司 | 用于在患有疼痛和导致肠生态失调和/或提高肠细菌移位风险之疾病的患者中治疗疼痛的羟考酮与纳洛酮的组合 |
| RU2017106028A (ru) | 2014-09-19 | 2018-10-22 | Дзе Проктер Энд Гэмбл Компани | Лекарственная форма фенилэфрина с пульсирующим высвобождением |
| US10278930B2 (en) | 2017-03-16 | 2019-05-07 | The Procter & Gamble Company | Method for relieving sinus congestion |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU71847A1 (tr) * | 1975-02-14 | 1977-01-05 | ||
| MX9306607A (es) * | 1992-10-26 | 1994-04-29 | Goedecke Ag | Dindihidrogeno-otorfosfato de tilidina, procedimiento para su obtencion y las preparaciones farmaceuticas que lo contienen. |
| US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| DE19710008A1 (de) * | 1997-03-12 | 1998-09-17 | Basf Ag | Feste, mindestens zweiphasige Zubereitungsformen eines Opioid-Analgeticums mit verzögerter Freisetzung |
| PT1073625E (pt) | 1998-04-28 | 2003-11-28 | Hexal Ag | Mesilato de tilidina processos para a sua preparacao e sua composicao farmaceutica |
-
1998
- 1998-12-23 DE DE19859636A patent/DE19859636A1/de not_active Ceased
-
1999
- 1999-12-23 TR TR2001/01864T patent/TR200101864T2/tr unknown
- 1999-12-23 JP JP2000590610A patent/JP2002533381A/ja active Pending
- 1999-12-23 SK SK892-2001A patent/SK284901B6/sk unknown
- 1999-12-23 EP EP99967009A patent/EP1140031B1/de not_active Expired - Lifetime
- 1999-12-23 WO PCT/EP1999/010381 patent/WO2000038656A1/de active IP Right Grant
- 1999-12-23 AT AT99967009T patent/ATE252377T1/de active
- 1999-12-23 US US09/869,033 patent/US6579536B1/en not_active Expired - Fee Related
- 1999-12-23 CA CA002355891A patent/CA2355891A1/en not_active Abandoned
- 1999-12-23 ES ES99967009T patent/ES2207334T3/es not_active Expired - Lifetime
- 1999-12-23 MX MXPA01006493A patent/MXPA01006493A/es not_active Application Discontinuation
- 1999-12-23 BR BR9916575-9A patent/BR9916575A/pt not_active IP Right Cessation
- 1999-12-23 DK DK99967009T patent/DK1140031T3/da active
- 1999-12-23 PT PT99967009T patent/PT1140031E/pt unknown
- 1999-12-23 AU AU22862/00A patent/AU770293B2/en not_active Ceased
- 1999-12-23 HU HU0104647A patent/HUP0104647A3/hu unknown
- 1999-12-23 PL PL348419A patent/PL199024B1/pl not_active IP Right Cessation
- 1999-12-23 NZ NZ512079A patent/NZ512079A/en unknown
- 1999-12-23 DE DE59907481T patent/DE59907481D1/de not_active Expired - Lifetime
- 1999-12-23 CZ CZ20012167A patent/CZ301628B6/cs not_active IP Right Cessation
-
2001
- 2001-06-20 ZA ZA200105040A patent/ZA200105040B/en unknown
- 2001-06-20 NO NO20013060A patent/NO320022B1/no not_active IP Right Cessation
- 2001-12-13 HK HK01108775A patent/HK1039273A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20013060L (no) | 2001-06-20 |
| EP1140031B1 (de) | 2003-10-22 |
| AU770293B2 (en) | 2004-02-19 |
| PL199024B1 (pl) | 2008-08-29 |
| US6579536B1 (en) | 2003-06-17 |
| HK1039273A1 (en) | 2002-04-19 |
| SK284901B6 (sk) | 2006-02-02 |
| MXPA01006493A (es) | 2002-06-04 |
| PL348419A1 (en) | 2002-05-20 |
| AU2286200A (en) | 2000-07-31 |
| JP2002533381A (ja) | 2002-10-08 |
| PT1140031E (pt) | 2004-03-31 |
| EP1140031A1 (de) | 2001-10-10 |
| DK1140031T3 (da) | 2003-12-01 |
| DE19859636A1 (de) | 2000-06-29 |
| DE59907481D1 (de) | 2003-11-27 |
| HUP0104647A3 (en) | 2003-12-29 |
| NO320022B1 (no) | 2005-10-10 |
| HUP0104647A2 (hu) | 2002-03-28 |
| ATE252377T1 (de) | 2003-11-15 |
| SK8922001A3 (en) | 2001-12-03 |
| ES2207334T3 (es) | 2004-05-16 |
| TR200101864T2 (tr) | 2002-01-21 |
| BR9916575A (pt) | 2001-09-18 |
| CZ301628B6 (cs) | 2010-05-05 |
| NZ512079A (en) | 2003-08-29 |
| WO2000038656A1 (de) | 2000-07-06 |
| NO20013060D0 (no) | 2001-06-20 |
| CZ20012167A3 (cs) | 2001-11-14 |
| CA2355891A1 (en) | 2000-07-06 |
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